Effect of HEPES buffer on the uptake and transport of p-glycoprotein substrates and large neutral amino acids

Molecular Pharmaceutics

Volumn 7, Issue 2, 2010, Pages 412-420

  Luo, Shuanghui ^a   Pal, Dhananjay ^a   Shah, Sujay J ^a   Kwatra, Deep ^a   Paturi, Kalyani D ^a   Mitra, Ashim K ^a  

^a UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

Author keywords

ATP dependent; HEPES; MDCK MDR1; P gp substrates; Transport; Uptake

Indexed keywords

4 (2 HYDROXYETHYL) 1 PIPERAZINEETHANESULFONIC ACID; ADENOSINE TRIPHOSPHATE; CYCLOSPORIN A; DIAZEPAM; GLUTAMIC ACID; GLYCOPROTEIN P; LOPINAVIR; PHENYLALANINE; RITONAVIR; VERAPAMIL;

AMINO ACID TRANSPORT; ANIMAL CELL; ARTICLE; CELL GROWTH; CONTROLLED STUDY; DIFFUSION; DRUG PENETRATION; DRUG TRANSPORT; DRUG UPTAKE; HUMAN; HUMAN CELL; MEMBRANE PERMEABILITY; NONHUMAN; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATE; AMINO ACIDS, NEUTRAL; ANIMALS; BIOLOGICAL TRANSPORT; CACO-2 CELLS; CELL LINE; CELL MEMBRANE PERMEABILITY; CYCLOSPORINE; DOGS; GLUTAMIC ACID; HEPES; HUMANS; P-GLYCOPROTEIN; PHENYLALANINE; PYRIMIDINONES; RITONAVIR; VERAPAMIL;

EID: 77950569257     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp900193e     Document Type: Article

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