Pharmacological profile of KR-33028, a highly selective inhibitor of Na+/H+ exchanger

European Journal of Pharmacology

Volumn 535, Issue 1-3, 2006, Pages 220-227

  Jung, Yi Sook ^a   Kim, Mi Young ^a   Kim, Mi Jeong ^a   Oh, Kwang Seok ^b   Yi, Kyu Yang ^b   Lee, Sunkyung ^b   Yoo, Sung Eun ^b   Lee, Byung Ho ^b  

^a Ajou University School of Medicine   (South Korea)

^b Korea Research Institute of Chemical Technology   (South Korea)

Author keywords

Cardioprotective effects; Hypoxia; Ischemia; KR 33028; Na+ H+ exchanger

Indexed keywords

4 CYANO(BENZO[B]THIOPHENE 2 CARBONYL)GUANIDINE; CARIPORIDE; CYTOCHROME C; KR 33028; PROTEIN INHIBITOR; SODIUM PROTON EXCHANGE PROTEIN; UNCLASSIFIED DRUG;

ACIDOSIS; ACUTE TOXICITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; CYTOSOL; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; DRUG SELECTIVITY; DYSPNEA; HEART MUSCLE CONTRACTILITY; HEART PROTECTION; ISCHEMIA; MALE; MITOCHONDRION; NECROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY;

ADENOSINE TRIPHOSPHATE; AMMONIUM CHLORIDE; ANIMALS; APOPTOSIS; BEHAVIOR, ANIMAL; BINDING, COMPETITIVE; CALCIUM; CARDIOTONIC AGENTS; CELL HYPOXIA; CELL LINE; CYTOSOL; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTE COUNT; FEMALE; GLYCOGEN; GUANIDINES; HEART; HUMANS; HYDROGEN-ION CONCENTRATION; IN SITU NICK-END LABELING; MALE; MITOCHONDRIA; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; ORGAN SIZE; PERFUSION; PHOSPHOCREATINE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CELL SURFACE; SODIUM-HYDROGEN ANTIPORTER; SPLEEN; THIOPHENES;

EID: 33645397147     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2006.01.041     Document Type: Article

References (25)

1. + exchange inhibitors for cardioprotective therapy: progress, problems and prospects J. Am. Coll. Cardiol. 39 2002 747 753
2. 2+ network J. Cell Biol. 136 1997 833 844
3. R.K. Emaus, R. Grunwald, and J.J. Lemasters Rhodamine 123 as a probe of transmembrane potential in isolated rat-liver mitochondria: spectral and metabolic properties Biochim. Biophys. Acta 850 1986 436 448
4. D.M. Filipovic, X. Meng, and W.B. Reeves Inhibition of PARP prevents oxidant-induced necrosis but not apoptosis in LLC-PK1 cells Am. J. Physiol. 277 1999 F428 F436
5. ATP channel and protein kinase C activation in heart-derived H9c2 cells J. Pharm. Sci. 92 2003 13 18
6. M. Karmazyn Role of sodium-hydrogen exchange in cardiac hypertrophy and heart failure: a novel and promising therapeutic target Basic Res. Cardiol. 96 2001 325 328
7. 2+ overload and mitochondrial death pathway in H9c2 cells Eur. J. Pharmacol. 525 2005 1 7
8. J.Y. Koh, and D.W. Choi Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay J. Neurosci. Methods 20 1987 83 90
9. G. Kroemer The mitochondrion as an integrator/coordinator of cell death pathways Cell Death Differ. 5 1998 547
10. B.H. Lee, H.W. Seo, and S.E. Yoo Cardioprotective effects of (2S, 3R, 4S)-N′-benzyl-N″-cyano-N-(3,4-dihydro-2-dimethoxymethyl-3-hydroxy-2- methyl-6-nitro-2H-benzopyran-4-yl)-guanidine (KR-31372) in rats and dogs Pharmacology 70 2004 74 82
11. + exchanger inhibitor, on functional and metabolic impairments produced by global ischemia and reperfusion in the perfused rat heart Eur. J. Pharmacol. 511 2005 175 182
12. + exchanger isoform-1 inhibition J. Med. Chem. 48 2005 2882 2891
13. + exchanger isoform-1 (NHE-1) inhibitors Bioorg. Med. Chem. Lett. 15 2005 2998 3001
14. B.H. Lee, K.Y. Yi, S. Lee, S. Lee, and S.E. Yoo Effects of KR-32570, a new sodium hydrogen exchanger inhibitor, on myocardial infarction and arrhythmias induced by ischemia and reperfusion Eur. J. Pharmacol. 523 2005 101 108
15. C.H. Leem, D. Lagadic-Gossmann, and R.D. Vaughan-Jones Characterization of intracellular pH regulation in the guinea-pig ventricular myocyte J. Physiol. 517 1999 159 180
16. C.H. Moon, Y.S. Jung, M.H. Kim, R.M. Park, S.H. Lee, and E.J. Baik Protein kinase C inhibitors attenuate protective effect of high glucose against hypoxic injury in H9c2 cardiac cells Jpn. J. Physiol. 50 2000 645 649
17. S. Orrenius, B. Zhivotovsky, and P. Nicotera Regulation of cell death: the calcium-apoptosis link Nat. Rev., Mol. Cell Biol. 4 2003 552 565
18. A. Roos, and W.F. Boron Intracellular pH Physiol. Rev. 61 1981 296 434
19. S.S. Smaili, Y.T. Hsu, A.C. Carvalho, T.R. Rosenstock, J.C. Sharpe, and R.J. Youle Mitochondria, calcium and pro-apoptotic proteins as mediators in cell death signaling Braz. J. Med. Biol. Res. 36 2003 183 190
20. + exchanger in hypoxia/re-oxygenation-induced neonatal rat cardiomyocyte apoptosis Eur. J. Pharmacol. 486 2004 121 131
21. J.A. Thomas, R.N. Buchsbaum, A. Zimniak, and E. Racker Intracellular pH measurements in Ehrlich ascites tumor cells utilizing spectroscopic probes generated in situ Biochemistry 18 1979 2210 2218
22. 2+ transients during the contractile cycle in adult rabbit cardiac myocytes Biochem. Biophys. Res. Commun. 236 1997 738 742
23. G.W. Wang, J.B. Klein, and Y.J. Kang Metallothionein inhibits doxorubicin-induced mitochondrial cytochrome c release and caspase-3 activation in cardiomyocytes J. Pharmacol. Exp. Ther. 298 2001 461 468
24. F. Wroblewski, and J.S. La Due Lactic dehydrogenase activity in blood Proc. Soc. Exp. Biol. Med. 90 1995 210 213
25. 2+ exchanger function during early and late relaxation in ventricular myocytes Am. J. Physiol. 273 1997 H2765 H2773