In vitro intestinal permeability of factor Xa inhibitors: Influence of chemical structure on passive transport and susceptibility to efflux

Pharmaceutical Research

Volumn 18, Issue 12, 2001, Pages 1735-1741

  Schipper, N G M ^a,b   Osterberg T ^a   Wrange, U ^a   Westberg, C ^a   Sokolowski, A ^a   Rai, R ^c   Young, W ^c   Sjostrom B ^a  

^a BIOVITRUM AB   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

^c Axys Pharmaceuticals Inc   (United States)

Author keywords

Caco 2; Efflux; Factor Xa inhibitors; Intestinal permeability; Oral absorption.

Indexed keywords

AMIDINE; BLOOD CLOTTING FACTOR 10A INHIBITOR; CARBAMIC ACID ESTER; CARBON 14; CARRIER PROTEIN; GLYCOPROTEIN P; GUANIDINE; IMIDAZOLE DERIVATIVE; MANNITOL; PNU 20001; PNU 200603; PNU 200647; PNU 200648; PNU 200681; PNU 200969; PROBENECID; TESTOSTERONE; TETRYLAMMONIUM CHLORIDE; TRITIUM; UNCLASSIFIED DRUG; VERAPAMIL; VINBLASTINE SULFATE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL LINE; CELL MEMBRANE PERMEABILITY; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG ABSORPTION; DRUG DEGRADATION; DRUG PENETRATION; DRUG STRUCTURE; DRUG TRANSPORT; EPITHELIUM CELL; EXPERIMENTAL MODEL; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; ILEUM; IN VITRO STUDY; INTESTINE MUCOSA PERMEABILITY; MALE; NONHUMAN; PASSIVE TRANSPORT; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

EID: 0035662950     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1013378731183     Document Type: Article

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