Natural extracts as possible protective agents of brain aging

Neurobiology of Aging

Volumn 23, Issue 5, 2002, Pages 891-897

  Bastianetto, Stéphane ^a   Quirion, Rémi ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Alzheimer's disease; Beta amyloid peptides; Brain aging; Ginkgo biloba extract; Neuroprotection; Nitric oxide; Quercetin, (+) catechin; Red wine; Resveratrol; Vitis vinifera

Indexed keywords

2 (1 THIENYL)ETHYL 3,4 DIHYDROXYBENZYLIDENE CYANOACETATE; 3 [3 TERT BUTYLTHIO 1 (4 CHLOROBENZYL) 5 ISOPROPYL 2 INDOLYL] 2,2 DIMETHYLPROPIONIC ACID; AMYLOID BETA PROTEIN; CATECHIN; GINKGO BILOBA EXTRACT; INDOMETACIN; NITRIC OXIDE; NITROPRUSSIDE SODIUM; POLYPHENOL DERIVATIVE; PROTEIN KINASE C; QUERCETIN; REACTIVE OXYGEN METABOLITE; RESVERATROL; TROLOX C; UNCLASSIFIED DRUG;

AGING; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BRAIN TOXICITY; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFECT; EMBRYO; ENZYME ACTIVITY; HIPPOCAMPUS; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; WINE;

AGING; AMYLOID BETA-PROTEIN; ANIMALS; ANTIOXIDANTS; CATECHIN; FLAVONOIDS; GINKGO BILOBA; HIPPOCAMPUS; NEURONS; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; PEPTIDE FRAGMENTS; PHENOLS; PLANT EXTRACTS; POLYMERS; QUERCETIN; RATS; RATS, SPRAGUE-DAWLEY; STILBENES; WINE;

EID: 0036752553     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-4580(02)00024-6     Document Type: Article

References (61)

1. Barkats M., Venault P., Christen Y., Cohen-Salmon C. Effect of long-term treatment with EGb 761 on age-dependent structural changes in the hippocampi of three inbred mouse strains. Life Sci. 121:1995;213-222.
2. Bastianetto S., Ramassamy C., Doré S., Christen Y., Poirier J., Quirion R. The G. biloba extract (EGb 761) protects hippocampal neurons against cell death induced by β-amyloid. Eur. J. Neurosci. 12:2000;1882-1890.
3. Bastianetto S., Zheng W.H., Quirion R. The G. biloba extract (EGb 761) protects and rescues hippocampal cells against nitric oxide-induced toxicity: involvement of its flavonoid constituents and protein kinase C. J. Neurochem. 74:2000;2268-2277.
4. Bastianetto S., Zheng W.H., Quirion R. Neuroprotective abilities of resveratrol and other red wine constituents against nitric oxide-related toxicity in cultured hippocampal neurons. Br. J. Pharmacol. 131:2000;711-720.
5. Behl C., Davis J.B., Lesley R., Schubert D. Hydrogen peroxide mediates amyloid-beta protein toxicity. Cell. 77:1994;817-827.
6. Bruce A.J., Malfroy B., Baudry M. Beta-amyloid toxicity in organotypic hippocampal cultures: protection by EUK-8 a synthetic catalytic free radical scavenger. Proc. Natl. Acad. Sci. U.S.A. 93:1996;2312-2316.
7. Butterfield D.A., Howard B., Yatin S., Koppal T., Drake J., Hensley K.et al. Elevated oxidative stress in models of normal brain aging and Alzheimer's disease. Life Sci. 65:1999;1883-1892.
8. Calabrese V., Bates T.E., Stella A.M. NO synthase and NO-dependent signal pathways in brain aging and neurodegenerative disorders: the role of oxidant/antioxidant balance. Neurochem. Res. 25:2000;1315-1341.
9. Chang PT. EGb 761 inhibits Aβ aggregation, disrupts Aβ fibrils and protects PC12 cells against Aβ-induced toxicity. In: Proceedings of the 2nd Annual Neurobiology of Aging Conference Brain Aging: Identifying Accelerators and Brakes, San Diego, 2001.
10. Chopin P., Briley M. Effects of four non-cholinergic cognitive enhancers in comparison with tacrine and galanthamine on scopolamine-induced amnesia in rats. Psychopharmacology. 106:1992;26-30.
11. Commenges D., Scotet V., Renaud S., Jacqmin-Gadda H., Barberger-Gateau P., Dartigues J.F. Intake of flavonoids and risk of dementia. Eur. J. Epidemiol. 16:2000;357-363.
12. Copani A., Bruno V., Battaglia G., Leanza G., Pellitteri R., Russo A.et al. Activation of metabotropic glutamate receptors protects cultured neurons against apoptosis induced by beta-amyloid peptide. Mol. Pharmacol. 47:1995;890-897.
13. Deschamps V., Barberger-Gateau P., Peuchant E., Orgogozo J.M. Nutritional factors in cerebral aging and dementia: epidemiological arguments for a role of oxidative stress. Neuroepidemiology. 20:2001;7-15.
14. Doré S., Kar S., Quirion R. Insulin-like growth factor I protects and rescues hippocampal neurons against β-amyloid- and human amylin-induced toxicity. Proc. Natl. Acad. Sci. U.S.A. 94:1997;4772-4777.
15. Drieu K. Preparation and definition of G. biloba extract. Press. Med. 15:1986;1455-1457.
16. Droy-Lefaix M.T., Menerath J.M., Szabo-Tosaki E., Guillaumin D., Doly M. Protective effect of EGb 761 on ischemia-reperfusion damage in the rat retina. Transplantation Proc. 27:1995;2861-2862.
17. Elias P.K., Elias M.F., D'Agostino R.B., Silbershatz H., Wolf P.A. Alcohol consumption and cognitive performance in the Framingham Heart Study. Am. J. Epidemiol. 150:1999;580-589.
18. Fautz R., Husein B., Hechenberger C. Application of the neutral red assay (NR assay) to monolayer cultures of primary hepatocytes: rapid colorimetric viability determination for the unscheduled DNA synthesis test (UDS). Mutat. Res. 253:1991;173-179.
19. German J.B., Walzem R.L. The health benefits of wine. Ann. Rev. Nutr. 20:2000;561-593.
20. Harris M.E., Hensley K., Butterfield D.A., Leedle A., Caney J.M. Direct evidence of oxidative injury produced by the Alzheimer's beta-amyloid peptide (1-40) in cultured hippocampal neurons. Exp. Neurol. 131:1995;193-202.
21. Hertog M.G., Kromhout D., Aravanis C., Blackburn H., Buzina R., Fidanza F.et al. Flavonoid intake and long-term risk of coronary heart disease and cancer in the seven countries study. Arch. Intern. Med. 155:1995;381-386.
22. Hofferberth B. The efficacy of EGb 761 in patients with senile dementia of the Alzheimer type, a double-blind, placebo-controlled study on different levels of investigation. Human Psychopharmacol. 9:1994;215-222.
23. Hyman B.T., Van Hoesen G.W., Damasio A.R., Barnes C.L. Alzheimer's disease: cell-specific pathology isolates the hippocampal formation. Science. 225:1984;1168-1170.
24. Iadecola C. Bright and dark sides of nitric oxide in ischemic brain injury. Trends Neurosci. 20:1997;132-139.
25. Inanami O., Watanabe Y., Syuto B., Nakano M., Tsuji M., Kuwabara M. Oral administration of (-)-catechin protects against ischemia-reperfusion-induced neuronal death in the Gerbil. Free Rad. Res. 29:1998;359-365.
26. Jenner P. Oxidative stress in Parkinson's disease and other neurodegenerative disorders. Pathol. Biol. 44:1996;57-64.
27. Johnson E.M. Possible role of neuronal apoptosis in Alzheimer's disease. Neurobiol. Aging. 2:1994;S187-89.
28. Jordán J., Galindo M.F., Miller R.J. Role of calpain- and interleukin-1 beta converting enzyme-like proteases in the beta-amyloid-induced death of rat hippocampal neurons in culture. J. Neurochem. 68:1997;1612-1621.
29. Joseph J.A., Denisova N.A., Bielinski D., Fisher D.R., Shukitt-Hale B. Oxidative stress protection and vulnerability in aging: putative nutritional implications for intervention. Mech. Aging Dev. 116:2000;141-153.
30. Joseph J.A., Shukitt-Hale B., Denisova N.A., Prior R.L., Cao G., Martin A.et al. Long-term dietary strawberry spinach or Vitamin E supplementation retards the onset of age-related neuronal signal-transduction and cognitive behavioral deficits. J. Neurosci. 18:1998;8047-8055.
31. Joseph J.A., Shukitt-Hale B., Denisova N.A., Bielinski D., Martin A., McEwen J.J.et al. Reversals of age-related declines in neuronal signal transduction cognitive and motor behavioral deficits with blueberry spinach or strawberry dietary supplementation. J. Neurosci. 19:1999;8114-8121.
32. Kristofikovà Z., Klaschka J. In vitro effect of G. biloba extract (EGb 761) on the activity of presynaptic cholinergic nerve terminals in rat hippocampus. Dement. Geriat. Cogn. Disord. 8:1997;43-48.
33. Law A., Gauthier S., Quirion R. Say NO to Alzheimer's disease: the putative links between nitric oxide and dementia of the Alzheimer's type. Brain Res. Rev. 35:2001;73-96.
34. Le Bars P.L., Kieser M., Itil K.Z. A 26-week analysis of a double-blind, placebo-controlled trial of the G. biloba extract EGb 761 in dementia. Dement. Geriatr. Cogn. Disord. 11:2000;230-237.
35. Leibovici D., Ritchie K., Ledesert B., Touchon J. The effects of wine and tobacco consumption on cognitive performance in the elderly: a longitudinal study of relative risk. Int. J. Epidemiol. 28:1999;77-81.
36. Levites Y., Weinreb O., Maor G., Youdim M.B., Mandel S. Green tea polyphenol (-)-epigallocatechin-3-gallate prevents N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurodegeneration. J. Neurochem. 78:2001;1073-1082.
37. Loo D.T., Copani A., Pike C.J., Whittemore E.R., Walencewicz A.J., Cotman C.W. Apoptosis is induced by beta-amyloid in cultured central nervous system neurons. Proc. Natl. Acad. Sci. U.S.A. 90:1993;7951-7955.
38. Marcocci L., Maguire J.J., Droy-Lefaix M.T., Packer L. The nitric oxide-scavenging properties of G. biloba extract EGb 761. Biochem. Biophys. Res. Commun. 201:1994;748-755.
39. Marcocci L., Packer L., Droy-Lefaix M.T., Sekaki A., Gardes-Albert M. Antioxidant action of G. biloba extract EGb 761. Meth. Enzymol. 234:1994;462-475.
40. Mattson M.P., Barger S.W., Begley J.G., Mark R.J. Calcium free radicals and excitotoxic neuronal death in primary cell culture. Meth. Cell. Biol. 46:1995;187-216.
41. Maurer K., Ihl R., Dierks T., Frölich L. Clinical efficacy of G. biloba special extract EGb 761 in dementia of the Alzheimer type. J. Psychiat. Res. 31:1997;645-655.
42. Mix J.A., Crews W.D. Jr. An examination of the efficacy of G. biloba extract EGb 761 on the neuropsychologic functioning of cognitively intact older adults. J. Altern. Comp. Med. 6:2000;219-229.
43. Moosmann B., Behl C. The antioxidant neuroprotective effects of estrogens and phenolic compounds are independent from their estrogenic properties. Proc. Natl. Acad. Sci. U.S.A. 96:1999;8867-8872.
44. Ni Y., Zhao B., Hou J., Xin W. Preventive effect of G. biloba extract on apoptosis in rat cerebellar neuronal cells induced by hydroxyl radicals. Neurosci. Lett. 214:1996;115-118.
45. Oberpichler H., Beck T., Abdel-Rahman M.M., Bielenberg B.W., Krieglstein J. Effects of G. biloba constituents related to protection against brain damage caused by hypoxia. Pharmacol. Res. Commun. 20:1988;349-368.
46. Obisesan T.O., Hirsh R., Kosoko O., Carlson L., Parrott M. Moderate wine consumption is associated with decreased odds of developing age-related macular degeneration in NHANES-1. J. Am. Ger. Soc. 46:1998;1-7.
47. Orgogozo J.M., Dartigues J.F., Lafont S., Letenneur L., Commenges D., Salomon R.et al. Wine consumption and dementia in the elderly: a prospective community study in the Bordeaux area. Rev. Neurologique. 153:1997;185-192.
48. 2+-loaded brain neurons. Brain Res. 635:1994;125-129.
49. Oyama Y., Chikahisa L., Ueha T., Kanemaru K., Noda K. G. biloba extract protects brain neurons against oxidative stress induced by hydrogen peroxide. Brain Res. 712:1996;349-352.
50. Sacco R.L., Elkind M., Boden-Albala B., Lin I.F., Kargman D.E., Hauser W.A.et al. The protective effect of moderate alcohol consumption on ischemic stroke. JAMA. 281:1999;53-60.
51. Sato M., Suzuki Y., Okuda T., Yokotsuka K. Contents of resveratrol piceid and their isomers in commercially available wines made from grapes cultivated in Japan. Biosci. Biotech. Biochem. 61:1997;1800-1805.
52. Sinha K, Chaudhary G, Kumar Guptar Y. Protective effect of resveratrol against oxidative stress in middle cerebral artery occlusion model of stroke in rats. Life Sci, in press.
53. Smith T.D., Calhoun M.E., Rapp P.R. Circuit and morphological specificity of synaptic change in the aged hippocampal formation. Neurobiol. Aging. 20:1999;357-358.
54. Smith M.A., Perry G., Richey P.L., Sayre L.M., Anderson V.E., Beal M.F.et al. Oxidative damage in Alzheimer's disease. Nature. 382:1996;120-121.
55. Subirade I., Fernandez I., Fernandez Y., Periquet A., Mitjavila S. Catechin protection of 3T3 Swiss fibroblasts in culture under oxidative stress. Biol. Trace. Element Res. 47:1995;313-319.
56. Virgili M., Contestabile A. Partial neuroprotection of in vivo excitotoxic brain damage by chronic administration of the red wine antioxidant agent, trans-resveratrol in rats. Neurosci. Lett. 281:2000;123-126.
57. Vrablic A.S., Castillo G.M., Cummings J.A., DeSantis D.A., Nochlin D., Snow A.D. The combination of PTI-00703 and G. biloba (Neurosharp™) is an effective inhibitor of Aβ amyloidosis associated with Alzheimer's disease and normal aging. Soc. Neurosci. Abst. 25:1999;1806.
58. Xin W., Wei T., Chen C., Ni Y., Zhao B., Hou J. Mechanisms of apoptosis in rat cerebellar granule cells induced by hydroxyl radicals and the effects of EGb 761 and its constituents. Toxicology. 148:2000;103-110.
59. Watanabe C.M., Wolffram S., Ader P., Rimbach G., Packer L., Maguire J.J.et al. The in vivo neuromodulatory effects of the herbal medicine G. biloba. Proc. Natl. Acad. Sci. U.S.A. 98:2001;6577-6580.
60. Winter J.C. The effects of an extract of G. biloba EGb 761 on cognitive behavior and longevity in the rat. Physiol. Behav. 63:1998;425-433.
61. Youdim K.A., Joseph J.A. A possible emerging role of phytochemicals in improving age-related neurological dysfunctions: a multiplicity of effects. Free Rad. Biol. Med. 30:2001;583-594.