An active-site phenylalanine directs substrate binding and C-H cleavage in the α-ketoglutarate-dependent dioxygenase AauD

Journal of the American Chemical Society

Volumn 132, Issue 14, 2010, Pages 5114-5120

  McCusker, Kevin P ^a   Klinman, Judith P ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; C-H BOND; C-H BOND CLEAVAGE; DEUTERIUM KINETIC ISOTOPE EFFECT; DIOXYGENASES; HYDROGEN DONOR; HYDROGEN-ATOM TRANSFER; HYDROPHOBIC CORE; INTERNUCLEAR DISTANCES; KETOGLUTARATE; OXYGEN ACTIVATIONS; SIDE CHAINS; SUBSTRATE BINDING; SUBSTRATE-DEPENDENT PROCESS; WILD TYPES;

AMINO ACIDS; DEUTERIUM; HYDROGEN BONDS; HYDROPHOBICITY; OXYGEN;

SUBSTRATES;

2 OXOGLUTARIC ACID; AMINO ACID; CARBON; DEUTERIUM; DIOXYGENASE; HYDROGEN; OXYGEN; PHENYLALANINE; TAUD PROTEIN; TAURINE; TAURINE ALPHA KETOGLUTARATE DIOXGENASE; UNCLASSIFIED DRUG; VALINE;

ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME KINETICS; ENZYME SUBSTRATE; HYDROPHOBICITY; PROTEIN EXPRESSION; QUANTUM MECHANICS; STEADY STATE;

CARBON; CATALYTIC DOMAIN; FERROUS COMPOUNDS; HYDROGEN; KINETICS; MIXED FUNCTION OXYGENASES; MODELS, MOLECULAR; PHENYLALANINE; SUBSTRATE SPECIFICITY;

EID: 77950817925     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja909416z     Document Type: Article

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