Naringin-induced bone morphogenetic protein-2 expression via PI3K, Akt, c-Fos/c-Jun and AP-1 pathway in osteoblasts

European Journal of Pharmacology

Volumn 588, Issue 2-3, 2008, Pages 333-341

  Wu, Jin Bin ^a   Fong, Yi Chin ^b   Tsai, Huei Yann ^a   Chen, Yuh Fung ^a   Tsuzuki, Minoru ^a,c   Tang, Chih Hsin ^a  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^c NIHON PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

BMP 2; Flavonoid; Naringin; Osteoblast; Osteoporosis

Indexed keywords

ALKALINE PHOSPHATASE; ANTISENSE OLIGONUCLEOTIDE; BONE MORPHOGENETIC PROTEIN 2; ESTRADIOL; MESSENGER RNA; NARINGENIN; OSTEOCALCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE FES; PROTEIN P85; STRESS ACTIVATED PROTEIN KINASE;

ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIOXIDANT ACTIVITY; ARTICLE; BONE ATROPHY; CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FETUS; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NONHUMAN; OSTEOBLAST; OSTEOLYSIS; OSTEOPOROSIS; OVARIECTOMY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BONE DENSITY; BONE MORPHOGENETIC PROTEINS; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; FLAVANONES; GENE EXPRESSION REGULATION; MICE; OSTEOBLASTS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-FOS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1; TRANSFORMING GROWTH FACTOR BETA;

EID: 44649083061     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.04.030     Document Type: Article

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