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Volumn 44, Issue 2, 2008, Pages 228-237

Molecular biology of the myocardial Na+/H+ exchanger

Author keywords

Cation binding; Gene splicing; Ischemia reperfusion; pH regulation; Promoter; Sodium hydrogen exchange; Sodium lithium exchange; Tissue distribution

Indexed keywords

SODIUM PROTON EXCHANGE PROTEIN 1;

EID: 39149087313     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2007.11.016     Document Type: Review
Times cited : (78)

References (131)
  • 2
    • 0027062761 scopus 로고
    • Role of bicarbonate in pH recovery from intracellular acidosis in the guinea-pig ventricular myocyte
    • Lagadic-Gossmann D., Buckler K.J., and Vaughan-Jones R.D. Role of bicarbonate in pH recovery from intracellular acidosis in the guinea-pig ventricular myocyte. J Physiol 458 (1992) 361-384
    • (1992) J Physiol , vol.458 , pp. 361-384
    • Lagadic-Gossmann, D.1    Buckler, K.J.2    Vaughan-Jones, R.D.3
  • 3
    • 0027102002 scopus 로고
    • Adrenaline and extracellular ATP switch between two modes of acid extrusion in the guinea-pig ventricular myocyte
    • Lagadic-Gossmann D., Vaughan-Jones R.D., and Buckler K.J. Adrenaline and extracellular ATP switch between two modes of acid extrusion in the guinea-pig ventricular myocyte. J Physiol 458 (1992) 385-407
    • (1992) J Physiol , vol.458 , pp. 385-407
    • Lagadic-Gossmann, D.1    Vaughan-Jones, R.D.2    Buckler, K.J.3
  • 6
    • 0037376625 scopus 로고    scopus 로고
    • + exchanger activity: signaling and significance
    • + exchanger activity: signaling and significance. Cardiovasc Res 57 (2003) 942-952
    • (2003) Cardiovasc Res , vol.57 , pp. 942-952
    • Avkiran, M.1    Haworth, R.S.2
  • 7
    • 0037028890 scopus 로고    scopus 로고
    • Na(+)/H(+) exchange inhibitors for cardioprotective therapy: progress, problems and prospects
    • Avkiran M., and Marber M.S. Na(+)/H(+) exchange inhibitors for cardioprotective therapy: progress, problems and prospects. J Am Coll Cardiol 39 (2002) 747-753
    • (2002) J Am Coll Cardiol , vol.39 , pp. 747-753
    • Avkiran, M.1    Marber, M.S.2
  • 9
    • 0035022395 scopus 로고    scopus 로고
    • + exchange inhibitors for the treatment of heart failure
    • + exchange inhibitors for the treatment of heart failure. Expert Opin Investig Drugs 10 (2001) 835-843
    • (2001) Expert Opin Investig Drugs , vol.10 , pp. 835-843
    • Karmazyn, M.1
  • 10
    • 0035137946 scopus 로고    scopus 로고
    • Myocardial protection during ventricular fibrillation by reduction of proton-driven sarcolemmal sodium influx
    • Gazmuri R.J., Hoffner E., Kalcheim J., Ho H., Patel M., Ayoub I.M., et al. Myocardial protection during ventricular fibrillation by reduction of proton-driven sarcolemmal sodium influx. J Lab Clin Med 137 (2001) 43-55
    • (2001) J Lab Clin Med , vol.137 , pp. 43-55
    • Gazmuri, R.J.1    Hoffner, E.2    Kalcheim, J.3    Ho, H.4    Patel, M.5    Ayoub, I.M.6
  • 11
    • 0034687597 scopus 로고    scopus 로고
    • Inhibition of the sodium-hydrogen exchanger with cariporide to prevent myocardial infarction in high-risk ischemic situations. Main results of the GUARDIAN trial. Guard during ischemia against necrosis (GUARDIAN) investigators
    • Theroux P., Chaitman B.R., Danchin N., Erhardt L., Meinertz T., Schroeder J.S., et al. Inhibition of the sodium-hydrogen exchanger with cariporide to prevent myocardial infarction in high-risk ischemic situations. Main results of the GUARDIAN trial. Guard during ischemia against necrosis (GUARDIAN) investigators. Circulation 102 (2000) 3032-3038
    • (2000) Circulation , vol.102 , pp. 3032-3038
    • Theroux, P.1    Chaitman, B.R.2    Danchin, N.3    Erhardt, L.4    Meinertz, T.5    Schroeder, J.S.6
  • 12
    • 0035890319 scopus 로고    scopus 로고
    • The Na(+)/H(+) exchange inhibitor eniporide as an adjunct to early reperfusion therapy for acute myocardial infarction. Results of the evaluation of the safety and cardioprotective effects of eniporide in acute myocardial infarction (ESCAMI) trial
    • Zeymer U., Suryapranata H., Monassier J.P., Opolski G., Davies J., Rasmanis G., et al. The Na(+)/H(+) exchange inhibitor eniporide as an adjunct to early reperfusion therapy for acute myocardial infarction. Results of the evaluation of the safety and cardioprotective effects of eniporide in acute myocardial infarction (ESCAMI) trial. J Am Coll Cardiol 38 (2001) 1644-1650
    • (2001) J Am Coll Cardiol , vol.38 , pp. 1644-1650
    • Zeymer, U.1    Suryapranata, H.2    Monassier, J.P.3    Opolski, G.4    Davies, J.5    Rasmanis, G.6
  • 14
    • 0001524408 scopus 로고    scopus 로고
    • + exchangers; Its known and putative members and what can be learned by comparing them with each other
    • Fliegel L. (Ed), R.G. Landes Company
    • + Exchanger (1996), R.G. Landes Company 295-307
    • (1996) + Exchanger , pp. 295-307
    • Frohlich, O.1
  • 19
    • 0029934130 scopus 로고    scopus 로고
    • + exchanger isoforms (NHE1 and NHE3) in polarized epithelial cell lines
    • + exchanger isoforms (NHE1 and NHE3) in polarized epithelial cell lines. J Cell Sci 109 (1996) 929-939
    • (1996) J Cell Sci , vol.109 , pp. 929-939
    • Noel, J.1    Roux, D.2    Pouyssegur, J.3
  • 26
    • 12544258841 scopus 로고    scopus 로고
    • + exchanger isoforms are distributed to Golgi and post-Golgi compartments and are involved in organelle pH regulation
    • + exchanger isoforms are distributed to Golgi and post-Golgi compartments and are involved in organelle pH regulation. J Biol Chem 280 (2005) 1561-1572
    • (2005) J Biol Chem , vol.280 , pp. 1561-1572
    • Nakamura, N.1    Tanaka, S.2    Teko, Y.3    Mitsui, K.4    Kanazawa, H.5
  • 29
    • 0036083415 scopus 로고    scopus 로고
    • Human Na(+)/H(+) exchanger isoform 6 is found in recycling endosomes of cells, not in mitochondria
    • Brett C.L., Wei Y., Donowitz M., and Rao R. Human Na(+)/H(+) exchanger isoform 6 is found in recycling endosomes of cells, not in mitochondria. Am J Physiol 282 (2002) C1031-C1041
    • (2002) Am J Physiol , vol.282
    • Brett, C.L.1    Wei, Y.2    Donowitz, M.3    Rao, R.4
  • 30
    • 0035907355 scopus 로고    scopus 로고
    • + exchanger localized to the trans-Golgi network
    • + exchanger localized to the trans-Golgi network. J Biol Chem 276 (2001) 17387-17394
    • (2001) J Biol Chem , vol.276 , pp. 17387-17394
    • Numata, M.1    Orlowski, J.2
  • 33
    • 0027931588 scopus 로고
    • + exchanger NHE-1 possesses N- and O-linked glycosylation restricted to the first N-terminal extracellular domain
    • + exchanger NHE-1 possesses N- and O-linked glycosylation restricted to the first N-terminal extracellular domain. Biochemistry 33 (1994) 10463-10469
    • (1994) Biochemistry , vol.33 , pp. 10463-10469
    • Counillon, L.1    Pouyssegur, J.2    Reithmeier, R.A.3
  • 35
    • 0034636804 scopus 로고    scopus 로고
    • Na(+)/H(+) exchanger NHE3 has 11 membrane spanning domains and a cleaved signal peptide: topology analysis using in vitro transcription/translation
    • Zizak M., Cavet M.E., Bayle D., Tse C.M., Hallen S., Sachs G., et al. Na(+)/H(+) exchanger NHE3 has 11 membrane spanning domains and a cleaved signal peptide: topology analysis using in vitro transcription/translation. Biochemistry 39 (2000) 8102-8112
    • (2000) Biochemistry , vol.39 , pp. 8102-8112
    • Zizak, M.1    Cavet, M.E.2    Bayle, D.3    Tse, C.M.4    Hallen, S.5    Sachs, G.6
  • 36
    • 0035966109 scopus 로고    scopus 로고
    • NHE6 protein possesses a signal peptide destined for endoplasmic reticulum membrane and localizes in secretory organelles of the cell
    • Miyazaki E., Sakaguchi M., Wakabayashi S., Shigekawa M., and Mihara K. NHE6 protein possesses a signal peptide destined for endoplasmic reticulum membrane and localizes in secretory organelles of the cell. J Biol Chem 276 (2001) 49221-49227
    • (2001) J Biol Chem , vol.276 , pp. 49221-49227
    • Miyazaki, E.1    Sakaguchi, M.2    Wakabayashi, S.3    Shigekawa, M.4    Mihara, K.5
  • 37
    • 0027392811 scopus 로고
    • + exchanger: identification of thiol-dependent transitions in apparent molecular size
    • + exchanger: identification of thiol-dependent transitions in apparent molecular size. Biochem J 289 (1993) 101-107
    • (1993) Biochem J , vol.289 , pp. 101-107
    • Fliegel, L.1    Haworth, R.S.2    Dyck, J.R.B.3
  • 38
    • 0028101308 scopus 로고
    • + exchanger isoforms NHE1 and NHE3 exist as stable dimers in membranes with a high degree of specificity for homodimers
    • + exchanger isoforms NHE1 and NHE3 exist as stable dimers in membranes with a high degree of specificity for homodimers. J Biol Chem 269 (1994) 2589-2596
    • (1994) J Biol Chem , vol.269 , pp. 2589-2596
    • Fafournoux, P.1    Noel, J.2    Pouysségur, J.3
  • 39
    • 4644271441 scopus 로고    scopus 로고
    • + exchanger NHE1 revealed by symmetrical intermolecular cross-linking and selective co-immunoprecipitation
    • + exchanger NHE1 revealed by symmetrical intermolecular cross-linking and selective co-immunoprecipitation. Biochemistry 43 (2004) 11135-11143
    • (2004) Biochemistry , vol.43 , pp. 11135-11143
    • Hisamitsu, T.1    Pang, T.2    Shigekawa, M.3    Wakabayashi, S.4
  • 40
    • 0016804597 scopus 로고
    • Coupling of lithium to sodium transport in human red cells
    • Haas M., Schooler J., and Tosteson D.C. Coupling of lithium to sodium transport in human red cells. Nature 258 (1975) 425-427
    • (1975) Nature , vol.258 , pp. 425-427
    • Haas, M.1    Schooler, J.2    Tosteson, D.C.3
  • 41
    • 0020637490 scopus 로고
    • Sodium-lithium countertransport in erythrocytes of hypertension prone families in Utah
    • Williams R.R., Hunt S.C., Kuida H., Smith J.B., and Ash K.O. Sodium-lithium countertransport in erythrocytes of hypertension prone families in Utah. Am J Epidemiol 118 (1983) 338-444
    • (1983) Am J Epidemiol , vol.118 , pp. 338-444
    • Williams, R.R.1    Hunt, S.C.2    Kuida, H.3    Smith, J.B.4    Ash, K.O.5
  • 42
    • 0023694034 scopus 로고
    • Hypertension and sodium-lithium countertransport in Utah pedigrees: evidence for major-locus inheritance
    • Hasstedt S.J., Wu L.L., Ash K.O., Kuida H., and Williams R.R. Hypertension and sodium-lithium countertransport in Utah pedigrees: evidence for major-locus inheritance. Am J Hum Genet 43 (1988) 14-22
    • (1988) Am J Hum Genet , vol.43 , pp. 14-22
    • Hasstedt, S.J.1    Wu, L.L.2    Ash, K.O.3    Kuida, H.4    Williams, R.R.5
  • 43
    • 8544222698 scopus 로고    scopus 로고
    • Elevated sodium-lithium countertransport activity in erythrocytes is predictive of the development of microalbuminuria in IDDM
    • Monciotti C.G., Semplicini A., Morocutti A., Maioli M., Cipollina M.R., Barzon I., et al. Elevated sodium-lithium countertransport activity in erythrocytes is predictive of the development of microalbuminuria in IDDM. Diabetologia 40 (1997) 654-661
    • (1997) Diabetologia , vol.40 , pp. 654-661
    • Monciotti, C.G.1    Semplicini, A.2    Morocutti, A.3    Maioli, M.4    Cipollina, M.R.5    Barzon, I.6
  • 44
    • 0018834154 scopus 로고
    • Increased sodium-lithium countertransport in red cells of patients with essential hypertension
    • Canessa M., Adragna N., Solomon H.S., Connolly T.M., and Tosteson D.C. Increased sodium-lithium countertransport in red cells of patients with essential hypertension. N Engl J Med 302 (1980) 772-776
    • (1980) N Engl J Med , vol.302 , pp. 772-776
    • Canessa, M.1    Adragna, N.2    Solomon, H.S.3    Connolly, T.M.4    Tosteson, D.C.5
  • 47
    • 0037983655 scopus 로고    scopus 로고
    • Alternative splicing of NHE-1 mediates Na-Li countertransport and associates with activity rate
    • Zerbini G., Maestroni A., Breviario D., Mangili R., and Casari G. Alternative splicing of NHE-1 mediates Na-Li countertransport and associates with activity rate. Diabetes 52 (2003) 1511-1518
    • (2003) Diabetes , vol.52 , pp. 1511-1518
    • Zerbini, G.1    Maestroni, A.2    Breviario, D.3    Mangili, R.4    Casari, G.5
  • 48
    • 33846870761 scopus 로고    scopus 로고
    • Structural and functional analysis of the Na(+)/H(+) exchanger
    • Slepkov E.R., Rainey J.K., Sykes B.D., and Fliegel L. Structural and functional analysis of the Na(+)/H(+) exchanger. Biochem J 401 (2007) 623-633
    • (2007) Biochem J , vol.401 , pp. 623-633
    • Slepkov, E.R.1    Rainey, J.K.2    Sykes, B.D.3    Fliegel, L.4
  • 49
    • 0025966286 scopus 로고
    • Exclusion of the Na(+)-H+ antiporter as a candidate gene in human essential hypertension
    • Lifton R.P., Hunt S.C., Williams R.R., Pouyssegur J., and Lalouel J.M. Exclusion of the Na(+)-H+ antiporter as a candidate gene in human essential hypertension. Hypertension 17 (1991) 8-14
    • (1991) Hypertension , vol.17 , pp. 8-14
    • Lifton, R.P.1    Hunt, S.C.2    Williams, R.R.3    Pouyssegur, J.4    Lalouel, J.M.5
  • 51
    • 0029840340 scopus 로고    scopus 로고
    • + exchanger that confer sensitivity to pharmacological antagonists
    • + exchanger that confer sensitivity to pharmacological antagonists. J Biol Chem 271 (1996) 19922-19927
    • (1996) J Biol Chem , vol.271 , pp. 19922-19927
    • Orlowski, J.1    Kandasamy, R.A.2
  • 53
    • 0027245907 scopus 로고
    • + exchanger gene (NHE1) and amplification of the mutated allele confer amiloride resistance upon chronic acidosis
    • + exchanger gene (NHE1) and amplification of the mutated allele confer amiloride resistance upon chronic acidosis. Proc Natl Acad Sci U S A 90 (1993) 4508-4512
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 4508-4512
    • Counillon, L.1    Franchi, A.2    Pouyssegur, J.3
  • 54
    • 0035942328 scopus 로고    scopus 로고
    • + exchanger reveal the participation of TM4 into a highly constrained sodium-binding site
    • + exchanger reveal the participation of TM4 into a highly constrained sodium-binding site. Biochemistry 40 (2001) 5095-5101
    • (2001) Biochemistry , vol.40 , pp. 5095-5101
    • Touret, N.1    Poujeol, P.2    Counillon, L.3
  • 55
    • 0035941272 scopus 로고    scopus 로고
    • + exchanger important for drug recognition and cation translocation
    • + exchanger important for drug recognition and cation translocation. J Biol Chem 276 (2001) 43792-43800
    • (2001) J Biol Chem , vol.276 , pp. 43792-43800
    • Khadilkar, A.1    Iannuzzi, P.2    Orlowski, J.3
  • 57
    • 0346963148 scopus 로고    scopus 로고
    • + and the interaction with amiloride derivatives
    • + and the interaction with amiloride derivatives. Biochemistry 42 (2003) 15361-15368
    • (2003) Biochemistry , vol.42 , pp. 15361-15368
    • Noel, J.1    Germain, D.2    Vadnais, J.3
  • 65
    • 2642569621 scopus 로고    scopus 로고
    • + exchange inhibition by cariporide on death and nonfatal myocardial infarction in patients undergoing coronary artery bypass graft surgery: The Expedition Study
    • (Abstract)
    • + exchange inhibition by cariporide on death and nonfatal myocardial infarction in patients undergoing coronary artery bypass graft surgery: The Expedition Study. Circulation 108 3M (2003) 2723 (Abstract)
    • (2003) Circulation , vol.108 , Issue.3 M , pp. 2723
    • Mentzer Jr., R.M.1
  • 66
    • 0025993390 scopus 로고
    • + exchanger, NHE-1, by phosphorylating a set of common sites
    • + exchanger, NHE-1, by phosphorylating a set of common sites. J Biol Chem 266 (1991) 19166-19171
    • (1991) J Biol Chem , vol.266 , pp. 19166-19171
    • Sardet, C.1    Fafournoux, P.2    Pouyssegur, J.3
  • 67
    • 0033551771 scopus 로고    scopus 로고
    • + exchanger in the rat myocardium by MAP-kinase-dependent pathways
    • + exchanger in the rat myocardium by MAP-kinase-dependent pathways. J Biol Chem 274 (1999) 22985-22992
    • (1999) J Biol Chem , vol.274 , pp. 22985-22992
    • Moor, A.N.1    Fliegel, L.2
  • 69
    • 0041355337 scopus 로고    scopus 로고
    • + exchanger NHE1 by sustained intracellular acidosis. Evidence for a novel mechanism mediated by the ERK pathway
    • + exchanger NHE1 by sustained intracellular acidosis. Evidence for a novel mechanism mediated by the ERK pathway. J Biol Chem 278 (2003) 31676-31684
    • (2003) J Biol Chem , vol.278 , pp. 31676-31684
    • Haworth, R.S.1    McCann, C.2    Snabaitis, A.K.3    Roberts, N.A.4    Avkiran, M.5
  • 70
    • 34250378750 scopus 로고    scopus 로고
    • + exchanger is mediated through phosphorylation of amino acids Ser770 and Ser771
    • + exchanger is mediated through phosphorylation of amino acids Ser770 and Ser771. J Biol Chem 282 (2007) 6292-6299
    • (2007) J Biol Chem , vol.282 , pp. 6292-6299
    • Malo, M.E.1    Li, L.2    Fliegel, L.3
  • 71
    • 0035844256 scopus 로고    scopus 로고
    • + exchanger isoform 1 (NHE1) in ischemic and ischemic-reperfused rat heart
    • + exchanger isoform 1 (NHE1) in ischemic and ischemic-reperfused rat heart. J Biol Chem 27 (2001) 16113-16122
    • (2001) J Biol Chem , vol.27 , pp. 16113-16122
    • Moor, A.1    Gan, X.T.2    Karmazyn, M.3    Fliegel, L.4
  • 76
    • 0034631854 scopus 로고    scopus 로고
    • Intracellular pH regulation by Na(+)/H(+) exchange requires phosphatidylinositol 4,5-bisphosphate
    • Aharonovitz O., Zaun H.C., Balla T., York J.D., Orlowski J., and Grinstein S. Intracellular pH regulation by Na(+)/H(+) exchange requires phosphatidylinositol 4,5-bisphosphate. J Cell Biol 150 (2000) 213-224
    • (2000) J Cell Biol , vol.150 , pp. 213-224
    • Aharonovitz, O.1    Zaun, H.C.2    Balla, T.3    York, J.D.4    Orlowski, J.5    Grinstein, S.6
  • 78
    • 0013572689 scopus 로고
    • + exchange activity in renal brush border membrane vesicle in response to metabolic acidosis: the role of glucocorticoids
    • + exchange activity in renal brush border membrane vesicle in response to metabolic acidosis: the role of glucocorticoids. Proc Natl Acad Sci U S A 81 (1984) 630-634
    • (1984) Proc Natl Acad Sci U S A , vol.81 , pp. 630-634
    • Kinsella, J.1    Cujdik, T.2    Sacktor, B.3
  • 81
    • 0025789879 scopus 로고
    • Differential regulation of Na/H antiporter by acid in renal epithelial cells and fibroblasts
    • Moe O.W., Miller R.T., Horie S., Cano A., Preisig P.A., and Alpern R.J. Differential regulation of Na/H antiporter by acid in renal epithelial cells and fibroblasts. J Clin Invest 88 (1991) 1703-1708
    • (1991) J Clin Invest , vol.88 , pp. 1703-1708
    • Moe, O.W.1    Miller, R.T.2    Horie, S.3    Cano, A.4    Preisig, P.A.5    Alpern, R.J.6
  • 83
    • 0028859824 scopus 로고
    • Induction of expression of the sodium-hydrogen exchanger in rat myocardium
    • Dyck J.R.B., Maddaford T., Pierce G.N., and Fliegel L. Induction of expression of the sodium-hydrogen exchanger in rat myocardium. Cardiovasc Res 29 (1995) 203-208
    • (1995) Cardiovasc Res , vol.29 , pp. 203-208
    • Dyck, J.R.B.1    Maddaford, T.2    Pierce, G.N.3    Fliegel, L.4
  • 90
    • 0034920855 scopus 로고    scopus 로고
    • Role of sodium-hydrogen exchange in cardiac hypertrophy and heart failure: a novel and promising therapeutic target
    • Karmazyn M. Role of sodium-hydrogen exchange in cardiac hypertrophy and heart failure: a novel and promising therapeutic target. Basic Res Cardiol 96 (2001) 325-328
    • (2001) Basic Res Cardiol , vol.96 , pp. 325-328
    • Karmazyn, M.1
  • 91
    • 0346848841 scopus 로고    scopus 로고
    • Aldosterone increases NHE-1 expression and induces NHE-1-dependent hypertrophy in neonatal rat ventricular myocytes
    • Karmazyn M., Liu Q., Gan X.T., Brix B.J., and Fliegel L. Aldosterone increases NHE-1 expression and induces NHE-1-dependent hypertrophy in neonatal rat ventricular myocytes. Hypertension 42 (2003) 1171-1176
    • (2003) Hypertension , vol.42 , pp. 1171-1176
    • Karmazyn, M.1    Liu, Q.2    Gan, X.T.3    Brix, B.J.4    Fliegel, L.5
  • 92
    • 4644297981 scopus 로고    scopus 로고
    • Role of NHE-1 in cardiac hypertrophy and heart failure. p. 211-219
    • Karmazyn M., Avkiran M., and Fliegel L. (Eds), Kluwer Academic Publishers, Boston 318 pp.
    • + Exchanger, From Molecular to Its Role in Disease (2003), Kluwer Academic Publishers, Boston 318 pp.
    • (2003) + Exchanger, From Molecular to Its Role in Disease
    • Karmazyn, M.1
  • 93
    • 0032547857 scopus 로고    scopus 로고
    • Stretch-induced alkalinization of feline papillary muscle: an autocrine-paracrine system
    • Cingolani H.E., Alvarez B.V., Ennis I.L., and Camilion de Hurtado M.C. Stretch-induced alkalinization of feline papillary muscle: an autocrine-paracrine system. Circ Res 83 (1998) 775-780
    • (1998) Circ Res , vol.83 , pp. 775-780
    • Cingolani, H.E.1    Alvarez, B.V.2    Ennis, I.L.3    Camilion de Hurtado, M.C.4
  • 94
    • 0028971509 scopus 로고
    • pHi regulation in myocardium of the spontaneously hypertensive rat. Compensated enhanced activity of the Na(+)-H+ exchanger
    • Perez N.G., Alvarez B.V., Camilion de Hurtado M.C., and Cingolani H.E. pHi regulation in myocardium of the spontaneously hypertensive rat. Compensated enhanced activity of the Na(+)-H+ exchanger. Circ Res 77 (1995) 1192-1200
    • (1995) Circ Res , vol.77 , pp. 1192-1200
    • Perez, N.G.1    Alvarez, B.V.2    Camilion de Hurtado, M.C.3    Cingolani, H.E.4
  • 95
    • 33947582886 scopus 로고    scopus 로고
    • Sodium-hydrogen exchanger, cardiac overload, and myocardial hypertrophy
    • Cingolani H.E., and Ennis I.L. Sodium-hydrogen exchanger, cardiac overload, and myocardial hypertrophy. Circulation 115 (2007) 1090-1100
    • (2007) Circulation , vol.115 , pp. 1090-1100
    • Cingolani, H.E.1    Ennis, I.L.2
  • 97
    • 18244380357 scopus 로고    scopus 로고
    • Sodium calcium exchanger plays a key role in alteration of cardiac function in response to pressure overload
    • Takimoto E., Yao A., Toko H., Takano H., Shimoyama M., Sonoda M., et al. Sodium calcium exchanger plays a key role in alteration of cardiac function in response to pressure overload. FASEB J 16 (2002) 373-378
    • (2002) FASEB J , vol.16 , pp. 373-378
    • Takimoto, E.1    Yao, A.2    Toko, H.3    Takano, H.4    Shimoyama, M.5    Sonoda, M.6
  • 98
    • 0033179237 scopus 로고    scopus 로고
    • Na(+) influx via Na(+)/H(+) exchange activates protein kinase C isozymes delta and epsilon in cultured neonatal rat cardiac myocytes
    • Hayasaki-Kajiwara Y., Kitano Y., Iwasaki T., Shimamura T., Naya N., Iwaki K., et al. Na(+) influx via Na(+)/H(+) exchange activates protein kinase C isozymes delta and epsilon in cultured neonatal rat cardiac myocytes. J Mol Cell Cardiol 31 (1999) 1559-1572
    • (1999) J Mol Cell Cardiol , vol.31 , pp. 1559-1572
    • Hayasaki-Kajiwara, Y.1    Kitano, Y.2    Iwasaki, T.3    Shimamura, T.4    Naya, N.5    Iwaki, K.6
  • 99
    • 0344837733 scopus 로고    scopus 로고
    • Sodium restriction prevents cardiac hypertrophy and oxidative stress in angiotensin II hypertension
    • Rugale C., Delbosc S., Cristol J.P., Mimran A., and Jover B. Sodium restriction prevents cardiac hypertrophy and oxidative stress in angiotensin II hypertension. Am J Physiol Heart Circ Physiol 284 (2003) H1744-H1750
    • (2003) Am J Physiol Heart Circ Physiol , vol.284
    • Rugale, C.1    Delbosc, S.2    Cristol, J.P.3    Mimran, A.4    Jover, B.5
  • 100
    • 33646771019 scopus 로고    scopus 로고
    • + exchanger isoform 1 inhibition is mediated by reduced mitogen-activated protein kinase activation secondary to improved mitochondrial integrity and decreased generation of mitochondrial-derived reactive oxygen species
    • + exchanger isoform 1 inhibition is mediated by reduced mitogen-activated protein kinase activation secondary to improved mitochondrial integrity and decreased generation of mitochondrial-derived reactive oxygen species. J Pharmacol Exp Ther 317 (2006) 1036-1043
    • (2006) J Pharmacol Exp Ther , vol.317 , pp. 1036-1043
    • Javadov, S.1    Baetz, D.2    Rajapurohitam, V.3    Zeidan, A.4    Kirshenbaum, L.A.5    Karmazyn, M.6
  • 102
    • 0037134401 scopus 로고    scopus 로고
    • Inhibition of Na(+)-H(+) exchange prevents hypertrophy, fibrosis, and heart failure in beta(1)-adrenergic receptor transgenic mice
    • Engelhardt S., Hein L., Keller U., Klambt K., and Lohse M.J. Inhibition of Na(+)-H(+) exchange prevents hypertrophy, fibrosis, and heart failure in beta(1)-adrenergic receptor transgenic mice. Circ Res 90 (2002) 814-819
    • (2002) Circ Res , vol.90 , pp. 814-819
    • Engelhardt, S.1    Hein, L.2    Keller, U.3    Klambt, K.4    Lohse, M.J.5
  • 103
    • 0034623812 scopus 로고    scopus 로고
    • Diabetes-induced vascular hypertrophy is accompanied by activation of Na(+)-H(+) exchange and prevented by Na(+)-H(+) exchange inhibition
    • Jandeleit-Dahm K., Hannan K.M., Farrelly C.A., Allen T.J., Rumble J.R., Gilbert R.E., et al. Diabetes-induced vascular hypertrophy is accompanied by activation of Na(+)-H(+) exchange and prevented by Na(+)-H(+) exchange inhibition. Circ Res 87 (2000) 1133-1140
    • (2000) Circ Res , vol.87 , pp. 1133-1140
    • Jandeleit-Dahm, K.1    Hannan, K.M.2    Farrelly, C.A.3    Allen, T.J.4    Rumble, J.R.5    Gilbert, R.E.6
  • 104
    • 0035957030 scopus 로고    scopus 로고
    • Signaling pathways responsible for fetal gene induction in the failing human heart: evidence for altered thyroid hormone receptor gene expression
    • Kinugawa K., Minobe W.A., Wood W.M., Ridgway E.C., Baxter J.D., Ribeiro R.C., et al. Signaling pathways responsible for fetal gene induction in the failing human heart: evidence for altered thyroid hormone receptor gene expression. Circulation 103 (2001) 1089-1094
    • (2001) Circulation , vol.103 , pp. 1089-1094
    • Kinugawa, K.1    Minobe, W.A.2    Wood, W.M.3    Ridgway, E.C.4    Baxter, J.D.5    Ribeiro, R.C.6
  • 105
    • 0023713203 scopus 로고
    • Protooncogene induction and reprogramming of cardiac gene expression produced by pressure overload
    • Izumo S., Nadal-Ginard B., and Mahdavi V. Protooncogene induction and reprogramming of cardiac gene expression produced by pressure overload. Proc Natl Acad Sci U S A 85 (1988) 339-343
    • (1988) Proc Natl Acad Sci U S A , vol.85 , pp. 339-343
    • Izumo, S.1    Nadal-Ginard, B.2    Mahdavi, V.3
  • 106
    • 0036299747 scopus 로고    scopus 로고
    • Developmental regulation of Na(+)/H(+) exchanger expression in fetal and neonatal mice
    • Rieder C.V., and Fliegel L. Developmental regulation of Na(+)/H(+) exchanger expression in fetal and neonatal mice. Am J Physiol 283 (2002) H273-H283
    • (2002) Am J Physiol , vol.283
    • Rieder, C.V.1    Fliegel, L.2
  • 107
    • 0037281190 scopus 로고    scopus 로고
    • + exchanger expression in the intact mouse
    • + exchanger expression in the intact mouse. Mol Cell Biochem 243 (2003) 87-95
    • (2003) Mol Cell Biochem , vol.243 , pp. 87-95
    • Rieder, C.V.1    Fliegel, L.2
  • 108
    • 0030978540 scopus 로고    scopus 로고
    • + exchanger during post-natal development in the rat: changes in mRNA expression and sarcolemmal activity
    • + exchanger during post-natal development in the rat: changes in mRNA expression and sarcolemmal activity. J Mol Cell Cardiol 29 (1997) 321-332
    • (1997) J Mol Cell Cardiol , vol.29 , pp. 321-332
    • Haworth, R.S.1    Yasutake, M.2    Brooks, G.3    Avkiran, M.4
  • 111
    • 0029001329 scopus 로고
    • Phylogenetically conserved sequences in the promoter of the rabbit sodium-hydrogen exchanger isoform 1 gene (NHE1 SLC9A1)
    • Blaurock N.C., Reboucas N.A., Kusnezov J.L., and Igarashi P. Phylogenetically conserved sequences in the promoter of the rabbit sodium-hydrogen exchanger isoform 1 gene (NHE1 SLC9A1). Biochim Biophys Acta 1262 (1995) 159-163
    • (1995) Biochim Biophys Acta , vol.1262 , pp. 159-163
    • Blaurock, N.C.1    Reboucas, N.A.2    Kusnezov, J.L.3    Igarashi, P.4
  • 115
    • 0026724957 scopus 로고
    • Role of protein kinase C and transcription factor AP-1 in the acid-induced increase in Na/H antiporter activity
    • Horie S., Moe O., Yamaji Y., Cano A., Miller R.T., and Alpern R.J. Role of protein kinase C and transcription factor AP-1 in the acid-induced increase in Na/H antiporter activity. Proc Natl Acad Sci U S A 89 (1992) 5236-5240
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 5236-5240
    • Horie, S.1    Moe, O.2    Yamaji, Y.3    Cano, A.4    Miller, R.T.5    Alpern, R.J.6
  • 116
    • 0029562218 scopus 로고
    • Role of C/EBP proteins in hepatic and vascular smooth muscle transcription of human NHE1 gene
    • Kolyada A.Y., Johns C.A., and Madias N.E. Role of C/EBP proteins in hepatic and vascular smooth muscle transcription of human NHE1 gene. Am J Physiol 269 (1995) C1408-C1416
    • (1995) Am J Physiol , vol.269
    • Kolyada, A.Y.1    Johns, C.A.2    Madias, N.E.3
  • 118
    • 0029937590 scopus 로고    scopus 로고
    • Regulation of NHE1 expression in L6 muscle cells
    • Yang W., Dyck J.R.B., and Fliegel L. Regulation of NHE1 expression in L6 muscle cells. Biochim Biophys Acta 1306 (1996) 107-113
    • (1996) Biochim Biophys Acta , vol.1306 , pp. 107-113
    • Yang, W.1    Dyck, J.R.B.2    Fliegel, L.3
  • 119
    • 0028906182 scopus 로고
    • + exchanger during neuronal differentiation of embryonal carcinoma cells
    • + exchanger during neuronal differentiation of embryonal carcinoma cells. J Biol Chem 270 (1995) 10420-10427
    • (1995) J Biol Chem , vol.270 , pp. 10420-10427
    • Dyck, J.R.B.1    Fliegel, L.2
  • 120
    • 0029833711 scopus 로고    scopus 로고
    • + exchanger gene expression. Role of a novel poly(dA:dT) element in regulation of the NHE1 promoter
    • + exchanger gene expression. Role of a novel poly(dA:dT) element in regulation of the NHE1 promoter. J Biol Chem 271 (1996) 20444-20449
    • (1996) J Biol Chem , vol.271 , pp. 20444-20449
    • Yang, W.1    Wang, H.2    Fliegel, L.3
  • 121
    • 0034834554 scopus 로고    scopus 로고
    • COUP-TF I and COUP-TFII regulate expression of the NHE through a nuclear hormone responsive element with enhancer activity
    • Fernandez-Rachubinski F., and Fliegel L. COUP-TF I and COUP-TFII regulate expression of the NHE through a nuclear hormone responsive element with enhancer activity. Eur J Biochem 268 (2001) 620-634
    • (2001) Eur J Biochem , vol.268 , pp. 620-634
    • Fernandez-Rachubinski, F.1    Fliegel, L.2
  • 123
    • 0030060047 scopus 로고    scopus 로고
    • Regulation of the NHE-1 promoter in the mammalian myocardium
    • Yang W., Dyck J.R.B., Wang H., and Fliegel L. Regulation of the NHE-1 promoter in the mammalian myocardium. Am J Physiol 270 (1996) H259-H266
    • (1996) Am J Physiol , vol.270
    • Yang, W.1    Dyck, J.R.B.2    Wang, H.3    Fliegel, L.4
  • 125
  • 126
    • 33748163520 scopus 로고    scopus 로고
    • Antioxidant actions contribute to the antihypertrophic effects of atrial natriuretic peptide in neonatal rat cardiomyocytes
    • Laskowski A., Woodman O.L., Cao A.H., Drummond G.R., Marshall T., Kaye D.M., et al. Antioxidant actions contribute to the antihypertrophic effects of atrial natriuretic peptide in neonatal rat cardiomyocytes. Cardiovasc Res 72 (2006) 112-123
    • (2006) Cardiovasc Res , vol.72 , pp. 112-123
    • Laskowski, A.1    Woodman, O.L.2    Cao, A.H.3    Drummond, G.R.4    Marshall, T.5    Kaye, D.M.6
  • 127
    • 27644442419 scopus 로고    scopus 로고
    • Endothelin-1-mediated increase in reactive oxygen species and NADPH Oxidase activity in hearts of aryl hydrocarbon receptor (AhR) null mice
    • Lund A.K., Peterson S.L., Timmins G.S., and Walker M.K. Endothelin-1-mediated increase in reactive oxygen species and NADPH Oxidase activity in hearts of aryl hydrocarbon receptor (AhR) null mice. Toxicol Sci 88 (2005) 265-273
    • (2005) Toxicol Sci , vol.88 , pp. 265-273
    • Lund, A.K.1    Peterson, S.L.2    Timmins, G.S.3    Walker, M.K.4
  • 128
    • 20944437464 scopus 로고    scopus 로고
    • Role of mitogen-activated protein kinase pathway in reactive oxygen species-mediated endothelin-1-induced beta-myosin heavy chain gene expression and cardiomyocyte hypertrophy
    • Cheng T.H., Shih N.L., Chen C.H., Lin H., Liu J.C., Chao H.H., et al. Role of mitogen-activated protein kinase pathway in reactive oxygen species-mediated endothelin-1-induced beta-myosin heavy chain gene expression and cardiomyocyte hypertrophy. J Biomed Sci 12 (2005) 123-133
    • (2005) J Biomed Sci , vol.12 , pp. 123-133
    • Cheng, T.H.1    Shih, N.L.2    Chen, C.H.3    Lin, H.4    Liu, J.C.5    Chao, H.H.6
  • 129
    • 33644936885 scopus 로고    scopus 로고
    • + exchanger 1 gene expression connects intracellular redox status with cells' sensitivity to death triggers
    • + exchanger 1 gene expression connects intracellular redox status with cells' sensitivity to death triggers. Cell Death Differ 13 (2006) 628-641
    • (2006) Cell Death Differ , vol.13 , pp. 628-641
    • Akram, S.1    Teong, H.F.2    Fliegel, L.3    Pervaiz, S.4    Clement, M.V.5
  • 130
    • 34548786801 scopus 로고    scopus 로고
    • Oxidative repression of NHE1 gene expression involves iron-mediated caspase activity
    • Kumar A.P., Chang M.K., Fliegel L., Pervaiz S., and Clement M.V. Oxidative repression of NHE1 gene expression involves iron-mediated caspase activity. Cell Death Differ 14 (2007) 1733-1746
    • (2007) Cell Death Differ , vol.14 , pp. 1733-1746
    • Kumar, A.P.1    Chang, M.K.2    Fliegel, L.3    Pervaiz, S.4    Clement, M.V.5
  • 131
    • 0041843136 scopus 로고    scopus 로고
    • + Exchanger, p. 1-15
    • Karmazyn M., Avkiran M., and Fliegel L. (Eds), Kluwer academic Publishers, Boston 318 pp.
    • + Exchanger, p. 1-15. In: Karmazyn M., Avkiran M., and Fliegel L. (Eds). From Molecular to Its Role in Disease (2003), Kluwer academic Publishers, Boston 318 pp.
    • (2003) From Molecular to Its Role in Disease
    • Spitzer, K.W.1    Vaughan-Jones, R.D.2


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