Gene inactivation of Na+H+ exchanger isoform 1 attenuates apoptosis and mitochondrial damage following transient focal cerebral ischemia

European Journal of Neuroscience

Volumn 28, Issue 1, 2008, Pages 51-61

  Wang, Yanping ^a   Luo, Jing ^a   Chen, Xinzhi ^a   Chen, Hai ^a   Cramer, Sam W ^a   Sun, Dandan ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Apoptosis inducing factor; Cytochrome c; HOE 642; Infarction; Neuronal death

Indexed keywords

APOPTOSIS INDUCING FACTOR; CARIPORIDE; CASPASE 3; CYTOCHROME C; SODIUM PROTON EXCHANGE PROTEIN 1; CATION TRANSPORT PROTEIN; HIF1A PROTEIN, MOUSE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; ISOPROTEIN; SLC9A1 PROTEIN, MOUSE; SODIUM PROTON EXCHANGE PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BODY TEMPERATURE; BRAIN BLOOD FLOW; BRAIN MITOCHONDRION; CELL DAMAGE; CHROMATIN CONDENSATION; CONTROLLED STUDY; ENZYME ACTIVATION; GENE INACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSIENT ISCHEMIC ATTACK; TYMPANIC TEMPERATURE; ANIMAL; ASTROCYTE; BLOOD FLOW; BRAIN; BRAIN CIRCULATION; BRAIN ISCHEMIA; CELL CULTURE; CELL NUCLEUS; CYTOLOGY; GENE SILENCING; GENETICS; METABOLISM; MITOCHONDRION; NERVE CELL; NICK END LABELING; PATHOLOGY; PHYSIOLOGY; TRANSGENIC MOUSE;

ANIMALS; APOPTOSIS; ASTROCYTES; BRAIN; BRAIN ISCHEMIA; CASPASE 3; CATION TRANSPORT PROTEINS; CELL NUCLEUS; CELLS, CULTURED; CEREBROVASCULAR CIRCULATION; CYTOCHROMES C; GENE SILENCING; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IN SITU NICK-END LABELING; MICE; MICE, TRANSGENIC; MITOCHONDRIA; NEURONS; PROTEIN ISOFORMS; REGIONAL BLOOD FLOW; SODIUM-HYDROGEN ANTIPORTER;

EID: 54049146994     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2008.06304.x     Document Type: Article

References (42)

1. + exchange inhibitors: potential mechanisms of action. Basic Res. Cardiol., 96, 306-311.
2. Barone, F.C., Knudsen, D.J., Nelson, A.H., Feuerstein, G.Z. & Willette, R.N. (1993) Mouse strain differences in susceptibility to cerebral ischemia are related to cerebral vascular anatomy. J. Cereb. Blood Flow Metab., 13, 683-692.
3. Bell, S.M., Schreiner, C.M., Schultheis, P.J., Miller, M.L., Evans, R.L., Vorhees, C.V., Shull, G.E. & Scott, W.J. (1999) Targeted disruption of the murine Nhe1 locus induces ataxia, growth retardation, and seizures. Am. J. Physiol., 276, C788-C795.
4. Brookes, P.S., Yoon, Y., Robotham, J.L., Anders, M.W. & Sheu, S.S. (2004) Calcium, ATP, and ROS: a mitochondrial love-hate triangle. Am. J. Physiol. Cell Physiol., 287, C817-C833.
5. Cao, G., Clark, R.S., Pei, W., Yin, W., Zhang, F., Sun, F.Y., Graham, S.H. & Chen, J. (2003) Translocation of apoptosis-inducing factor in vulnerable neurons after transient cerebral ischemia and in neuronal cultures after oxygen-glucose deprivation. J. Cereb. Blood Flow Metab., 23, 1137-1150.
6. Chakrabarti, S., Hoque, A.N. & Karmazyn, M. (1997) A rapid ischemia- induced apoptosis in isolated rat hearts and its attenuation by the sodium- hydrogen exchange inhibitor HOE 642 (cariporide). J. Mol. Cell. Cardiol., 29, 3169-3174.
7. Chen, J., Nagayama, T., Jin, K., Stetler, R.A., Zhu, R.L., Graham, S.H. & Simon, R.P. (1998) Induction of caspase-3-like protease may mediate delayed neuronal death in the hippocampus after transient cerebral ischemia. J. Neurosci., 18, 4914-4928.
8. Chen, H., Luo, J., Kintner, D.B., Shull, G.E. & Sun, D. (2005) Na+-dependent chloride transporter (NKCC1)-null mice exhibit less gray and white matter damage after focal cerebral ischemia. J. Cereb. Blood Flow Metab., 25, 54-66.
9. Christophe, M. & Nicolas, S. (2006) Mitochondria: a target for neuroprotective interventions in cerebral ischemia-reperfusion. Curr. Pharm. Des., 12, 739-757.
10. Clark, W.M., Lessov, N.S., Dixon, M.P. & Eckenstein, F. (1997) Monofilament intraluminal middle cerebral artery occlusion in the mouse. Neurol. Res., 19, 641-648.
11. Dyck, J.R., Maddaford, T.G., Pierce, G.N. & Fliegel, L. (1995) Induction of expression of the sodium-hydrogen exchanger in rat myocardium. Cardio- vasc. Res., 29, 203-208.
12. + exchanger NHE1 gene and its 5′-flanking region. Mol. Cell. Biochem., 210, 91-99.
13. Fujimura, M., Morita-Fujimura, Y., Murakami, K., Kawase, M. & Chan, P.H. (1998) Cytosolic redistribution of cytochrome c after transient focal cerebral ischemia in rats. J. Cereb. Blood Flow Metab., 18, 1239-1247.
14. Graham, S.H. & Chen, J. (2001) Programmed cell death in cerebral ischemia. J. Cereb. Blood Flow Metab., 21, 99-109.
15. + exchange: structure, regulation, and its role in heart disease. Circ. Res., 85, 777-786.
16. + exchanger: a target for cardiac therapeutic intervention. Curr. Drug Targets Cardiovasc. Haematol. Disord., 5, 323-335.
17. + exchange activity in response to in vitro ischemia in part depends on activation of extracellular signal-regulatory kinase. Am. J. Physiol. Cell Physiol., 289, C934-C945.
18. Kintner, D.B., Wang, Y. & Sun, D. (2007) Role of membrane ion transport proteins in cerebral ischemic damage. Front. Biosci., 12, 762-770.
19. 2+ exchange inhibitors in attenuating ischemia-reperfusion injury. Can. J. Cardiol., 21, 509-516.
20. + exchanger isoform 1-null mice after in vitro and in vivo ischemia. J. Neurosci., 25, 11256-11268.
21. Luo, J., Kintner, D.B., Shull, G.E. & Sun, D. (2007) ERK1/2-p90RSK- mediated phosphorylation of Na(+)/H(+) exchanger isoform 1. A role in ischemic neuronal death. J. Biol. Chem., 282, 28274-28284.
22. Majid, A., He, Y.Y., Gidday, J.M., Kaplan, S.S., Gonzales, E.R., Park, T.S., Fenstermacher, J.D., Wei, L., Choi, D.W. & Hsu, C.Y. (2000) Differences in vulnerability to permanent focal cerebral ischemia among 3 common mouse strains. Stroke, 31, 2707-2714.
23. + exchanger is mediated through phosphorylation of amino acids Ser770 and Ser771. J. Biol. Chem., 282, 6292-6299.
24. Matsumori, Y., Hong, S.M., Aoyama, K., Fan, Y., Kayama, T., Sheldon, R.A., Vexler, Z.S., Ferriero, D.M., Weinstein, P.R. & Liu, J. (2005) Hsp70 overexpression sequesters AIF and reduces neonatal hypoxic/ischemic brain injury. J. Cereb. Blood Flow Metab., 25, 899-910.
25. Miller, R.T., Counillon, L., Pages, G., Lifton, R.P., Sardet, C. & Pouyssegur, J. (1991) Structure of the ′-flanking regulatory region and gene for the human growth factor-activatable Na/H exchanger NHE-1. J. Biol. Chem., 266, 10813-10819.
26. Murakami, K., Kondo, T. & Chan, P.H. (1997a) Reperfusion following focal cerebral ischemia alters distribution of neuronal cells with DNA fragmen-tation in mice. Brain Res., 751, 160-164.
27. Murakami, K., Kondo, T., Epstein, C.J. & Chan, P.H. (1997b) Overexpression of CuZn-superoxide dismutase reduces hippocampal injury after global ischemia in transgenic mice. Stroke, 28, 1797-1804.
28. + exchange inhibitor cariporide (HOE 642) on cardiac function and cardiomyocyte cell death in rat ischaemic-reperfused heart. Clin. Exp. Pharmacol. Physiol., 27, 387-393.
29. Pedersen, S.F. (2006) The Na(+)/H (+) exchanger NHE1 in stress-induced signal transduction: implications for cell proliferation and cell death. Pflugers Arch., 452, 249-259.
30. Schaller, B. & Graf, R. (2004) Cerebral ischemia and reperfusion: the pathophysiologic concept as a basis for clinical therapy. J. Cereb. Blood Flow Metab., 24, 351-371.
31. Shimoda, L.A., Fallon, M., Pisarcik, S., Wang, J. & Semenza, G.L. (2006) HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes. Am. J. Physiol. Lung Cell. Mol. Physiol., 291, L941-L949.
32. Siesjo, B.K. (1992) Pathophysiology and treatment of focal cerebral ischemia. Part II: mechanisms of damage and treatment. J. Neurosurg., 77, 337-354.
33. Stromer, H., de Groot, M.C., Horn, M., Faul, C., Leupold, A., Morgan, J.P., Scholz, W. & Neubauer, S. (2000) Na(+)/H(+) exchange inhibition with HOE642 improves postischemic recovery due to attenuation of Ca(2+) overload and prolonged acidosis on reperfusion. Circulation, 101, 2749-2755.
34. + exchanger in hypoxia/re-oxygenation-induced neonatal rat cardiomyocyte apoptosis. Eur. J. Pharmacol., 486, 121-131.
35. Suzuki, Y., Matsumoto, Y., Ikeda, Y., Kondo, K., Ohashi, N. & Umemura, K. (2002) SM-20220, a Na(+)/H(+) exchanger inhibitor: effects on ischemic brain damage through edema and neutrophil accumulation in a rat middle cerebral artery occlusion model. Brain Res., 945, 242-248.
36. Swanson, R.A., Morton, M.T., Tsao-Wu, G., Savalos, R.A., Davidson, C. & Sharp, F.R. (1990) A semiautomated method for measuring brain infarct volume. J. Cereb. Blood Flow Metab., 10, 290-293.
37. + exchange inhibitor, inhibits the mitochondrial death pathway. Circulation, 108, 2275-2281.
38. 2+ overload and PTP opening. Am. J. Physiol. Heart Circ. Physiol., 293, H3517-H3523.
39. + exchanger are resistant to cardiac ischemia- reperfusion injury. Circ. Res., 93, 776-782.
40. + exchanger. Am. J. Physiol. Renal Physiol., 284, F829-F839.
41. Zhao, H., Yenari, M.A., Cheng, D., Sapolsky, R.M. & Steinberg, G.K. (2005) Biphasic cytochrome c release after transient global ischemia and its inhibition by hypothermia. J. Cereb. Blood Flow Metab., 25, 1119-1129.
42. + exchanger 1 deficiency alters gene expression in mouse brain. Physiol Genomics, 18, 331-339.