Crohn's disease as an immune deficiency?

The Lancet

Volumn 374, Issue 9692, 2009, Pages 769-770

  Coulombe, François ^a   Behr, Marcel A ^a  

^a MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BACTERIAL INFECTION; CROHN DISEASE; DISEASE PREDISPOSITION; IMMUNE DEFICIENCY; IMMUNE RESPONSE; INFLAMMATION; INNATE IMMUNITY; PATHOGENESIS; PRIORITY JOURNAL;

EID: 69449097214     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0140-6736(09)61576-2     Document Type: Note

References (8)

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2. Behr M.A., and Schurr E. Mycobacteria in Crohn's disease: a persistent hypothesis. Inflamm Bowel Dis 12 (2006) 1000-1004
3. Hugot J.P., Chamaillard M., Zouali H., et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411 (2001) 599-603
4. Hampe J., Franke A., Rosenstiel P., et al. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet 39 (2007) 207-211
5. Parkes M., Barrett J.C., Prescott N.J., et al. Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nat Genet 39 (2007) 830-832
6. Segal A.W., and Loewi G. Neutrophil dysfunction in Crohn's disease. Lancet 2 (1976) 219-221
7. Marks D.J., Harbord M.W., MacAllister R., et al. Defective acute inflammation in Crohn's disease: a clinical investigation. Lancet 367 (2006) 668-678
8. Coulombe F., Divangahi M., Veyrier F., et al. Increased NOD2-mediated recognition of N-glycolyl muramyl dipeptide. J Exp Med (2009) 10.1084/jem.20081779 published online July 6.