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Volumn 44, Issue 1, 2010, Pages 65-79

The role of cyclooxygenases in neurotoxicity of amyloid β peptides in Alzheimer's disease;Znaczenie cyklooksygenaz w neurotoksyczności peptydów amyloidu β w chorobie Alzheimera

Author keywords

Alzheimer's disease; Amyloid ; Cyclooxygenase; Inflammation

Indexed keywords

AMYLOID BETA PROTEIN; OLIGOMER; PROSTAGLANDIN SYNTHASE;

EID: 77951273883     PISSN: 00283843     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0028-3843(14)60407-2     Document Type: Review
Times cited : (6)

References (121)
  • 2
    • 5644239087 scopus 로고    scopus 로고
    • Alzheimer disease: Mechanistic understanding predicts novel therapies
    • Selkoe DJ. Alzheimer disease: mechanistic understanding predicts novel therapies. Ann Intern Med 2004; 140: 627-638.
    • (2004) Ann Intern Med , vol.140 , pp. 627-638
    • Selkoe, D.J.1
  • 3
    • 85031336695 scopus 로고    scopus 로고
    • Peptydy amyloidu beta w mózgu starczym i w patomechanizmie choroby Alzheimera
    • Strosznajder J.B., Mossakowski J.M. (red.). Upowszechnianie Nauki - Oświata "UN-O", Warszawa
    • Strosznajder J.B., Łałowski M.M. Peptydy amyloidu beta w mózgu starczym i w patomechanizmie choroby Alzheimera. W: Strosznajder J.B., Mossakowski J.M. (red.). Mózg a starzenie. Upowszechnianie Nauki - Oświata "UN-O", Warszawa 2001.
    • (2001) Mózg a Starzenie
    • Strosznajder, J.B.1    Łałowski, M.M.2
  • 4
    • 0037135111 scopus 로고    scopus 로고
    • The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
    • DOI 10.1126/science.1072994
    • Hardy J., Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 2002; 297: 353-356. (Pubitemid 34790756)
    • (2002) Science , vol.297 , Issue.5580 , pp. 353-356
    • Hardy, J.1    Selkoe, D.J.2
  • 5
    • 0026646605 scopus 로고
    • Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids
    • i wsp.
    • Seubert P., Vigo-Pelfrey C., Esch F. i wsp. Isolation and quantification of soluble Alzheimer's beta-peptide from biological fluids. Nature 1992; 359: 325-327.
    • (1992) Nature , vol.359 , pp. 325-327
    • Seubert, P.1    Vigo-Pelfrey, C.2    Esch, F.3
  • 6
    • 0027258525 scopus 로고
    • The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease
    • Jarrett J.T., Berger E.P., Lansbury P.T. Jr. The carboxy terminus of the beta amyloid protein is critical for the seeding of amyloid formation: implications for the pathogenesis of Alzheimer's disease. Biochemistry 1993; 32: 4693-4697.
    • (1993) Biochemistry , vol.32 , pp. 4693-4697
    • Jarrett, J.T.1    Berger, E.P.2    Lansbury Jr., P.T.3
  • 7
    • 0025753852 scopus 로고
    • The molecular pathology of Alzheimer's disease
    • Selkoe DJ. The molecular pathology of Alzheimer's disease. Neuron 1991; 6: 487-498.
    • (1991) Neuron , vol.6 , pp. 487-498
    • Selkoe, D.J.1
  • 9
    • 0033570337 scopus 로고    scopus 로고
    • Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons
    • i wsp.
    • Hartley D.M., Walsh D.M., Ye C.P. i wsp. Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons. J Neurosci 1999; 19: 8876-8884.
    • (1999) J Neurosci , vol.19 , pp. 8876-8884
    • Hartley, D.M.1    Walsh, D.M.2    Ye, C.P.3
  • 10
    • 33645038471 scopus 로고    scopus 로고
    • A specific amyloid-beta protein assembly in the brain impairs memory
    • i wsp.
    • Lesné S., Koh M.T., Kotilinek L. i wsp. A specific amyloid-beta protein assembly in the brain impairs memory. Nature 2006; 440: 352-357.
    • (2006) Nature , vol.440 , pp. 352-357
    • Lesné, S.1    Koh, M.T.2    Kotilinek, L.3
  • 11
    • 33645505550 scopus 로고    scopus 로고
    • Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: A potent role for trimers
    • i wsp.
    • Townsend M., Shankar G.M., Mehta T. i wsp. Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers. J Physiol 2006; 572: 477-492.
    • (2006) J Physiol , vol.572 , pp. 477-492
    • Townsend, M.1    Shankar, G.M.2    Mehta, T.3
  • 12
    • 0032590054 scopus 로고    scopus 로고
    • Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease
    • i wsp.
    • McLean C.A., Cherny R.A., Eraser F.W. i wsp. Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease. Ann Neurol 1999; 46: 860-866.
    • (1999) Ann Neurol , vol.46 , pp. 860-866
    • McLean, C.A.1    Cherny, R.A.2    Eraser, F.W.3
  • 14
    • 0037041426 scopus 로고    scopus 로고
    • Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo
    • DOI 10.1038/416535a
    • Walsh D.M., Klyubin I., Fadeeva J.V. i wsp. Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 2002; 416: 535-539. (Pubitemid 34288854)
    • (2002) Nature , vol.416 , Issue.6880 , pp. 535-539
    • Walsh, D.M.1    Klyubin, I.2    Fadeeva, J.V.3    Cullen, W.K.4    Anwyl, R.5    Wolfe, M.S.6    Rowan, M.J.7    Selkoe, D.J.8
  • 15
    • 33947314641 scopus 로고    scopus 로고
    • Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway
    • i wsp.
    • Shankar G.M., Bloodgood B.L., Townsend M. i wsp. Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. J Neurosci 2007; 27: 2866-2875.
    • (2007) J Neurosci , vol.27 , pp. 2866-2875
    • Shankar, G.M.1    Bloodgood, B.L.2    Townsend, M.3
  • 16
    • 0037015020 scopus 로고    scopus 로고
    • The Alzheimer's a beta-peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration
    • i wsp.
    • Johnson LV, Leitner WE, Rivest A.J. i wsp. The Alzheimer's A beta-peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration. Proc Natl Acad Sci USA 2002; 99: 11830-11835.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 11830-11835
    • Johnson, L.V.1    Leitner, W.E.2    Rivest, A.J.3
  • 17
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimer's disease: Genes, proteins, and therapy
    • Selkoe DJ. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev 2001; 81: 741-766.
    • (2001) Physiol Rev , vol.81 , pp. 741-766
    • Selkoe, D.J.1
  • 18
    • 4944258716 scopus 로고    scopus 로고
    • The role of inflammation in Alzheimer's disease
    • Tuppo E.E., Arias H.R. The role of inflammation in Alzheimer's disease. Int J Biochem Cell Biol 2005; 37: 289-305.
    • (2005) Int J Biochem Cell Biol , vol.37 , pp. 289-305
    • Tuppo, E.E.1    Arias, H.R.2
  • 19
    • 0029795517 scopus 로고    scopus 로고
    • Inflammation, Abeta deposition, and neurofibrillary tangle formation as correlates of Alzheimer's disease neurodegeneration
    • Lue L.F., Brachova L., Civin WH. i wsp. Inflammation, A beta deposition, and neurofibrillary tangle formation as correlates of Alzheimer's disease neurodegeneration. J Neuropathol Exp Neurol 1996; 55: 1083-1088. (Pubitemid 26338020)
    • (1996) Journal of Neuropathology and Experimental Neurology , vol.55 , Issue.10 , pp. 1083-1088
    • Lue, L.-F.1    Brachova, L.2    Civin, W.H.3    Rogers, J.4
  • 20
    • 0035866060 scopus 로고    scopus 로고
    • Beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis
    • i wsp.
    • Combs C.K., Karlo J.C., Kao S-C. i wsp. beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis. J Neurosci 2001; 21: 1179-1188.
    • (2001) J Neurosci , vol.21 , pp. 1179-1188
    • Combs, C.K.1    Karlo, J.C.2    Kao, S.-C.3
  • 21
    • 0035695987 scopus 로고    scopus 로고
    • Gene expression profiling of amyloid beta peptide-stimulated human post-mortem brain microglia
    • DOI 10.1016/S0197-4580(01)00306-2, PII S0197458001003062
    • Walker D.G., Lue L.F., Beach T.G. Gene expression profiling of amyloid beta peptide-stimulated human post-mortem brain microglia. Neurobiol Aging 2001; 22: 957-966. (Pubitemid 34066564)
    • (2001) Neurobiology of Aging , vol.22 , Issue.6 , pp. 957-966
    • Walker, D.G.1    Lue, L.-F.2    Beach, T.G.3
  • 22
    • 32544456878 scopus 로고    scopus 로고
    • Glia as a therapeutic target: Selective suppression of human amyloid-beta-induced upregulation of brain proinflammatory cytokine production attenuates neurodegeneration
    • i wsp.
    • Ralay Ranaivo H., Craft J.M., Hu W. i wsp. Glia as a therapeutic target: selective suppression of human amyloid-beta-induced upregulation of brain proinflammatory cytokine production attenuates neurodegeneration. J Neurosci 2006; 26: 662-670.
    • (2006) J Neurosci , vol.26 , pp. 662-670
    • Ralay Ranaivo, H.1    Craft, J.M.2    Hu, W.3
  • 24
    • 0035936004 scopus 로고    scopus 로고
    • Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease
    • in t'Veld B., Ruitenberg A., Hofman A. Nonsteroidal antiinflammatory drugs and the risk of Alzheimer's disease. N Engl J Med 2001; 345: 1515-1521.
    • (2001) N Engl J Med , vol.345 , pp. 1515-1521
    • T'Veld, B.1    Ruitenberg, A.2    Hofman, A.3
  • 25
    • 0038375640 scopus 로고    scopus 로고
    • Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: Systematic review and meta-analysis of observational studies
    • Etminan M., Gill S., Samii A. Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: systematic review and meta-analysis of observational studies. BMJ 2003; 327: 128. (Pubitemid 36876203)
    • (2003) British Medical Journal , vol.327 , Issue.7407 , pp. 128-131
    • Etminan, M.1    Gill, S.2    Samii, A.3
  • 28
    • 0036499224 scopus 로고    scopus 로고
    • Prostaglandins as modulators of immunity
    • i wsp.
    • Harris S.G., Padilla J., Koumas L. i wsp. Prostaglandins as modulators of immunity. Trends Immunol 2002; 23: 144-150.
    • (2002) Trends Immunol , vol.23 , pp. 144-150
    • Harris, S.G.1    Padilla, J.2    Koumas, L.3
  • 29
    • 0345861750 scopus 로고    scopus 로고
    • Synaptic lipid signaling: Significance of polyunsaturated fatty acids and plateled-activating factor
    • Bazan N.G. Synaptic lipid signaling: significance of polyunsaturated fatty acids and plateled-activating factor. J Lipid Res 2003; 44: 2221-2233.
    • (2003) J Lipid Res , vol.44 , pp. 2221-2233
    • Bazan, N.G.1
  • 30
    • 0030479496 scopus 로고    scopus 로고
    • Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2
    • Smith W.L., Garavito R.M., DeWitt D.L. Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2. J Biol Chem 1996; 271: 33157-33160.
    • (1996) J Biol Chem , vol.271 , pp. 33157-33160
    • Smith, W.L.1    Garavito, R.M.2    DeWitt, D.L.3
  • 31
    • 0027293391 scopus 로고
    • Expression of mRNA for cyclooxygenase-1 and cyclooxygenase-2 in human tissues
    • O'Neill G.P., Ford-Hutchinson A.W. Expression of mRNA for cyclooxygenase-1 and cyclooxygenase-2 in human tissues. FEBS Lett 1993; 330: 156-160. (Pubitemid 23265121)
    • (1993) FEBS Letters , vol.330 , Issue.2 , pp. 156-160
    • O'Neill, G.P.1    Ford-Hutchinson, A.W.2
  • 32
    • 77951279168 scopus 로고    scopus 로고
    • Cyklooksygenazy. I. Rola w odczynie zapalnym
    • Kołaczkowska E. Cyklooksygenazy. I. Rola w odczynie zapalnym. Post Biol Kom 2002; 29: 533-554.
    • (2002) Post Biol Kom , vol.29 , pp. 533-554
    • Kołaczkowska, E.1
  • 33
    • 0036156424 scopus 로고    scopus 로고
    • Cyclooxygenase-2 - 10 years later
    • Hinz B., Brune K. Cyclooxygenase-2 - 10 years later. J Pharmacol Exp Ther 2002; 300: 367-375.
    • (2002) J Pharmacol Exp Ther , vol.300 , pp. 367-375
    • Hinz, B.1    Brune, K.2
  • 34
    • 1842714301 scopus 로고    scopus 로고
    • Neuroinflammation, COX-2, and ALS - A dual role?
    • Consilvio C., Vincent A.M., Feldman E.L. Neuroinflammation, COX-2, and ALS - a dual role? Exp Neurol 2004; 187: 1-10.
    • (2004) Exp Neurol , vol.187 , pp. 1-10
    • Consilvio, C.1    Vincent, A.M.2    Feldman, E.L.3
  • 35
    • 25644445318 scopus 로고    scopus 로고
    • Acetaminophen and the cyclooxygenase-3 puzzle: Sorting out facts, fictions, and uncertainties
    • Kis B., Snipes J.A., Busija D.W. Acetaminophen and the cyclooxygenase-3 puzzle: sorting out facts, fictions, and uncertainties. J Pharmacol Exp Ther 2005; 315: 1-7.
    • (2005) J Pharmacol Exp Ther , vol.315 , pp. 1-7
    • Kis, B.1    Snipes, J.A.2    Busija, D.W.3
  • 36
    • 4444333049 scopus 로고    scopus 로고
    • Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases
    • Minghetti L. Cyclooxygenase-2 (COX-2) in inflammatory and degenerative brain diseases. J Neuropathol Exp Neurol 2004; 63: 901-910. (Pubitemid 39202493)
    • (2004) Journal of Neuropathology and Experimental Neurology , vol.63 , Issue.9 , pp. 901-910
    • Minghetti, L.1
  • 38
    • 0014117395 scopus 로고
    • Identification of prostaglandins in central nervous tissues of the cat and chicken
    • Horton E.W., Main I.H. Identification of prostaglandins in central nervous tissues of the cat and chicken. Br J Pharmacol Chemother 1967; 30: 582-602.
    • (1967) Br J Pharmacol Chemother , vol.30 , pp. 582-602
    • Horton, E.W.1    Main, I.H.2
  • 39
    • 0013933124 scopus 로고
    • Spontaneous and evoked release of prostaglandins from cerebral cortex of anesthetized cats
    • Ramwell P.W., Shaw J.E. Spontaneous and evoked release of prostaglandins from cerebral cortex of anesthetized cats. Am J Physiol 1966; 211: 125-134.
    • (1966) Am J Physiol , vol.211 , pp. 125-134
    • Ramwell, P.W.1    Shaw, J.E.2
  • 40
    • 0038391161 scopus 로고    scopus 로고
    • Deficits in spatial learning and synaptic plasticity induced by the rapid and competitive broad-spectrum cyclooxygenase inhibitor ibuprofen are reversed by increasing endogenous brain-derived neurotrophic factor
    • DOI 10.1046/j.1460-9568.2003.02643.x
    • Shaw K.N., Commins S., O'Mara S.M. Deficits in spatial learning and synaptic plasticity induced by the rapid and competitive broad-spectrum cyclooxygenase inhibitor Ibuprofen are reversed by increasing endogenous brain-derived neurotrophic factor. Eur J Neurosci 2003; 17: 2438-2446. (Pubitemid 36793752)
    • (2003) European Journal of Neuroscience , vol.17 , Issue.11 , pp. 2438-2446
    • Shaw, K.N.1    Commins, S.2    O'Mara, S.M.3
  • 41
    • 0027290813 scopus 로고
    • Expression of a mitogen-inducible cyclooxygenase in brain neurons: Regulation by synaptic activity and glucocorticoids
    • DOI 10.1016/0896-6273(93)90192-T
    • Yamagata K., Andreasson K.I., Kaufmann W.E. i wsp. Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids. Neuron 1993; 11: 371-386. (Pubitemid 23250354)
    • (1993) Neuron , vol.11 , Issue.2 , pp. 371-386
    • Yamagata, K.1    Andreasson, K.I.2    Kaufmann, W.E.3    Barnes, C.A.4    Worley, P.F.5
  • 42
    • 0028010036 scopus 로고
    • Eicosanoids in synaptic transmission
    • Piomelli D. Eicosanoids in synaptic transmission. Crit Rev Neurobiol 1994; 8: 65-83.
    • (1994) Crit Rev Neurobiol , vol.8 , pp. 65-83
    • Piomelli, D.1
  • 43
    • 0036082805 scopus 로고    scopus 로고
    • 2 signaling in hippocampal long-term synaptic plasticity
    • Chen C, Magee J.C., Bazan N.G. Cyclooxygenase-2 regulates prostaglandin E-2 signaling in hippocampal long-term synaptic plasticity. J Neurophysiol 2002; 87: 2851-2857. (Pubitemid 34670665)
    • (2002) Journal of Neurophysiology , vol.87 , Issue.6 , pp. 2851-2857
    • Chen, C.1    Magee, J.C.2    Bazan, N.G.3
  • 44
    • 12544250740 scopus 로고    scopus 로고
    • Endogenous PGE2 regulates membrane excitability and synaptic transmission in hippocampal CA1 pyramidal neurons
    • Chen C., Bazan N.G. Endogenous PGE2 regulates membrane excitability and synaptic transmission in hippocampal CA1 pyramidal neurons. J Neurophysiol 2005; 93: 929-941.
    • (2005) J Neurophysiol , vol.93 , pp. 929-941
    • Chen, C.1    Bazan, N.G.2
  • 45
    • 0028969527 scopus 로고
    • Different intracellular locations for prostaglandin endoperoxide H synthase-1 and -2
    • i wsp.
    • Morita I., Schindler M., Regier M.K. i wsp. Different intracellular locations for prostaglandin endoperoxide H synthase-1 and -2. J Biol Chem 1995; 270: 10902-10908.
    • (1995) J Biol Chem , vol.270 , pp. 10902-10908
    • Morita, I.1    Schindler, M.2    Regier, M.K.3
  • 47
    • 0031821321 scopus 로고    scopus 로고
    • Indomethacin reverses the microglial response to amyloid beta-protein
    • i wsp.
    • Netland E.E., Newton J.L., Majocha L.E. i wsp. Indomethacin reverses the microglial response to amyloid beta-protein. Neurobiol Aging 1998; 19: 201-204.
    • (1998) Neurobiol Aging , vol.19 , pp. 201-204
    • Netland, E.E.1    Newton, J.L.2    Majocha, L.E.3
  • 48
    • 0031900411 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drug use and Alzheimer-type pathology in aging
    • Mackenzie I.R., Munoz D.G. Nonsteroidal anti-inflammatory drug use and Alzheimer-type pathology in aging. Neurology 1998; 50: 986-990.
    • (1998) Neurology , vol.50 , pp. 986-990
    • Mackenzie, I.R.1    Munoz, D.G.2
  • 49
    • 0035141118 scopus 로고    scopus 로고
    • Cyclooxygenase expression in microglia and neurons in Alzheimer's disease and control brain
    • i wsp.
    • Hoozemans J.J., Rozemuller A.J., Janssen I. i wsp. Cyclooxygenase expression in microglia and neurons in Alzheimer's disease and control brain. Acta Neuropathol 2001; 101: 2-8.
    • (2001) Acta Neuropathol , vol.101 , pp. 2-8
    • Hoozemans, J.J.1    Rozemuller, A.J.2    Janssen, I.3
  • 50
    • 0032605115 scopus 로고    scopus 로고
    • Expression of cyclooxygenase-2 in astrocytes of human brain after global ischemia
    • i wsp.
    • Maślińska D., Woźniak R., Kaliszek A. i wsp. Expression of cyclooxygenase-2 in astrocytes of human brain after global ischemia. Folia Neuropathol 1999; 37: 75-79.
    • (1999) Folia Neuropathol , vol.37 , pp. 75-79
    • Maślińska, D.1    Woźniak, R.2    Kaliszek, A.3
  • 51
    • 0032969529 scopus 로고    scopus 로고
    • Expression of COX-2 by normal and reactive astrocytes in the adult rat central nervous system
    • i wsp.
    • Hirst W.D., Young K.A., Newton R. i wsp. Expression of COX-2 by normal and reactive astrocytes in the adult rat central nervous system. Mol Cell Neurosci 1999; 13: 57-68.
    • (1999) Mol Cell Neurosci , vol.13 , pp. 57-68
    • Hirst, W.D.1    Young, K.A.2    Newton, R.3
  • 52
    • 0032896588 scopus 로고    scopus 로고
    • Cyclooxygenase-2: Molecular biology, pharmacology, and neurobiology
    • O'Banion M.K. Cyclooxygenase-2: molecular biology, pharmacology, and neurobiology. Crit Rev Neurobiol 1999; 13: 45-82.
    • (1999) Crit Rev Neurobiol , vol.13 , pp. 45-82
    • O'Banion, M.K.1
  • 53
    • 33646117738 scopus 로고    scopus 로고
    • Amyloid beta peptide (25-35) activates protein kinase C leading to cyclooxygenase-2 induction and prostaglandin E2 release in primary midbrain astrocytes
    • i wsp.
    • Hüll M., Müksch B., Akundi R.S. i wsp. Amyloid beta peptide (25-35) activates protein kinase C leading to cyclooxygenase-2 induction and prostaglandin E2 release in primary midbrain astrocytes. Neurochem Int 2006; 48: 663-672.
    • (2006) Neurochem Int , vol.48 , pp. 663-672
    • Hüll, M.1    Müksch, B.2    Akundi, R.S.3
  • 54
    • 0032518514 scopus 로고    scopus 로고
    • Prostaglandins stimulate calcium-dependent glutamate release in astrocytes
    • i wsp.
    • Bezzi P., Carmignoto G., Pasti L. i wsp. Prostaglandins stimulate calcium-dependent glutamate release in astrocytes. Nature 1998; 391: 281-285.
    • (1998) Nature , vol.391 , pp. 281-285
    • Bezzi, P.1    Carmignoto, G.2    Pasti, L.3
  • 58
    • 0035653648 scopus 로고    scopus 로고
    • Central and peripheral roles of prostaglandins in pain and their interactions with novel neuropeptides nociceptin and nocistatin
    • PII S0168010201002899
    • Ito S., Okuda-Ashitaka E., Minami T. Central and peripheral roles of prostaglandins in pain and their interactions with novel neuropeptides nociceptin and nocistatin. Neurosci Res 2001; 41: 299-332. (Pubitemid 33733750)
    • (2001) Neuroscience Research , vol.41 , Issue.4 , pp. 299-332
    • Ito, S.1    Okuda-Ashitaka, E.2    Minami, T.3
  • 59
    • 0030787985 scopus 로고    scopus 로고
    • Involvement of cyclooxygenase-2 in LPS-induced fever and regulation of its mRNA by LPS in the rat brain
    • i wsp.
    • Cao C., Matsumura K., Yamagata K. i wsp. Involvement of cyclooxygenase-2 in LPS-induced fever and regulation of its mRNA by LPS in the rat brain. Am J Physiol 1997; 272: R1712-R1725.
    • (1997) Am J Physiol , vol.272
    • Cao, C.1    Matsumura, K.2    Yamagata, K.3
  • 61
    • 0029811901 scopus 로고    scopus 로고
    • Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: A review of 17 epidemiologic studies
    • McGeer P.L., Schulzer M., McGeer E.G. Arthritis and inflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiological studies. Neurology 1996; 47: 425-432. (Pubitemid 26324038)
    • (1996) Neurology , vol.47 , Issue.2 , pp. 425-432
    • McGeer, P.L.1    Schulzer, M.2    McGeer, E.G.3
  • 62
    • 0035696257 scopus 로고    scopus 로고
    • Do NSAIDs prevent Alzheimer's disease? And, if so, why? The epidemiological evidence
    • Zandi P.P., Breitner J.C. Do NSAIDs prevent Alzheimer's disease? And, if so, why? The epidemiological evidence. Neurobiol Aging 2001; 22: 811-817.
    • (2001) Neurobiol Aging , vol.22 , pp. 811-817
    • Zandi, P.P.1    Breitner, J.C.2
  • 63
    • 0033178889 scopus 로고    scopus 로고
    • Regional distribution of cyclooxygenase-2 in the hippocampal formation in Alzheimer's disease
    • DOI 10.1002/(SICI)1097-4547(19990801)57:3<295::AID-JNR1>3.0.CO;2-0
    • Ho L., Pieroni C., Winger D. i wsp. Regional distribution of cyclooxygenase-2 in the hippocampal formation in Alzheimer's disease. J Neurosci Res 1999; 57: 295-303. (Pubitemid 29339785)
    • (1999) Journal of Neuroscience Research , vol.57 , Issue.3 , pp. 295-303
    • Ho, L.1    Pieroni, C.2    Winger, D.3    Purohit, D.P.4    Aisen, P.S.5    Pasinetti, G.M.6
  • 64
    • 0032551633 scopus 로고    scopus 로고
    • Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain
    • DOI 10.1016/S0306-4522(98)00218-8, PII S0306452298002188
    • Pasinetti G.M., Aisen P.S. Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain. Neuroscience 1998; 87: 319-324. (Pubitemid 28370892)
    • (1998) Neuroscience , vol.87 , Issue.2 , pp. 319-324
    • Pasinetti, G.M.1    Aisen, P.S.2
  • 65
    • 20444377686 scopus 로고    scopus 로고
    • Regulation of cyclooxygenase-2 system by interleukin-1beta through mitogen-activated protein kinase signaling pathways: A comparative study of human neuroglioma and neuroblastoma cells
    • Moolwaney A.S., Igwe A.J. Regulation of cyclooxygenase-2 system by interleukin-1beta through mitogen-activated protein kinase signaling pathways: a comparative study of human neuroglioma and neuroblastoma cells. Brain Res Mol Brain Res 2005; 137: 202-212.
    • (2005) Brain Res Mol Brain Res , vol.137 , pp. 202-212
    • Moolwaney, A.S.1    Igwe, A.J.2
  • 66
    • 19444377638 scopus 로고    scopus 로고
    • Beta-amyloid-induced apoptosis is associated with cyclooxygenase-2 up-regulation via the mitogen-activated protein kinase-NF-kappaB signaling pathway
    • Jang J.H., Surh Y.J. Beta-amyloid-induced apoptosis is associated with cyclooxygenase-2 up-regulation via the mitogen-activated protein kinase-NF-kappaB signaling pathway. Free Rad Biol Med 2005; 38: 1604-1613.
    • (2005) Free Rad Biol Med , vol.38 , pp. 1604-1613
    • Jang, J.H.1    Surh, Y.J.2
  • 67
    • 0036323485 scopus 로고    scopus 로고
    • Cyclin D1 and cyclin e are co-localized with cyclooxygenase 2 (COX-2) in pyramidal neurons in Alzheimer disease temporal cortex
    • i wsp.
    • Hoozemans J.J., Brückner M.K., Rozemuller A.J. i wsp. Cyclin D1 and cyclin E are co-localized with cyclooxygenase 2 (COX-2) in pyramidal neurons in Alzheimer disease temporal cortex. J Neuropathol Exp Neurol 2002; 61: 678-688.
    • (2002) J Neuropathol Exp Neurol , vol.61 , pp. 678-688
    • Hoozemans, J.J.1    Brückner, M.K.2    Rozemuller, A.J.3
  • 68
    • 0035693794 scopus 로고    scopus 로고
    • Downregulation of neuronal cyclooxygenase-2 expression in end stage Alzheimer's disease
    • Yermakova A.V., O'Banion M.K. Downregulation of neuronal cyclooxygenase-2 expression in end stage Alzheimer's disease. Neurobiol Aging 2001; 22: 823-836.
    • (2001) Neurobiol Aging , vol.22 , pp. 823-836
    • Yermakova, A.V.1    O'Banion, M.K.2
  • 69
    • 33644541112 scopus 로고    scopus 로고
    • Neuroinflammation and regeneration in the early stages of Alzheimer's disease pathology
    • DOI 10.1016/j.ijdevneu.2005.11.001, PII S0736574805001425, Neural Signal Transduction in Health and Disease - Cytokinesd, Mitochondrial Dysfunction and Transport Processes
    • Hoozemans J.J., Veerhuis R., Rozemuller J.M. i wsp. Neuroinflammation and regeneration in the early stages of Alzheimer's disease pathology. Int J Dev Neurosci 2006; 24: 157-165. (Pubitemid 43294622)
    • (2006) International Journal of Developmental Neuroscience , vol.24 , Issue.2-3 , pp. 157-165
    • Hoozemans, J.J.M.1    Veerhuis, R.2    Rozemuller, J.M.3    Eikelenboom, P.4
  • 71
    • 30744441143 scopus 로고    scopus 로고
    • 2 mediates neuronal damage by amyloid-beta or prions which activates microglial cells
    • DOI 10.1016/j.neuropharm.2005.09.008, PII S0028390805003515
    • Bate C., Kempster S., Williams A. Prostaglandin D2 mediates neuronal damage by amyloid-beta or prions which activates microglial cells. Neuropharmacology 2006; 50: 229-237. (Pubitemid 43100008)
    • (2006) Neuropharmacology , vol.50 , Issue.2 , pp. 229-237
    • Bate, C.1    Kempster, S.2    Williams, A.3
  • 72
    • 17444410014 scopus 로고    scopus 로고
    • Microglial EP2 as a new target to increase amyloid beta phagocytosis and decrease amyloid beta-induced damage to neurons
    • i wsp.
    • Shie F.S., Montine K.S., Breyer R.M. i wsp. Microglial EP2 as a new target to increase amyloid beta phagocytosis and decrease amyloid beta-induced damage to neurons. Brain Pathol 2005; 15: 134-138.
    • (2005) Brain Pathol , vol.15 , pp. 134-138
    • Shie, F.S.1    Montine, K.S.2    Breyer, R.M.3
  • 76
    • 33746433950 scopus 로고    scopus 로고
    • Cycloxygenase-2 activity promotes cognitive deficits but not increased amyloid burden in a model of Alzheimer's disease in a sex-dimorphic pattern
    • DOI 10.1016/j.neuroscience.2006.05.001, PII S030645220600621X
    • Melnikova T., Savonenko A., Wang Q. i wsp. Cyclooxygenase-2 activity promotes cognitive deficits but not increased amyloid burden in a model of Alzheimer's disease in a sex-dimorphic pattern. Neuroscience 2006; 141: 1149-1162. (Pubitemid 44128685)
    • (2006) Neuroscience , vol.141 , Issue.3 , pp. 1149-1162
    • Melnikova, T.1    Savonenko, A.2    Wang, Q.3    Liang, X.4    Hand, T.5    Wu, L.6    Kaufmann, W.E.7    Vehmas, A.8    Andreasson, K.I.9
  • 77
    • 0036227488 scopus 로고    scopus 로고
    • Cyclooxygenase (COX)-2 and cell cycle activity in a transgenic mouse model of Alzheimer's disease neuropathology
    • DOI 10.1016/S0197-4580(01)00282-2, PII S0197458001002822
    • Xiang Z., Ho L., Valdellon J. i wsp. Cyclooxygenase (COX)-2 and cell cycle activity in a transgenic mouse model of Alzheimer's disease neuropathology. Neurobiol Aging 2002; 23: 327-334. (Pubitemid 34312015)
    • (2002) Neurobiology of Aging , vol.23 , Issue.3 , pp. 327-334
    • Xiang, Z.1    Ho, L.2    Valdellon, J.3    Borchelt, D.4    Kelley, K.5    Spielman, L.6    Aisen, P.S.7    Pasinetti, G.M.8
  • 78
    • 26444548179 scopus 로고    scopus 로고
    • Differential effects of COX inhibitors against beta-amyloid-induced neurotoxicity in human neuroblastoma cells
    • DOI 10.1016/j.neuint.2005.06.012, PII S0197018605001853
    • Ferrera P., Arias C. Differential effects of COX inhibitors against beta-amyloid-induced neurotoxicity in human neuroblastoma cells. Neurochem Int 2005; 47: 589-596. (Pubitemid 41437904)
    • (2005) Neurochemistry International , vol.47 , Issue.8 , pp. 589-596
    • Ferrera, P.1    Arias, C.2
  • 79
    • 0037323054 scopus 로고    scopus 로고
    • 2 pathway in production of reactive oxygen species in Alzheimer's disease
    • DOI 10.1023/A:1022389503105
    • Andersen J.M., Myhre O., Fonnum F. Discussion of the role of the extracellular signal-regulated kinase-phospholipase A2 pathway in production of reactive oxygen species in Alzheimer's disease. Neurochem Res 2003; 28: 319-326. (Pubitemid 36207355)
    • (2003) Neurochemical Research , vol.28 , Issue.2 , pp. 319-326
    • Andersen, J.M.1    Myhre, O.2    Fonnum, F.3
  • 80
    • 0035013564 scopus 로고    scopus 로고
    • Brain oxidative stress in animal models of accelerated aging and the age-related neurodegenerative disorders, Alzheimer's disease and Huntington's disease
    • Butterfield D.A., Howard B.J., LaFontaine M.A. Brain oxidative stress in animal models of accelerated aging and the age-related neurodegenerative disorders, Alzheimer's disease and Huntington's disease. Curr Med Chem 2001; 8: 815-828.
    • (2001) Curr Med Chem , vol.8 , pp. 815-828
    • Butterfield, D.A.1    Howard, B.J.2    LaFontaine, M.A.3
  • 81
    • 2442433807 scopus 로고    scopus 로고
    • Peroxidase Activity of Cyclooxygenase-2 (COX-2) cross-links beta-amyloid (Abeta) and generates Abeta-COX-2 hetero-oligomers that are increased in Alzheimer's disease
    • i wsp.
    • Nagano S., Huang X., Moir R.D. i wsp. Peroxidase Activity of Cyclooxygenase-2 (COX-2) cross-links beta-amyloid (Abeta) and generates Abeta-COX-2 hetero-oligomers that are increased in Alzheimer's disease. J Biol Chem 2004; 279: 14673-14678.
    • (2004) J Biol Chem , vol.279 , pp. 14673-14678
    • Nagano, S.1    Huang, X.2    Moir, R.D.3
  • 82
    • 17444365094 scopus 로고    scopus 로고
    • Cyclooxygenase-dependent lipid-modification of brain proteins
    • i wsp.
    • Boutaud O., Andreasson K.I., Zagol-Ikapitte I. i wsp. Cyclooxygenase-dependent lipid-modification of brain proteins. Brain Pathol 2005; 15: 139-142.
    • (2005) Brain Pathol , vol.15 , pp. 139-142
    • Boutaud, O.1    Andreasson, K.I.2    Zagol-Ikapitte, I.3
  • 83
    • 23844500606 scopus 로고    scopus 로고
    • Prostaglandin H (2)-derived adducts of proteins correlate with Alzheimer's disease severity
    • i wsp.
    • Zagol-Ikapitte I., Masterson T.S., Amarnath V. i wsp. Prostaglandin H (2)-derived adducts of proteins correlate with Alzheimer's disease severity. J Neurochem 2005; 94: 1140-1145.
    • (2005) J Neurochem , vol.94 , pp. 1140-1145
    • Zagol-Ikapitte, I.1    Masterson, T.S.2    Amarnath, V.3
  • 84
    • 0034923671 scopus 로고    scopus 로고
    • Neuronal apoptosis at the G1/S cell cycle checkpoint
    • Liu D.X., Greene L.A. Neuronal apoptosis at the G1/S cell cycle checkpoint. Cell Tissue Res 2001; 305: 217-228.
    • (2001) Cell Tissue Res , vol.305 , pp. 217-228
    • Liu, D.X.1    Greene, L.A.2
  • 85
    • 0036231413 scopus 로고    scopus 로고
    • Role of cyclooxygenase-2 in neuronal cell cycle activity and glutamate-mediated excitotoxicity
    • Mirjany M., Ho L., Pasinetti M.G. Role of cyclooxygenase-2 in neuronal cell cycle activity and glutamate-mediated excitotoxicity. J Pharmacol Exp Ther 2002; 301: 494-499.
    • (2002) J Pharmacol Exp Ther , vol.301 , pp. 494-499
    • Mirjany, M.1    Ho, L.2    Pasinetti, M.G.3
  • 86
    • 0031661968 scopus 로고    scopus 로고
    • The cell division cycle and the pathophysiology of Alzheimer's disease
    • Nagy Z., Esiri M.M., Smith A.D. The cell division cycle and the pathophysiology of Alzheimer's disease. Neuroscience 1998; 87: 731-739.
    • (1998) Neuroscience , vol.87 , pp. 731-739
    • Nagy, Z.1    Esiri, M.M.2    Smith, A.D.3
  • 87
    • 1842576590 scopus 로고    scopus 로고
    • Neuronal COX-2 expression and phosphorylation of pRb precede p38 MAPK activation and neurofibrillary changes in AD temporal cortex
    • i wsp.
    • Hoozemans J.J., Veerhuis R., Rozemuller A.J. i wsp. Neuronal COX-2 expression and phosphorylation of pRb precede p38 MAPK activation and neurofibrillary changes in AD temporal cortex. Neurobiol Dis 2004; 15: 492-499.
    • (2004) Neurobiol Dis , vol.15 , pp. 492-499
    • Hoozemans, J.J.1    Veerhuis, R.2    Rozemuller, A.J.3
  • 88
    • 0030000385 scopus 로고    scopus 로고
    • The role of anti-inflammatory drugs in the prevention and treatment of Alzheimer's disease
    • Breitner J.C. The role of anti-inflammatory drugs in the prevention and treatment of Alzheimer's disease. Annu Rev Med 1996; 47: 401-411.
    • (1996) Annu Rev Med , vol.47 , pp. 401-411
    • Breitner, J.C.1
  • 89
    • 0038268656 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drugs and cyclooxygenase in Alzheimer's disease
    • i wsp.
    • Hoozemans J.J., Veerhuis R., Rozemuller A.J. i wsp. Non-steroidal anti-inflammatory drugs and cyclooxygenase in Alzheimer's disease. Curr Drug Targets 2003; 4: 461-468.
    • (2003) Curr Drug Targets , vol.4 , pp. 461-468
    • Hoozemans, J.J.1    Veerhuis, R.2    Rozemuller, A.J.3
  • 90
    • 0038064189 scopus 로고    scopus 로고
    • Pharmacologic agents associated with a preventive effect on Alzheimer's disease: A review of the epidemiologic evidence
    • i wsp.
    • in t'Veld B.A., Launer L.J., Breteler M.M. i wsp. Pharmacologic agents associated with a preventive effect on Alzheimer's disease: a review of the epidemiologic evidence. Epidemiol Rev 2002; 24: 248-268.
    • (2002) Epidemiol Rev , vol.24 , pp. 248-268
    • T'Veld, B.A.1    Launer, L.J.2    Breteler, M.M.3
  • 91
    • 0038375640 scopus 로고    scopus 로고
    • Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: Systematic review and meta-analysis of observational studies
    • Etminan M., Gill S., Samii A. Effect of non-steroidal anti-inflammatory drugs on risk of Alzheimer's disease: systematic review and meta-analysis of observational studies. BMJ 2003; 327: 128.
    • (2003) BMJ , vol.327 , pp. 128
    • Etminan, M.1    Gill, S.2    Samii, A.3
  • 92
    • 0025332027 scopus 로고
    • Antiinflammatory drugs and Alzheimer's disease
    • i wsp.
    • McGeer P.L., McGeer E., Rogers J. i wsp. Antiinflammatory drugs and Alzheimer's disease. Lancet 1990; 335: 1037.
    • (1990) Lancet , vol.335 , pp. 1037
    • McGeer, P.L.1    McGeer, E.2    Rogers, J.3
  • 93
    • 0036812560 scopus 로고    scopus 로고
    • From epidemiology to therapeutic trials with anti-inflammatory drugs in Alzheimer's disease: The role of NSAIDs and cyclooxygenase in beta-amyloidosis and clinical dementia
    • Pasinetti G.M. From epidemiology to therapeutic trials with anti-inflammatory drugs in Alzheimer's disease: the role of NSAIDs and cyclooxygenase in beta-amyloidosis and clinical dementia. J Alzheimers Dis 2002; 4: 435-445.
    • (2002) J Alzheimers Dis , vol.4 , pp. 435-445
    • Pasinetti, G.M.1
  • 94
    • 0029021217 scopus 로고
    • Do nonsteroidal anti-inflammatory drugs decrease the risk for Alzheimer's disease? The Rotterdam study
    • i wsp.
    • Andersen K., Launer L.J., Ott A. i wsp. Do nonsteroidal anti-inflammatory drugs decrease the risk for Alzheimer's disease? The Rotterdam study. Neurology 1995; 45: 1441-1445.
    • (1995) Neurology , vol.45 , pp. 1441-1445
    • Andersen, K.1    Launer, L.J.2    Ott, A.3
  • 95
    • 0035696167 scopus 로고    scopus 로고
    • Postmortem studies of the effect of anti-inflammatory drugs on Alzheimer-type pathology and associated inflammation
    • Mackenzie I.R. Postmortem studies of the effect of anti-inflammatory drugs on Alzheimer-type pathology and associated inflammation. Neurobiol Aging 2001; 22: 819-822.
    • (2001) Neurobiol Aging , vol.22 , pp. 819-822
    • Mackenzie, I.R.1
  • 96
    • 0035829592 scopus 로고    scopus 로고
    • A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity
    • i wsp.
    • Weggen S., Eriksen J.L., Das P. i wsp. A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity. Nature 2001; 414: 212-216.
    • (2001) Nature , vol.414 , pp. 212-216
    • Weggen, S.1    Eriksen, J.L.2    Das, P.3
  • 97
    • 85047691727 scopus 로고    scopus 로고
    • NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta42 in vivo
    • i wsp.
    • Eriksen J.L., Sagi S.A., Smith T.E. i wsp. NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta42 in vivo. J Clin Invest 2003; 112: 440-449.
    • (2003) J Clin Invest , vol.112 , pp. 440-449
    • Eriksen, J.L.1    Sagi, S.A.2    Smith, T.E.3
  • 98
    • 0041876229 scopus 로고    scopus 로고
    • Evidence that non-steroidal anti-inflammatory drugs decrease amyloid beta42 production by direct modulation of gamma-secretase activity
    • i wsp.
    • Weggen S., Eriksen J.L., Sagi S.A. i wsp. Evidence that non-steroidal anti-inflammatory drugs decrease amyloid beta42 production by direct modulation of gamma-secretase activity. J Biol Chem 2003; 278: 31831-31837.
    • (2003) J Biol Chem , vol.278 , pp. 31831-31837
    • Weggen, S.1    Eriksen, J.L.2    Sagi, S.A.3
  • 99
    • 0242609178 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs and peroxisome proliferator- activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase
    • i wsp.
    • Sastre M., Dewachter I., Landreth G.E. i wsp. Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase. J Neurosci 2003; 23: 9796-9804.
    • (2003) J Neurosci , vol.23 , pp. 9796-9804
    • Sastre, M.1    Dewachter, I.2    Landreth, G.E.3
  • 100
    • 27144513779 scopus 로고    scopus 로고
    • Non-steroidal anti-inflammatory drugs have anti-amyloidogenic effects for Alzheimer's beta-amyloid fibrils in vitro
    • i wsp.
    • Hirohata M., Ono K., Naiki H. i wsp. Non-steroidal anti-inflammatory drugs have anti-amyloidogenic effects for Alzheimer's beta-amyloid fibrils in vitro. Neuropharmacology 2005; 49: 1088-1099.
    • (2005) Neuropharmacology , vol.49 , pp. 1088-1099
    • Hirohata, M.1    Ono, K.2    Naiki, H.3
  • 101
    • 0031013395 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other nonsteroidal anti-inflammatory drugs
    • i wsp.
    • Lehmann J.M., Lenhard J.M., Oliver B.B. i wsp. Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other nonsteroidal anti-inflammatory drugs. J Biol Chem 1997; 272: 3406-3410.
    • (1997) J Biol Chem , vol.272 , pp. 3406-3410
    • Lehmann, J.M.1    Lenhard, J.M.2    Oliver, B.B.3
  • 102
    • 0034813586 scopus 로고    scopus 로고
    • Regulation of beta-amyloid stimulated proinflammatory responses by peroxisome proliferators-activated receptor alpha
    • i wsp.
    • Combs C.K., Bates P., Karlo J.C. i wsp. Regulation of beta-amyloid stimulated proinflammatory responses by peroxisome proliferators-activated receptor alpha. Neurochem Int 2001; 39: 449-457.
    • (2001) Neurochem Int , vol.39 , pp. 449-457
    • Combs, C.K.1    Bates, P.2    Karlo, J.C.3
  • 103
    • 0028896679 scopus 로고
    • Nonsteroidal anti-inflammatory drugs in Alzheimer's disease
    • i wsp.
    • Rich J.B., Rastrusson D.X., Folstein M.F. i wsp. Nonsteroidal anti-inflammatory drugs in Alzheimer's disease. Neurology 1995; 45: 51-55.
    • (1995) Neurology , vol.45 , pp. 51-55
    • Rich, J.B.1    Rastrusson, D.X.2    Folstein, M.F.3
  • 104
    • 0027268393 scopus 로고
    • Clinical trial of indomethacin in Alzheimer's disease
    • i wsp.
    • Rogers J., Kirby L.C., Hempelman S.R. i wsp. Clinical trial of indomethacin in Alzheimer's disease. Neurology 1993; 43: 1609-1611.
    • (1993) Neurology , vol.43 , pp. 1609-1611
    • Rogers, J.1    Kirby, L.C.2    Hempelman, S.R.3
  • 105
    • 0033551547 scopus 로고    scopus 로고
    • A double-blind, placebo-controlled trial of diclofenac/misoprostol in Alzheimer's disease
    • i wsp.
    • Scharf S., Mander A., Ugoni A. i wsp. A double-blind, placebo-controlled trial of diclofenac/misoprostol in Alzheimer's disease. Neurology 1999; 53: 197-201.
    • (1999) Neurology , vol.53 , pp. 197-201
    • Scharf, S.1    Mander, A.2    Ugoni, A.3
  • 106
    • 33749484294 scopus 로고    scopus 로고
    • Efficacy and safety of MPC-7869 (R-flurbiprofen), a selective Abeta42-lowering agent, in Alzheimer's disease (AD): Results of a 12-month phase 2 trial and i-year follow-on study
    • i wsp.
    • Wilcock G.K., Black S.E., Haworth J. i wsp. Efficacy and safety of MPC-7869 (R-flurbiprofen), a selective Abeta42-lowering agent, in Alzheimer's disease (AD): Results of a 12-month phase 2 trial and i-year follow-on study. Alzheimers Dement 2006; 2: S81-S82.
    • (2006) Alzheimers Dement , vol.2
    • Wilcock, G.K.1    Black, S.E.2    Haworth, J.3
  • 107
    • 0037638809 scopus 로고    scopus 로고
    • Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: A randomized controlled trial
    • i wsp.
    • Aisen P.S., Schafer K.A., Grundman M. i wsp. Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial. JAMA 2003; 289: 2819-2826.
    • (2003) JAMA , vol.289 , pp. 2819-2826
    • Aisen, P.S.1    Schafer, K.A.2    Grundman, M.3
  • 108
    • 33845803191 scopus 로고    scopus 로고
    • Long-term efficacy and safety of celecoxib in Alzheimer's disease
    • i wsp.
    • Soininen H., West C., Robbins J. i wsp. Long-term efficacy and safety of celecoxib in Alzheimer's disease. Dement Geriatr Cogn Disord 2007; 23: 8-21.
    • (2007) Dement Geriatr Cogn Disord , vol.23 , pp. 8-21
    • Soininen, H.1    West, C.2    Robbins, J.3
  • 109
    • 0034620538 scopus 로고    scopus 로고
    • A randomized controlled trial of prednisone in Alzheimer's disease
    • i wsp.
    • Aisen P.S., Davis K.L., Berg J.D. i wsp. A randomized controlled trial of prednisone in Alzheimer's disease. Neurology 2000; 54: 588-593.
    • (2000) Neurology , vol.54 , pp. 588-593
    • Aisen, P.S.1    Davis, K.L.2    Berg, J.D.3
  • 110
    • 32044463387 scopus 로고    scopus 로고
    • Coxibs and Alzheimer's disease: Should they stay or should they go
    • Firuzi O., Praticò D. Coxibs and Alzheimer's disease: should they stay or should they go. Ann Neurol 2006; 59: 219-228.
    • (2006) Ann Neurol , vol.59 , pp. 219-228
    • Firuzi, O.1    Praticò, D.2
  • 111
    • 32944466122 scopus 로고    scopus 로고
    • Is there a future for cyclooxygenase inhibitors in Alzheimer's disease?
    • i wsp.
    • Ho L., Qin W., Stetka B.S. i wsp. Is there a future for cyclooxygenase inhibitors in Alzheimer's disease? CNS Drugs 2006; 20: 85-98.
    • (2006) CNS Drugs , vol.20 , pp. 85-98
    • Ho, L.1    Qin, W.2    Stetka, B.S.3
  • 112
    • 33845702374 scopus 로고    scopus 로고
    • Risk of cardiovascular events in patients receiving celecoxib: A meta-analysis of randomized clinical trials
    • i wsp.
    • White W.B., West C.R., Borer J.S. i wsp. Risk of cardiovascular events in patients receiving celecoxib: a meta-analysis of randomized clinical trials. Am J Cardiol 2007; 99: 91-98.
    • (2007) Am J Cardiol , vol.99 , pp. 91-98
    • White, W.B.1    West, C.R.2    Borer, J.S.3
  • 113
    • 33845865385 scopus 로고    scopus 로고
    • Cardiovascular events in clinical trials involving over 41,000 patients evaluating the cyclooxygenase-2 inhibitor celecoxib
    • i wsp.
    • White W.B., Borer J.S., Gorelick P.B. i wsp. Cardiovascular events in clinical trials involving over 41,000 patients evaluating the cyclooxygenase-2 inhibitor celecoxib. Ann Rheum Dis 2006; 65: 411-417.
    • (2006) Ann Rheum Dis , vol.65 , pp. 411-417
    • White, W.B.1    Borer, J.S.2    Gorelick, P.B.3
  • 114
    • 33751378367 scopus 로고    scopus 로고
    • Do selective COX-2 inhibitors increase the risk of cerebrovascular events? A meta-analysis of randomized controlled trials
    • Chen L.C., Ashcroft D.M. Do selective COX-2 inhibitors increase the risk of cerebrovascular events? A meta-analysis of randomized controlled trials. J Clin Pharm Ther 2006; 31: 565-576.
    • (2006) J Clin Pharm Ther , vol.31 , pp. 565-576
    • Chen, L.C.1    Ashcroft, D.M.2
  • 115
    • 33745921486 scopus 로고    scopus 로고
    • Meta-analysis: Cardiovascular events associated with nonsteroidal anti-inflammatory drugs
    • i wsp.
    • Salpeter S.R., Gregor P., Ormiston T.M. i wsp. Meta-analysis: cardiovascular events associated with nonsteroidal anti-inflammatory drugs. Am J Med 2006; 119: 552-559.
    • (2006) Am J Med , vol.119 , pp. 552-559
    • Salpeter, S.R.1    Gregor, P.2    Ormiston, T.M.3
  • 116
    • 0037067048 scopus 로고    scopus 로고
    • Peripheral infection evokes exaggerated sickness behaviour in pre-clinical murine prion disease
    • Combrinck M.I., Perry V.H., Cunningham C. Peripheral infection evokes exaggerated sickness behaviour in pre-clinical murine prion disease. Neuroscience 2002; 112: 7-11.
    • (2002) Neuroscience , vol.112 , pp. 7-11
    • Combrinck, M.I.1    Perry, V.H.2    Cunningham, C.3
  • 117
    • 0038354036 scopus 로고    scopus 로고
    • Systemic infection, interleukin 1beta, and cognitive decline in Alzheimer's disease
    • i wsp.
    • Holmes C., El-Okl M., Williams A.L. i wsp. Systemic infection, interleukin 1beta, and cognitive decline in Alzheimer's disease. J Neurol Neurosurg Psychiatry 2003; 74: 788-789.
    • (2003) J Neurol Neurosurg Psychiatry , vol.74 , pp. 788-789
    • Holmes, C.1    El-Okl, M.2    Williams, A.L.3
  • 118
    • 34250784090 scopus 로고    scopus 로고
    • Inhibitor of cyclooxygenase-2 protects against amyloid beta peptide-evoked memory impairment in mice
    • Cakała M., Malik A.R., Strosznajder J.B. Inhibitor of cyclooxygenase-2 protects against amyloid beta peptide-evoked memory impairment in mice. Pharmacol Rep 2007; 59: 164-172.
    • (2007) Pharmacol Rep , vol.59 , pp. 164-172
    • Cakała, M.1    Malik, A.R.2    Strosznajder, J.B.3
  • 119
    • 32244432739 scopus 로고    scopus 로고
    • Prostaglandin E2 EP1 receptors: Downstream effectors of COX-2 neurotoxicity
    • i wsp.
    • Kawano T., Anrather J., Zhou P. i wsp. Prostaglandin E2 EP1 receptors: downstream effectors of COX-2 neurotoxicity. Nat Med 2006; 12: 225-229.
    • (2006) Nat Med , vol.12 , pp. 225-229
    • Kawano, T.1    Anrather, J.2    Zhou, P.3
  • 120
    • 36349029592 scopus 로고    scopus 로고
    • Involvement of prostaglandin E2 in production of amyloid-beta peptides both in vitro and in vivo
    • i wsp.
    • Hoshino T, Nakaya T, Homan T. i wsp. Involvement of prostaglandin E2 in production of amyloid-beta peptides both in vitro and in vivo. J Biol Chem 2007; 282: 32676-32688.
    • (2007) J Biol Chem , vol.282 , pp. 32676-32688
    • Hoshino, T.1    Nakaya, T.2    Homan, T.3
  • 121
    • 39749188810 scopus 로고    scopus 로고
    • Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticity
    • i wsp.
    • Kotilinek L.A., Westerman M.A., Wang Q. i wsp. Cyclooxygenase-2 inhibition improves amyloid-beta-mediated suppression of memory and synaptic plasticity. Brain 2008; 131: 651-664.
    • (2008) Brain , vol.131 , pp. 651-664
    • Kotilinek, L.A.1    Westerman, M.A.2    Wang, Q.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.