Protective effect of TEMPOL derivatives against light-induced retinal damage in rats

Investigative Ophthalmology and Visual Science

Volumn 48, Issue 4, 2007, Pages 1900-1905

  Tanito, Masaki ^a   Li, Feng ^a   Elliott, Michael H ^a   Dittmar, Mark ^a   Anderson, Robert E ^a,b  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 HYDROXY 4 CYCLOPROPANECARBONYLOXY 2,2,6,6 TETRAMETHYLPIPERIDINE HYDROCHLORIDE; 4 HYDROXYHEXENAL; 4 HYDROXYNONENAL; ALDEHYDE DERIVATIVE; ANTIOXIDANT; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID; OT 551; OT 674; UNCLASSIFIED DRUG; 4-HYDROXY-2-NONENAL; ALDEHYDE; AMINE OXIDE; HYDROXYLAMINE; TEMPOL; TEMPOL H; TEMPOL-H;

ANALYTIC METHOD; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; ELECTRORETINOGRAM; LIGHT EXPOSURE; NEUROPROTECTION; NONHUMAN; OXIDATION; PHOTORECEPTOR; PRIORITY JOURNAL; PROTEIN MODIFICATION; RAT; RETINA INJURY; WESTERN BLOTTING; ANIMAL; DRUG EFFECT; ELECTRORETINOGRAPHY; INTRAPERITONEAL DRUG ADMINISTRATION; LIGHT; LIPID PEROXIDATION; METABOLISM; PATHOPHYSIOLOGY; RADIATION EXPOSURE; RADIATION INJURY; RETINA; RETINA DEGENERATION; SPIN LABELING; SPRAGUE DAWLEY RAT;

ALDEHYDES; ANIMALS; BLOTTING, WESTERN; CYCLIC N-OXIDES; ELECTRORETINOGRAPHY; HYDROXYLAMINE; INJECTIONS, INTRAPERITONEAL; LIGHT; LIPID PEROXIDATION; RADIATION INJURIES, EXPERIMENTAL; RATS; RATS, SPRAGUE-DAWLEY; RETINA; RETINAL DEGENERATION; SPIN LABELS;

EID: 34248334629     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.06-1057     Document Type: Article

References (27)

1. Cruickshanks KJ, Klein R, Klein BE. Sunlight and age-related macular degeneration. The Beaver Dam Eye Study. Arch Ophthalmol. 1993;111:514-518.
2. Cideciyan AV, Hood DC, Huang Y, et al. Disease sequence from mutant rhodopsin allele to rod and cone photoreceptor degeneration in man. Proc Natl Acad Sci USA. 1998;95:7103-7108.
3. Byrnes GA, Chang B, Loose I, Miller SA, Benson WE. Prospective incidence of photic maculopathy after cataract surgery. Am J Ophthalmol. 1995;119:231-232.
4. Tanito M, Masutani H, Kim YC, Nishikawa M, Ohira A, Yodoi J. Sulforaphane induces thioredoxin through the antioxidant-responsive element and attenuates retinal light damage in mice. Invest Ophthalmol Vis Sci. 2005;46:979-987.
5. Wiegand RD, Giusto NM, Rapp LM, Anderson RE. Evidence for rod outer segment lipid peroxidation following constant illumination of the rat retina. Invest Ophthalmol Vis Sci. 1983;24:1433-1435.
6. Organisciak DT, Darrow RM, Jiang YI, Marak GE, Blanks JC. Protection by dimethylthiourea against retinal light damage in rats. Invest Ophthalmol Vis Sci. 1992;33:1599-1609.
7. Tanito M, Yoshida Y, Kaidzu S, Ohira A, Niki E. Detection of lipid peroxidation in light-exposed mouse retina assessed by oxidative stress markers, total hydroxyoctadecadienoic acid and 8-iso-prostaglandin F(2alpha). Neurosci Lett. 2006;398:63-68.
8. De La Paz MA, Anderson RE. Lipid peroxidation in rod outer segments: role of hydroxyl radical and lipid hydroperoxides. Invest Ophthalmol Vis Sci. 1992;33:2091-2096.
9. Uchida K, Stadtman ER. Modification of histidine residues in proteins by reaction with 4-hydroxynonenal. Proc Natl Acad Sci USA. 1992;89:4544-4548.
10. Tanito M, Kwon YW, Kondo N, et al. Cytoprotective effects of geranylgeranylacetone against retinal photooxidative damage. J Neurosci. 2005;25:2396-2404.
11. Organisciak DT, Wang HM, Li ZY, Tso MO. The protective effect of ascorbate in retinal light damage of rats. Invest Ophthalmol Vis Sci. 1985;26:1580-1588.
12. Tanito M, Masutani H, Nakamura H, Ohira A, Yodoi J. Cytoprotective effect of thioredoxin against retinal photic injury in mice. Invest Ophthalmol Vis Sci. 2002;43:1162-1167.
13. Tanito M, Masutani H, Nakamura H, Oka S, Ohira A, Yodoi J. Attenuation of retinal photooxidative damage in thioredoxin transgenic mice. Neurosci Lett. 2002;326:142-146.
14. Donovan M, Carmody RJ, Cotter TG. Light-induced photoreceptor apoptosis in vivo requires neuronal nitric-oxide synthase and guanylate cyclase activity and is caspase-3-independent. J Biol Chem. 2001;276:23000-23008.
15. Kaldi I, Dittmar M, Pierce P, Anderson RE. L-NAME protects against acute light damage in albino rats, but not against retinal degeneration in P23H and S334ter transgenic rats. Exp Eye Res. 2003;76:453-461.
16. Ranchon I, LaVail MM, Kotake Y, Anderson RE. Free radical trap phenyl-N-tert-butylnitrone protects against light damage but does not rescue P23H and S334ter rhodopsin transgenic rats from inherited retinal degeneration. J Neurosci. 2003;23:6050-6057.
17. Tomita H, Kotake Y, Anderson RE. Mechanism of protection from light-induced retinal degeneration by the synthetic antioxidant phenyl-N-tert-butylnitrone. Invest Ophthalmol Vis Sci. 2005;46:427-434.
18. Mitchell JB, Samuni A, Krishna MC, et al. Biologically active metal-independent superoxide dismutase mimics. Biochemistry. 1990;29:2802-2807.
19. Sasaki H, Lin LR, Yokoyama T, Sevilla MD, Reddy VN, Giblin FJ. TEMPOL protects against lens DNA strand breaks and cataract in the x-rayed rabbit. Invest Ophthalmol Vis Sci. 1998;39:544-552.
20. Zigler JS Jr, Qin C, Kamiya T, et al. Tempol-H inhibits opacification of lenses in organ culture. Free Radic Biol Med. 2003;35:1194-1202.
21. Tanito M, Elliott MH, Kotake Y, Anderson RE. Protein modifications by 4-hydroxynonenal and 4-hydroxyhexenal in light-exposed rat retina. Invest Ophthalmol Vis Sci. 2005;46:3859-3868.
22. Toyokuni S, Miyake N, Hiai H, et al. The monoclonal antibody specific for the 4-hydroxy-2-nonenal histidine adduct. FEBS Lett. 1995;359:189-191.
23. Wang M, Lam TT, Fu J, Tso MO. TEMPOL, a superoxide dismutase mimic, ameliorates light-induced retinal degeneration. Res Commun Mol Pathol Pharmacol. 1995;89:291-305.
24. Yamamoto M, Lidia K, Gong H, Onitsuka S, Kotani T, Ohira A. Changes in manganese superoxide dismutase expression after exposure of the retina to intense light. Histochem J. 1999;31:81-87.
25. Mittag TW, Bayer AU, La VM. Light-induced retinal damage in mice carrying a mutated SOD I gene. Exp Eye Res. 1999;69:677-683.
26. Ohishi K, Zhang XM, Moriwaki S, Hiramitsu T, Matsugo S. Iron release analyses from ferritin by visible light irradiation. Free Radic Res. 2005;39:875-882.
27. Li ZL, Lam S, Tso MO. Desferrioxamine ameliorates retinal photic injury in albino rats. Curr Eye Res. 1991;10:133-144.