메뉴 건너뛰기




Volumn 223, Issue 6, 2009, Pages 401-410

Emerging pharmacologic therapies for wet age-related macular degeneration

Author keywords

Age related macular degeneration; Anti inflammatory; Antiangiogenesis; Choroidal neovascularization; Target therapy; Vascular epithelial growth factor

Indexed keywords

ACR 1905; AGN 21174; ANECORTAVE; ARC 1905; ATG 003; BEVACIZUMAB; BEVASIRANIB; COMBRETASTATIN A4 PHOSPHATE; E 10030; JSM 6427; MONTANIDE ISA 51; OT 551; PAZOPANIB; PEGAPTANIB; PIGMENT EPITHELIUM DERIVED FACTOR; PLACEBO; POT 4; PROTEIN TYROSINE KINASE INHIBITOR; RANIBIZUMAB; RAPAMYCIN; RECOMBINANT PROTEIN; SIRNA 027; TG 100801; TRIAMCINOLONE ACETONIDE; UNCLASSIFIED DRUG; VASCULAR ENDOTHELIAL GROWTH FACTOR TRAP EYE; VASCULOTROPIN INHIBITOR; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2; VATALANIB; VERTEPORFIN; VOLOCIXIMAB;

EID: 67650705517     PISSN: 00303755     EISSN: None     Source Type: Journal    
DOI: 10.1159/000228926     Document Type: Article
Times cited : (65)

References (95)
  • 1
    • 0028859859 scopus 로고
    • The relationship of age-related maculopathy, cataract, and glaucoma to visual acuity
    • Klein R, Wang Q, Klein BE, Moss SE, Meuer SM: The relationship of age-related maculopathy, cataract, and glaucoma to visual acuity. Invest Ophthalmol Vis Sci 1995; 36: 182-191.
    • (1995) Invest Ophthalmol Vis Sci , vol.36 , pp. 182-191
    • Klein, R.1    Wang, Q.2    Klein, B.E.3    Moss, S.E.4    Meuer, S.M.5
  • 2
    • 0037211158 scopus 로고    scopus 로고
    • Common eye diseases of elderly people: Identifying and treating causes of vision loss
    • Harvey PT: Common eye diseases of elderly people: identifying and treating causes of vision loss. Gerontology 2003; 49: 1-11.
    • (2003) Gerontology , vol.49 , pp. 1-11
    • Harvey, P.T.1
  • 3
    • 0026668107 scopus 로고
    • Immunohistochemical and histochemical properties of surgically excised subretinal neovascular membranes in age-related macular degeneration
    • Grossniklaus HE, Martinez JA, Brown VB, Lambert HM, Sternberg P, Capone A, et al: Immunohistochemical and histochemical properties of surgically excised subretinal neovascular membranes in age-related macular degeneration. Am J Ophthalmol 1992; 114: 464-472.
    • (1992) Am J Ophthalmol , vol.114 , pp. 464-472
    • Grossniklaus, H.E.1    Martinez, J.A.2    Brown, V.B.3    Lambert, H.M.4    Sternberg, P.5    Capone, A.6
  • 4
    • 4143136640 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: Basic science and clinical progress
    • DOI 10.1210/er.2003-0027
    • Ferrara N: Vascular endothelial growth factor: basic science and clinical progress. Endocr Rev 2004; 25: 581-611. (Pubitemid 39099316)
    • (2004) Endocrine Reviews , vol.25 , Issue.4 , pp. 581-611
    • Ferrara, N.1
  • 5
    • 14844357211 scopus 로고    scopus 로고
    • The vascular endothelial growth factor (VEGF) family: Angiogenic factors in health and disease
    • Holmes DI, Zachary L: The vascular endothelial growth factor (VEGF) family: angiogenic factors in health and disease. Genome Biol 2005; 6: 209.
    • (2005) Genome Biol , vol.6 , pp. 209
    • Holmes, D.I.1    Zachary, L.2
  • 6
    • 0037900481 scopus 로고    scopus 로고
    • Placental growth factor, a member of the VEGF family, contributes to the development of choroidal neovascularization
    • Rakic JM, Lambert V, Devy L, Luttun A, Carmeliet P, Claes C, et al: Placental growth factor, a member of the VEGF family, contributes to the development of choroidal neovascularization. Invest Ophthalmol Vis Sci 2003; 44: 3186-3193.
    • (2003) Invest Ophthalmol Vis Sci , vol.44 , pp. 3186-3193
    • Rakic, J.M.1    Lambert, V.2    Devy, L.3    Luttun, A.4    Carmeliet, P.5    Claes, C.6
  • 8
    • 0036959644 scopus 로고    scopus 로고
    • Preclinical and phase 1A clinical evaluation of an anti-VEGF pegylated aptamer (EYE001) for the treatment of exudative age-related macular degeneration
    • Eyetech Study Group
    • Eyetech Study Group: Preclinical and phase 1A clinical evaluation of an anti-VEGF pegylated aptamer (EYE001) for the treatment of exudative age-related macular degeneration. Retina 2002; 22: 143-152.
    • (2002) Retina , vol.22 , pp. 143-152
  • 12
    • 33749451356 scopus 로고    scopus 로고
    • Ranibizumab versus verteporfin for neovascular age-related macular degeneration
    • Brown DM, Kaiser PK, Michels M, Soubrane G, Heier JS, Kim RY, et al: Ranibizumab versus verteporfin for neovascular age-related macular degeneration. N Engl J Med 2006; 355: 1432-1444.
    • (2006) N Engl J Med , vol.355 , pp. 1432-1444
    • Brown, D.M.1    Kaiser, P.K.2    Michels, M.3    Soubrane, G.4    Heier, J.S.5    Kim, R.Y.6
  • 13
    • 38349172455 scopus 로고    scopus 로고
    • Randomized, double-masked, sham-controlled trial of ranibizumab for neovascular age-related macular degeneration: PIER Study year 1
    • Regillo CD, Brown DM, Abraham P, Yue H, Ianchulev T, Schneider S, Shams N: Randomized, double-masked, sham-controlled trial of ranibizumab for neovascular age-related macular degeneration: PIER Study year 1. Am J Ophthalmol 2008; 145: 239-248.
    • (2008) Am J Ophthalmol , vol.145 , pp. 239-248
    • Regillo, C.D.1    Brown, D.M.2    Abraham, P.3    Yue, H.4    Ianchulev, T.5    Schneider, S.6    Shams, N.7
  • 14
    • 43049176776 scopus 로고    scopus 로고
    • Ranibizumab combined with verteporfin photodynamic therapy in neovascular age-related macular degeneration (FOCUS): Year 2 results
    • Antoszyk AN, Tuomi L, Chung CY, Singh A, and FOCUS Study Group: Ranibizumab combined with verteporfin photodynamic therapy in neovascular age-related macular degeneration (FOCUS): year 2 results. Am J Ophthalmol 2008; 145: 862-874.
    • (2008) Am J Ophthalmol , vol.145 , pp. 862-874
    • Antoszyk, A.N.1    Tuomi, L.2    Chung, C.Y.3    Singh, A.4    Study Group, F.5
  • 17
    • 20144372969 scopus 로고    scopus 로고
    • Systemic bevacizumab (Avastin) therapy for neovascular age-related macular degeneration twelveweek results of an uncontrolled open-label clinical study
    • Michels S, Rosenfeld PJ, Puliafito CA, Marcus EN, Venkatraman AS: Systemic bevacizumab (Avastin) therapy for neovascular age-related macular degeneration twelveweek results of an uncontrolled open-label clinical study. Ophthalmology 2005; 112: 1035-1047.
    • (2005) Ophthalmology , vol.112 , pp. 1035-1047
    • Michels, S.1    Rosenfeld, P.J.2    Puliafito, C.A.3    Marcus, E.N.4    Venkatraman, A.S.5
  • 20
    • 65349138513 scopus 로고    scopus 로고
    • Outcome of bevacizumab (Avastin) injection in patients with age-related macular degeneration and low visual acuity
    • Ehrlich R, Weinberger D: Outcome of bevacizumab (Avastin) injection in patients with age-related macular degeneration and low visual acuity. Retina 2008; 28: 1302-1307.
    • (2008) Retina , vol.28 , pp. 1302-1307
    • Ehrlich, R.1    Weinberger, D.2
  • 21
    • 51149109372 scopus 로고    scopus 로고
    • How to treat recurrences after Avastin treatment for neovascular AMD: Stick to Avastin or switch to Lucentis?
    • Wolf A, Kook D, Strauss R, Kampik A, Haritoglou C: How to treat recurrences after Avastin treatment for neovascular AMD: stick to Avastin or switch to Lucentis? Br J Ophthalmol 2008; 92: 1297-1298.
    • (2008) Br J Ophthalmol , vol.92 , pp. 1297-1298
    • Wolf, A.1    Kook, D.2    Strauss, R.3    Kampik, A.4    Haritoglou, C.5
  • 24
    • 0036287302 scopus 로고    scopus 로고
    • Prevention of thecal angiogenesis, antral follicular growth, and ovulation in the primate by treatment with vascular endothelial growth factor Trap R1R2
    • Wulff C, Wilson H, Wiegand SJ, Rudge JS, Fraser HM: Prevention of thecal angiogenesis, antral follicular growth, and ovulation in the primate by treatment with vascular endothelial growth factor Trap R1R2. Endocrinology 2002; 143: 2797-2807.
    • (2002) Endocrinology , vol.143 , pp. 2797-2807
    • Wulff, C.1    Wilson, H.2    Wiegand, S.J.3    Rudge, J.S.4    Fraser, H.M.5
  • 25
    • 33747874091 scopus 로고    scopus 로고
    • A phase i trial of an IV-administered vascular endothelial growth factor trap for treatment in patients with choroidal neovascularization due to age-related macular degeneration
    • Nguyen QD, Shah SM, Hafiz G, Quinlan E, Sung J, Chu K, Cedarbaum JM, Campochiaro PA: A phase I trial of an IV-administered vascular endothelial growth factor trap for treatment in patients with choroidal neovascularization due to age-related macular degeneration. Ophthalmology 2006; 113: 1521-1522.
    • (2006) Ophthalmology , vol.113 , pp. 1521-1522
    • Nguyen, Q.D.1    Shah, S.M.2    Hafiz, G.3    Quinlan, E.4    Sung, J.5    Chu, K.6    Cedarbaum, J.M.7    Campochiaro, P.A.8
  • 31
    • 70350570833 scopus 로고    scopus 로고
    • Accessed January 2008 at
    • OPKO's SiRNA Drug for AMD Shows Promise. Accessed January 2008 at: http:// www.retinalphysician.com/article.aspx? article=101325
    • OPKO's SiRNA Drug for AMD Shows Promise
  • 33
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N, Gerber HP, LeCouter J: The biology of VEGF and its receptors. Nat Med 2003; 9: 669-676.
    • (2003) Nat Med , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    Lecouter, J.3
  • 34
    • 70350574400 scopus 로고    scopus 로고
    • Vascular permeability factor (VPF)/vascular endothelial growth factor (VEGFR-1) modulates mitogenic activity of VEGFR-2 in endothelial cells
    • Zeng H, Dvorak HF, Muchopadhyay D: Vascular permeability factor (VPF)/vascular endothelial growth factor (VEGFR-1) modulates mitogenic activity of VEGFR-2 in endothelial cells. J Biol Chem 2000; 159: 993-10008.
    • (2000) J Biol Chem , vol.159 , pp. 993-10008
    • Zeng, H.1    Dvorak, H.F.2    Muchopadhyay, D.3
  • 35
    • 0035972251 scopus 로고    scopus 로고
    • Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis
    • Hellström M, Gerhardt H, Kalén K, Li X, Eriksson U, Wolburg H, et al: Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis. J Cell Biol 2001; 153: 543-553.
    • (2001) J Cell Biol , vol.153 , pp. 543-553
    • Hellström, M.1    Gerhardt, H.2    Kalén, K.3    Li, X.4    Eriksson, U.5    Wolburg, H.6
  • 36
    • 0031834239 scopus 로고    scopus 로고
    • A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF
    • Benjamin LE, Hemo I, Keshet E: A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF. Development 1998; 125: 1591-1598.
    • (1998) Development , vol.125 , pp. 1591-1598
    • Benjamin, L.E.1    Hemo, I.2    Keshet, E.3
  • 37
    • 33744728068 scopus 로고    scopus 로고
    • Inhibition of plateletderived growth factor B signalling enhances the efficacy of anti-vascular endothelial growth factor therapy in multiple models of ocular neovascularization
    • Jo N, Maihos C, Ju M: Inhibition of plateletderived growth factor B signalling enhances the efficacy of anti-vascular endothelial growth factor therapy in multiple models of ocular neovascularization. Am J Pathol 2006; 168: 2036-2053.
    • (2006) Am J Pathol , vol.168 , pp. 2036-2053
    • Jo, N.1    Maihos, C.2    Ju, M.3
  • 38
    • 41149178633 scopus 로고    scopus 로고
    • Topical administration of multi-targeted kinase inhibitor suppresses choroidal neovascularization and retinal edema
    • Doukas J, Mahesh S, Umeda N, Kachi S, Akiyama H, Yokoi K, et al: Topical administration of multi-targeted kinase inhibitor suppresses choroidal neovascularization and retinal edema. J Cell Physiol 2008; 216: 29-37.
    • (2008) J Cell Physiol , vol.216 , pp. 29-37
    • Doukas, J.1    Mahesh, S.2    Umeda, N.3    Kachi, S.4    Akiyama, H.5    Yokoi, K.6
  • 41
    • 33748979577 scopus 로고    scopus 로고
    • Antivascular endothelial growth factor agents and their development: Therapeutic implications in ocular diseases
    • Kaiser PK: Antivascular endothelial growth factor agents and their development: therapeutic implications in ocular diseases. Am J Ophthalmol 2006; 142: 660-668.
    • (2006) Am J Ophthalmol , vol.142 , pp. 660-668
    • Kaiser, P.K.1
  • 43
    • 39049095199 scopus 로고    scopus 로고
    • Pazopanib, a potent orally administered smallmolecule multitargeted tyrosine kinase inhibitor for renal cell carcinoma
    • Sonpavde G, Hutson TE, Sternberg CN: Pazopanib, a potent orally administered smallmolecule multitargeted tyrosine kinase inhibitor for renal cell carcinoma. Expert Opin Investig Drugs 2008; 17: 253-261.
    • (2008) Expert Opin Investig Drugs , vol.17 , pp. 253-261
    • Sonpavde, G.1    Hutson, T.E.2    Sternberg, C.N.3
  • 45
    • 31444440290 scopus 로고    scopus 로고
    • Suppression of ocular neovascularization with siRNA targeting VEGF receptor 1
    • Shen J, Sarmul R, Silva RL, Akiyama H, Liu H, Saishin Y, et al: Suppression of ocular neovascularization with siRNA targeting VEGF receptor 1. Gene Ther 2006; 13: 225-234.
    • (2006) Gene Ther , vol.13 , pp. 225-234
    • Shen, J.1    Sarmul, R.2    Silva, R.L.3    Akiyama, H.4    Liu, H.5    Saishin, Y.6
  • 51
    • 18844453162 scopus 로고    scopus 로고
    • Evidence for an inflammatory process in age-related macular degeneration gains new support
    • Bok D: Evidence for an inflammatory process in age-related macular degeneration gains new support. Proc Natl Acad Sci USA 2005; 102: 7053-7054.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 7053-7054
    • Bok, D.1
  • 52
    • 0036978519 scopus 로고    scopus 로고
    • Macrophage and retinal pigment epithelium expression of angiogenic cytokines in choroidal neovascularization
    • Grossniklaus HE, Ling JX, Wallace TM, Dithmar S, Lawson DH, Cohen C, et al: Macrophage and retinal pigment epithelium expression of angiogenic cytokines in choroidal neovascularization. Mol Vis 2002; 8: 119-126.
    • (2002) Mol Vis , vol.8 , pp. 119-126
    • Grossniklaus, H.E.1    Ling, J.X.2    Wallace, T.M.3    Dithmar, S.4    Lawson, D.H.5    Cohen, C.6
  • 53
    • 70350569067 scopus 로고
    • Early stages of age-related macular degeneration: An immunofluorescence and electron microscopic study
    • Van der Schaft TL, Mooy CM, Bruijn WC, Jong PT: Early stages of age-related macular degeneration: an immunofluorescence and electron microscopic study. Br J Ophthalmol 1993; 81: 38-47.
    • (1993) Br J Ophthalmol , vol.81 , pp. 38-47
    • Van Der Schaft, T.L.1    Mooy, C.M.2    Bruijn, W.C.3    Jong, P.T.4
  • 54
    • 70350569068 scopus 로고    scopus 로고
    • The effect of anecortave acetate on VEGF message and protein levels in hypoxic Muller cells and in rat OIR
    • E-abstr 4177
    • Yang R, McColm JR, Bingaman DP, Penn JS: The effect of anecortave acetate on VEGF message and protein levels in hypoxic Muller cells and in rat OIR. Invest Ophthalmol Vis Sci 2005; 46:E-abstr 4177.
    • (2005) Invest Ophthalmol Vis Sci , vol.46
    • Yang, R.1    McColm, J.R.2    Bingaman, D.P.3    Penn, J.S.4
  • 55
    • 33748778410 scopus 로고    scopus 로고
    • Local delivery of anecortave acetate inhibits the expression of retinal IGF-1/ IGF-1 receptor in the rat OIR model
    • E-abstr 4135
    • Liu C, Gu X, Wang W, Bingaman DO, Bingaman H: Local delivery of anecortave acetate inhibits the expression of retinal IGF-1/ IGF-1 receptor in the rat OIR model. Invest Ophthalmol Vis Sci 2005; 46:E-abstr 4135.
    • (2005) Invest Ophthalmol Vis Sci , vol.46
    • Liu, C.1    Gu, X.2    Wang, W.3    Bingaman, D.O.4    Bingaman, H.5
  • 57
    • 29644440836 scopus 로고    scopus 로고
    • Anecortave acetate (15 milligrams) versus photodynamic therapy for treatment of subfoveal neovascularization in age-related macular degeneration
    • Slakter JS, Bochow T, D'Amico DJ, Marks B, Jerdan J, Sullivan EK, et al: Anecortave acetate (15 milligrams) versus photodynamic therapy for treatment of subfoveal neovascularization in age-related macular degeneration. Ophthalmology 2006; 113: 3-13.
    • (2006) Ophthalmology , vol.113 , pp. 3-13
    • Slakter, J.S.1    Bochow, T.2    D'Amico, D.J.3    Marks, B.4    Jerdan, J.5    Sullivan, E.K.6
  • 58
    • 0037653669 scopus 로고    scopus 로고
    • A randomized clinical trial of a single dose of intravitreal triamcinolone acetonide for neovascular age-related macular degeneration: One-year results
    • Gillies MC, Simpson JM, Luo W, Penfold P, Hunyor AB, Chua W, et al: A randomized clinical trial of a single dose of intravitreal triamcinolone acetonide for neovascular age-related macular degeneration: one-year results. Arch Ophthalmol 2003; 121: 667-673.
    • (2003) Arch Ophthalmol , vol.121 , pp. 667-673
    • Gillies, M.C.1    Simpson, J.M.2    Luo, W.3    Penfold, P.4    Hunyor, A.B.5    Chua, W.6
  • 59
    • 27744543923 scopus 로고    scopus 로고
    • The glucocorticoid triamcinolone acetonide inhibits osmotic swelling of retinal glial cells via stimulation of endogenous adenosine signaling
    • Uckermann O, Kutzera F, Wolf A, Pannicke T, Reichenbach A, Wiedemann P, et al: The glucocorticoid triamcinolone acetonide inhibits osmotic swelling of retinal glial cells via stimulation of endogenous adenosine signaling. J Pharmacol Exp Ther 2005; 315: 1036-1045.
    • (2005) J Pharmacol Exp Ther , vol.315 , pp. 1036-1045
    • Uckermann, O.1    Kutzera, F.2    Wolf, A.3    Pannicke, T.4    Reichenbach, A.5    Wiedemann, P.6
  • 64
    • 0031755148 scopus 로고    scopus 로고
    • Nuclear factor kappa B: A pivotal role in the systemic inflammatory response syndrome and new target for therapy
    • Christman JW, Lancaster LH, Blackwell TS: Nuclear factor kappa B: a pivotal role in the systemic inflammatory response syndrome and new target for therapy. Intensive Care Med 1998; 24: 1131-1138.
    • (1998) Intensive Care Med , vol.24 , pp. 1131-1138
    • Christman, J.W.1    Lancaster, L.H.2    Blackwell, T.S.3
  • 67
  • 68
    • 0035417875 scopus 로고    scopus 로고
    • Mechanisms associated with tumor vascular shut-down induced by combretastatin A-4 phosphate: Intravital microscopy and measurement of vascular permeability
    • Tozer GM, Prise VE, Wilson J: Mechanisms associated with tumor vascular shut-down induced by combretastatin A-4 phosphate: intravital microscopy and measurement of vascular permeability. Cancer Res 2001; 61: 6413-6422.
    • (2001) Cancer Res , vol.61 , pp. 6413-6422
    • Tozer, G.M.1    Prise, V.E.2    Wilson, J.3
  • 72
    • 0036184047 scopus 로고    scopus 로고
    • Pigment epithelium- derived factor suppresses ischemia-induced retinal neovascularization and VEGFinduced migration and growth
    • Duh EJ, Yang HS, Suzuma I, Miyagi M, Youngman E, Mori K, et al: Pigment epithelium- derived factor suppresses ischemia-induced retinal neovascularization and VEGFinduced migration and growth. Invest Ophthalmol Vis Sci 2002; 43: 821-829.
    • (2002) Invest Ophthalmol Vis Sci , vol.43 , pp. 821-829
    • Duh, E.J.1    Yang, H.S.2    Suzuma, I.3    Miyagi, M.4    Youngman, E.5    Mori, K.6
  • 73
    • 0036297886 scopus 로고    scopus 로고
    • Regression of ocular neovascularization in response to increased expression of pigment epithelium-derived factor
    • Mori K, Gehlbach P, Ando A, McVey D, Wei L, Campochiaro PA: Regression of ocular neovascularization in response to increased expression of pigment epithelium-derived factor. Invest Ophthalmol Vis Sci 2002; 43: 2428-2434.
    • (2002) Invest Ophthalmol Vis Sci , vol.43 , pp. 2428-2434
    • Mori, K.1    Gehlbach, P.2    Ando, A.3    McVey, D.4    Wei, L.5    Campochiaro, P.A.6
  • 74
    • 32944481724 scopus 로고    scopus 로고
    • Adenoviral vector-delivered pigment epithelium-derived factor for neovascular age-related macular degeneration: Results of a phase i clinical trial
    • Campochiaro PA, Nguyen QD, Shah SM, Klein ML, Holz E, Frank RN, et al: Adenoviral vector-delivered pigment epithelium-derived factor for neovascular age-related macular degeneration: results of a phase I clinical trial. Hum Gene Ther 2006; 17: 167-176.
    • (2006) Hum Gene Ther , vol.17 , pp. 167-176
    • Campochiaro, P.A.1    Nguyen, Q.D.2    Shah, S.M.3    Klein, M.L.4    Holz, E.5    Frank, R.N.6
  • 75
    • 0035514256 scopus 로고    scopus 로고
    • An open-label, phase I, single administration, dose-escalation study of ADGVPEDF.11D (ADPEDF) in neovascular age-related macular degeneration (AMD)
    • Rasmussen H, Chu KW, Campochairo P, Gehlbach PL, Haller JA, Handa JT, et al: An open-label, phase I, single administration, dose-escalation study of ADGVPEDF.11D (ADPEDF) in neovascular age-related macular degeneration (AMD). Hum Gene Ther 2001; 12: 2029-2032.
    • (2001) Hum Gene Ther , vol.12 , pp. 2029-2032
    • Rasmussen, H.1    Chu, K.W.2    Campochairo, P.3    Gehlbach, P.L.4    Haller, J.A.5    Handa, J.T.6
  • 77
  • 83
    • 0036174289 scopus 로고    scopus 로고
    • Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: Involvement of vascular endothelial growth factor
    • Guba M, Breitenbuch PV, Geissler E, Koehl G, Steinbauer M, Jauch K: Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor. Nat Med 2002; 8: 128-135.
    • (2002) Nat Med , vol.8 , pp. 128-135
    • Guba, M.1    Breitenbuch, P.V.2    Geissler, E.3    Koehl, G.4    Steinbauer, M.5    Jauch, K.6
  • 88
    • 84888136922 scopus 로고    scopus 로고
    • (accessed March 18, 2008)
    • Glossary of Clinical Trials Terms. http:// clinicaltrials.gov/ct2/info/ glossary (accessed March 18, 2008).
    • Glossary of Clinical Trials Terms
  • 89
    • 0035996280 scopus 로고    scopus 로고
    • Efficacy of Prinomastat (AG3340), a matrix metalloprotease inhibitor, in treatment of retinal neovascularization
    • Garcia C, Bartsch DU, Rivero ME, Hagedorn M, McDermott CD, Bergeron-Lynn G, et al: Efficacy of Prinomastat (AG3340), a matrix metalloprotease inhibitor, in treatment of retinal neovascularization. Curr Eye Res 2002; 24: 33-38.
    • (2002) Curr Eye Res , vol.24 , pp. 33-38
    • Garcia, C.1    Bartsch, D.U.2    Rivero, M.E.3    Hagedorn, M.4    McDermott, C.D.5    Bergeron-Lynn, G.6
  • 90
    • 8544270082 scopus 로고    scopus 로고
    • Pharmacological Therapy for Macular Degeneration Study Group: Interferon alfa-2a is ineffective for patients with choroidal neovascularization secondary to age-related macular degeneration: Results of a prospective randomized placebo-controlled clinical trial
    • Pharmacological Therapy for Macular Degeneration Study Group: Interferon alfa-2a is ineffective for patients with choroidal neovascularization secondary to age-related macular degeneration: results of a prospective randomized placebo-controlled clinical trial. Arch Ophthalmol 1997; 115: 865-872.
    • (1997) Arch Ophthalmol , vol.115 , pp. 865-872
  • 95
    • 33846973642 scopus 로고    scopus 로고
    • Triple therapy for choroidal neovascularization due to age-related macular degeneration: Verteporfin PDT, bevacizumab, and dexamethasone
    • Augustin AJ, Puls S, Offermann I: Triple therapy for choroidal neovascularization due to age-related macular degeneration: verteporfin PDT, bevacizumab, and dexamethasone. Retina 2007; 27: 133-140.
    • (2007) Retina , vol.27 , pp. 133-140
    • Augustin, A.J.1    Puls, S.2    Offermann, I.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.