Acute tumor vascular effects following fractionated radiotherapy in human lung cancer: In vivo whole tumor assessment using volumetric perfusion computed tomography

International Journal of Radiation Oncology Biology Physics

Volumn 67, Issue 2, 2007, Pages 417-424

  Ng, Quan Sing ^a   Goh, Vicky ^a   Milner, Jessica ^a   Padhani, Anwar R ^a   Saunders, Michele I ^a   Hoskin, Peter J ^a  

^a MOUNT VERNON HOSPITAL   (United Kingdom)

Author keywords

Fractionated radiotherapy; Functional imaging; Lung cancer; Perfusion computed tomography; Tumor perfusion

Indexed keywords

FRACTIONATED RADIOTHERAPY; FUNCTIONAL IMAGING; PERFUSION COMPUTED TOMOGRAPHY; TUMOR PERFUSION;

COMPUTERIZED TOMOGRAPHY; MEDICAL IMAGING; ONCOLOGY; PATIENT TREATMENT; PULMONARY DISEASES; RADIOTHERAPY;

TUMORS;

IOBITRIDOL; UNCLASSIFIED DRUG; XENETIX 300;

ARTICLE; BLOOD VESSEL PERMEABILITY; BLOOD VOLUME; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DOSIMETRY; DRUG DOSE REDUCTION; FEMALE; HUMAN; HUMAN TISSUE; IN VIVO STUDY; LUNG NON SMALL CELL CANCER; MALE; PALLIATIVE THERAPY; PRIORITY JOURNAL; RADIATION DOSE; RADIATION DOSE FRACTIONATION; RADIATION RESPONSE; STATISTICAL SIGNIFICANCE; STUDENT T TEST; TREATMENT DURATION; TUMOR VASCULARIZATION; TUMOR VOLUME; VASCULAR TUMOR;

BLOOD VOLUME; CAPILLARY PERMEABILITY; CARCINOMA, NON-SMALL-CELL LUNG; FEMALE; HUMANS; LUNG NEOPLASMS; MALE; PALLIATIVE CARE; PROSPECTIVE STUDIES; RADIOTHERAPY DOSAGE; REPRODUCIBILITY OF RESULTS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 33846220224     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2006.10.005     Document Type: Article

References (25)

1. Jemal A., Murray T., Ward E., et al. Cancer statistics 2005. CA Cancer J Clin 55 (2005) 10-30
2. Herbst R.S., Onn A., and Sandler A. Angiogenesis and lung cancer: Prognostic and therapeutic implications. J Clin Oncol 23 (2005) 3243-3256
3. Garcia-Barros M., Paris F., Cordon-Cardo C., et al. Tumor response to radiotherapy regulated by endothelial cell apoptosis. Science 300 (2003) 1155-1159
4. Thomlinson R.H., and Gray L.H. The histological structure of some human lung cancers and the possible implications for radiotherapy. Br J Cancer 9 (1955) 539-549
5. Ng Q.S., Goh V., Fichte H., et al. Lung cancer perfusion at multi-detector row CT: Reproducibility of whole tumor quantitative measurements. Radiology 239 (2006) 547-553
6. Patlak C.S., Balsberg R.G., and Fernstmacher J.D. Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab 3 (1983) 1-7
7. Bland J.M., and Altman D.G. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1 (1986) 307-310
8. Miles K.A., and Griffiths M.R. Perfusion CT: A worthwhile enhancement?. Br J Radiol 76 (2003) 220-231
9. Miles K.A., Charnsangavej C., Lee F.T., et al. Application of CT in the investigation of angiogenesis in oncology. Acad Radiol 7 (2000) 840-850
10. Yi C.A., Lee K.S., Kim E.A., et al. Solitary pulmonary nodules: Dynamic enhanced multi-detector row CT study and comparison with vascular endothelial growth factor and microvessel density. Radiology 233 (2004) 191-199
11. Tateishi U., Nishihara H., Tsukamoto E., et al. Lung tumors evaluated with FDG-PET and dynamic CT: The relationship between vascular density and glucose metabolism. J Comput Assist Tomogr 26 (2002) 185-190
12. Ng Q.S., Goh V., Klotz E., et al. Quantitative assessment of lung cancer perfusion using MDCT: Does measurement reproducibility improve with greater tumor volume coverage?. Am J Roentgenol 187 (2006) 1079-1084
13. Endrich B., Reinhold H.S., Gross J.F., et al. Tissue perfusion inhomogeneity during early tumor growth in rats. J Natl Cancer Inst 62 (1979) 387-395
14. Moeller B.J., Cao Y., Li C.Y., et al. Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: Role of reoxygenation, free radicals, and stress granules. Cancer Cell 5 (2004) 429-441
15. Lund E.L., Hog A., Olsen M.W., et al. Differential regulation of VEGF, HIF1alpha and angiopoietin-1, -2 and -4 by hypoxia and ionizing radiation in human glioblastoma. Int J Cancer 108 (2004) 833-838
16. Ando S., Nojima K., Majima H., et al. Evidence for mRNA expression of vascular endothelial growth factor by X-ray irradiation in a lung squamous carcinoma cell line. Cancer Lett 132 (1998) 75-80
17. Crokart N., Jordan B.F., Baudelet C., et al. Early reoxygenation in tumors after irradiation: Determining factors and consequences for radiotherapy regimens using daily multiple fractions. Int J Radiat Oncol Biol Phys 63 (2005) 901-910
18. Harvey C., Dooher A., Morgan J., et al. Eur J Radiol 30 (1999) 221-226
19. de Vries A., Griebel J., Kremser C., et al. Monitoring of tumor microcirculation during fractionated radiation therapy in patients with rectal carcinoma: Preliminary results and implications for therapy. Radiology 217 (2000) 385-391
20. Sahani D.V., Kalva S.P., Hamberg L.M., et al. Assessing tumor perfusion and treatment response in rectal cancer with multisection CT: Initial observations. Radiology 234 (2005) 785-792
21. Miller K.D., Sweeney C.J., and Sledge Jr. G.W. Redefining the target: Chemotherapeutics as antiangiogenics. J Clin Oncol 15:19 (2001) 1195-1206
22. Williams K.J., Telfer B.A., Brave S., et al. ZD6474, a potent inhibitor of vascular endothelial growth factor signaling, combined with radiotherapy: Schedule-dependent enhancement of antitumor activity. Clin Cancer Res 10 (2004) 8587-8593
23. Zips D., Krause M., Hessel F., et al. Experimental study on different combination schedules of VEGF-receptor inhibitor PTK787/ZK222584 and fractionated irradiation. Anticancer Res 23 (2003) 3869-3876
24. Glynne-Jones R., and Sebag-Montefiore D. Chemoradiation schedules-what radiotherapy?. Eur J Cancer 38 (2002) 258-269
25. Anscher M.S., Chen L., Rabbani Z., et al. Recent progress in defining mechanisms and potential targets for prevention of normal tissue injury after radiation therapy. Int J Radiat Oncol Biol Phys 62 (2005) 255-259