-
1
-
-
0344676389
-
An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice
-
Ambati J, Anand A, Fernandez S, Sakurai E, Lynn BC, Kuziel WA, Rollins BJ, Ambati BK. 2003. An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice. Nat Med 9:1390-1397.
-
(2003)
Nat Med
, vol.9
, pp. 1390-1397
-
-
Ambati, J.1
Anand, A.2
Fernandez, S.3
Sakurai, E.4
Lynn, B.C.5
Kuziel, W.A.6
Rollins, B.J.7
Ambati, B.K.8
-
2
-
-
34347332327
-
Enhanced accumulation of A2E in individuals homozygous or heterozygous for mutations in BEST1 (VMD2)
-
Bakall B, Radu RA, Stanton JB, Burke JM, McKay BS, Wadelius C, Mullins RF, Stone EM, Travis GH, Marmorstein AD. 2007. Enhanced accumulation of A2E in individuals homozygous or heterozygous for mutations in BEST1 (VMD2). Exp Eye Res 85:34-43.
-
(2007)
Exp Eye Res
, vol.85
, pp. 34-43
-
-
Bakall, B.1
Radu, R.A.2
Stanton, J.B.3
Burke, J.M.4
McKay, B.S.5
Wadelius, C.6
Mullins, R.F.7
Stone, E.M.8
Travis, G.H.9
Marmorstein, A.D.10
-
3
-
-
2442648066
-
Inhibition of the ATP-driven proton pump in RPE lysosomes by the major lipofuscin fluorophore A2-E may contribute to the pathogenesis of age-related macular degeneration
-
Bergmann M, Schutt F, Holz FG, Kopitz J. 2004. Inhibition of the ATP-driven proton pump in RPE lysosomes by the major lipofuscin fluorophore A2-E may contribute to the pathogenesis of age-related macular degeneration. FASEB J 18:562-564.
-
(2004)
FASEB J
, vol.18
, pp. 562-564
-
-
Bergmann, M.1
Schutt, F.2
Holz, F.G.3
Kopitz, J.4
-
4
-
-
12144289446
-
Mutations in ABCA4 result in accumulation of lipofuscin before slowing of the retinoid cycle: A reappraisal of the human disease sequence
-
Cideciyan AV, Aleman TS, Swider M, Schwartz SB, Steinberg JD, Brucker AJ, Maguire AM, Bennett J, Stone EM, Jacobson SG. 2004. Mutations in ABCA4 result in accumulation of lipofuscin before slowing of the retinoid cycle: A reappraisal of the human disease sequence. Hum Mol Genet 13:525-534.
-
(2004)
Hum Mol Genet
, vol.13
, pp. 525-534
-
-
Cideciyan, A.V.1
Aleman, T.S.2
Swider, M.3
Schwartz, S.B.4
Steinberg, J.D.5
Brucker, A.J.6
Maguire, A.M.7
Bennett, J.8
Stone, E.M.9
Jacobson, S.G.10
-
5
-
-
11844269325
-
Transmission of light to the aging human retina: Possible implications for age related macular degeneration
-
Dillon J, Zheng L, Merriam JC, Gaillard ER. 2004. Transmission of light to the aging human retina: Possible implications for age related macular degeneration. Exp Eye Res 79:753-759.
-
(2004)
Exp Eye Res
, vol.79
, pp. 753-759
-
-
Dillon, J.1
Zheng, L.2
Merriam, J.C.3
Gaillard, E.R.4
-
6
-
-
0027410970
-
Retinal age pigments generated by self-assembling lysosomotropic detergents
-
Eldred GE, Lasky MR. 1993. Retinal age pigments generated by self-assembling lysosomotropic detergents. Nature 361:724-726.
-
(1993)
Nature
, vol.361
, pp. 724-726
-
-
Eldred, G.E.1
Lasky, M.R.2
-
8
-
-
0021752680
-
Age-related macular degeneration and blindness due to neovascular maculopathy
-
Ferris FL, Fine SL, Hyman L. 1984. Age-related macular degeneration and blindness due to neovascular maculopathy. Arch Ophthalmol 102:1640-1642.
-
(1984)
Arch Ophthalmol
, vol.102
, pp. 1640-1642
-
-
Ferris, F.L.1
Fine, S.L.2
Hyman, L.3
-
10
-
-
0037133673
-
The lipofuscin component A2E selectively inhibits phagolysosomal degradation of photoreceptor phospholipid by the retinal pigment epithelium
-
Finnemann SC, Leung LW, Rodriguez-Boulan E. 2002. The lipofuscin component A2E selectively inhibits phagolysosomal degradation of photoreceptor phospholipid by the retinal pigment epithelium. Proc Natl Acad Sci USA 99:3842-3847.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 3842-3847
-
-
Finnemann, S.C.1
Leung, L.W.2
Rodriguez-Boulan, E.3
-
11
-
-
0035794148
-
Retinoids induce fibroblast growth factor-2 production in endothelial cells via retinoic acid receptor alpha activation and stimulate angiogenesis in vitro and in vivo
-
Gaetano C, Catalano A, Illi B, Felici A, Minucci S, Palumbo R, Facchiano F, Mangoni A, Mancarella S, Muhlhauser J, Capogrossi MC. 2001. Retinoids induce fibroblast growth factor-2 production in endothelial cells via retinoic acid receptor alpha activation and stimulate angiogenesis in vitro and in vivo. Circ Res 88:E38-E47.
-
(2001)
Circ Res
, vol.88
-
-
Gaetano, C.1
Catalano, A.2
Illi, B.3
Felici, A.4
Minucci, S.5
Palumbo, R.6
Facchiano, F.7
Mangoni, A.8
Mancarella, S.9
Muhlhauser, J.10
Capogrossi, M.C.11
-
12
-
-
33847073347
-
Progression of geographic atrophy and impact of fundus autofluorescence patterns in age-related macular degeneration
-
Holz FG, Bindewald-Wittich A, Fleckenstein M, Dreyhaupt J, Scholl HP, Schmitz-Valckenberg S. 2007. Progression of geographic atrophy and impact of fundus autofluorescence patterns in age-related macular degeneration. Am J Ophthalmol 143:463-472.
-
(2007)
Am J Ophthalmol
, vol.143
, pp. 463-472
-
-
Holz, F.G.1
Bindewald-Wittich, A.2
Fleckenstein, M.3
Dreyhaupt, J.4
Scholl, H.P.5
Schmitz-Valckenberg, S.6
-
13
-
-
45549107669
-
A2E, a pigment of the lipofuscin of retinal pigment epithelial cells, is an endogenous ligand for retinoic acid receptor
-
Iriyama A, Fujiki R, Inoue Y, Takahashi H, Tamaki Y, Takezawa S, Takeyama K, Jang WD, Kato S, Yanagi Y. 2008. A2E, a pigment of the lipofuscin of retinal pigment epithelial cells, is an endogenous ligand for retinoic acid receptor. J Biol Chem 283:11947-11953.
-
(2008)
J Biol Chem
, vol.283
, pp. 11947-11953
-
-
Iriyama, A.1
Fujiki, R.2
Inoue, Y.3
Takahashi, H.4
Tamaki, Y.5
Takezawa, S.6
Takeyama, K.7
Jang, W.D.8
Kato, S.9
Yanagi, Y.10
-
14
-
-
0030994732
-
Expression of vascular endothelial growth factor in experimental choroidal neovascularization
-
Ishibashi T, Hata Y, Yoshikawa H, Nakagawa K, Sueishi K, Inomata H. 1997. Expression of vascular endothelial growth factor in experimental choroidal neovascularization. Graefes Arch Clin Exp Ophthalmol 235:159-167.
-
(1997)
Graefes Arch Clin Exp Ophthalmol
, vol.235
, pp. 159-167
-
-
Ishibashi, T.1
Hata, Y.2
Yoshikawa, H.3
Nakagawa, K.4
Sueishi, K.5
Inomata, H.6
-
15
-
-
43049125831
-
Inhibition of choroidal neovascularization by blocking vascular endothelial growth factor receptor tyrosine kinase
-
Kami J, Muranaka K, Yanagi Y, Obata R, Tamaki Y, Shibuya M. 2008. Inhibition of choroidal neovascularization by blocking vascular endothelial growth factor receptor tyrosine kinase. Jpn J Ophthalmol 52:91-98.
-
(2008)
Jpn J Ophthalmol
, vol.52
, pp. 91-98
-
-
Kami, J.1
Muranaka, K.2
Yanagi, Y.3
Obata, R.4
Tamaki, Y.5
Shibuya, M.6
-
16
-
-
0034721937
-
Ligand typespecific interactions of peroxisome proliferator-activated receptor gamma with transcriptional coactivators
-
Kodera Y, Takeyama K, Murayama A, Suzawa M, Masuhiro Y, Kato S. 2000. Ligand typespecific interactions of peroxisome proliferator-activated receptor gamma with transcriptional coactivators. J Biol Chem 275:33201-33204.
-
(2000)
J Biol Chem
, vol.275
, pp. 33201-33204
-
-
Kodera, Y.1
Takeyama, K.2
Murayama, A.3
Suzawa, M.4
Masuhiro, Y.5
Kato, S.6
-
17
-
-
0027742148
-
Inhibition of tumor cellinduced angiogenesis by retinoids, 1,25-dihydroxyvitamin D3 and their combination
-
Majewski S, Szmurlo A, Marczak M, Jablonska S, Bollag W. 1993. Inhibition of tumor cellinduced angiogenesis by retinoids, 1,25-dihydroxyvitamin D3 and their combination. Cancer Lett 75:35-39.
-
(1993)
Cancer Lett
, vol.75
, pp. 35-39
-
-
Majewski, S.1
Szmurlo, A.2
Marczak, M.3
Jablonska, S.4
Bollag, W.5
-
18
-
-
33750305221
-
Systemic bevacizumab (Avastin) therapy for neovascular age-related macular degeneration: Twenty-four-week results of an uncontrolled open-label clinical study
-
Moshfeghi AA, Rosenfeld PJ, Puliafito CA, Michels S, Marcus EN, Lenchus JD, Venkatraman AS. 2006. Systemic bevacizumab (Avastin) therapy for neovascular age-related macular degeneration: Twenty-four-week results of an uncontrolled open-label clinical study. Ophthalmology 113:2002-2011.
-
(2006)
Ophthalmology
, vol.113
, pp. 2002-2011
-
-
Moshfeghi, A.A.1
Rosenfeld, P.J.2
Puliafito, C.A.3
Michels, S.4
Marcus, E.N.5
Lenchus, J.D.6
Venkatraman, A.S.7
-
19
-
-
0032438193
-
Isolation and one-step preparation of A2E and iso-A2E, fluorophores from human retinal pigment epithelium
-
Parish CA, Hashimoto M, Nakanishi K, Dillon J, Sparrow J. 1998. Isolation and one-step preparation of A2E and iso-A2E, fluorophores from human retinal pigment epithelium. Proc Natl Acad Sci USA 95:14609-14613.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 14609-14613
-
-
Parish, C.A.1
Hashimoto, M.2
Nakanishi, K.3
Dillon, J.4
Sparrow, J.5
-
20
-
-
0028075088
-
Modulation of bovine microvascular endothelial cell proteolytic properties by inhibitors of angiogenesis
-
Pepper MS, Vassalli JD, Wilks JW, Schweigerer L, Orci L, Montesano R. 1994. Modulation of bovine microvascular endothelial cell proteolytic properties by inhibitors of angiogenesis. J Cell Biochem 55:419-434.
-
(1994)
J Cell Biochem
, vol.55
, pp. 419-434
-
-
Pepper, M.S.1
Vassalli, J.D.2
Wilks, J.W.3
Schweigerer, L.4
Orci, L.5
Montesano, R.6
-
21
-
-
33847012234
-
All-trans retinoic acid induces in vitro angiogenesis via retinoic acid receptor: Possible involvement of paracrine effects of endogenous vascular endothelial growth factor signaling
-
Saito A, Sugawara A, Uruno A, Kudo M, Kagechika H, Sato Y, Owada Y, Kondo H, Sato M, Kurabayashi M, Imaizumi M, Tsuchiya S, Ito S. 2007. All-trans retinoic acid induces in vitro angiogenesis via retinoic acid receptor: Possible involvement of paracrine effects of endogenous vascular endothelial growth factor signaling. Endocrinology 148:1412-1423.
-
(2007)
Endocrinology
, vol.148
, pp. 1412-1423
-
-
Saito, A.1
Sugawara, A.2
Uruno, A.3
Kudo, M.4
Kagechika, H.5
Sato, Y.6
Owada, Y.7
Kondo, H.8
Sato, M.9
Kurabayashi, M.10
Imaizumi, M.11
Tsuchiya, S.12
Ito, S.13
-
23
-
-
33745641375
-
Correlation between the area of increased autofluorescence surrounding geographic atrophy and disease progression in patients with AMD
-
Schmitz-Valckenberg S, Bindewald-Wittich A, Dolar-Szczasny J, Dreyhaupt J, Wolf S, Scholl HP, Holz FG. 2006. Correlation between the area of increased autofluorescence surrounding geographic atrophy and disease progression in patients with AMD. Invest Ophthalmol Vis Sci 47:2648-2654.
-
(2006)
Invest Ophthalmol Vis Sci
, vol.47
, pp. 2648-2654
-
-
Schmitz-Valckenberg, S.1
Bindewald-Wittich, A.2
Dolar-Szczasny, J.3
Dreyhaupt, J.4
Wolf, S.5
Scholl, H.P.6
Holz, F.G.7
-
24
-
-
0035106148
-
Intrachoroidal neovascularization in transgenic mice overexpressing vascular endothelial growth factor in the retinal pigment epithelium
-
Schwesinger C, Yee C, Rohan RM, Joussen AM, Fernandez A, Meyer TN, Poulaki V, Ma JJ, Redmond TM, Liu S, Adamis AP, D'Amato RJ. 2001. Intrachoroidal neovascularization in transgenic mice overexpressing vascular endothelial growth factor in the retinal pigment epithelium. Am J Pathol 158:1161-1172.
-
(2001)
Am J Pathol
, vol.158
, pp. 1161-1172
-
-
Schwesinger, C.1
Yee, C.2
Rohan, R.M.3
Joussen, A.M.4
Fernandez, A.5
Meyer, T.N.6
Poulaki, V.7
Ma, J.J.8
Redmond, T.M.9
Liu, S.10
Adamis, A.P.11
D'Amato, R.J.12
-
25
-
-
0037316832
-
Fundus autofluorescence and age-related macular degeneration
-
Spaide RF. 2003. Fundus autofluorescence and age-related macular degeneration. Ophthalmology 110:392-399.
-
(2003)
Ophthalmology
, vol.110
, pp. 392-399
-
-
Spaide, R.F.1
-
26
-
-
18044366931
-
RPE lipofuscin and its role in retinal pathobiology
-
Sparrow JR, Boulton M. 2005. RPE lipofuscin and its role in retinal pathobiology. Exp Eye Res 80:595-606.
-
(2005)
Exp Eye Res
, vol.80
, pp. 595-606
-
-
Sparrow, J.R.1
Boulton, M.2
-
27
-
-
0034086115
-
The lipofuscin fluorophore A2E mediates blue light-induced damage to retinal pigmented epithelial cells
-
Sparrow JR, Nakanishi K, Parish CA. 2000. The lipofuscin fluorophore A2E mediates blue light-induced damage to retinal pigmented epithelial cells. Invest Ophthalmol Vis Sci 41:1981-1989.
-
(2000)
Invest Ophthalmol Vis Sci
, vol.41
, pp. 1981-1989
-
-
Sparrow, J.R.1
Nakanishi, K.2
Parish, C.A.3
-
28
-
-
0037705336
-
A2Eepoxides damage DNA in retinal pigment epithelial cells. Vitamin E and other antioxidants inhibit A2E-epoxide formation
-
Sparrow JR, Vollmer-Snarr HR, Zhou J, Jang YP, Jockusch S, Itagaki Y,NakanishiK. 2003. A2Eepoxides damage DNA in retinal pigment epithelial cells. Vitamin E and other antioxidants inhibit A2E-epoxide formation. J Biol Chem 278:18207-18213.
-
(2003)
J Biol Chem
, vol.278
, pp. 18207-18213
-
-
Sparrow, J.R.1
Vollmer-Snarr, H.R.2
Zhou, J.3
Jang, Y.P.4
Jockusch, S.5
Itagaki, Y.6
Nakanishi, K.7
-
29
-
-
41949130800
-
N-(4-hydroxyphenyl) retinamide augments laser-induced choroidal neovascularization in mice
-
Sreekumar PG, Zhou J, Sohn J, Spee C, Ryan SJ, Maurer BJ, Kannan R, Hinton DR. 2008. N-(4-hydroxyphenyl) retinamide augments laser-induced choroidal neovascularization in mice. Invest Ophthalmol Vis Sci 49:1210-1220.
-
(2008)
Invest Ophthalmol Vis Sci
, vol.49
, pp. 1210-1220
-
-
Sreekumar, P.G.1
Zhou, J.2
Sohn, J.3
Spee, C.4
Ryan, S.J.5
Maurer, B.J.6
Kannan, R.7
Hinton, D.R.8
-
30
-
-
0034671726
-
Age-related macular degeneration. The lipofusion component N-retinyl-Nretinylidene ethanolamine detaches proapoptotic proteins from mitochondria and induces apoptosis in mammalian retinal pigment epithelial cells
-
Suter M, Reme C, Grimm C, Wenzel A, Jaattela M, Esser P, Kociok N, Leist M, Richter C. 2000. Age-related macular degeneration. The lipofusion component N-retinyl-Nretinylidene ethanolamine detaches proapoptotic proteins from mitochondria and induces apoptosis in mammalian retinal pigment epithelial cells. J Biol Chem 275:39625-39630.
-
(2000)
J Biol Chem
, vol.275
, pp. 39625-39630
-
-
Suter, M.1
Reme, C.2
Grimm, C.3
Wenzel, A.4
Jaattela, M.5
Esser, P.6
Kociok, N.7
Leist, M.8
Richter, C.9
-
31
-
-
33749150348
-
A novel vascular endothelial growth factor receptor 2 inhibitor, SU11248, suppresses choroidal neovascularization in vivo
-
Takahashi H, Obata R, Tamaki Y. 2006. A novel vascular endothelial growth factor receptor 2 inhibitor, SU11248, suppresses choroidal neovascularization in vivo. J Ocul Pharmacol Ther 22:213-218.
-
(2006)
J Ocul Pharmacol Ther
, vol.22
, pp. 213-218
-
-
Takahashi, H.1
Obata, R.2
Tamaki, Y.3
-
32
-
-
34648846532
-
Murine ccl2/cx3cr1 deficiency results in retinal lesions mimicking human age-related macular degeneration
-
Tuo J, Bojanowski CM, Zhou M, Shen D, Ross RJ, RosenbergKI, Cameron DJ, Yin C, Kowalak JA, Zhuang Z, Zhang K, Chan CC. 2007. Murine ccl2/cx3cr1 deficiency results in retinal lesions mimicking human age-related macular degeneration. Invest Ophthalmol Vis Sci 48:3827-3836.
-
(2007)
Invest Ophthalmol Vis Sci
, vol.48
, pp. 3827-3836
-
-
Tuo, J.1
Bojanowski, C.M.2
Zhou, M.3
Shen, D.4
Ross, R.J.5
Rosenberg, K.I.6
Cameron, D.J.7
Yin, C.8
Kowalak, J.A.9
Zhuang, Z.10
Zhang, K.11
Chan, C.C.12
-
34
-
-
0033531921
-
Positive and negative modulation of vitamin D receptor function by transforming growth factor-beta signaling through smad proteins
-
Yanagi Y, Suzawa M, Kawabata M, Miyazono K, Yanagisawa J, Kato S. 1999. Positive and negative modulation of vitamin D receptor function by transforming growth factor-beta signaling through smad proteins. J Biol Chem 274:12971-12974.
-
(1999)
J Biol Chem
, vol.274
, pp. 12971-12974
-
-
Yanagi, Y.1
Suzawa, M.2
Kawabata, M.3
Miyazono, K.4
Yanagisawa, J.5
Kato, S.6
-
35
-
-
0036846562
-
Subconjunctival administration of bucillamine suppresses choroidal neovascularization in rat
-
Yanagi Y, Tamaki Y, Obata R, Muranaka K, Homma N, Matsuoka H, Mano H. 2002. Subconjunctival administration of bucillamine suppresses choroidal neovascularization in rat. Invest Ophthalmol Vis Sci 43:3495-3499.
-
(2002)
Invest Ophthalmol Vis Sci
, vol.43
, pp. 3495-3499
-
-
Yanagi, Y.1
Tamaki, Y.2
Obata, R.3
Muranaka, K.4
Homma, N.5
Matsuoka, H.6
Mano, H.7
-
36
-
-
34250719381
-
Evaluation of the safety of xenon/ bandpass light in vitrectomy using the A2E-laden RPE model
-
Yanagi Y, Iriyama A, Jang WD, Kadonosono K. 2007. Evaluation of the safety of xenon/ bandpass light in vitrectomy using the A2E-laden RPE model. Graefes Arch Clin Exp Ophthalmol 245:677-681.
-
(2007)
Graefes Arch Clin Exp Ophthalmol
, vol.245
, pp. 677-681
-
-
Yanagi, Y.1
Iriyama, A.2
Jang, W.D.3
Kadonosono, K.4
-
37
-
-
26444478610
-
The potential role of amyloid beta in the pathogenesis of age-related macular degeneration
-
Yoshida T, Ohno-Matsui K, Ichinose S, Sato T, Iwata N, Saido TC, Hisatomi T, Mochizuki M, Morita I. 2005. The potential role of amyloid beta in the pathogenesis of age-related macular degeneration. J Clin Invest 115:2793-2800.
-
(2005)
J Clin Invest
, vol.115
, pp. 2793-2800
-
-
Yoshida, T.1
Ohno-Matsui, K.2
Ichinose, S.3
Sato, T.4
Iwata, N.5
Saido, T.C.6
Hisatomi, T.7
Mochizuki, M.8
Morita, I.9
-
38
-
-
15244351557
-
Mechanisms for the induction of HNE- MDA- and AGE-adducts, RAGE and VEGF in retinal pigment epithelial cells
-
Zhou J, Cai B, Jang YP, Pachydaki S, Schmidt AM, Sparrow JR. 2005. Mechanisms for the induction of HNE- MDA- and AGE-adducts, RAGE and VEGF in retinal pigment epithelial cells. Exp Eye Res 80:567-580.
-
(2005)
Exp Eye Res
, vol.80
, pp. 567-580
-
-
Zhou, J.1
Cai, B.2
Jang, Y.P.3
Pachydaki, S.4
Schmidt, A.M.5
Sparrow, J.R.6
-
39
-
-
33750814597
-
Complement activation by photooxidation products of A2E, a lipofuscin constituent of the retinal pigment epithelium
-
Zhou J, Jang YP, Kim SR, Sparrow JR. 2006. Complement activation by photooxidation products of A2E, a lipofuscin constituent of the retinal pigment epithelium. Proc Natl Acad Sci USA 103:16182-16187.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 16182-16187
-
-
Zhou, J.1
Jang, Y.P.2
Kim, S.R.3
Sparrow, J.R.4
|