Overexpression of the NHE1 isoform of the Na+/H+ exchanger causes elevated apoptosis in isolated cardiomyocytes after hypoxia/reoxygenation challenge

Molecular and Cellular Biochemistry

Volumn 338, Issue 1-2, 2010, Pages 47-57

  Karki, Pratap ^a   Fliegel, Larry ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Apoptosis; Cardiomyocyte; Hypoxia; Intracellular pH; Ischemia reperfusion; Na+ H+ exchanger

Indexed keywords

ADENOVIRUS VECTOR; CALRETICULIN; CASPASE 3; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN DISULFIDE ISOMERASE; SODIUM PROTON EXCHANGE PROTEIN; SODIUM PROTON EXCHANGE PROTEIN 1; GUANIDINE DERIVATIVE; ISOPROTEIN; N-(2-METHYL-4,5-BIS(METHYLSULFONYL)BENZOYL)GUANIDINE; SLC9A1 PROTEIN, RAT; SULFONE;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL ISOLATION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE OVEREXPRESSION; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HYPOXIA; NEWBORN; NONHUMAN; RAT; REOXYGENATION; REPERFUSION INJURY; WESTERN BLOTTING; ANIMAL; ANOXIA; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CYTOLOGY; GENETICS; HUMAN; METABOLISM; PH; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; ANOXIA; APOPTOSIS; CASPASE 3; CELLS, CULTURED; GUANIDINES; HUMANS; HYDROGEN-ION CONCENTRATION; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; PROTEIN ISOFORMS; RATS; RATS, SPRAGUE-DAWLEY; SODIUM-HYDROGEN ANTIPORTER; SULFONES;

ADENOVIRIDAE; MAMMALIA;

EID: 77951294721     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-009-0337-5     Document Type: Article

References (54)

1. L Fliegel 2005 The Na(+)/H(+) exchanger isoform 1 Int J Biochem Cell Biol 37 33 37 10.1016/j.biocel.2004.02.006 1:CAS:528:DC%2BD2cXnslKgs78%3D 15381146 (Pubitemid 39286020)
2. + antiporter Cell 56 271 280 10.1016/0092-8674(89) 90901-X 1:CAS:528:DyaK3cXhs1Sn 2536298 (Pubitemid 19050300)
3. + exchanger in metastasis Nat Rev Cancer 5 786 795 10.1038/nrc1713 1:CAS:528:DC%2BD2MXhtVGjs7bK 16175178 (Pubitemid 41400778)
4. + exchange inhibitors: potential mechanisms of action Basic Res Cardiol 96 306 311 10.1007/s003950170037 1:CAS:528: DC%2BD3MXmtF2qu78%3D 11518185 (Pubitemid 32700566)
5. M Lazdunski C Frelin P Vigne 1985 The sodium/hydrogen exchange system in cardiac cells. Its biochemical and pharmacological properties and its role in regulating internal concentrations of sodium and internal pH J Mol Cell Cardiol 17 1029 1042 10.1016/S0022-2828(85)80119-X 1:CAS:528:DyaL28XkvFamsQ%3D%3D 3001319 (Pubitemid 16200867)
6. M Karmazyn M Sawyer L Fliegel 2005 The Na(+)/H(+) exchanger: a target for cardiac therapeutic intervention Curr Drug Targets Cardiovasc Haematol Disord 5 323 335 10.2174/1568006054553417 1:CAS:528:DC%2BD2MXotFaiu7g%3D 16101565 (Pubitemid 41131703)
7. M Avkiran MS Marber 2002 Na(+)/H(+) exchange inhibitors for cardioprotective therapy: progress, problems and prospects J Am Coll Cardiol 39 747 753 10.1016/S0735-1097(02)01693-5 1:CAS:528:DC%2BD38XisVGltb0%3D 11869836 (Pubitemid 34185318)
8. + exchanger FEBS Lett 279 25 29 10.1016/0014-5793(91)80241-T 1:CAS:528:DyaK3MXhvVSlsLg%3D 1704856
9. + exchanger NHE1 in rat myocardium Am J Physiol 276 H709 H717 1:CAS:528:DyaK1MXhtlCktLg%3D 9950874
10. EA Dumont CP Reutelingsperger JF Smits MJ Daemen PA Doevendans HJ Wellens L Hofstra 2001 Real-time imaging of apoptotic cell-membrane changes at the single-cell level in the beating murine heart Nat Med 7 1352 1355 10.1038/nm1201-1352 1:CAS:528:DC%2BD3MXovFKmtrY%3D 11726977 (Pubitemid 34007941)
11. J Kajstura W Cheng K Reiss WA Clark EH Sonnenblick S Krajewski JC Reed G Olivetti P Anversa 1996 Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats Lab Invest 74 86 107 1:STN:280:DyaK287lsVWmsQ%3D%3D 8569201
12. EA Dumont L Hofstra WL van Heerde S van den Eijnde PA Doevendans E DeMuinck MA Daemen JF Smits P Frederik HJ Wellens MJ Daemen CP Reutelingsperger 2000 Cardiomyocyte death induced by myocardial ischemia and reperfusion: measurement with recombinant human annexin-V in a mouse model Circulation 102 1564 1568 1:CAS:528:DC%2BD3cXntFKnsbw%3D 11004148
13. A Saraste K Pulkki M Kallajoki K Henriksen M Parvinen LM Voipio-Pulkki 1997 Apoptosis in human acute myocardial infarction Circulation 95 320 323 1:STN:280:DyaK2s7mtFWrtA%3D%3D 9008443
14. JP Veinot DA Gattinger H Fliss 1997 Early apoptosis in human myocardial infarcts Hum Pathol 28 485 492 10.1016/S0046-8177(97)90039-3 1:CAS:528:DyaK2sXjtFWls78%3D 9104950 (Pubitemid 27175091)
15. JW Hoffman Jr TB Gilbert RS Poston EP Silldorff 2004 Myocardial reperfusion injury: etiology, mechanisms, and therapies J Extra Corpor Technol 36 391 411 15679285
16. + exchanger isoform 1 attenuates apoptosis and mitochondrial damage following transient focal cerebral ischemia Eur J Neurosci 28 51 61 10.1111/j.1460-9568.2008.06304.x 18662334
17. Y Zhang J Chen F Zhang Q Xia 2006 Cariporide attenuates myocardial ischaemia, reperfusion injury and apoptosis in isolated rat hearts Acta Cardiol 61 637 641 10.2143/AC.61.6.2017963 17205921 (Pubitemid 46008430)
18. + exchanger Eur J Pharmacol 535 220 227 10.1016/j.ejphar.2006.01.041 1:CAS:528:DC%2BD28XjtFGlsro%3D 16516883
19. S Chakrabarti AN Hoque M Karmazyn 1997 A rapid ischemia-induced apoptosis in isolated rat hearts and its attenuation by the sodium-hydrogen exchange inhibitor HOE 642 (cariporide) J Mol Cell Cardiol 29 3169 3174 10.1006/jmcc.1997.0561 1:CAS:528:DyaK2sXotVGgsLk%3D 9405190 (Pubitemid 27510782)
20. S Javadov A Choi V Rajapurohitam A Zeidan AG Basnakian M Karmazyn 2008 NHE-1 inhibition-induced cardioprotection against ischaemia/reperfusion is associated with attenuation of the mitochondrial permeability transition Cardiovasc Res 77 416 424 10.1093/cvr/cvm039 1:CAS:528:DC%2BD1cXis12rsr8%3D 18006455 (Pubitemid 351197641)
21. + exchanger in hypoxia/re-oxygenation- induced neonatal rat cardiomyocyte apoptosis Eur J Pharmacol 486 121 131 10.1016/j.ejphar.2003.12.016 1:CAS:528:DC%2BD2cXht1yqtbk%3D 14975701 (Pubitemid 38224523)
22. RA Humphreys JV Haist S Chakrabarti Q Feng JM Arnold M Karmazyn 1999 Orally administered NHE1 inhibitor cariporide reduces acute responses to coronary occlusion and reperfusion Am J Physiol 276 H749 H757 1:CAS:528:DyaK1MXhtlCktbo%3D 9950878
23. S Garg L Hofstra C Reutelingsperger J Narula 2003 Apoptosis as a therapeutic target in acutely ischemic myocardium Curr Opin Cardiol 18 372 377 10.1097/00001573-200309000-00009 12960470 (Pubitemid 37153690)
24. + exchanger attenuates the deterioration of ventricular function during pacing-induced heart failure in rabbits Cardiovasc Res 63 273 282 10.1016/j.cardiores.2004.04.014 1:CAS:528:DC%2BD2cXlsFymurc%3D 15249185 (Pubitemid 38906660)
25. CD Garciarena CI Caldiz EL Portiansky GE Chiappe de Cingolani IL Ennis 2009 Chronic NHE-1 blockade induces an antiapoptotic effect in the hypertrophied heart J Appl Physiol 106 1325 1331 10.1152/japplphysiol.91300.2008 1:CAS:528:DC%2BD1MXltVyht7k%3D 19179646
26. + exchanger-mediated cardiac ischemia-reperfusion injury Circulation 113 2516 2523 10.1161/CIRCULATIONAHA.105.563486 1:CAS:528:DC%2BD28Xksl2hs7w%3D 16717153 (Pubitemid 43948030)
27. + exchanger regulation for cardiac protection: a RSKy approach? Curr Opin Pharmacol 8 133 140 10.1016/j.coph.2007.12.007 1:CAS:528:DC%2BD1cXjtlGksLw%3D 18222727
28. + exchanger isoform 1 is mediated through phosphorylation of amino acids Ser726 and Ser729 Am J Physiol Cell Physiol 295 C883 C896 10.1152/ajpcell.00574.2007 1:CAS:528:DC%2BD1cXht1ymtLbE 18701649
29. AR Khaled AN Moor A Li K Kim DK Ferris K Muegge RJ Fisher L Fliegel SK Durum 2001 Trophic factor withdrawal: p38 mitogen-activated protein kinase activates NHE1, which induces intracellular alkalinization Mol Cell Biol 21 7545 7557 10.1128/MCB.21.22.7545-7557.2001 1:CAS:528:DC%2BD3MXnvVWlsLk%3D 11604491 (Pubitemid 32988766)
30. + exchange. Structure, regulation, and its role in heart disease Circ Res 85 777 786 1:CAS:528:DyaK1MXntV2lt7c%3D 10532945
31. + exchanger activity and expression in human ventricular myocardium J Am Coll Cardiol 36 534 540 10.1016/S0735-1097(00)00730- 0 1:CAS:528:DC%2BD3cXlvFGitrw%3D 10933369 (Pubitemid 30624018)
32. JRB Dyck T Maddaford GN Pierce L Fliegel 1995 Induction of expression of the sodium-hydrogen exchanger in rat myocardium Cardiovascular Res 29 203 208 1:CAS:528:DyaK2MXkslGhtLo%3D
33. + exchange isoform 1 mRNA expression in isolated rat hearts Am J Physiol 277 H993 H998 1:CAS:528:DyaK1MXmt1Gjt7o%3D 10484421
34. + exchanger-directed protein kinases in the ischemic and ischemic-reperfused rat myocardium J Biol Chem 27 16113 16122 10.1074/jbc.M100519200
35. + exchanger in the rat myocardium by MAP-kinase-dependent pathways J Biol Chem 274 22985 22992 10.1074/jbc.274.33. 22985 1:CAS:528:DyaK1MXltlKnsbw%3D 10438464 (Pubitemid 29388041)
36. E Coccaro F Mraiche M Malo H Vandertol-Vanier B Bullis M Robertson L Fliegel 2007 Expression and characterization of the Na(+)/H(+) exchanger in the mammalian myocardium Mol Cell Biochem 302 145 155 10.1007/s11010-007-9436-3 1:CAS:528:DC%2BD2sXotVOjs74%3D 17431747 (Pubitemid 47202330)
37. + exchanger Eur J Biochem 268 4674 4685 10.1046/j.1432-1327.2001.02391.x 1:CAS:528:DC%2BD3MXmslGnsbc%3D 11532004 (Pubitemid 34203416)
38. JK Kim A Pedram M Razandi ER Levin 2006 Estrogen prevents cardiomyocyte apoptosis through inhibition of reactive oxygen species and differential regulation of p38 kinase isoforms J Biol Chem 281 6760 6767 10.1074/jbc. M511024200 1:CAS:528:DC%2BD28XhvFOgsbc%3D 16407188 (Pubitemid 43847612)
39. + exchanger is mediated through phosphorylation of amino acids Ser770 and Ser771 J Biol Chem 282 6292 6299 10.1074/jbc.M611073200 1:CAS:528:DC%2BD2sXitVCis74%3D 17209041 (Pubitemid 47100880)
40. + exchanger J Biol Chem 280 17863 17872 10.1074/jbc.M409608200 1:CAS:528:DC%2BD2MXjsl2hsr8%3D 15677483 (Pubitemid 41389027)
41. + exchanger and ischemia-reperfusion injury in the myocardium Am J Physiol Heart Circ Physiol 292 H2237 H2247 10.1152/ajpheart.00855.2006 1:CAS:528:DC%2BD2sXlslSiu7w%3D 17209001 (Pubitemid 47084604)
42. + exchanger isoform 1 facilitates cardiomyocyte embryonic stem cell differentiation Am J Physiol Heart Circ Physiol 296 H159 H170 10.1152/ajpheart.00375.2008 1:CAS:528:DC%2BD1MXhtVOhsro%3D 19011045
43. + exchanger through phosphorylation of amino acids Ser770 and Ser771 Am J Physiol Heart Circ Physiol 297 H846 H858 10.1152/ajpheart.01231.2008 1:CAS:528:DC%2BD1MXhtVahtrbK 19542484
44. A Stephanou B Brar Z Liao T Scarabelli RA Knight DS Latchman 2001 Distinct initiator caspases are required for the induction of apoptosis in cardiac myocytes during ischaemia versus reperfusion injury Cell Death Differ 8 434 435 10.1038/sj.cdd.4400846 1:CAS:528:DC%2BD3MXktVOmtrs%3D 11550095 (Pubitemid 32409614)
45. AR Cook SC Bardswell S Pretheshan K Dighe GS Kanaganayagam RI Jabr S Merkle MS Marber S Engelhardt M Avkiran 2009 Paradoxical resistance to myocardial ischemia and age-related cardiomyopathy in NHE1 transgenic mice: a role for ER stress? J Mol Cell Cardiol 46 225 233 10.1016/j.yjmcc.2008.10.013 1:CAS:528:DC%2BD1MXntVGltA%3D%3D 19027022
46. + exchanger J Mol Cell Cardiol 44 228 237 1:CAS:528: DC%2BD1cXitVehs70%3D 18191941
47. + exchanger, R.G. Landes Company, Austin, TX, pp 295-307
48. ER Slepkov JK Rainey BD Sykes L Fliegel 2007 Structural and functional analysis of the Na(+)/H(+) exchanger Biochem J 401 623 633 10.1042/BJ20061062 1:CAS:528:DC%2BD2sXhsFGltr0%3D 17209804 (Pubitemid 46219256)
49. + exchanger Can J Physiol Pharmacol 84 1081 1095 10.1139/Y06-065 1:CAS:528:DC%2BD2sXhvFWgsbw%3D 17218973 (Pubitemid 46465921)
50. K Okada T Minamino Y Tsukamoto, et al. 2004 Prolonged endoplasmic reticulum stress in hypertrophic and failing heart after aortic constriction: possible contribution of endoplasmic reticulum stress to cardiac myocyte apoptosis Circulation 110 705 712 10.1161/01.CIR.0000137836.95625.D4 15289376 (Pubitemid 39056270)
51. J Liu W Mao B Ding CS Liang 2008 ERKs/p53 signal transduction pathway is involved in doxorubicin-induced apoptosis in H9c2 cells and cardiomyocytes Am J Physiol Heart Circ Physiol 295 H1956 H1965 10.1152/ajpheart.00407.2008 1:CAS:528:DC%2BD1cXhsVWktbzO 18775851
52. B Zhou LJ Wu S Tashiro S Onodera F Uchiumi T Ikejima 2007 Activation of extracellular signal-regulated kinase during silibinin-protected, isoproterenol-induced apoptosis in rat cardiac myocytes is tyrosine kinase pathway-mediated and protein kinase C-dependent Acta Pharmacol Sin 28 803 810 10.1111/j.1745-7254.2007.00472.x 1:CAS:528:DC%2BD2sXmsFentbo%3D 17506939 (Pubitemid 46817427)
53. CM Jiang LP Han HZ Li YB Qu ZR Zhang R Wang CQ Xu WM Li 2008 Calcium-sensing receptors induce apoptosis in cultured neonatal rat ventricular cardiomyocytes during simulated ischemia/reperfusion Cell Biol Int 32 792 800 10.1016/j.cellbi.2008.03.009 1:CAS:528:DC%2BD1cXms1ajsrw%3D 18455448
54. + exchanger-1 inhibitor, on glutamate-induced neuronal cell death and ischemia-induced cerebral infarct Brain Res 1248 22 30 10.1016/j.brainres.2008.10.061 1:CAS:528:DC%2BD1cXhsFansrjJ 19022230