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Volumn 16, Issue 5, 2010, Pages 896-902

The path to Crohn's disease: Is mucosal pathology a secondary event

Author keywords

Crohn's disease; Mucosal damage; Pathogenesis

Indexed keywords

ACUTE GASTROENTERITIS; CHRONIC INFLAMMATION; CROHN DISEASE; DISEASE EXACERBATION; DISEASE PREDISPOSITION; ENTERITIS; GASTROINTESTINAL TRACT; GENETIC ANALYSIS; HUMAN; INNATE IMMUNITY; INTESTINE FLORA; INTESTINE MUCOSA; INTRACELLULAR BACTERIUM; LISTERIA MONOCYTOGENES; LYMPHOID TISSUE; MACROPHAGE; MESENTERY; MYCOBACTERIUM; NONHUMAN; PATHOPHYSIOLOGY; PHENOTYPE; PRIORITY JOURNAL; RELAPSE; REVIEW; SALMONELLA; ULCERATIVE COLITIS;

EID: 77950639454     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1002/ibd.21171     Document Type: Review
Times cited : (51)

References (58)
  • 1
    • 33845340501 scopus 로고    scopus 로고
    • A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
    • Duerr RH, Taylor KD, Brant SR, et al. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science. 2006;314:1461-1463.
    • (2006) Science , vol.314 , pp. 1461-1463
    • Duerr, R.H.1    Taylor, K.D.2    Brant, S.R.3
  • 3
    • 0035978651 scopus 로고    scopus 로고
    • Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
    • Hugot JP, Chamaillard M, Zouali H, et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature. 2001;411:599-603.
    • (2001) Nature , vol.411 , pp. 599-603
    • Hugot, J.P.1    Chamaillard, M.2    Zouali, H.3
  • 4
    • 0035978533 scopus 로고    scopus 로고
    • A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
    • Ogura Y, Bonen DK, Inohara N, et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature. 2001; 411:603-606.
    • (2001) Nature , vol.411 , pp. 603-606
    • Ogura, Y.1    Bonen, D.K.2    Inohara, N.3
  • 5
    • 34247554965 scopus 로고    scopus 로고
    • Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
    • Rioux JD, Xavier RJ, Taylor KD, et al. Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. Nat Genet. 2007;39:596-604.
    • (2007) Nat Genet. , vol.39 , pp. 596-604
    • Rioux, J.D.1    Xavier, R.J.2    Taylor, K.D.3
  • 6
    • 0032903908 scopus 로고    scopus 로고
    • The transcriptional program in the response of human fibroblasts to serum
    • Iyer VR, Eisen MB, Ross DT, et al. The transcriptional program in the response of human fibroblasts to serum. Science. 1999;283:83-87.
    • (1999) Science , vol.283 , pp. 83-87
    • Iyer, V.R.1    Eisen, M.B.2    Ross, D.T.3
  • 7
    • 33646778482 scopus 로고    scopus 로고
    • The Montreal classification of inflammatory bowel disease: Controversies, consensus, and implications
    • Satsangi. J, Silverberg MS, Vermeire S, et al. The Montreal classification of inflammatory bowel disease: controversies, consensus, and implications. Gut. 2006;55:749-753.
    • (2006) Gut. , vol.55 , pp. 749-753
    • Satsangi, J.1    Silverberg, M.S.2    Vermeire, S.3
  • 8
    • 34248136828 scopus 로고    scopus 로고
    • Inflammatory bowel disease: Cause and immunobiology
    • Baumgart DC, Carding SR. Inflammatory bowel disease: cause and immunobiology. Lancet. 2007;369:1627-1640.
    • (2007) Lancet , vol.369 , pp. 1627-1640
    • Baumgart, D.C.1    Carding, S.R.2
  • 9
    • 33846031522 scopus 로고    scopus 로고
    • Is Crohn's disease due to defective immunity
    • DOI 10.1136/gut.2006.095588
    • Korzenik. JR. Is Crohn's disease due to defective immunity? Gut. 2007;56:2-5. (Pubitemid 46044879)
    • (2007) Gut , vol.56 , Issue.1 , pp. 2-5
    • Korzenik, J.R.1
  • 10
    • 67349250428 scopus 로고    scopus 로고
    • The gut microbiota shapes intestinal immune responses during health and disease
    • Round JL, Mazmanian SK, The gut microbiota shapes intestinal immune responses during health and disease. Nat Rev Immunol. 2009; 9:313-323.
    • (2009) Nat Rev Immunol. , vol.9 , pp. 313-323
    • Round, J.L.1    Mazmanian, S.K.2
  • 11
    • 33344466383 scopus 로고    scopus 로고
    • Defective acute inflammation in Crohn's disease: A clinical investigation
    • Marks DJ, Harbord MW, MacAllister R, et al. Defective acute inflammation in Crohn's disease: a clinical investigation. Lancet. 2006;367: 668-678.
    • (2006) Lancet , vol.367 , pp. 668-678
    • Marks, D.J.1    Harbord, M.W.2    MacAllister, R.3
  • 12
    • 0017162599 scopus 로고
    • Neutrophil dysfunction in Crohn's disease
    • Segal AW, Loewi G. Neutrophil dysfunction in Crohn's disease. Lancet. 1976;2:219-221.
    • (1976) Lancet , vol.2 , pp. 219-221
    • Segal, A.W.1    Loewi, G.2
  • 13
    • 3442877820 scopus 로고    scopus 로고
    • Gastrointestinal involvement in chronic granulomatous disease
    • Marciano BE, Rosenzweig SD, Kleiner DE, et al. Gastrointestinal involvement in chronic granulomatous disease. Pediatrics. 2004;114: 462-468.
    • (2004) Pediatrics , vol.114 , pp. 462-468
    • Marciano, B.E.1    Rosenzweig, S.D.2    Kleiner, D.E.3
  • 14
    • 69549121823 scopus 로고    scopus 로고
    • Revisiting Crohn's disease as a primary immunodeficiency of macrophages
    • Casanova JL, Abel L. Revisiting Crohn's disease as a primary immunodeficiency of macrophages. J Exp Med. 2009;206:1839-1843.
    • (2009) J Exp Med. , vol.206 , pp. 1839-1843
    • Casanova, J.L.1    Abel, L.2
  • 15
    • 69449097214 scopus 로고    scopus 로고
    • Crohn's disease as an immune deficiency
    • Coulombe F, Behr MA. Crohn's disease as an immune deficiency? Lancet. 2009;374:769-770.
    • (2009) Lancet , vol.374 , pp. 769-770
    • Coulombe, F.1    Ma, B.2
  • 16
    • 34347338690 scopus 로고    scopus 로고
    • Sequence variants in the autophagy gene IRGM. and multiple other replicating loci contribute to Crohn's disease susceptibility
    • Parkes M, Barrett JC, Prescott NJ, et al. Sequence variants in the autophagy gene IRGM. and multiple other replicating loci contribute to Crohn's disease susceptibility. Nat Genet. 2007;39:830-832.
    • (2007) Nat Genet. , vol.39 , pp. 830-832
    • Parkes, M.1    Barrett, J.C.2    Prescott, N.J.3
  • 17
    • 0032568984 scopus 로고    scopus 로고
    • Type IV pili, transient bacterial aggregates, and virulence of enteropathogenic Escherichia coli
    • Bieber D, Ramer SW, Wu CY, et al. Type IV pili, transient bacterial aggregates, and virulence of enteropathogenic Escherichia coli. Science. 1998;280:2114-2118.
    • (1998) Science , vol.280 , pp. 2114-2118
    • Bieber, D.1    Ramer, S.W.2    Wu, C.Y.3
  • 19
    • 54849422372 scopus 로고    scopus 로고
    • Subcellular alterations that lead to diarrhea during bacterial pathogenesis
    • Guttman JA, Finlay BB. Subcellular alterations that lead to diarrhea during bacterial pathogenesis. Trends Microbiol. 2008;16:535-542.
    • (2008) Trends Microbiol. , vol.16 , pp. 535-542
    • Guttman, J.A.1    Finlay, B.B.2
  • 20
    • 0022372162 scopus 로고
    • Animal models of inflammatory bowel disease-an overview
    • Strober W. Animal models of inflammatory bowel disease-an overview. Dig Dis Sci. 1985;30:3S-10S.
    • (1985) Dig Dis Sci. , vol.30
    • Strober, W.1
  • 21
    • 0029114193 scopus 로고
    • Current concepts of the etiology and pathogenesis of ulcerative colitis and Crohn's disease
    • Sartor RB. Current concepts of the etiology and pathogenesis of ulcerative colitis and Crohn's disease. Gastroenterol Clin North Am. 1995; 24:475-507.
    • (1995) Gastroenterol Clin North Am. , vol.24 , pp. 475-507
    • Sartor, R.B.1
  • 22
    • 48749084893 scopus 로고    scopus 로고
    • Genome-wide association studies: A new window into immune-mediated diseases
    • Xavier RJ, Rioux JD. Genome-wide association studies: a new window into immune-mediated diseases. Nat Rev Immunol. 2008;8:631-643.
    • (2008) Nat Rev Immunol. , vol.8 , pp. 631-643
    • Xavier, R.J.1    Rioux, J.D.2
  • 23
    • 44349104723 scopus 로고    scopus 로고
    • New global map of Crohn's disease: Genetic, environmental, and socioeconomic correlations
    • Economou M, Pappas G. New global map of Crohn's disease: Genetic, environmental, and socioeconomic correlations. Inflamm Bowel Dis. 2008;14:709-720.
    • (2008) Inflamm Bowel Dis. , vol.14 , pp. 709-720
    • Economou, M.1    Pappas, G.2
  • 24
    • 33748999808 scopus 로고    scopus 로고
    • CARD15/NOD2 mutations in Crohn's disease
    • Hugot JP. CARD15/NOD2 mutations in Crohn's disease. Ann N Y Acad Sci. 2006;1072:9-18.
    • (2006) Ann N y Acad Sci. , vol.1072 , pp. 9-18
    • Hugot, J.P.1
  • 25
    • 34547173613 scopus 로고    scopus 로고
    • Estimating the odds ratios of Crohn disease for the main CARD15/NOD2 mutations using a conditional maximum likelihood method in pedigrees collected via affected family members
    • Pascoe L, Zouali H, Sahbatou M, et al. Estimating the odds ratios of Crohn disease for the main CARD15/NOD2 mutations using a conditional maximum likelihood method in pedigrees collected via affected family members. Eur J Hum Genet. 2007;15:864-871.
    • (2007) Eur J Hum Genet. , vol.15 , pp. 864-871
    • Pascoe, L.1    Zouali, H.2    Sahbatou, M.3
  • 26
    • 13244292161 scopus 로고    scopus 로고
    • Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract
    • Kobayashi KS, Chamaillard M, Ogura Y, et al. Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science. 2005;307:731-734.
    • (2005) Science , vol.307 , pp. 731-734
    • Kobayashi, K.S.1    Chamaillard, M.2    Ogura, Y.3
  • 27
    • 0142123222 scopus 로고    scopus 로고
    • Role of Nod2 in the response of macrophages to Toll-like receptor agonists
    • Pauleau AL, Murray PJ. Role of Nod2 in the response of macrophages to Toll-like receptor agonists. Mol Cell Biol. 2003;23:7531-7539.
    • (2003) Mol Cell Biol. , vol.23 , pp. 7531-7539
    • Pauleau, A.L.1    Murray, P.J.2
  • 28
    • 44349124113 scopus 로고    scopus 로고
    • The genetics and immunopathogenesis of inflammatory bowel disease
    • Cho JH. The genetics and immunopathogenesis of inflammatory bowel disease. Nat Rev Immunol. 2008;8:458-466.
    • (2008) Nat Rev Immunol. , vol.8 , pp. 458-466
    • Cho, J.H.1
  • 29
    • 0012722659 scopus 로고    scopus 로고
    • Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection
    • Girardin SE, Boneca IG, Viala J, et al. Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem. 2003;278:8869-8872.
    • (2003) J Biol Chem. , vol.278 , pp. 8869-8872
    • Girardin, S.E.1    Boneca, I.G.2    Viala, J.3
  • 30
    • 0037458665 scopus 로고    scopus 로고
    • Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease
    • Inohara N, Ogura Y, Fontalba A, et al. Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease. J Biol Chem. 2003;278:5509-5512.
    • (2003) J Biol Chem. , vol.278 , pp. 5509-5512
    • Inohara, N.1    Ogura, Y.2    Fontalba, A.3
  • 31
    • 1142292747 scopus 로고    scopus 로고
    • Mice deficient in LRG47 display increased susceptibility to mycobacterial infection associated with the induction of lymphopenia
    • Feng CG, Collazo-Custodio CM, Eckhaus M, et al. Mice deficient in LRG47 display increased susceptibility to mycobacterial infection associated with the induction of lymphopenia. J Immunol. 2004;172:1163-1168.
    • (2004) J Immunol. , vol.172 , pp. 1163-1168
    • Feng, C.G.1    Collazo-Custodio, C.M.2    Eckhaus, M.3
  • 32
    • 10944253145 scopus 로고    scopus 로고
    • Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages
    • Gutierrez MG, Master SS, Singh SB, et al. Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Cell. 2004;119:753-766.
    • (2004) Cell , vol.119 , pp. 753-766
    • Gutierrez, M.G.1    Master, S.S.2    Singh, S.B.3
  • 33
    • 13444310671 scopus 로고    scopus 로고
    • Immune control of phagosomal bacteria by p47 GTPases
    • MacMicking JD. Immune control of phagosomal bacteria by p47 GTPases. Curr Opin Microbiol. 2005;8:74-82.
    • (2005) Curr Opin Microbiol. , vol.8 , pp. 74-82
    • MacMicking, J.D.1
  • 34
    • 0142240338 scopus 로고    scopus 로고
    • Immune control of tuberculosis by IFN-gamma-inducible LRG-47
    • MacMicking JD, Taylor GA, McKinney JD. Immune control of tuberculosis by IFN-gamma-inducible LRG-47. Science. 2003;302:654-659.
    • (2003) Science , vol.302 , pp. 654-659
    • MacMicking, J.D.1    Taylor, G.A.2    McKinney, J.D.3
  • 35
    • 69449105914 scopus 로고    scopus 로고
    • Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease
    • Smith AM, Rahman FZ, Hayee B, et al. Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease. J Exp Med. 2009;206:1883-1897.
    • (2009) J Exp Med. , vol.206 , pp. 1883-1897
    • Smith, A.M.1    Rahman, F.Z.2    Hayee, B.3
  • 36
    • 70350451119 scopus 로고    scopus 로고
    • NOD2 regulates hematopoietic cell function during graft-versus-host disease
    • Penack O, Smith OM, Cunningham-Bussel A, et al. NOD2 regulates hematopoietic cell function during graft-versus-host disease. J Exp Med. 2009;206:2101-2110.
    • (2009) J Exp Med. , vol.206 , pp. 2101-2110
    • Penack, O.1    Smith, O.M.2    Cunningham-Bussel, A.3
  • 37
    • 0033565283 scopus 로고    scopus 로고
    • A single amino acid in E-cadherin responsible for host specificity towards the human pathogen Listeria monocytogenes
    • Lecuit M, Dramsi S, Gottardi C, et al. A single amino acid in E-cadherin responsible for host specificity towards the human pathogen Listeria monocytogenes. EMBO J. 1999;18:3956-3963.
    • (1999) EMBO J , vol.18 , pp. 3956-3963
    • Lecuit, M.1    Dramsi, S.2    Gottardi, C.3
  • 38
    • 54549086452 scopus 로고    scopus 로고
    • Conjugated action of two speciesspecific invasion proteins for fetoplacental listeriosis
    • Disson O, Grayo S, Huillet E, et al. Conjugated action of two speciesspecific invasion proteins for fetoplacental listeriosis. Nature. 2008; 455:1114-1118.
    • (2008) Nature , vol.455 , pp. 1114-1118
    • Disson, O.1    Grayo, S.2    Huillet, E.3
  • 39
    • 0035368519 scopus 로고    scopus 로고
    • A transgenic model for listeriosis: Role of internalin in crossing the intestinal barrier
    • Lecuit M, Vandormael-Pournin S, Lefort J, et al. A transgenic model for listeriosis: role of internalin in crossing the intestinal barrier. Science. 2001;292:1722-1725.
    • (2001) Science , vol.292 , pp. 1722-1725
    • Lecuit, M.1    Vandormael-Pournin, S.2    Lefort, J.3
  • 40
    • 0037408494 scopus 로고    scopus 로고
    • Pretreatment of mice with streptomycin provides a Salmonella entérica serovar Typhimurium colitis model that allows analysis of both pathogen and host
    • Barthel M, Hapfelmeier S, Quintanilla-M.artinez L, et al. Pretreatment of mice with streptomycin provides a Salmonella entérica serovar Typhimurium colitis model that allows analysis of both pathogen and host. Infect Immun. 2003;71:2839-2858.
    • (2003) Infect Immun. , vol.71 , pp. 2839-2858
    • Barthel, M.1    Hapfelmeier, S.2    Quintanilla-Martinez, L.3
  • 41
    • 34248349001 scopus 로고    scopus 로고
    • Invasion and persistence of Mycobacterium avium subsp. paratuberculosis during early stages of Johne's disease in calves
    • Wu CW, Livesey M, Schmoller SK, et al. Invasion and persistence of Mycobacterium avium subsp. paratuberculosis during early stages of Johne's disease in calves. Infect Immun. 2007;75:2110-2119.
    • (2007) Infect Immun. , vol.75 , pp. 2110-2119
    • Wu, C.W.1    Livesey, M.2    Schmoller, S.K.3
  • 42
    • 0014284570 scopus 로고
    • Experimental paratuberculosis in sheep after oral, intratracheal, or intravenous inoculation lesions and demonstration of etiologic agent
    • Kluge JP, Merkal RS, Monlux WS, et al. Experimental paratuberculosis in sheep after oral, intratracheal, or intravenous inoculation lesions and demonstration of etiologic agent. Am J Vet Res. 1968;29:953-962.
    • (1968) Am J Vet Res. , vol.29 , pp. 953-962
    • Kluge, J.P.1    Merkal, R.S.2    Monlux, W.S.3
  • 43
    • 38349133365 scopus 로고    scopus 로고
    • The forgotten role of lymphangitis in Crohn's disease
    • Van Kruiningen HJ, Colombel JF. The forgotten role of lymphangitis in Crohn's disease. Gut. 2008;57:1-4.
    • (2008) Gut. , vol.57 , pp. 1-4
    • Van Kruiningen, H.J.1    Colombel, J.F.2
  • 44
    • 0021266269 scopus 로고
    • Natural history of recurrent Crohn's disease at the ileocolonic anastomosis after curative surgery
    • Rutgeerts P, Geboes K, Vantrappen G, et al. Natural history of recurrent Crohn's disease at the ileocolonic anastomosis after curative surgery. Gut. 1984;25:665-672.
    • (1984) Gut. , vol.25 , pp. 665-672
    • Rutgeerts, P.1    Geboes, K.2    Vantrappen, G.3
  • 45
    • 0025887076 scopus 로고
    • Effect of faecal stream diversion on recurrence of Crohn's disease in the neoterminal ileum
    • Rutgeerts P, Goboes K, Peeters M, et al. Effect of faecal stream diversion on recurrence of Crohn's disease in the neoterminal ileum. Lancet. 1991;338:771-774.
    • (1991) Lancet , vol.338 , pp. 771-774
    • Rutgeerts, P.1    Goboes, K.2    Peeters, M.3
  • 46
    • 34249886868 scopus 로고    scopus 로고
    • CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn disease
    • Barnich N, Carvalho FA, Classer AL, et al. CEACAM6 acts as a receptor for adherent-invasive E. coli, supporting ileal mucosa colonization in Crohn disease. J Clin Invest. 2007;117:1566-1574.
    • (2007) J Clin Invest. , vol.117 , pp. 1566-1574
    • Barnich, N.1    Carvalho, F.A.2    Classer, A.L.3
  • 47
    • 34547952781 scopus 로고    scopus 로고
    • Bugging of the intestinal mucosa
    • Abraham. C, Cho JH, Bugging of the intestinal mucosa. N Engl J Med. 2007;357:708-710.
    • (2007) N Engl J Med. , vol.357 , pp. 708-710
    • Abraham, C.1    Cho, J.H.2
  • 48
    • 21044447748 scopus 로고    scopus 로고
    • High prevalence of Mycobacterium avium subspecies paratuberculosis IS900 DNA in gut tissues from individuals with Crohn's disease
    • DOI 10.1136/gut.2004.045526
    • Autschbach F, Eisold S, Hinz U, et al. High prevalence of Mycobacterium avium subspecies paratuberculosis IS900 DNA in gut tissues from individuals with Crohn's disease. Gut. 2005;54:944-949. (Pubitemid 40873906)
    • (2005) Gut , vol.54 , Issue.7 , pp. 944-949
    • Autschbach, F.1    Eisold, S.2    Hinz, U.3    Zinser, S.4    Linnebacher, M.5    Giese, T.6    Loffler, T.7    Buchler, M.W.8    Schmidt, J.9
  • 49
    • 35348857386 scopus 로고    scopus 로고
    • Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases
    • Frank DN, St Amand AL, Feldman RA, et al. Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc Natl Acad Sci U S A. 2007;104: 13780-13785.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 13780-13785
    • Frank, D.N.1    St Amand, A.L.2    Feldman, R.A.3
  • 50
    • 54849421128 scopus 로고    scopus 로고
    • Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant
    • Kuballa P, Huett A, Rioux JD, et al. Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant. PLoS ONE. 2008;3:e3391.
    • (2008) PLoS ONE , vol.3
    • Kuballa, P.1    Huett, A.2    Rioux, J.D.3
  • 51
    • 0034651738 scopus 로고    scopus 로고
    • Virulent Mycobacterium tuberculosis strains evade apoptosis of infected alveolar macrophages
    • Keane J, Remold HG, Kornfeld H. Virulent Mycobacterium tuberculosis strains evade apoptosis of infected alveolar macrophages. J Immunol. 2000;164:2016-2020.
    • (2000) J Immunol. , vol.164 , pp. 2016-2020
    • Keane, J.1    Remold, H.G.2    Kornfeld, H.3
  • 52
    • 0242268398 scopus 로고    scopus 로고
    • Acute infection and macrophage subversion by Mycobacterium tuberculosis require a specialized secretion system
    • Stanley SA, Raghavan S, Hwang WW, et al. Acute infection and macrophage subversion by Mycobacterium tuberculosis require a specialized secretion system. Proc Natl Acad Sci U S A. 2003; 100:13001-13006.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 13001-13006
    • Stanley, S.A.1    Raghavan, S.2    Hwang, W.W.3
  • 53
    • 0030481130 scopus 로고    scopus 로고
    • Mycobacterium-containing phagosomes are accessible to early endosomes and reflect a transitional state in normal phagosome biogenesis
    • Sturgill-Koszycki S, Schaible UE, Russell DG. Mycobacterium-containing phagosomes are accessible to early endosomes and reflect a transitional state in normal phagosome biogenesis. EMBO J. 1996;15: 6960-6968.
    • (1996) EMBO J , vol.15 , pp. 6960-6968
    • Sturgill-Koszycki, S.1    Schaible, U.E.2    Russell, D.G.3
  • 54
    • 39749115051 scopus 로고    scopus 로고
    • Chronic enteric salmonella infection in mice leads to severe and persistent intestinal fibrosis
    • Grassl GA, Valdez Y, Bergstrom KS, et al. Chronic enteric salmonella infection in mice leads to severe and persistent intestinal fibrosis. Gastroenterology. 2008;134:768-780.
    • (2008) Gastroenterology , vol.134 , pp. 768-780
    • Grassl, G.A.1    Valdez, Y.2    Bergstrom, K.S.3
  • 55
    • 1642279261 scopus 로고    scopus 로고
    • +/+ Mice and Can Be Reactivated by IFNγ Neutralization
    • DOI 10.1084/jem.20031319
    • Monack DM, Bouley DM, Falkow S. Salmonella typhimurium persists within macrophages in the mesenteric lymph nodes of chronically infected Nramp1+/+ mice and can be reactivated by IFNgamma neutralization. J Exp Med. 2004;199:231-241. (Pubitemid 38129703)
    • (2004) Journal of Experimental Medicine , vol.199 , Issue.2 , pp. 231-241
    • Monack, D.M.1    Bouley, D.M.2    Falkow, S.3
  • 56
    • 2942750218 scopus 로고    scopus 로고
    • Assessment of Crohn's disease activity in the small bowel with MR and conventional enteroclysis: Preliminary results
    • Gourtsoyiannis N, Papanikolaou N, Grammatikakis J, et al. Assessment of Crohn's disease activity in the small bowel with MR and conventional enteroclysis: preliminary results. Eur Radiol. 2004;14:1017-1024.
    • (2004) Eur Radiol. , vol.14 , pp. 1017-1024
    • Gourtsoyiannis, N.1    Papanikolaou, N.2    Grammatikakis, J.3
  • 57
    • 34147213316 scopus 로고    scopus 로고
    • Mesenteric fat in Crohn's disease: A pathogenetic hallmark or an innocent bystander
    • Peyrin-Biroulet L, Chamaillard M, Gonzalez F, et al. Mesenteric fat in Crohn's disease: a pathogenetic hallmark or an innocent bystander? Gut. 2007;56:577-583.
    • (2007) Gut. , vol.56 , pp. 577-583
    • Peyrin-Biroulet, L.1    Chamaillard, M.2    Gonzalez, F.3
  • 58
    • 63449119636 scopus 로고    scopus 로고
    • Where are all the Mycobacterium avium subspecies paratuberculosis in patients with Crohn's disease
    • Pierce ES. Where are all the Mycobacterium avium subspecies paratuberculosis in patients with Crohn's disease? PLoS Pathog. 2009;5: e1000234.
    • (2009) PLoS Pathog. , vol.5
    • Pierce, E.S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.