Type IV pili, transient bacterial aggregates, and virulence of enteropathogenic escherichia coli

Science

Volumn 280, Issue 5372, 1998, Pages 2114-2118

  Bieber, David ^a,b   Ramer, Sandra W ^a,b   Wu, Cheng Yen ^a,b   Murray, William J ^c   Tobe, Toru ^d   Fernandez, Rosemary ^a,b   Schoolnik, Gary K ^a,b  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY MEDICAL CENTER   (United States)

^c SAN JOSE STATE UNIVERSITY   (United States)

^d UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL VIRULENCE; BACTERIUM ADHERENCE; BACTERIUM PILUS; DIARRHEA; ESCHERICHIA COLI; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ADOLESCENT; ADULT; AGGLUTINATION; BACTERIAL ADHESION; CELL MEMBRANE; DIARRHEA; EPITHELIAL CELLS; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; FIMBRIAE, BACTERIAL; HUMANS; INTESTINAL MUCOSA; MIDDLE AGED; MUTATION; OPERON; PHENOTYPE; TUMOR CELLS, CULTURED; VIRULENCE;

EID: 0032568984     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.280.5372.2114     Document Type: Review

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50. Scanning electron microscopy was performed at the Microscope and Graphic Imaging Center, California State University, Hayward (N. R. Smith, Director) and at the SETI Institute, NASA Ames Research Center. The studies of volunteers were performed in the General Clinical Research Center (GCRC) at Stanford University Medical Center. Supported by Health and Human Services grants 1R03-DK52038 and 1R01-Al39521 from the National Institutes of Health and by Health and Human Services grant M01-RR00070 from the General Clinical Research Program, National Institutes of Health. We thank D. Kaiser, B. Stocker, and B. W. Brown for helpful suggestions and critical reading of the manuscript; R. Valdivia and S. Falkow for providing the GFP plasmid; S. R. Kushner for providing pWKS plasmids; J. Giron for providing the BFP antiserum; J. Engel for the suggestion to use GFP to mark the individual bacteria; the nursing staff of the GCRC and the volunteers for their participation in the study; and N. Smith and K. Kato for their advice and generous use of the SEMs.