Activation of extracellular signal-regulated kinase during silibinin-protected, isoproterenol-induced apoptosis in rat cardiac myocytes is tyrosine kinase pathway-mediated and protein kinase C-dependent

Acta Pharmacologica Sinica

Volumn 28, Issue 6, 2007, Pages 803-810

  Zhou, Bei ^a   Wu, Li Jun ^a   Tashiro, Shin Ichi ^b   Onodera, Satoshi ^b   Uchiumi, Fumiaki ^c   Ikejima, Takashi ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b SHOWA PHARMACEUTICAL UNIVERSITY   (Japan)

^c TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

Mitogen activated protein kinases; Protein kinase C; Rat cardiac myocytes; Silibinin; Tyrosine kinase

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; GENISTEIN; GW 5074; ISOPRENALINE; MANUMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NITROBLUE TETRAZOLIUM; PROTEIN KINASE C; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE; RAF PROTEIN; RAS PROTEIN; SILIBININ; STAUROSPORINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; HEART MUSCLE CELL; HEART PROTECTION; NEWBORN; NICK END LABELING; NITROBLUE TETRAZOLIUM TEST; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; WESTERN BLOTTING;

ADRENERGIC BETA-AGONISTS; ANIMALS; ANTIOXIDANTS; APOPTOSIS; CELLS, CULTURED; ENZYME ACTIVATION; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; ISOPROTERENOL; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MOLECULAR STRUCTURE; MYOCYTES, CARDIAC; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE C; PROTEIN-TYROSINE KINASES; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SILYMARIN;

EID: 34249325190     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2007.00472.x     Document Type: Article

References (42)

1. Berenji K, Drazner MH, Rothermel BA, Hill JA. Does load induced ventricular hypertrophy progress to systolic heart failure Am J Physiol Heart Circ Physiol 2005 289 : H8 H16.
2. Frey N, Katus HA, Olson EN, Hill JA. Hypertrophy of the heart: a new therapeutic target Circulation 2004 109 : 1580 9.
3. Francis GS, Chon JN, Johnson G, Rector TS, Goldman S, Simon A. Plasma norepinephrine, plasma renin activity, and congestive heart failure. Relations to survival and the effects of therapy in V-HeFT II. The V-HeFT VA Cooperative Studies Group. Circulation, 1993 87 (Suppl 6 VI40 8.
4. Communal C, Singh K, Pimentel DR, Colucci WS. Norepinephrine stimulates apoptosis in adult rat ventricular myocytes by activation of the β-adrenergic pathway. Circulation, 1998 98 : 1329 34.
5. Li LH, Wu LJ, Zhou B, Wu Z, Tashiro S, Onodera S, et al. Silymarin prevents UV irradiation-induced A375-S2 cell apoptosis. Biol Pharm Bull, 2004 27 : 1031 6.
6. Vaziri H, Dessain SK, Eaton EN, Imai SI, Frye RA, Pandita TK, et al. SIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell, 2001 107 : 149 59.
7. Luo J, Nikolaev AY, Imai S, Chen D, Su F, Shiloh A, et al. Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell, 2001 107 : 137 48.
8. Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, Kessler B, et al. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science, 2004 305 : 390 2.
9. Valenzuela A, Guerra R, Videla LA. Antioxidant properties of the flavonoids silymarin and (+)-cyanidanol-3: comparison with butylated hydroxyanisole and butylated hydroxytoluene. Planta Med, 1986 6 : 438 40.
10. Kang JS, Jeon YJ, Park SK, Yang KH, Kim HM. Protection against lipopolysaccharide-induced sepsis and inhibition of interleukin-1β and prostaglandin E2 synthesis by silymarin. Biochem Pharmacol, 2004 67 : 175 81.
11. Higmi Y, Shimokawa I. Apoptosis in the aging process. Cell Tissue Res, 2000 301 : 125 32.
12. Zhang YP, Herman B. Ageing and apoptosis: mechanisms of ageing and development. Mech Aging Dev, 2002 123 : 245 60.
13. Campisi J. Cellular senescence and apoptosis: how cellular responses might influence aging phenotypes. Exp Gerontol, 2003 38 : 5 11.
14. Ping P, Zhang J, Zheng YT, Li RC, Dawn B, Tang XL, et al. Demonstration of selective protein kinase C-dependent activation of Src and Lck tyrosine kinases during ischemic preconditioning in conscious rabbits. Circ Res, 1999 85 : 542 50.
15. Post GR, Brown JH. G protein-coupled receptors and signaling pathways regulating growth responses. FASEB J, 1996 10 : 741 9.
16. Lowy DR, Willumsen BM. Function and regulation of Ras. Annu Rev Biochem, 1993 62 : 851 91.
17. Mattingly RR, Macara IG. Phosphorylation-dependent activation of the Ras-GRF/CDC25Mm exchange factor by muscarinic receptors and G-protein βγ subunits. Nature, 1996 382 : 268 70.
18. Marais R, Light Y, Paterson HF, Marshall CJ. Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation. EMBO J, 1995 14 : 3136 45.
19. Jelinek T, Dent P, Sturgill TW, Weber MJ. Ras-induced activation of Raf-1 is dependent on tyrosine phosphorylation. Mol Cell Biol, 1996 16 : 1027 34.
20. Fabian JR., Daar IO, Morrison DK. Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase. Mol Cell Biol, 1993 13 : 7170 9.
21. Wang X, Wu BW, Wu DM. Effects of AMP579 and adenosine on L-type Ca2+ current in isolated rat ventricular myocytes. Acta Pharmacol Sin, 2005 26 : 559 62.
22. Esposito G, Rapacciuolo A, Naga Prasad SV. Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress. Circulation, 2002 105 : 85 92.
23. Kyriakis JM, App H, Zhang XF, Banerjee P, Brautigan DL, Rapp UR, et al. Raf-1 activates MAP kinase-kinase. Nature, 1992 358 : 417 21.
24. Tian ZJ, Cui W, Li YJ, Hao YM, Du J, Liu F. Different contributions of STAT3, ERK1/2, and PI3-K signaling to cardiomyocyte hypertrophy by cardiotrophin- 1. Acta Pharmacol Sin, 2004 25 : 1157 64.
25. Mark L, Hugo AK, Norbert F. Novel molecular targets in the treatment of cardiac hypertrophy. Recent Pat Cardiovas Drug Discov, 2006 1 : 1 20.
26. Clerk A, Sugden PH. Untangling the web: specific signaling from PKC isoforms to MAPK cascades. Circ Res, 2001 89 : 847 9.
27. Kaburagi S, Hasegawa K, Morimoto T. The role of endothelin converting enzyme-1 in the development of α1-adrenergic-stimulated hypertrophy in cultured neonatal rat cardiac myocytes. Circulation, 1999 99 : 292 8.
28. Lasek W, Wankowicz A, Kuc K, Feleszko W, Golab J, Giermasz A. Augmentation of antitumor efficacy by the combination of actinomycin D with tumor necrosis factor-alpha and interferon-gamma on amelanoma model in mice. Cancer Immunol Immunother, 1995 40 : 315 21.
29. Suzuki K, Hino M, Kutsuna H, Hato F, Sakamoto C, Takahashi T. Selective activation of p38 mitogen-activated protein kinase cascade in human neutrophils stimulated by IL-1β. J Immunol, 2001 167 : 5940 7.
30. Marais R, Light Y, Mason C, Paterson H, Olson MF, Marshall CJ. Requirement of Ras-GTP/Raf complexes for activation of Raf-1 by protein kinase C. Science, 1998 280 : 109 12.
31. Clerk A, Pham FH, Fuller SJ. Regulation of mitogen activated protein kinases in cardiac myocytes through the small G protein Rac1. Mol Cell Biol, 2001 21 : 1173 84.
32. Wang L., Proud CG. Ras/Erk signaling is essential for activation of protein synthesis by Gq protein-coupled receptor agonists in adult cardiomyocytes. Circ Res, 2002 91 : 821 9.
33. Clerk A, Sugden PH. Small guanine nucleotide-binding proteins and myocardial hypertrophy. Circ Res, 2000 86 : 1019 23.
34. Sugden PH, Clerk A. Regulation of ERK subgroup of MAP kinase cascades through G protein-coupled receptors. Cell Signal, 1997 9 : 337 51.
35. Buday L, Downward J. Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor. Cell, 1993 73 : 611 20.
36. Lowenstein EJ, Daly RJ, Batzer AG, Li W, Margolis B, Lammers R, et al. The SH2 and SH3 domain-containing protein Grb2 links receptor tyrosine kinases to ras signaling. Cell, 1992 70 : 431 42.
37. Bolli R. The late phase of preconditioning. Circ Res, 2000 87 : 972 83.
38. Tong H, Chen W, Steenbergen C, Murphy E. Ischemic preconditioning activates phosphatidylinositol-3-kinase upstream of protein kinase C. Circ Res, 2000 87 : 309 15.
39. Ping P, Zhang J, Pierce WM Jr., Bolli R. Functional proteomic analysis of protein kinase C signaling complexes in the normal heart and during cardioprotection. Circ Res, 2001 88 : 59 62.
40. Goke M, Kanai M, Lynch-Devaney K, Podolsky DK. Rapid mitogen-activated protein kinase activation by transforming growth factor α in wounded rat intestinal epithelial cells. Gastroenterology, 1998 114 : 697 705.
41. Yamazaki T, Komuro I, Kudo S, Zuo Y, Shiojima I, Mizuno T, et al. Mechanical stress activates protein kinase cascade of phosphorylation in neonatal rat cardiac myocytes. J Clin Invest, 1995 96 : 438 46.
42. Takahashi M, Berk BC. Mitogen-activated protein kinase (ERK1/2) activation by shear stress and adhesion in endothelial cells. J Clin Invest, 1996 99 : 2623 31.