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Volumn 13, Issue 13, 1999, Pages 1623-1627

Modulation of P-glycoprotein function in human lymphocytes and Caco-2 cell monolayers by HIV-1 protease inhibitors

Author keywords

Caco 2 cells; Lymphocytes; P glycoprotein; Protease inhibitor; Rhodamine 123; Saquinavir

Indexed keywords

GLYCOPROTEIN P; INDINAVIR; KETOCONAZOLE; NELFINAVIR; PROTEINASE INHIBITOR; RHODAMINE 123; RITONAVIR; SAQUINAVIR; VERAPAMIL;

EID: 0033371825     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-199909100-00004     Document Type: Article
Times cited : (150)

References (16)
  • 1
    • 0031914446 scopus 로고    scopus 로고
    • Saquinavir soft gel capsule formulation
    • Perry C, Noble S. Saquinavir soft gel capsule formulation. Drugs 1998, 53:461-486.
    • (1998) Drugs , vol.53 , pp. 461-486
    • Perry, C.1    Noble, S.2
  • 2
    • 0031024382 scopus 로고    scopus 로고
    • Selective biotransformation of the human immunodeficiency virus protease inhibitor saquinavir by human small intestinal cytochrome P-450
    • Fitzsimmons ME, Collins JM. Selective biotransformation of the human immunodeficiency virus protease inhibitor saquinavir by human small intestinal cytochrome P-450. Drug Metab Dispos 1997, 25:256-267.
    • (1997) Drug Metab Dispos , vol.25 , pp. 256-267
    • Fitzsimmons, M.E.1    Collins, J.M.2
  • 3
    • 0030852009 scopus 로고    scopus 로고
    • Differential inhibition of cytochrome P450 isoforms by the protease inhibitors ritonavir, saquinavir and indinavir
    • Eagling VE, Back DJ, Barry MG. Differential inhibition of cytochrome P450 isoforms by the protease inhibitors ritonavir, saquinavir and indinavir. Br J Clin Pharmacol 1997, 44:190-194.
    • (1997) Br J Clin Pharmacol , vol.44 , pp. 190-194
    • Eagling, V.E.1    Back, D.J.2    Barry, M.G.3
  • 4
    • 0028943992 scopus 로고
    • In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors
    • Condra JH, Schleif WA, Blahy OM, et al. In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors. Nature 1995, 374:569-571.
    • (1995) Nature , vol.374 , pp. 569-571
    • Condra, J.H.1    Schleif, W.A.2    Blahy, O.M.3
  • 5
    • 0029028792 scopus 로고
    • Overlapping substrate specificities and tissue distribution of cytochrome P4503A and P-glycoprotein: Implications for drug delivery and activity in cancer chemotherapy
    • Wacher VJ, Wu CY, Benet LZ. Overlapping substrate specificities and tissue distribution of cytochrome P4503A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy. Mol Carcinogen 1995, 13:129-134.
    • (1995) Mol Carcinogen , vol.13 , pp. 129-134
    • Wacher, V.J.1    Wu, C.Y.2    Benet, L.Z.3
  • 6
    • 0023447098 scopus 로고
    • Cellular localisation of the multidrug-resistance gene product P-glycoprotein in normal human tissues
    • Thiebaut F, Tsuruo T, Hamada H, et al. Cellular localisation of the multidrug-resistance gene product P-glycoprotein in normal human tissues. Proc Natl Acad Sci USA 1987, 84:7735-7738.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 7735-7738
    • Thiebaut, F.1    Tsuruo, T.2    Hamada, H.3
  • 7
    • 0027181852 scopus 로고
    • Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells
    • Hunter J, Jepson MA, Tsuruo T, et al. Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells. J Biol Chem 1993, 268:14991-14997.
    • (1993) J Biol Chem , vol.268 , pp. 14991-14997
    • Hunter, J.1    Jepson, M.A.2    Tsuruo, T.3
  • 8
    • 0031896882 scopus 로고    scopus 로고
    • Active apical secretory efflux of the HIV protease inhibitors saquinavir and ritonavir in Caco-2 cell monalayers
    • Alsenz J, Steffen H, Rainer A. Active apical secretory efflux of the HIV protease inhibitors saquinavir and ritonavir in Caco-2 cell monalayers. Pharm Res 1998, 15:423-428.
    • (1998) Pharm Res , vol.15 , pp. 423-428
    • Alsenz, J.1    Steffen, H.2    Rainer, A.3
  • 9
    • 0031775155 scopus 로고    scopus 로고
    • Sanctuary sites in HIV-1 infection
    • Hoetelmans RMW. Sanctuary sites in HIV-1 infection. Antiviral Ther 1998, 3:13-17.
    • (1998) Antiviral Ther , vol.3 , pp. 13-17
    • Hoetelmans, R.M.W.1
  • 10
    • 0026465461 scopus 로고
    • Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes
    • Chaudhary PM, Mechetner EB, Roninson IB. Expression and activity of the multidrug resistance P-glycoprotein in human peripheral blood lymphocytes. Blood 1992, 11:2735-2739.
    • (1992) Blood , vol.11 , pp. 2735-2739
    • Chaudhary, P.M.1    Mechetner, E.B.2    Roninson, I.B.3
  • 11
    • 0032540001 scopus 로고    scopus 로고
    • HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter
    • Lee CGL, Gottesman MM, Cardarelli CO, et al. HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter. Biochemistry 1998, 37:3594-3601.
    • (1998) Biochemistry , vol.37 , pp. 3594-3601
    • Lee, C.G.L.1    Gottesman, M.M.2    Cardarelli, C.O.3
  • 12
    • 0029846735 scopus 로고    scopus 로고
    • Abnormal expression of a 170-kilodalton P-glycoprotein encoded by MDR1 gene, a metabolically active efflux pump, in CD4+ and CD8+ T cells from patients with human immunodeficiency virus type 1 infection
    • Andreana A, Aggarwal S, Gollapudi S, et al. Abnormal expression of a 170-kilodalton P-glycoprotein encoded by MDR1 gene, a metabolically active efflux pump, in CD4+ and CD8+ T cells from patients with human immunodeficiency virus type 1 infection. AIDS Res Hum Retroviruses 1996, 12:1457-1462.
    • (1996) AIDS Res Hum Retroviruses , vol.12 , pp. 1457-1462
    • Andreana, A.1    Aggarwal, S.2    Gollapudi, S.3
  • 13
    • 0019430432 scopus 로고
    • Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil
    • Isuruo T, Iida H, Tsukagoshi S, Sakurai Y. Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil. Cancer Res 1981, 41:1967-1972.
    • (1981) Cancer Res , vol.41 , pp. 1967-1972
    • Isuruo, T.1    Iida, H.2    Tsukagoshi, S.3    Sakurai, Y.4
  • 14
    • 0028098101 scopus 로고
    • Ketoconazole effectively reverses multidrug resistance in highly resistant KB cells
    • Siegsmund MJ, Cardarelli C, Aksentijevich I, et al. Ketoconazole effectively reverses multidrug resistance in highly resistant KB cells. J Urol 1994, 151:485-491.
    • (1994) J Urol , vol.151 , pp. 485-491
    • Siegsmund, M.J.1    Cardarelli, C.2    Aksentijevich, I.3
  • 15
    • 0031054507 scopus 로고    scopus 로고
    • Saquinavir pharmacokinetics alone and in combination with ritonavir in HIV-infected patients
    • Merry C, Barry MG, Mulcahy F, et al. Saquinavir pharmacokinetics alone and in combination with ritonavir in HIV-infected patients. AIDS 1997, 11:F29-F33.
    • (1997) AIDS , vol.11
    • Merry, C.1    Barry, M.G.2    Mulcahy, F.3
  • 16
    • 0030830568 scopus 로고    scopus 로고
    • Saquinavir pharmacokinetics alone and in combination with nelfinavir in HIV-infected patients
    • Merry C, Barry MG, Mulcahy F, et al. Saquinavir pharmacokinetics alone and in combination with nelfinavir in HIV-infected patients, AIDS 1997, 11:F117-F120.
    • (1997) AIDS , vol.11
    • Merry, C.1    Barry, M.G.2    Mulcahy, F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.