Effects of DL-α-lipoic acid on peripheral nerve conduction, blood flow, energy metabolism, and oxidative stress in experimental diabetic neuropathy

Diabetes

Volumn 49, Issue 6, 2000, Pages 1006-1015

  Stevens, Martin J ^a,b   Obrosova, Irina ^a   Cao, Xianghui ^a   Van Huysen, Carol ^a   Greene, Douglas A ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

THIOCTIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD FLOW; CONTROLLED STUDY; DIABETIC NEUROPATHY; DRUG EFFECT; ENERGY METABOLISM; FATTY ACID METABOLISM; HYPERGLYCEMIA; MALE; MITOCHONDRIAL RESPIRATION; NERVE CONDUCTION; NONHUMAN; OXIDATIVE STRESS; PERIPHERAL NERVE; PRIORITY JOURNAL; RAT; STREPTOZOCIN DIABETES;

EID: 0034038502     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.49.6.1006     Document Type: Article

References (63)

1. Greene DA, Steven MJ, Obrosova I, Feldman EL: Glucose-induced oxidative stress and programmed cell death in diabetic neuropathy. Eur J Pharmacol 375:217-223, 1999
2. Garrett NE, Malcangio M, Dewhurst M, Tomlinson DR: Alpha-lipoic acid corrects neuropeptide deficits in diabetic rats via induction of trophic support. Neurosci Lett 222:191-194, 1997
3. Nickander KK, McPhee BR, Low PA, Tritschler H: Alpha-lipoic acid: antioxidant potency against lipid peroxidation of neural tissues in vitro and implications for diabetic neuropathy. Free Radic Biol Med 21:631-639, 1996
4. Low PA, Yao JK, Kishi Y, Tritschler HJ, Schmelzer JD, Zollman PJ, Nickander KK: Peripheral nerve energy metabolism in experimental diabetic neuropathy. Neurosci Res Comm 21:49-56, 1997
5. Cameron NE, Cotter MA, Archibald V, Dines KC, Maxfield EK: Anti-oxidant and pro-oxidant effects on nerve conduction velocity, endoneurial blood flow and oxygen tension in non-diabetic and streptozotocin-diabetic rats. Diabetologia 37:449-459, 1994
6. Karasu C, Dewhurst M, Stevens EJ, Tomlinson DR: Effects of anti-oxidant treatment on sciatic nerve dysfunction in streptozotocin-diabetic rats: comparison with essential fatty acids. Diabetologia 38:129-134, 1995
7. Cameron NE, Cotter MA, Maxfield EK: Anti-oxidant treatment prevents the development of peripheral nerve dysfunction in streptozotocin-diabetic rats. Diabetologia 36:299-304, 1993
8. Nagamatsu M, Nickander KK, Schmelzer JD, Ray A, Wittrock DA, Tritschler H, Low PA: Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy. Diabetes Care 18:1160-1167, 1995
9. Aruoma OI, Halliwell B, Hoey BM, Butler J: The antioxidant action of taurine, hypotaurine and their metabolic precursors. Biochem J 256:251-255, 1988
10. Low PA, Nickander KK: Oxygen free radical effects in sciatic nerve in experimental diabetes. Diabetes 40:873-877, 1991
11. Hermenegildo C, Raya A, Roma J, Romero FJ: Decreased glutathione peroxidase activity in sciatic nerve of alloxan-induced diabetic mice and its correlation with blood glucose levels. Neurochem Res 18:893-896, 1993
12. Stevens MJ, Lattimer SA, Kamijo M, Van Huysen C, Sima AA, Greene DA: Osmotically-induced nerve taurine depletion and the compatible osmolyte hypothesis in experimental diabetic neuropathy in the rat. Diabetologia 36:608-614, 1993
13. Cameron NE, Cotter MA: Neurovascular dysfunction in diabetic rats: potential contribution of autoxidation and free radicals examined using transition metal chelating agents. J Clin Invest 96:1159-1163, 1995
14. Tuck RR, Schmelzer JD, Low PA: Endoneurial blood flow and oxygen tension in the sciatic nerves of rats with experimental diabetic neuropathy. Brain 107:935-950, 1984
15. Cameron NE, Cotter MA, Hohman TC: Interactions between essential fatty acid, prostenoid, polyol pathway and nitric oxide metabolism in the neurovascular deficit of diabetic rats. Diabetologia 39:172-182, 1996
16. +)-ATPase in the slowing of nerve conduction in the streptozotocin diabetic rat. J Clin Invest 94:853-859, 1994
17. Dewhurst M, Omawari N, Tomlinson DR: Aminoguanidine: effects of endoneurial vasoactive nitric oxide and on motor nerve conduction velocity in control and streptozotocin-diabetic rats. Br J Pharmacol 120:593-598, 1997
18. Wautier J-L, Zoukourian C, Chappey O, Wautier M-P, Gouillausseau P-J, Cao R, Hori O, Stern D, Schmidt AM: Receptor-mediated endothelial cell dysfunction in diabetic vasculopathy: soluble receptor for advanced glycation end products blocks hyperpermeability in diabetic rats. J Clin Invest 97:238-243, 1996
19. Yan SD, Schmidt AM, Anderson GM, Zhang J, Brett J, Zou YS, Pinsky D, Stern D: Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins. J Biol Chem 269:9889-9897, 1994
20. Bierhaus A, Chevion S, Chevion M, Hofmann M, Quehenberger P, Illmer T, Luther T, Berenstein E, Tritschler H, Muller M, Wahl P, Ziegler R, Nawroth PP: Advanced glycation end product-induced activation of NF-κB is suppressed by α-lipoic acid in cultured endothelial cells. Diabetes 46:1481-1490, 1997
21. Park DS, Morris EJ, Stefanis L, Troy CM, Shelanski ML, Geller HM, Greene LA: Multiple pathways of neuronal death induced by DNA-damaging agents, NGF deprivation, and oxidative stress. J Neurosci 18:830-840, 1998
22. Luo Y, Umegaki H, Wang X, Abe R, Roth GS: Dopamine induces apoptosis through an oxidation-involved SAPK/JNK activation pathway. J Biol Chem 273:3756-3764, 1998
23. Hall NC, Carney JM, Plante OJ, Cheng M, Butterfield DA: Effect of 2-cyclohexene-1-one-induced glutathione diminution on ischemia/reperfusion-induced alterations in the physical state of brain synaptosomal membrane proteins and lipids. Neuroscience 77:283-290, 1997
24. Jackson GR, Apffel L, Werrbach-Perez K, Perez-Polo JR: Role of nerve growth factor in oxidant-antioxidant balance and neuronal injury. I. Stimulation of hydrogen peroxide resistance. J Neurosci Res 25:360-368, 1990
25. Nistico G, Ciriolo MR, Fiskin K, Iannone M, de Martino A, Rotilio G: NGF restores decrease in catalase activity and increases superoxide dismutase and glutathione peroxidase activity in the brain of aged rats. Free Radic Biol Med 12:177-181, 1992
26. Cameron NE, Cotter MA: Metabolic and vascular factors in the pathogenesis of diabetic neuropathy. Diabetes 46 (Suppl. 2):31S-37S, 1997
27. Packer L, Witt EH, Tritschler H-J: Antioxidant properties and clinical applications of alpha-lipoic acid and dihydrolipoic acid. In Handbook of Antioxidants. Cadenas E, Packer L, Eds. New York, Marcel Dekker, 1995, p. 545-591
28. Ziegler D, Hanefeld M, Ruhnau KJ, Meibner HP, Lobisch M, Schutte K, Gries FA, the ALADIN Study Group: Treatment of symptomatic diabetic peripheral neuropathy with the anti-oxidant α-lipoic acid. Diabetologia 38:1425-1433, 1995
29. Cameron NE, Cotter MA, Horrobin DH, Tritschler HJ: Effects of alpha-lipoic acid on neurovascular function in diabetic rats: interaction with essential fatty acids. Diabetologia 41:390-399, 1998
30. Stewart MA, Passonneau JV, Lowry OH: Substrate changes in peripheral nerve during ischaemia and Wallerian degeneration. J Neurochem 12:719-727, 1965
31. Habig WH, Pabst MJ, Jakoby WB: Glutathione S-transferases: the first enzymatic step in mercapturic acid formation. J Biol Chem 249:7130-7139, 1974
32. Romero FJ, Monsalve E, Hermenegildo C, Puertas FJ, Higueras V, Nies E, Segura-Aguilar J, Roma J: Oxygen toxicity in the nervous tissue: comparison of the antioxidant defense of rat brain and sciatic nerve. Neurochem Res 16:157-161, 1991
33. Lowry OH, Passonneau JV: A Flexible Sysytem of Enzymatic Analysis. Orlando, FL, Academic Press, 1972, p. 195-213
34. Williamson DH, Lund P, Krebs HA: The redox state of free nicotinamide-adenine dinucleotide in the cytoplasm and mitochondria of rat liver. Biochem J 103:514-527, 1967
35. Masuda T, Dobson GP, Veech RL: The Gibbs-Donnan near-equilibrium system of heart. J Biol Chem 265:20321-20334, 1990
36. Stevens MJ, Lattimer SA, Feldman EL, Helton ED, Millington DS, Sima AAF, Greene DA: Acetyl-L-carnitine deficiency as a cause of altered nerve myo-inositol content, Na,K-ATPase activity, and motor conduction velocity in the streptozotocin-diabetic rat. Metabolism 45:865-872, 1996
37. Bergmeyer HU, Gruber W, Gutmann I: D-sorbitol. In Methods of Enzymatic Analysis. Bergmeyer HU, Ed. Weinheim, Germany, Verlag Chemie, 1974, p. 1323-1330
38. Holmes EW: Coupled enzymatic assay for the determination of sucrose. Anal Biochem 244:103-109, 1997
39. Weissbach A: Myo-inositol. In Methods of Enzymatic Analysis. Bergmeyer HU, Ed. Weinheim, Germany, Verlag Chemie, 1974, p. 1333-1336
40. Greene DA, Lattimer SA, Carroll PB, Fernstrom JD, Finegold DN: A defect in sodium-dependent amino acid uptake in diabetic rabbit peripheral nerve: correction by an aldose reductase inhibitor or myo-inositol administration. J Clin Invest 85:1657-1665, 1990
41. Parry GJ, Kozu H: Piroxicam may reduce the rate of progression of experimental diabetic neuropathy. Neurology 40:1446-1449, 1990
42. Sasaki H, Naka K, Kishi Y, Furuta M, Sanke T, Mukoyama M, Nanjo K: The absence of synergism between the effects of an aldose reductase inhibitor, epalrestat, and a vasodilator, cilostazol, on the nerve conduction slowing and the myelinated fiber atrophy in streptozotocin-induced diabetic rats. Exp Neurol 146:466-470, 1997
43. Stevens EJ, Carrington AL, Tomlinson DR: Nerve ischaemia in diabetic rats: time-course of development, effect of insulin treatment plus comparison of streptozotocin and BB models. Diabetologia 37:43-48, 1994
44. +-ATPase in diabetic nerve by protein kinase C agonists. Am J Physiol 256:E264-E269, 1989
45. Ritchie JM: The oxygen consumption of mammalian non-myelinated nerve fibres at rest and during activity. J Physiol (Lond) 188:309-329, 1967
46. Thurston JH, McDouglas DB Jr, Hauhart RE, Schulz DW: Effects of acute, sub-acute, and chronic diabetes on carbohydrate and energy metabolism in rat sciatic nerve: relation to mechanisms of peripheral neuropathy. Diabetes 44:190-195, 1995
47. Low PA, Ward K, Schmelzer JD, Brimijoin S: Ischemic conduction failure and energy metabolism in experimental diabetic neuropathy. Am J Physiol 248:E457-E462, 1985
48. Magwere T, Naik YS, Hasler JA: Primaquine alters antioxidant enzyme profiles in rat liver and kidney. Free Radic Res 27:173-179, 1997
49. Greene DA, Lewis RA, Lattimer SA, Brown MJ: Selective effects of myo-inositol administration on sciatic and tibial motor nerve conduction parameters in the streptozocin-diabetic rat. Diabetes 31:573-578, 1982
50. Landowne D, Ritchie JM: The binding of tritiated ouabain to mammalian non-myelinated nerve fibres. J Physiol (Lond) 207:529-537, 1970
51. DeLuca DC, Hinds T, Winter CG: Carbonyl cyanide phenylhydrazones as probes of the anionic activator site of the human erythrocyte glutathione adduct transport ATPase. Arch Biochem Biophys 342:182-186, 1997
52. Fernandez-Checa JC, Kaplowitz N, Garcia-Ruiz C, Colell A, Miranda M, Mari M, Ardite E, Morales A: GSH transport in mitochondria: defense against TNF-induced oxidative stress and alcohol-induced defect. Am J Physiol 273: G7-G17, 1997
53. Martensson J, Lai JC, Meister A: High-affinity transport of glutathione is part of a multicomponent system essential for mitochondrial function. Proc Natl Acad Sci U S A 87:7185-7189, 1990
54. Radi R, Turrens JF, Chang LY, Bush KM, Crapo JD, Freeman BA: Detection of catalase in rat heart mitochondria. J Biol Chem 266:22028-22034, 1991
55. McKernan TB, Woods EB, Lash LH: Uptake of glutathione by renal cortical mitochondria. Arch Biochem Biophys 288:653-663, 1991
56. Li YP, Lombardini JB: Taurine inhibits protein kinase C-catalyzed phosphorylation of specific proteins in a rat cortical P2 fraction. J Neurochem 56:1747-1753, 1991
57. Gragera RR, Muniz E, Martinez-Rodgriguez R: Neuromediators in the cerebellar blood-brain barrier and its microenvironment: immunocytochemical demonstration of taurine, glycine, serotonin, thiamin and AATase. J Hirnforsch 35:31-38, 1994
58. Kamata K, Sugiura M, Kojima S, Kasuya Y: Restoration of endothelium-dependent relaxation in both hypercholesterolemia and diabetes by chronic taurine. Eur J Pharmacol 303:47-53, 1996
59. Maitra I, Serbinova E, Trischler H, Packer L: α-Lipoic acid prevents buthionine sulfoximine-induced cataract formation in newborn rats. Free Radic Biol Med 18:823-829, 1995
60. Borgese N, D'Arrigo A, De Silvestris M, Pietrini G: NADH-cytochrome b5 reductase and cytochrome b5: the problem of posttranslational targeting to the endoplasmic reticulum. Subcell Biochem 21:313:341, 1993
61. Rodriguez JC, Rivera M: Conversion of mitochondrial cytochrome b5 into a species capable of performing the efficient coupled oxidation of heme. Biochemistry 37:13082-13090, 1998
62. Villalba JM, Navarro F, Gomez-Diaz C, Arroyo A, Bello RI, Navas P: Role of cytochrome b5 reductase on the antioxidant function of coenzyme Q in the plasma membrane. Mol Aspects Med 18 (Suppl. 1):S7-S13, 1997
63. Obrosova IG, Fathalla L, Lang HJ, Greene DA: Evaluation of a sorbitol dehydrogenase inhibitor on diabetic peripheral nerve metabolism: a prevention study. Diabetologia 42:1187-1194, 1999