메뉴 건너뛰기




Volumn 1068, Issue 1, 2006, Pages 66-73

Hypoxia and HIF-1α in chondrogenesis

Author keywords

Chondrocytes; HIF 1 ; Hypoxia; VEGF; VHL

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; HIF1A PROTEIN, HUMAN; VON HIPPEL LINDAU PROTEIN;

EID: 33744764250     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1346.009     Document Type: Conference Paper
Times cited : (55)

References (46)
  • 1
    • 4444257379 scopus 로고    scopus 로고
    • The biology of hypoxia: The role of oxygen sensing in development, normal function, and disease
    • Giaccia, A., M. Simon & R. Johnson. 2004. The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease. Genes Dev. 18 : 2183 2194.
    • (2004) Genes Dev. , vol.18 , pp. 2183-2194
    • Giaccia, A.1    Simon, M.2    Johnson, R.3
  • 2
    • 0032882169 scopus 로고    scopus 로고
    • Hypoxic microenvironment within an embryo induces apoptosis and is essential for proper morphological development
    • Chen, E., M. Fujinaga & A. Giaccia. 1999. Hypoxic microenvironment within an embryo induces apoptosis and is essential for proper morphological development. Teratology 60 : 215 225.
    • (1999) Teratology , vol.60 , pp. 215-225
    • Chen, E.1    Fujinaga, M.2    Giaccia, A.3
  • 3
    • 0038688373 scopus 로고    scopus 로고
    • The complexities of skeletal biology
    • Karsenty, G. 2003. The complexities of skeletal biology. Nature 423 : 316 318.
    • (2003) Nature , vol.423 , pp. 316-318
    • Karsenty, G.1
  • 4
    • 0028836022 scopus 로고
    • Toward a molecular understanding of skeletal development
    • Erlebacher, A. et al. 1995. Toward a molecular understanding of skeletal development. Cell 80 : 371 378.
    • (1995) Cell , vol.80 , pp. 371-378
    • Erlebacher, A.1
  • 5
    • 0038687536 scopus 로고    scopus 로고
    • Developmental regulation of the growth plate
    • Kronenberg, H. 2003. Developmental regulation of the growth plate. Nature 423 : 332 336.
    • (2003) Nature , vol.423 , pp. 332-336
    • Kronenberg, H.1
  • 6
    • 0347915661 scopus 로고    scopus 로고
    • PTHrP, PTH, and the PTH/PTHrP receptor in endochondral bone development
    • Schipani, E. & S. Provot. 2003. PTHrP, PTH, and the PTH/PTHrP receptor in endochondral bone development. Birth Defects Res. Part C Embryo Today 69 : 352 362.
    • (2003) Birth Defects Res. Part C Embryo Today , vol.69 , pp. 352-362
    • Schipani, E.1    Provot, S.2
  • 7
    • 0346963598 scopus 로고    scopus 로고
    • MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes
    • Vu, T. et al. 1998. MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes. Cell. 93 : 411 422.
    • (1998) Cell. , vol.93 , pp. 411-422
    • Vu, T.1
  • 8
    • 0036339867 scopus 로고    scopus 로고
    • Skeletal defects in VEGF120/120 mice reveal multiple roles for VEGF in skeletogenesis
    • Zelzer, E. et al. 2002. Skeletal defects in VEGF120/120 mice reveal multiple roles for VEGF in skeletogenesis. Development 129 : 1893 1904.
    • (2002) Development , vol.129 , pp. 1893-1904
    • Zelzer, E.1
  • 9
    • 0343530603 scopus 로고    scopus 로고
    • Direct relationship between radiobiological hypoxia in tumors and monoclonal antibody detection of EF5 cellular adducts
    • Lee, J. et al. 1996. Direct relationship between radiobiological hypoxia in tumors and monoclonal antibody detection of EF5 cellular adducts. Int. J. Cancer 67 : 372 378.
    • (1996) Int. J. Cancer , vol.67 , pp. 372-378
    • Lee, J.1
  • 10
    • 0035499204 scopus 로고    scopus 로고
    • Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival
    • Schipani, E. et al. 2001. Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival. Genes Dev. 15 : 2865 2876.
    • (2001) Genes Dev. , vol.15 , pp. 2865-2876
    • Schipani, E.1
  • 11
    • 0029842459 scopus 로고    scopus 로고
    • Oxygen sensing and molecular adaptation to hypoxia
    • Bunn, H. & R. Poyton. 1996. Oxygen sensing and molecular adaptation to hypoxia. Physiol. Rev. 76 : 839 885.
    • (1996) Physiol. Rev. , vol.76 , pp. 839-885
    • Bunn, H.1    Poyton, R.2
  • 12
    • 20544465985 scopus 로고    scopus 로고
    • Regulation of transcription and translation by hypoxia
    • Liu, L. & M. Simon. 2004. Regulation of transcription and translation by hypoxia. Cancer Biol. Ther. 3 : 492 497.
    • (2004) Cancer Biol. Ther. , vol.3 , pp. 492-497
    • Liu, L.1    Simon, M.2
  • 13
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza, G. 2003. Targeting HIF-1 for cancer therapy. Nat. Rev. Cancer 3 : 721 732.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 721-732
    • Semenza, G.1
  • 15
    • 0037098081 scopus 로고    scopus 로고
    • How oxygen makes its presence felt
    • Kaelin, W.G.J. 2002. How oxygen makes its presence felt. Genes Dev. 16 : 1441 1445.
    • (2002) Genes Dev. , vol.16 , pp. 1441-1445
    • Kaelin, W.G.J.1
  • 16
    • 0035917808 scopus 로고    scopus 로고
    • Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
    • Jaakkola, P. et al. 2001. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science. 292 : 468 472.
    • (2001) Science. , vol.292 , pp. 468-472
    • Jaakkola, P.1
  • 17
    • 0037035851 scopus 로고    scopus 로고
    • Structure of an HIF-1alpha-pVHL complex: Hydroxyproline recognition in signaling
    • Min, J. et al. 2002. Structure of an HIF-1alpha-pVHL complex: hydroxyproline recognition in signaling. Science 296 : 1886 1889.
    • (2002) Science , vol.296 , pp. 1886-1889
    • Min, J.1
  • 18
    • 0037131271 scopus 로고    scopus 로고
    • Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha
    • Chan, D. et al. 2002. Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha. J. Biol. Chem. 277 : 40112 40117.
    • (2002) J. Biol. Chem. , vol.277 , pp. 40112-40117
    • Chan, D.1
  • 19
    • 0033051828 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumor suppressor protein: New perspectives
    • Ohh, M. & W.G. Kaelin. 1999. The von Hippel-Lindau tumor suppressor protein: new perspectives. Mol. Med. Today 5 : 257 263.
    • (1999) Mol. Med. Today , vol.5 , pp. 257-263
    • Ohh, M.1    Kaelin, W.G.2
  • 20
    • 0032538797 scopus 로고    scopus 로고
    • Signal transduction in hypoxic cells: Inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha
    • Kallio, P.J. et al. 1998. Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha. EMBO J. 17 : 6573 6586.
    • (1998) EMBO J. , vol.17 , pp. 6573-6586
    • Kallio, P.J.1
  • 21
    • 3142622910 scopus 로고    scopus 로고
    • The hypoxic tumor microenvironment and gene expression
    • Leo, C., A. Giaccia & N. Denko. 2004. The hypoxic tumor microenvironment and gene expression. Semin. Radiat. Oncol. 14 : 207 214.
    • (2004) Semin. Radiat. Oncol. , vol.14 , pp. 207-214
    • Leo, C.1    Giaccia, A.2    Denko, N.3
  • 22
    • 8844284460 scopus 로고    scopus 로고
    • Genetic analysis of pathways regulated by the von Hippel-Lindau tumor suppressor in Caenorhabditis elegans
    • Bishop, T. et al. 2004. Genetic analysis of pathways regulated by the von Hippel-Lindau tumor suppressor in Caenorhabditis elegans. PLoS. Biol. 2 : e289.
    • (2004) PLoS. Biol. , vol.2
    • Bishop, T.1
  • 23
    • 0032100732 scopus 로고    scopus 로고
    • HIF 1 alpha is required for solid tumor formation and embryonic vascularization
    • Ryan, H.E., J. Lo & R.S. Johnson. 1998. HIF 1 alpha is required for solid tumor formation and embryonic vascularization. EMBO J. 17 : 3005 3015.
    • (1998) EMBO J. , vol.17 , pp. 3005-3015
    • Ryan, H.E.1    Lo, J.2    Johnson, R.S.3
  • 24
    • 15444342958 scopus 로고    scopus 로고
    • Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1alpha
    • Iyer, N. et al. 1998a. Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1alpha. Genes Dev. 12 : 149 162.
    • (1998) Genes Dev. , vol.12 , pp. 149-162
    • Iyer, N.1
  • 25
    • 0032581277 scopus 로고    scopus 로고
    • Role of HIF-1alpha in hypoxia mediated apoptosis, cell proliferation and tumour angiogenesis
    • Carmeliet, P. et al. 1998. Role of HIF-1alpha in hypoxia mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 394 : 485 490.
    • (1998) Nature , vol.394 , pp. 485-490
    • Carmeliet, P.1
  • 26
    • 0030847165 scopus 로고    scopus 로고
    • Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice
    • Gnarra, J. et al. 1997. Defective placental vasculogenesis causes embryonic lethality in VHL-deficient mice. Proc. Natl. Acad. Sci. USA 94 : 9102 9107.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 9102-9107
    • Gnarra, J.1
  • 27
    • 2542644319 scopus 로고    scopus 로고
    • Deletion of Vhlh in chondrocytes reduces cell proliferation and increases matrix deposition during growth plate development
    • Pfander, D. et al. 2004. Deletion of Vhlh in chondrocytes reduces cell proliferation and increases matrix deposition during growth plate development. Development 131 : 2497 2508.
    • (2004) Development , vol.131 , pp. 2497-2508
    • Pfander, D.1
  • 28
    • 0038325620 scopus 로고    scopus 로고
    • HIF-1alpha controls extracellular matrix synthesis by epiphyseal chondrocytes
    • Pfander, D. et al. 2003. HIF-1alpha controls extracellular matrix synthesis by epiphyseal chondrocytes. J. Cell. Sci. 116 : 1819 1826.
    • (2003) J. Cell. Sci. , vol.116 , pp. 1819-1826
    • Pfander, D.1
  • 29
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara, N., H. Gerber & J. LeCouter. 2003. The biology of VEGF and its receptors. Nat. Med. 9 : 669 676.
    • (2003) Nat. Med. , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.2    Lecouter, J.3
  • 30
    • 2542629644 scopus 로고    scopus 로고
    • Expression of VEGF isoforms by epiphyseal chondrocytes during low-oxygen tension is HIF-1 alpha dependent
    • Cramer, T. et al. 2004. Expression of VEGF isoforms by epiphyseal chondrocytes during low-oxygen tension is HIF-1 alpha dependent. Osteoarthritis Cartilage 12 : 433 439.
    • (2004) Osteoarthritis Cartilage , vol.12 , pp. 433-439
    • Cramer, T.1
  • 31
    • 2542631833 scopus 로고    scopus 로고
    • VEGFA is necessary for chondrocyte survival during bone development
    • Zelzer, E. et al. 2004. VEGFA is necessary for chondrocyte survival during bone development. Development 131 : 2161 2171.
    • (2004) Development , vol.131 , pp. 2161-2171
    • Zelzer, E.1
  • 32
    • 0033027858 scopus 로고    scopus 로고
    • VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation
    • Gerber, H. et al. 1999. VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation. Nat. Med. 5 : 623 628.
    • (1999) Nat. Med. , vol.5 , pp. 623-628
    • Gerber, H.1
  • 33
    • 0036166701 scopus 로고    scopus 로고
    • Impaired angiogenesis and endochondral bone formation in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188
    • Maes, C. et al. 2002. Impaired angiogenesis and endochondral bone formation in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188. Mech. Dev. 111 : 61 73.
    • (2002) Mech. Dev. , vol.111 , pp. 61-73
    • Maes, C.1
  • 34
    • 0038093327 scopus 로고    scopus 로고
    • Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development
    • Ivkovic, S., B. Yoon, et al. 2003. Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development. Development 130 : 2779 2791.
    • (2003) Development , vol.130 , pp. 2779-2791
    • Ivkovic, S.1    Yoon, B.2
  • 35
    • 0034914814 scopus 로고    scopus 로고
    • Tissue specific regulation of VEGF expression during bone development requires Cbfa1/Runx2
    • Zelzer, E. et al. 2001. Tissue specific regulation of VEGF expression during bone development requires Cbfa1/Runx2. Mech. Dev. 106 : 97 106.
    • (2001) Mech. Dev. , vol.106 , pp. 97-106
    • Zelzer, E.1
  • 36
    • 1342289558 scopus 로고    scopus 로고
    • Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival
    • Maes, C. et al. 2004. Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival. J. Clin. Invest. 113 : 188 199.
    • (2004) J. Clin. Invest. , vol.113 , pp. 188-199
    • Maes, C.1
  • 37
    • 7944224442 scopus 로고    scopus 로고
    • Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis
    • Tang, N. et al. 2004. Loss of HIF-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis. Cancer Cell 6 : 485 495.
    • (2004) Cancer Cell , vol.6 , pp. 485-495
    • Tang, N.1
  • 38
    • 0041357164 scopus 로고    scopus 로고
    • BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis
    • Danial, N. et al. 2003. BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis. Nature 424 : 952 956.
    • (2003) Nature , vol.424 , pp. 952-956
    • Danial, N.1
  • 39
    • 4744343476 scopus 로고    scopus 로고
    • Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes
    • Biju, M. et al. 2004. Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes. Mol. Cell. Biol. 24 : 9038 9047.
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 9038-9047
    • Biju, M.1
  • 40
    • 1942453828 scopus 로고    scopus 로고
    • Identification of the hypoxia-inducible factor 1 alpha-responsive HGTD-P gene as a mediator in the mitochondrial apoptotic pathway
    • Lee, M. et al. 2004. Identification of the hypoxia-inducible factor 1 alpha-responsive HGTD-P gene as a mediator in the mitochondrial apoptotic pathway. Mol. Cell. Biol. 24 : 3918 3927.
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 3918-3927
    • Lee, M.1
  • 41
    • 0034255036 scopus 로고    scopus 로고
    • Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia
    • Bruick, R. 2000. Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia. Proc. Natl. Acad. Sci. USA 97 : 9082 9087.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 9082-9087
    • Bruick, R.1
  • 42
    • 0035237410 scopus 로고    scopus 로고
    • Genetic determinants that influence hypoxia-induced apoptosis
    • Alarcon, R., N. Denko, A. Giaccia. 2001. Genetic determinants that influence hypoxia-induced apoptosis. Novartis Found. Symp. 240 : 115 128.
    • (2001) Novartis Found. Symp. , vol.240 , pp. 115-128
    • Alarcon, R.1    Denko, N.2    Giaccia, A.3
  • 43
    • 0141869070 scopus 로고    scopus 로고
    • Investigating hypoxic tumor physiology through gene expression patterns
    • Denko, N. et al. 2003. Investigating hypoxic tumor physiology through gene expression patterns. Oncogene 22 : 5907 5914.
    • (2003) Oncogene , vol.22 , pp. 5907-5914
    • Denko, N.1
  • 44
    • 0037214282 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxia
    • Goda, N. et al. 2003. Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxia. Mol. Cell. Biol. 23 : 359 369.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 359-369
    • Goda, N.1
  • 45
    • 0345164318 scopus 로고    scopus 로고
    • The VHL tumor-suppressor gene paradigm
    • Kaelin, W. & E. Maher. 1998. The VHL tumor-suppressor gene paradigm. Trends Genet. 14 : 423 426.
    • (1998) Trends Genet. , vol.14 , pp. 423-426
    • Kaelin, W.1    Maher, E.2
  • 46
    • 0033567213 scopus 로고    scopus 로고
    • Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation
    • St-Jacques, B., M. Hammerschmidt & A. McMahon. 1999. Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Genes Dev. 15 : 2072 2086.
    • (1999) Genes Dev. , vol.15 , pp. 2072-2086
    • St-Jacques, B.1    Hammerschmidt, M.2    McMahon, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.