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Volumn 119, Issue 3-5, 2010, Pages 97-104

Neuroimmunomodulatory steroids in alzheimer dementia

Author keywords

Alzheimer disease; Apoptosis; Autoimmunity; Glycoregulation; Steroids

Indexed keywords

AMYLOID BETA PROTEIN; GLUCOCORTICOID; PRASTERONE; REACTIVE OXYGEN METABOLITE; STEROID; TAU PROTEIN;

EID: 77950296602     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2010.02.007     Document Type: Review
Times cited : (23)

References (110)
  • 1
    • 0035225988 scopus 로고    scopus 로고
    • Neurosteroid 7-hydroxylation products in the brain
    • Morfin R., Stárka L. Neurosteroid 7-hydroxylation products in the brain. Int. Rev. Neurobiol. 2001, 46:79-95.
    • (2001) Int. Rev. Neurobiol. , vol.46 , pp. 79-95
    • Morfin, R.1    Stárka, L.2
  • 5
    • 0036151721 scopus 로고    scopus 로고
    • Initial and subsequent approach for the synthesis of 18FDG
    • Fowler J.S., Ido T. Initial and subsequent approach for the synthesis of 18FDG. Semin. Nucl. Med. 2002, 32:6-12.
    • (2002) Semin. Nucl. Med. , vol.32 , pp. 6-12
    • Fowler, J.S.1    Ido, T.2
  • 6
    • 17844364259 scopus 로고    scopus 로고
    • Brain glucose metabolism in the early and specific diagnosis of Alzheimer disease. FDG-PET studies in MCI and AD
    • Mosconi L. Brain glucose metabolism in the early and specific diagnosis of Alzheimer disease. FDG-PET studies in MCI and AD. Eur. J. Nucl. Med. Mol. Imageing 2005, 32:486-510.
    • (2005) Eur. J. Nucl. Med. Mol. Imageing , vol.32 , pp. 486-510
    • Mosconi, L.1
  • 7
    • 1642344700 scopus 로고    scopus 로고
    • Hippocampal glucose metabolism is associated with cerebrospinal fluid estrogen levels in postmenopausal women with Alzheimer disease
    • Schönknecht P., Henze M., Hunt A., Klinga K., Haberkorn U., Schröder J. Hippocampal glucose metabolism is associated with cerebrospinal fluid estrogen levels in postmenopausal women with Alzheimer disease. Psychiatry Res. 2003, 124:125-127.
    • (2003) Psychiatry Res. , vol.124 , pp. 125-127
    • Schönknecht, P.1    Henze, M.2    Hunt, A.3    Klinga, K.4    Haberkorn, U.5    Schröder, J.6
  • 8
    • 51249114495 scopus 로고    scopus 로고
    • Estrogen regulation of glucose metabolism and mitochondrial function: therapeutic implications for prevention of Alzheimer disease
    • Brinton R.D. estrogen regulation of glucose metabolism and mitochondrial function: therapeutic implications for prevention of Alzheimer disease. Adv. Drug. Deliv. Rev. 2008, 60:1504-1511.
    • (2008) Adv. Drug. Deliv. Rev. , vol.60 , pp. 1504-1511
    • Brinton, R.D.1
  • 12
    • 0032983691 scopus 로고    scopus 로고
    • Activities of key glycolytic enzymes in the brains of patients with Alzheimer disease
    • Bigl M., Brückner M.K., Arendt T., Bigl V., Eschrich K. Activities of key glycolytic enzymes in the brains of patients with Alzheimer disease. J. Neural Transm. 1999, 106:499-511.
    • (1999) J. Neural Transm. , vol.106 , pp. 499-511
    • Bigl, M.1    Brückner, M.K.2    Arendt, T.3    Bigl, V.4    Eschrich, K.5
  • 13
    • 0029820954 scopus 로고    scopus 로고
    • Changes of activity and isozyme pattern of phosphofructokinase in the brains of patients with Alzheimer disease
    • Bigl M., Bleyl A.D., Zedlick D., Arendt T., Bigl V., Eschrich K. Changes of activity and isozyme pattern of phosphofructokinase in the brains of patients with Alzheimer disease. J. Neurochem. 1996, 67:1164-1171.
    • (1996) J. Neurochem. , vol.67 , pp. 1164-1171
    • Bigl, M.1    Bleyl, A.D.2    Zedlick, D.3    Arendt, T.4    Bigl, V.5    Eschrich, K.6
  • 14
    • 0031737226 scopus 로고    scopus 로고
    • Abnormalities of mitochondrial enzymes in Alzheimer disease
    • Gibson G.E., Sheu K.F., Blass J.P. Abnormalities of mitochondrial enzymes in Alzheimer disease. J. Neural Transm. 1998, 105:855-870.
    • (1998) J. Neural Transm. , vol.105 , pp. 855-870
    • Gibson, G.E.1    Sheu, K.F.2    Blass, J.P.3
  • 15
    • 34147146944 scopus 로고    scopus 로고
    • A new glucocorticoid hypothesis of brain ageing: implication for Alzheimer's disease
    • Landfield P.W., Blalock E.M., Chen K.C., Porter N.M. A new glucocorticoid hypothesis of brain ageing: implication for Alzheimer's disease. Curr. Alzheimer Res. 2007, 4:205-212.
    • (2007) Curr. Alzheimer Res. , vol.4 , pp. 205-212
    • Landfield, P.W.1    Blalock, E.M.2    Chen, K.C.3    Porter, N.M.4
  • 17
    • 1242315660 scopus 로고    scopus 로고
    • Dehydroepiandrosterone, glucose-6-phosphate dehydrogenase, and longevity
    • Schwartz A.G., Pashko L.L. Dehydroepiandrosterone, glucose-6-phosphate dehydrogenase, and longevity. Ageing Res. Rev. 2004, 3:171-187.
    • (2004) Ageing Res. Rev. , vol.3 , pp. 171-187
    • Schwartz, A.G.1    Pashko, L.L.2
  • 18
    • 34447569486 scopus 로고    scopus 로고
    • Alzheimer' s disease, oxidative stress and gammahydroxybutyrate
    • Mamelak M. Alzheimer' s disease, oxidative stress and gammahydroxybutyrate. Neurobiol. Aging 2007, 28:1340-1360.
    • (2007) Neurobiol. Aging , vol.28 , pp. 1340-1360
    • Mamelak, M.1
  • 19
    • 33751244248 scopus 로고    scopus 로고
    • Dehydroepiandrosterone metabolites and their interactions in humans
    • Chalbot S., Morfin R. Dehydroepiandrosterone metabolites and their interactions in humans. Drug Metabol. Drug Interact. 2006, 22:1-23.
    • (2006) Drug Metabol. Drug Interact. , vol.22 , pp. 1-23
    • Chalbot, S.1    Morfin, R.2
  • 20
    • 0141533183 scopus 로고    scopus 로고
    • Dehydroepiandrosterone 7-hydroxylase CYP7B: predominant expression in primate hippocampus and reduced expression in Alzheimer disease
    • Yau J.L., Rasmuson S., Andrew R., Graham M., Noble J., Olsson T., Fuchs E., Lathe R., Seckl J.R. Dehydroepiandrosterone 7-hydroxylase CYP7B: predominant expression in primate hippocampus and reduced expression in Alzheimer disease. Neuroscience 2003, 121:307-314.
    • (2003) Neuroscience , vol.121 , pp. 307-314
    • Yau, J.L.1    Rasmuson, S.2    Andrew, R.3    Graham, M.4    Noble, J.5    Olsson, T.6    Fuchs, E.7    Lathe, R.8    Seckl, J.R.9
  • 21
    • 33746232050 scopus 로고    scopus 로고
    • Inter-conversion of 7alpha- and 7beta-hydroxy-dehydroepiandrosterone by the human 11beta-hydroxysteroid dehydrogenase type I
    • Muller C., Pompon D., Urban P., Morfin R. Inter-conversion of 7alpha- and 7beta-hydroxy-dehydroepiandrosterone by the human 11beta-hydroxysteroid dehydrogenase type I. J. Steroid Biochem. Mol. Biol. 2006, 99:215-222.
    • (2006) J. Steroid Biochem. Mol. Biol. , vol.99 , pp. 215-222
    • Muller, C.1    Pompon, D.2    Urban, P.3    Morfin, R.4
  • 22
    • 34547780802 scopus 로고    scopus 로고
    • 7Alpha- and 7beta-hydroxy-epiandrosterone as substrates and inhibitors for the human 11beta-hydroxysteroid dehydrogenase type I
    • Hennebert O., Pernelle C., Ferroud C., Morfin R. 7Alpha- and 7beta-hydroxy-epiandrosterone as substrates and inhibitors for the human 11beta-hydroxysteroid dehydrogenase type I. J. Steroid Biochem. Mol. Biol. 2007, 105:159-165.
    • (2007) J. Steroid Biochem. Mol. Biol. , vol.105 , pp. 159-165
    • Hennebert, O.1    Pernelle, C.2    Ferroud, C.3    Morfin, R.4
  • 25
    • 33747104566 scopus 로고    scopus 로고
    • Links between Alzheimer disease and diabetes
    • Sun M.K., Alkon D.L. Links between Alzheimer disease and diabetes. Drugs Today (Barc.) 2006, 42:481-489.
    • (2006) Drugs Today (Barc.) , vol.42 , pp. 481-489
    • Sun, M.K.1    Alkon, D.L.2
  • 27
    • 34147173277 scopus 로고    scopus 로고
    • Insulin resistance and Alzheimer disease pathogenesis: potential mechanisms and implications for treatment
    • Craft S. Insulin resistance and Alzheimer disease pathogenesis: potential mechanisms and implications for treatment. Curr. Alzheimer Res. 2007, 4:147-152.
    • (2007) Curr. Alzheimer Res. , vol.4 , pp. 147-152
    • Craft, S.1
  • 28
    • 62449142597 scopus 로고    scopus 로고
    • The role of metabolic disorders in Alzheimer disease and vascular dementia: two roads converged
    • Craft S. The role of metabolic disorders in Alzheimer disease and vascular dementia: two roads converged. Arch. Neurol. 2009, 66:300-305.
    • (2009) Arch. Neurol. , vol.66 , pp. 300-305
    • Craft, S.1
  • 30
    • 43449139156 scopus 로고    scopus 로고
    • Relationship between non-genomic actions of estrogens and insulin resistace
    • Alonso A., González C. Relationship between non-genomic actions of estrogens and insulin resistace. Infect. Disord. Drug Targets 2008, 8:48-51.
    • (2008) Infect. Disord. Drug Targets , vol.8 , pp. 48-51
    • Alonso, A.1    González, C.2
  • 32
    • 52349103202 scopus 로고    scopus 로고
    • Low testosterone and the association with type II diabetes
    • Farrell J.B., Deshmukh A., Baghaie A.A. Low testosterone and the association with type II diabetes. Diabetes Educ. 2008, 34:799-806.
    • (2008) Diabetes Educ. , vol.34 , pp. 799-806
    • Farrell, J.B.1    Deshmukh, A.2    Baghaie, A.A.3
  • 33
    • 58149310816 scopus 로고    scopus 로고
    • The dark side of testosterone deficiency: II. Type II diabetes and insulin resistance
    • Traish A.M., Saad F., Guay A. The dark side of testosterone deficiency: II. Type II diabetes and insulin resistance. J. Androl. 2009, 30:23-32.
    • (2009) J. Androl. , vol.30 , pp. 23-32
    • Traish, A.M.1    Saad, F.2    Guay, A.3
  • 34
    • 0242720394 scopus 로고    scopus 로고
    • Relationship between testosterone, sex hormone binding globulin and plasma amyloid beta peptide 40 in older men with subjective memory loss or dementia, J
    • Gillett M.J., Martins R.N., Clarnette R.M., Chubb S.A., Bruce D.G., Yeap B.B. Relationship between testosterone, sex hormone binding globulin and plasma amyloid beta peptide 40 in older men with subjective memory loss or dementia, J. Alzheimers Dis. 2003, 5:267-269.
    • (2003) Alzheimers Dis. , vol.5 , pp. 267-269
    • Gillett, M.J.1    Martins, R.N.2    Clarnette, R.M.3    Chubb, S.A.4    Bruce, D.G.5    Yeap, B.B.6
  • 35
    • 1042276576 scopus 로고    scopus 로고
    • Plasma testosterone levels in Alzheimer and Parkinson diseases
    • Okun M.S., DeLong M.R., Hanfelt J., Gearing M., Levey A. Plasma testosterone levels in Alzheimer and Parkinson diseases. Neurology 2004, 62:411-413.
    • (2004) Neurology , vol.62 , pp. 411-413
    • Okun, M.S.1    DeLong, M.R.2    Hanfelt, J.3    Gearing, M.4    Levey, A.5
  • 37
    • 59849099422 scopus 로고    scopus 로고
    • Testosterone effects on cognition in health and disease
    • Cherrier M.M. Testosterone effects on cognition in health and disease. Front. Horm. Res. 2009, 37:150-162.
    • (2009) Front. Horm. Res. , vol.37 , pp. 150-162
    • Cherrier, M.M.1
  • 38
    • 33845598391 scopus 로고    scopus 로고
    • Vitamin D deficiency is associated with low mood and worse cognitive performance in older adults
    • Wilkins C.H., Sheline Y.I., Roe C.M., Birge S.J., Morris J.C. Vitamin D deficiency is associated with low mood and worse cognitive performance in older adults. Am. J. Geriatr. Psychiatry 2006, 14:1032-1040.
    • (2006) Am. J. Geriatr. Psychiatry , vol.14 , pp. 1032-1040
    • Wilkins, C.H.1    Sheline, Y.I.2    Roe, C.M.3    Birge, S.J.4    Morris, J.C.5
  • 39
    • 54049152001 scopus 로고    scopus 로고
    • Prevalence of vitamin D insufficiency in patients with Parkinson disease and Alzheimer disease
    • Evatt M.L., Delong M.R., Khazai N., Rosen A., Triche S., Tangpricha V. Prevalence of vitamin D insufficiency in patients with Parkinson disease and Alzheimer disease. Arch. Neurol. 2008, 65:1348-1352.
    • (2008) Arch. Neurol. , vol.65 , pp. 1348-1352
    • Evatt, M.L.1    Delong, M.R.2    Khazai, N.3    Rosen, A.4    Triche, S.5    Tangpricha, V.6
  • 42
    • 36048933985 scopus 로고    scopus 로고
    • Dehydroepiandrosterone administration counteracts oxidative imbalance and advanced glycation end product formation in type II diabetic patients
    • Brignardello E., Runzo C., Aragno M., Catalano M.G., Cassader M., Perin P.C., Boccuzzi G. Dehydroepiandrosterone administration counteracts oxidative imbalance and advanced glycation end product formation in type II diabetic patients. Diabetes Care 2007, 30:2922-2927.
    • (2007) Diabetes Care , vol.30 , pp. 2922-2927
    • Brignardello, E.1    Runzo, C.2    Aragno, M.3    Catalano, M.G.4    Cassader, M.5    Perin, P.C.6    Boccuzzi, G.7
  • 43
    • 34547972464 scopus 로고    scopus 로고
    • 17Beta-oestradiol partially attenuates the inhibition of nitric oxide synthase-3 by advanced glycation end-products in human platelets
    • Chen L., Liu Y., Cui B., Mi Q., Huang Y., Fan L., Chen Q., Tang J., Ferro A., Ji Y. 17Beta-oestradiol partially attenuates the inhibition of nitric oxide synthase-3 by advanced glycation end-products in human platelets. Clin. Exp. Pharmacol. Physiol. 2007, 34:972-978.
    • (2007) Clin. Exp. Pharmacol. Physiol. , vol.34 , pp. 972-978
    • Chen, L.1    Liu, Y.2    Cui, B.3    Mi, Q.4    Huang, Y.5    Fan, L.6    Chen, Q.7    Tang, J.8    Ferro, A.9    Ji, Y.10
  • 44
    • 0037305211 scopus 로고    scopus 로고
    • Advanced glycation end products cause lipid peroxidation in the human neuronal cell line SH-SY5Y
    • Gasic-Milenkovic J., Loske C., Münch G. Advanced glycation end products cause lipid peroxidation in the human neuronal cell line SH-SY5Y. J. Alzheimers Dis. 2003, 5:25-30.
    • (2003) J. Alzheimers Dis. , vol.5 , pp. 25-30
    • Gasic-Milenkovic, J.1    Loske, C.2    Münch, G.3
  • 45
    • 34548306686 scopus 로고    scopus 로고
    • The molecular link between beta- and gamma-secretase activity on the amyloid beta precursor protein
    • Tabaton M., Tamagno E. The molecular link between beta- and gamma-secretase activity on the amyloid beta precursor protein. Cell. Mol. Life Sci. 2007, 64:2211-2218.
    • (2007) Cell. Mol. Life Sci. , vol.64 , pp. 2211-2218
    • Tabaton, M.1    Tamagno, E.2
  • 46
    • 0037038816 scopus 로고    scopus 로고
    • Beta-secretase (BACE) as a drug target for Alzheimer disease
    • Vassar R. Beta-secretase (BACE) as a drug target for Alzheimer disease. Adv. Drug Deliv. Rev. 2002, 54:1589-1602.
    • (2002) Adv. Drug Deliv. Rev. , vol.54 , pp. 1589-1602
    • Vassar, R.1
  • 47
    • 42149130900 scopus 로고    scopus 로고
    • BACE1 structure and function in health and Alzheimer disease
    • Cole S.L., Vassar R. BACE1 structure and function in health and Alzheimer disease. Curr. Alzheimer Res. 2008, 5:100-120.
    • (2008) Curr. Alzheimer Res. , vol.5 , pp. 100-120
    • Cole, S.L.1    Vassar, R.2
  • 48
    • 0242668890 scopus 로고    scopus 로고
    • Estrogen-induced cell signalling in a cellular model of Alzheimer disease
    • Goodenough S., Schäfer M., Behl C. Estrogen-induced cell signalling in a cellular model of Alzheimer disease. J. Steroid Biochem. Mol Biol. 2003, 84:301-305.
    • (2003) J. Steroid Biochem. Mol Biol. , vol.84 , pp. 301-305
    • Goodenough, S.1    Schäfer, M.2    Behl, C.3
  • 50
    • 33748253471 scopus 로고    scopus 로고
    • Glucocorticoids increase amyloid-beta and tau pathology in a mouse model of Alzheimer disease
    • Green K.N., Billings L.M., Roozendaal B., McGaugh J.L., LaFerla F.M. Glucocorticoids increase amyloid-beta and tau pathology in a mouse model of Alzheimer disease. J. Neurosci. 2006, 26:9047-9056.
    • (2006) J. Neurosci. , vol.26 , pp. 9047-9056
    • Green, K.N.1    Billings, L.M.2    Roozendaal, B.3    McGaugh, J.L.4    LaFerla, F.M.5
  • 52
    • 40749099059 scopus 로고    scopus 로고
    • Androgen regulation of beta-amyloid protein and the risk of Alzheimer disease
    • Rosario E.R., Pike C.J. Androgen regulation of beta-amyloid protein and the risk of Alzheimer disease. Brain Res. Rev. 2008, 57:444-453.
    • (2008) Brain Res. Rev. , vol.57 , pp. 444-453
    • Rosario, E.R.1    Pike, C.J.2
  • 55
    • 4644223293 scopus 로고    scopus 로고
    • Estrogen increases brain expression of the mRNA encoding transthyretin, an amyloid beta scavenger protein
    • Tang Y.P., Haslam S.Z., Conrad S.E., Sisk C.L. Estrogen increases brain expression of the mRNA encoding transthyretin, an amyloid beta scavenger protein. J. Alzheimers Dis. 2004, 6:413-420.
    • (2004) J. Alzheimers Dis. , vol.6 , pp. 413-420
    • Tang, Y.P.1    Haslam, S.Z.2    Conrad, S.E.3    Sisk, C.L.4
  • 56
    • 26844546899 scopus 로고    scopus 로고
    • Genistein, a natural product from soy, is a potent inhibitor of transthyretin amyloidosis
    • Green N.S., Foss T.R., Kelly J.W. Genistein, a natural product from soy, is a potent inhibitor of transthyretin amyloidosis. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:14545-14550.
    • (2005) Proc. Natl. Acad. Sci. U.S.A. , vol.102 , pp. 14545-14550
    • Green, N.S.1    Foss, T.R.2    Kelly, J.W.3
  • 57
    • 10944227282 scopus 로고    scopus 로고
    • Tau phosphorylation: physiological and pathological consequences
    • Stoothoff W.H., Johnson G.V. Tau phosphorylation: physiological and pathological consequences. Biochim. Biophys. Acta 2005, 1739:280-297.
    • (2005) Biochim. Biophys. Acta , vol.1739 , pp. 280-297
    • Stoothoff, W.H.1    Johnson, G.V.2
  • 58
    • 33846054445 scopus 로고    scopus 로고
    • The role of tau phosphorylation in the pathogenesis of Alzheimer disease
    • Mi K., Johnson G.V. The role of tau phosphorylation in the pathogenesis of Alzheimer disease. Curr. Alzheimer Res. 2006, 3:449-463.
    • (2006) Curr. Alzheimer Res. , vol.3 , pp. 449-463
    • Mi, K.1    Johnson, G.V.2
  • 59
    • 33747425620 scopus 로고    scopus 로고
    • GSK-3 is essential in the pathogenesis of Alzheimer disease
    • Takashima A. GSK-3 is essential in the pathogenesis of Alzheimer disease. J. Alzheimers Dis. 2006, 9(Suppl. 3):309-317.
    • (2006) J. Alzheimers Dis. , vol.9 , Issue.3 SUPPL. , pp. 309-317
    • Takashima, A.1
  • 60
    • 0036316691 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase is a central mediator of NMDA receptor signalling to MAP kinase (Erk1/2), Akt/PKB and CREB in striatal neurones
    • Perkinton M.S., Ip J.K., Wood G.L., Crossthwaite A.J., Williams R.J. Phosphatidylinositol 3-kinase is a central mediator of NMDA receptor signalling to MAP kinase (Erk1/2), Akt/PKB and CREB in striatal neurones. J. Neurochem. 2002, 80:239-254.
    • (2002) J. Neurochem. , vol.80 , pp. 239-254
    • Perkinton, M.S.1    Ip, J.K.2    Wood, G.L.3    Crossthwaite, A.J.4    Williams, R.J.5
  • 62
    • 57249108291 scopus 로고    scopus 로고
    • Phosphorylation of tau at Ser214 mediates its interaction with 14-3-3 protein: implications for the mechanism of tau aggregation
    • Sadik G., Tanaka T., Kato K., Yamamori H., Nessa B.N., Morihara T., Takeda M. Phosphorylation of tau at Ser214 mediates its interaction with 14-3-3 protein: implications for the mechanism of tau aggregation. J. Neurochem. 2009, 108:33-43.
    • (2009) J. Neurochem. , vol.108 , pp. 33-43
    • Sadik, G.1    Tanaka, T.2    Kato, K.3    Yamamori, H.4    Nessa, B.N.5    Morihara, T.6    Takeda, M.7
  • 63
    • 0037246583 scopus 로고    scopus 로고
    • Phosphorylated protein kinases associated with neuronal and glial tau deposits in argyrophilic grain disease
    • Ferrer I., Barrachina M., Tolnay M., Rey M.J., Vidal N., Carmona M., Blanco R., Puig B. Phosphorylated protein kinases associated with neuronal and glial tau deposits in argyrophilic grain disease. Brain Pathol. 2003, 13:62-78.
    • (2003) Brain Pathol. , vol.13 , pp. 62-78
    • Ferrer, I.1    Barrachina, M.2    Tolnay, M.3    Rey, M.J.4    Vidal, N.5    Carmona, M.6    Blanco, R.7    Puig, B.8
  • 64
    • 25844458239 scopus 로고    scopus 로고
    • Current advances on different kinases involved in tau phosphorylation, and implications in Alzheimer disease and tauopathies
    • Ferrer I., Gomez-Isla T., Puig B., Freixes M., Ribé E., Dalfó E., Avila J. Current advances on different kinases involved in tau phosphorylation, and implications in Alzheimer disease and tauopathies. Curr. Alzheimer Res. 2005, 2:3-18.
    • (2005) Curr. Alzheimer Res. , vol.2 , pp. 3-18
    • Ferrer, I.1    Gomez-Isla, T.2    Puig, B.3    Freixes, M.4    Ribé, E.5    Dalfó, E.6    Avila, J.7
  • 65
    • 33846212717 scopus 로고    scopus 로고
    • Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration
    • Wang J.Z., Grundke-Iqbal I., Iqbal K. Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration. Eur. J. Neurosci. 2007, 25:59-68.
    • (2007) Eur. J. Neurosci. , vol.25 , pp. 59-68
    • Wang, J.Z.1    Grundke-Iqbal, I.2    Iqbal, K.3
  • 67
    • 44949226185 scopus 로고    scopus 로고
    • 17Beta-estradiol attenuates glycogen synthase kinase-3beta activation and tau hyperphosphorylation in Akt-independent manner
    • Shi H.R., Zhu L.Q., Wang S.H., Liu X.A., Tian Q., Zhang Q., Wang Q., Wang J.Z. 17Beta-estradiol attenuates glycogen synthase kinase-3beta activation and tau hyperphosphorylation in Akt-independent manner. J. Neural Transm. 2008, 115:879-888.
    • (2008) J. Neural Transm. , vol.115 , pp. 879-888
    • Shi, H.R.1    Zhu, L.Q.2    Wang, S.H.3    Liu, X.A.4    Tian, Q.5    Zhang, Q.6    Wang, Q.7    Wang, J.Z.8
  • 68
    • 48349124965 scopus 로고    scopus 로고
    • Estradiol attenuates tau hyperphosphorylation induced by upregulation of protein kinase-A
    • Liu X.A., Zhu L.Q., Zhang Q., Shi H.R., Wang S.H., Wang Q., Wang J.Z. Estradiol attenuates tau hyperphosphorylation induced by upregulation of protein kinase-A. Neurochem. Res. 2008, 33:1811-1820.
    • (2008) Neurochem. Res. , vol.33 , pp. 1811-1820
    • Liu, X.A.1    Zhu, L.Q.2    Zhang, Q.3    Shi, H.R.4    Wang, S.H.5    Wang, Q.6    Wang, J.Z.7
  • 70
    • 33750468310 scopus 로고    scopus 로고
    • Alzheimer's disease, brain immune privilege and memory: a hypothesis
    • Arshavsky Y.L. Alzheimer's disease, brain immune privilege and memory: a hypothesis. J. Neural Transm. 2006, 113:1697-1707.
    • (2006) J. Neural Transm. , vol.113 , pp. 1697-1707
    • Arshavsky, Y.L.1
  • 72
    • 0036887723 scopus 로고    scopus 로고
    • Steroid and sterol 7-hydroxylation: ancient pathways
    • Lathe R. Steroid and sterol 7-hydroxylation: ancient pathways. Steroids 2002, 67:967-977.
    • (2002) Steroids , vol.67 , pp. 967-977
    • Lathe, R.1
  • 73
    • 0036217056 scopus 로고    scopus 로고
    • Involvement of steroids and cytochromes P(450) species in the triggering of immune defenses
    • Morfin R. Involvement of steroids and cytochromes P(450) species in the triggering of immune defenses. J. Steroid Biochem. Mol. Biol. 2002, 80:273-290.
    • (2002) J. Steroid Biochem. Mol. Biol. , vol.80 , pp. 273-290
    • Morfin, R.1
  • 74
    • 0032889058 scopus 로고    scopus 로고
    • Dehydroepiandrosterone sulfate decreases the interleukin-2-mediated overactivity of the natural killer cell compartment in senile dementia of the Alzheimer type
    • Solerte S.B., Fioravanti M., Schifino N., Cuzzoni G., Fontana I., Vignati G., Govoni S., Ferrari E. Dehydroepiandrosterone sulfate decreases the interleukin-2-mediated overactivity of the natural killer cell compartment in senile dementia of the Alzheimer type. Dement. Geriatr. Cogn. Disord. 1999, 10:21-27.
    • (1999) Dement. Geriatr. Cogn. Disord. , vol.10 , pp. 21-27
    • Solerte, S.B.1    Fioravanti, M.2    Schifino, N.3    Cuzzoni, G.4    Fontana, I.5    Vignati, G.6    Govoni, S.7    Ferrari, E.8
  • 78
    • 36148981110 scopus 로고    scopus 로고
    • The pharmacological exploitation of cholesterol 7alpha-hydroxylase, the key enzyme in bile acid synthesis: from binding resins to chromatin remodelling to reduce plasma cholesterol
    • Gilardi F., Mitro N., Godio C., Scotti E., Caruso D., Crestani M., De Fabiani E. The pharmacological exploitation of cholesterol 7alpha-hydroxylase, the key enzyme in bile acid synthesis: from binding resins to chromatin remodelling to reduce plasma cholesterol. Pharmacol. Ther. 2007, 116:449-472.
    • (2007) Pharmacol. Ther. , vol.116 , pp. 449-472
    • Gilardi, F.1    Mitro, N.2    Godio, C.3    Scotti, E.4    Caruso, D.5    Crestani, M.6    De Fabiani, E.7
  • 79
    • 0036009146 scopus 로고    scopus 로고
    • Regulation of cholesterol-7alpha-hydroxylase: BAREly missing a SHP
    • Davis R.A., Miyake J.H., Hu T.Y., Spann N.J. Regulation of cholesterol-7alpha-hydroxylase: BAREly missing a SHP. J. Lipid Res. 2002, 43:533-543.
    • (2002) J. Lipid Res. , vol.43 , pp. 533-543
    • Davis, R.A.1    Miyake, J.H.2    Hu, T.Y.3    Spann, N.J.4
  • 80
    • 33745529832 scopus 로고    scopus 로고
    • Bile acids and cytokines inhibit the human cholesterol 7 alpha-hydroxylase gene via the JNK/c-jun pathway in human liver cells
    • Li T., Jahan A., Chiang J.Y. Bile acids and cytokines inhibit the human cholesterol 7 alpha-hydroxylase gene via the JNK/c-jun pathway in human liver cells. Hepatology 2006, 43:1202-1210.
    • (2006) Hepatology , vol.43 , pp. 1202-1210
    • Li, T.1    Jahan, A.2    Chiang, J.Y.3
  • 81
    • 33644697202 scopus 로고    scopus 로고
    • Tumour necrosis factor-alpha stimulates dehydroepiandrosterone metabolism in human fibroblast-like synoviocytes: a role for nuclear factor-kappaB and activator protein-1 in the regulation of expression of cytochrome p450 enzyme 7b
    • Dulos J., Kaptein A., Kavelaars A., Heijnen C., Boots A. Tumour necrosis factor-alpha stimulates dehydroepiandrosterone metabolism in human fibroblast-like synoviocytes: a role for nuclear factor-kappaB and activator protein-1 in the regulation of expression of cytochrome p450 enzyme 7b. Arthritis Res. Ther. 2005, 7:R1271-R1280.
    • (2005) Arthritis Res. Ther. , vol.7
    • Dulos, J.1    Kaptein, A.2    Kavelaars, A.3    Heijnen, C.4    Boots, A.5
  • 82
    • 33847183893 scopus 로고    scopus 로고
    • Glucocorticoids may initiate Alzheimer disease: a potential therapeutic role for mifepristone (RU-486)
    • Dhikav V., Anand K.S. Glucocorticoids may initiate Alzheimer disease: a potential therapeutic role for mifepristone (RU-486). Med. Hypotheses 2007, 68:1088-1092.
    • (2007) Med. Hypotheses , vol.68 , pp. 1088-1092
    • Dhikav, V.1    Anand, K.S.2
  • 84
    • 20944438570 scopus 로고    scopus 로고
    • C-1073 (mifepristone) in the adjunctive treatment of Alzheimer disease
    • DeBattista C., Belanoff J.K. C-1073 (mifepristone) in the adjunctive treatment of Alzheimer disease. Curr. Alzheimer Res. 2005, 2:125-129.
    • (2005) Curr. Alzheimer Res. , vol.2 , pp. 125-129
    • DeBattista, C.1    Belanoff, J.K.2
  • 87
    • 33746318600 scopus 로고    scopus 로고
    • Hypothalamic-pituitary-adrenal axis, glucocorticoids, and neurologic disease
    • Herman J.P., Seroogy K. Hypothalamic-pituitary-adrenal axis, glucocorticoids, and neurologic disease. Neurol. Clin. 2006, 24:461-481.
    • (2006) Neurol. Clin. , vol.24 , pp. 461-481
    • Herman, J.P.1    Seroogy, K.2
  • 88
    • 17844405278 scopus 로고    scopus 로고
    • Glucocorticoid regulation of glial responses during hippocampal neurodegeneration and regeneration
    • Nichols N.R., Agolley D., Zieba M., Bye N. Glucocorticoid regulation of glial responses during hippocampal neurodegeneration and regeneration. Brain Res. Brain Res. Rev. 2005, 48:287-301.
    • (2005) Brain Res. Brain Res. Rev. , vol.48 , pp. 287-301
    • Nichols, N.R.1    Agolley, D.2    Zieba, M.3    Bye, N.4
  • 91
    • 55849139115 scopus 로고    scopus 로고
    • Neurosteroid dehydroepiandrosterone exerts anti-apoptotic effects by membrane-mediated, integrated genomic and non-genomic pro-survival signalling pathways
    • Charalampopoulos I., Margioris A.N., Gravanis A. Neurosteroid dehydroepiandrosterone exerts anti-apoptotic effects by membrane-mediated, integrated genomic and non-genomic pro-survival signalling pathways. J. Neurochem. 2008, 107:1457-1469.
    • (2008) J. Neurochem. , vol.107 , pp. 1457-1469
    • Charalampopoulos, I.1    Margioris, A.N.2    Gravanis, A.3
  • 92
    • 0037203907 scopus 로고    scopus 로고
    • Dehydroepiandrosterone (DHEA) and its sulfated derivative (DHEAS) regulate apoptosis during neurogenesis by triggering the Akt signalling pathway in opposing ways
    • Zhang L., Li B., Ma W., Barker J.L., Chang Y.H., Zhao W., Rubinow D.R. Dehydroepiandrosterone (DHEA) and its sulfated derivative (DHEAS) regulate apoptosis during neurogenesis by triggering the Akt signalling pathway in opposing ways. Brain Res. Mol. Brain Res. 2002, 98:58-66.
    • (2002) Brain Res. Mol. Brain Res. , vol.98 , pp. 58-66
    • Zhang, L.1    Li, B.2    Ma, W.3    Barker, J.L.4    Chang, Y.H.5    Zhao, W.6    Rubinow, D.R.7
  • 93
    • 1142297621 scopus 로고    scopus 로고
    • IGF-I signalling prevents dehydroepiandrosterone (DHEA)-induced apoptosis in hypothalamic neurons
    • Lin S.Y., Cui H., Yusta B., Belsham D.D. IGF-I signalling prevents dehydroepiandrosterone (DHEA)-induced apoptosis in hypothalamic neurons. Mol. Cell. Endocrinol. 2004, 214:127-135.
    • (2004) Mol. Cell. Endocrinol. , vol.214 , pp. 127-135
    • Lin, S.Y.1    Cui, H.2    Yusta, B.3    Belsham, D.D.4
  • 94
    • 0032997908 scopus 로고    scopus 로고
    • Estrogen modulates neuronal Bcl-xL expression and beta-amyloid-induced apoptosis: relevance to Alzheimer disease
    • Pike C.J. Estrogen modulates neuronal Bcl-xL expression and beta-amyloid-induced apoptosis: relevance to Alzheimer disease. J. Neurochem. 1999, 72:1552-1563.
    • (1999) J. Neurochem. , vol.72 , pp. 1552-1563
    • Pike, C.J.1
  • 98
    • 0242467828 scopus 로고    scopus 로고
    • 17 Beta-estradiol alleviates synergistic oxidative stress resulting from folate deprivation and amyloid-beta treatment
    • Shea T.B., Ortiz D. 17 Beta-estradiol alleviates synergistic oxidative stress resulting from folate deprivation and amyloid-beta treatment. J. Alzheimers Dis. 2003, 5:323-327.
    • (2003) J. Alzheimers Dis. , vol.5 , pp. 323-327
    • Shea, T.B.1    Ortiz, D.2
  • 99
    • 51649127553 scopus 로고    scopus 로고
    • Estradiol and neurodegenerative oxidative stress
    • Nilsen J. Estradiol and neurodegenerative oxidative stress. Front. Neuroendocrinol. 2008, 29:463-475.
    • (2008) Front. Neuroendocrinol. , vol.29 , pp. 463-475
    • Nilsen, J.1
  • 100
    • 0033586349 scopus 로고    scopus 로고
    • Dehydroepiandrosterone (DHEA) protects hippocampal cells from oxidative stress-induced damage
    • Bastianetto S., Ramassamy C., Poirier J., Quirion R. Dehydroepiandrosterone (DHEA) protects hippocampal cells from oxidative stress-induced damage. Brain Res. Mol. Brain Res. 1999, 66:35-41.
    • (1999) Brain Res. Mol. Brain Res. , vol.66 , pp. 35-41
    • Bastianetto, S.1    Ramassamy, C.2    Poirier, J.3    Quirion, R.4
  • 101
    • 0031024098 scopus 로고    scopus 로고
    • Glucocorticoids enhance oxidative stress-induced cell death in hippocampal neurons in vitro
    • Behl C., Lezoualc'h F., Trapp T., Widmann M., Skutella T., Holsboer F. Glucocorticoids enhance oxidative stress-induced cell death in hippocampal neurons in vitro. Endocrinology 1997, 138:101-106.
    • (1997) Endocrinology , vol.138 , pp. 101-106
    • Behl, C.1    Lezoualc'h, F.2    Trapp, T.3    Widmann, M.4    Skutella, T.5    Holsboer, F.6
  • 103
    • 65249104851 scopus 로고    scopus 로고
    • Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases
    • Dong X.X., Wang Y., Qin Z.H. Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases. Acta Pharmacol. Sin. 2009, 30:379-387.
    • (2009) Acta Pharmacol. Sin. , vol.30 , pp. 379-387
    • Dong, X.X.1    Wang, Y.2    Qin, Z.H.3
  • 104
    • 0347624528 scopus 로고    scopus 로고
    • Impact of the selective estrogen receptor modulator, raloxifene, on neuronal survival and outgrowth following toxic insults associated with ageing and Alzheimer disease
    • O'Neill K., Chen S., Brinton R.D. Impact of the selective estrogen receptor modulator, raloxifene, on neuronal survival and outgrowth following toxic insults associated with ageing and Alzheimer disease. Exp. Neurol. 2004, 185:63-80.
    • (2004) Exp. Neurol. , vol.185 , pp. 63-80
    • O'Neill, K.1    Chen, S.2    Brinton, R.D.3
  • 105
    • 34748914235 scopus 로고    scopus 로고
    • Activation of the androgen receptor alters the intracellular calcium response to glutamate in primary hippocampal neurons and modulates sarco/endoplasmic reticulum calcium ATPase 2 transcription
    • Foradori C.D., Werner S.B., Sandau U.S., Clapp T.R., Handa R.J. Activation of the androgen receptor alters the intracellular calcium response to glutamate in primary hippocampal neurons and modulates sarco/endoplasmic reticulum calcium ATPase 2 transcription. Neuroscience 2007, 149:155-164.
    • (2007) Neuroscience , vol.149 , pp. 155-164
    • Foradori, C.D.1    Werner, S.B.2    Sandau, U.S.3    Clapp, T.R.4    Handa, R.J.5
  • 106
    • 0029919873 scopus 로고    scopus 로고
    • Neurosteroids: molecular mechanisms of action and psychopharmacological significance
    • Rupprecht R., Hauser C.A., Trapp T., Holsboer F. Neurosteroids: molecular mechanisms of action and psychopharmacological significance. J. Steroid Biochem. Mol. Biol. 1996, 56:163-168.
    • (1996) J. Steroid Biochem. Mol. Biol. , vol.56 , pp. 163-168
    • Rupprecht, R.1    Hauser, C.A.2    Trapp, T.3    Holsboer, F.4
  • 108
    • 0033953033 scopus 로고    scopus 로고
    • Neurosteroids: biosynthesis and function of these novel neuromodulators
    • Compagnone N.A., Mellon S.H. Neurosteroids: biosynthesis and function of these novel neuromodulators. Front. Neuroendocrinol. 2000, 21:1-56.
    • (2000) Front. Neuroendocrinol. , vol.21 , pp. 1-56
    • Compagnone, N.A.1    Mellon, S.H.2
  • 109
    • 0036972396 scopus 로고    scopus 로고
    • Improving Alzheimer disease-related cognitive deficits with sigma1 receptor agonists
    • Maurice T. Improving Alzheimer disease-related cognitive deficits with sigma1 receptor agonists. Drug News Perspect. 2002, 15:617-625.
    • (2002) Drug News Perspect. , vol.15 , pp. 617-625
    • Maurice, T.1
  • 110
    • 0345305672 scopus 로고    scopus 로고
    • Neurosteroids: cerebrospinal fluid levels for Alzheimer's disease and vascular dementia diagnostics
    • Kim S.B., Hill M., Kwak Y.T., Hampl R., Jo D.H., Morfin R. Neurosteroids: cerebrospinal fluid levels for Alzheimer's disease and vascular dementia diagnostics. J. Clin. Endocrinol. Metab. 2003, 88:199-206.
    • (2003) J. Clin. Endocrinol. Metab. , vol.88 , pp. 199-206
    • Kim, S.B.1    Hill, M.2    Kwak, Y.T.3    Hampl, R.4    Jo, D.H.5    Morfin, R.6


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