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Volumn 25, Issue 5, 2007, Pages 537-550

Hexosamine induction of oxidative stress, hypertrophy and laminin expression in renal mesangial cells: Effect of the anti-oxidant α-lipoic acid

Author keywords

lipoic acid; Cell death; Extracellular matrix; Hexosamine; Mesangial cell; Oxidative stress

Indexed keywords

AZASERINE; CYCLIN D1; GLUCOSE; HEXOSAMINE; LAMININ; REACTIVE OXYGEN METABOLITE; STREPTOZOCIN; THIOCTIC ACID;

EID: 34548802931     PISSN: 02636484     EISSN: 10990844     Source Type: Journal    
DOI: 10.1002/cbf.1358     Document Type: Article
Times cited : (37)

References (48)
  • 2
    • 0020505163 scopus 로고
    • Diabetic glomerulopathy: Structural characteristics of the early and advanced stages
    • Osterby R, Gundersen HG, Horlyck A, Nyberg G, Westberg G. Diabetic glomerulopathy: structural characteristics of the early and advanced stages. Diabetes 1983; 32: 79-82.
    • (1983) Diabetes , vol.32 , pp. 79-82
    • Osterby, R.1    Gundersen, H.G.2    Horlyck, A.3    Nyberg, G.4    Westberg, G.5
  • 3
    • 0033857113 scopus 로고    scopus 로고
    • Aldose reductase and the role of the polyol pathway in diabetic nephropathy
    • Dulop M. Aldose reductase and the role of the polyol pathway in diabetic nephropathy. Kidney Int Suppl 2000; 77: S3-S12.
    • (2000) Kidney Int Suppl , vol.77
    • Dulop, M.1
  • 4
    • 28044449557 scopus 로고    scopus 로고
    • Advanced glycation end products and diabetic nephropathy
    • Thomas MC, Forbes JM, Cooper ME. Advanced glycation end products and diabetic nephropathy. Am J Ther 2005; 12: 562-572.
    • (2005) Am J Ther , vol.12 , pp. 562-572
    • Thomas, M.C.1    Forbes, J.M.2    Cooper, M.E.3
  • 5
    • 0029076281 scopus 로고
    • Hyperglycemia and diabetic kidney disease. The case for transforming growth factor-beta as a key mediator
    • Sharma K, Ziyadeh FN. Hyperglycemia and diabetic kidney disease. The case for transforming growth factor-beta as a key mediator. Diabetes 1995; 44: 1139-1146.
    • (1995) Diabetes , vol.44 , pp. 1139-1146
    • Sharma, K.1    Ziyadeh, F.N.2
  • 6
    • 0031227891 scopus 로고    scopus 로고
    • Role of growth hormone, insulin-like growth factors (IGFs) and IGF-binding proteins in the renal complications of diabetes
    • Flyvbjerg A. Role of growth hormone, insulin-like growth factors (IGFs) and IGF-binding proteins in the renal complications of diabetes. Kidney In. 1997; 52: S12-S19.
    • (1997) Kidney In , vol.52
    • Flyvbjerg, A.1
  • 7
    • 0031871668 scopus 로고    scopus 로고
    • Contribution of growth factors and IGF-1 to early diabetic nephropathy in type 1 diabetes
    • Cummings EA, Sochett EB, Dekker MG, Lawson ML, Daneman D. Contribution of growth factors and IGF-1 to early diabetic nephropathy in type 1 diabetes. Diabetes 1998; 47: 1341-1346.
    • (1998) Diabetes , vol.47 , pp. 1341-1346
    • Cummings, E.A.1    Sochett, E.B.2    Dekker, M.G.3    Lawson, M.L.4    Daneman, D.5
  • 8
    • 9544226451 scopus 로고    scopus 로고
    • Overexpression of glutamine:fructose-6-phosphate amidotransferase in transgenic mice leads to insulin resistance
    • Herbert LF, Jr., Zhou J, Daniel MC, Crook ED, et al. Overexpression of glutamine:fructose-6-phosphate amidotransferase in transgenic mice leads to insulin resistance. J Clin Invest 1996; 98: 930-936.
    • (1996) J Clin Invest , vol.98 , pp. 930-936
    • Herbert Jr., L.F.1    Zhou, J.2    Daniel, M.C.3    Crook, E.D.4
  • 9
    • 0031975643 scopus 로고    scopus 로고
    • High glucose-induced transforming growth factor β1 production is mediated by the hexosamine pathway in porcine glomerular mesangial cells
    • Kolm-Litty V, Sauer U, Nerlich A, Lehmann R, Schleicher ED. High glucose-induced transforming growth factor β1 production is mediated by the hexosamine pathway in porcine glomerular mesangial cells. J Clin Invest 1998; 101: 160-169.
    • (1998) J Clin Invest , vol.101 , pp. 160-169
    • Kolm-Litty, V.1    Sauer, U.2    Nerlich, A.3    Lehmann, R.4    Schleicher, E.D.5
  • 10
    • 0034455277 scopus 로고    scopus 로고
    • Hexosamines and nutrient sensing
    • Rossetti L. Hexosamines and nutrient sensing. Endocrinology 2000; 141: 1922-1925.
    • (2000) Endocrinology , vol.141 , pp. 1922-1925
    • Rossetti, L.1
  • 11
    • 0035490104 scopus 로고    scopus 로고
    • The hexosamine biosynthesis pathway-mediated fibronectin synthesis in mesangial cells is associated with increases in CREB phosphorylation and nuclear CRE binding. The involvement of protein kinase A and C
    • Singh LP, Andy JC, Anyamale V, Greene K, Alexander M, Crook ED. The hexosamine biosynthesis pathway-mediated fibronectin synthesis in mesangial cells is associated with increases in CREB phosphorylation and nuclear CRE binding. The involvement of protein kinase A and C. Diabetes 2001; 50: 2355-2362.
    • (2001) Diabetes , vol.50 , pp. 2355-2362
    • Singh, L.P.1    Andy, J.C.2    Anyamale, V.3    Greene, K.4    Alexander, M.5    Crook, E.D.6
  • 12
    • 2542453754 scopus 로고    scopus 로고
    • Activation of the hexosamine pathway leads to phosphorylation of insulin receptor substrate-1 on Ser307 and Ser612 and impairs the phosphatidylinositol 3-kinase/Art/mammalian target of rapamycin insulin biosynthetic pathway in RIN pancreatic β-cells
    • Andreozzi F, D'Alessandris C, Federici M, et al. Activation of the hexosamine pathway leads to phosphorylation of insulin receptor substrate-1 on Ser307 and Ser612 and impairs the phosphatidylinositol 3-kinase/Art/mammalian target of rapamycin insulin biosynthetic pathway in RIN pancreatic β-cells. Endocrinology 2004; 145: 2845-2857.
    • (2004) Endocrinology , vol.145 , pp. 2845-2857
    • Andreozzi, F.1    D'Alessandris, C.2    Federici, M.3
  • 13
    • 33644873810 scopus 로고    scopus 로고
    • Hexosamines, insulin resistance, and the complications of diabetes: Current status
    • Buse MA. Hexosamines, insulin resistance, and the complications of diabetes: current status. Am J Physiol Endocrinol Metab 2005; 290: E1-E8.
    • (2005) Am J Physiol Endocrinol Metab , vol.290
    • Buse, M.A.1
  • 14
    • 0034703095 scopus 로고    scopus 로고
    • O-Glycosylation of nuclear and cytosolic proteins. Dynamic interplay between O-GlcNAc and O-phosphate
    • Comer F-I, Hart GW. O-Glycosylation of nuclear and cytosolic proteins. Dynamic interplay between O-GlcNAc and O-phosphate. J Biol Chem 2000; 22: 29179-29182.
    • (2000) J Biol Chem , vol.22 , pp. 29179-29182
    • Comer, F.-I.1    Hart, G.W.2
  • 15
    • 0034710891 scopus 로고    scopus 로고
    • Hyperglycemia induced mitochondrial superoxide production activates the hexosamine pathway and induces plasminogen inhibitor-1 expression by increasing Sp1 glycosylation
    • Du XL, Edelstein D, Rossetti L, et al. Hyperglycemia induced mitochondrial superoxide production activates the hexosamine pathway and induces plasminogen inhibitor-1 expression by increasing Sp1 glycosylation. Proc Natl Acad Sci USA 2000; 97: 12222-12226.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 12222-12226
    • XL, D.1    Edelstein, D.2    Rossetti, L.3
  • 16
    • 0035811072 scopus 로고    scopus 로고
    • O-linkage of N-acetylglucosamine to Spl activation domain inhibits its transcriptional capacity
    • Yang X, Su K, Roos MD, Chang Q, Paterson AJ, Kudlow JE. O-linkage of N-acetylglucosamine to Spl activation domain inhibits its transcriptional capacity. Proc Natl Acad Sci USA 2001; 98: 6611-6616.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 6611-6616
    • Yang, X.1    Su, K.2    Roos, M.D.3    Chang, Q.4    Paterson, A.J.5    Kudlow, J.E.6
  • 17
    • 33644778091 scopus 로고    scopus 로고
    • IGF-1 increases laminin, cyclin Dl, and p21Cip1 expression in glomerular mesangial cells: An investigation of the intracellular signaling pathway and cell-cycle progression
    • Jiang Y, Cheng DW, Levi E, Singh LP. IGF-1 increases laminin, cyclin Dl, and p21Cip1 expression in glomerular mesangial cells: an investigation of the intracellular signaling pathway and cell-cycle progression. J Cell Biochem 2006; 98: 208-220.
    • (2006) J Cell Biochem , vol.98 , pp. 208-220
    • Jiang, Y.1    Cheng, D.W.2    Levi, E.3    Singh, L.P.4
  • 18
    • 0031963693 scopus 로고    scopus 로고
    • Developmental biology of glomerular basement membrane components
    • Miner JH. Developmental biology of glomerular basement membrane components. Curr Opin Nephrol Hypertens 1998; 7: 13-19.
    • (1998) Curr Opin Nephrol Hypertens , vol.7 , pp. 13-19
    • Miner, J.H.1
  • 19
    • 0034686077 scopus 로고    scopus 로고
    • Recombinant laminin-8 (α4β1γ1). Production, purification, and interactions with integrins
    • Kortesmaa J, Yurchenco P, Tryggvason K. Recombinant laminin-8 (α4β1γ1). Production, purification, and interactions with integrins. J Biol Chem 2000; 275: 14853-14859.
    • (2000) J Biol Chem , vol.275 , pp. 14853-14859
    • Kortesmaa, J.1    Yurchenco, P.2    Tryggvason, K.3
  • 20
    • 0038130561 scopus 로고    scopus 로고
    • Laminin-8/9 is synthesized by rat glomerular mesangial cells and is required for PDGF-induced mesangial cell migration
    • Hansen K, Abrass CK. Laminin-8/9 is synthesized by rat glomerular mesangial cells and is required for PDGF-induced mesangial cell migration. Kidney Int 2003; 64: 110-111.
    • (2003) Kidney Int , vol.64 , pp. 110-111
    • Hansen, K.1    Abrass, C.K.2
  • 21
    • 0036829796 scopus 로고    scopus 로고
    • Activation of cyclin D1-cdk4 and Cdk4-directed phosphorylation of RB protein in diabetic mesangial hypertrophy
    • Feliers D, Meredith AF, Riley DJ. Activation of cyclin D1-cdk4 and Cdk4-directed phosphorylation of RB protein in diabetic mesangial hypertrophy. Diabetes 2002; 51: 3290-3299.
    • (2002) Diabetes , vol.51 , pp. 3290-3299
    • Feliers, D.1    Meredith, A.F.2    Riley, D.J.3
  • 22
    • 0037371582 scopus 로고    scopus 로고
    • The lack of cyclin kinase inhibitor p27(Kip1) ameliorates progression of diabetic nephropathy
    • Awazu M, Omori S, Ishikura K, Hida M, Fujita H. The lack of cyclin kinase inhibitor p27(Kip1) ameliorates progression of diabetic nephropathy. J Am Soc Nephrol 2003; 14: 819-822.
    • (2003) J Am Soc Nephrol , vol.14 , pp. 819-822
    • Awazu, M.1    Omori, S.2    Ishikura, K.3    Hida, M.4    Fujita, H.5
  • 23
    • 0347628818 scopus 로고    scopus 로고
    • p21Waf1/Cip1 as a therapeutic target in breast and other cancers
    • Weiss RH. p21Waf1/Cip1 as a therapeutic target in breast and other cancers. Cancer Cell 2003; 4: 425-429.
    • (2003) Cancer Cell , vol.4 , pp. 425-429
    • Weiss, R.H.1
  • 24
    • 20044376702 scopus 로고    scopus 로고
    • The pathobiology of diabetic complications. A unifying mechanism
    • Brownlee M. The pathobiology of diabetic complications. A unifying mechanism. Diabetes 2005; 54: 1615-1625.
    • (2005) Diabetes , vol.54 , pp. 1615-1625
    • Brownlee, M.1
  • 25
    • 0042867408 scopus 로고    scopus 로고
    • Reactive oxygen-species-regulated signaling pathways in diabetic nephropathy
    • Lee HB, Yu MR, Yang Y, Jiang Z, Ha H. Reactive oxygen-species-regulated signaling pathways in diabetic nephropathy. J Am Soc Nephrol 2003; 14: S241-S245.
    • (2003) J Am Soc Nephrol , vol.14
    • Lee, H.B.1    Yu, M.R.2    Yang, Y.3    Jiang, Z.4    Ha, H.5
  • 26
  • 27
    • 0035174786 scopus 로고    scopus 로고
    • Effects of diatary supplementation of alpha-lipoic acid on early glomerular injury in diabetes mellitus
    • Melhem MF, Craven PA, Derubertis FR. Effects of diatary supplementation of alpha-lipoic acid on early glomerular injury in diabetes mellitus. J Am Soc Nephrol 2001; 12: 124-133.
    • (2001) J Am Soc Nephrol , vol.12 , pp. 124-133
    • Melhem, M.F.1    Craven, P.A.2    Derubertis, F.R.3
  • 28
    • 32844463572 scopus 로고    scopus 로고
    • In high glucose protein kinase C-zeta activation is required for mesangial cell generation of reactive oxygen species
    • Kwan J, Wang H, Munk S, Xia L, Goldberg HJ, Whiteside CI. In high glucose protein kinase C-zeta activation is required for mesangial cell generation of reactive oxygen species. Kidney Int 2005; 68: 2526-2541.
    • (2005) Kidney Int , vol.68 , pp. 2526-2541
    • Kwan, J.1    Wang, H.2    Munk, S.3    Xia, L.4    Goldberg, H.J.5    Whiteside, C.I.6
  • 29
    • 26844519964 scopus 로고    scopus 로고
    • Diabetes causes inhibition of glucose-6-phosphate dehydrogenase via activation of PKA, which contributes to oxidative stress in rat kidney cortex
    • Xu Y, Osborne BW, Stanton RC. Diabetes causes inhibition of glucose-6-phosphate dehydrogenase via activation of PKA, which contributes to oxidative stress in rat kidney cortex. Am J Physiol Renal Physiol 2005; 289: F1040-F1047.
    • (2005) Am J Physiol Renal Physiol , vol.289
    • Xu, Y.1    Osborne, B.W.2    Stanton, R.C.3
  • 30
    • 0033679319 scopus 로고    scopus 로고
    • Hexosamine regulation of glucose-mediated laminin synthesis in mesangial cells involves protein kinase A and C
    • Singh LP, Crook ED. Hexosamine regulation of glucose-mediated laminin synthesis in mesangial cells involves protein kinase A and C. Am J Physiol Renal Physiol 2000; 279: F646-F654.
    • (2000) Am J Physiol Renal Physiol , vol.279
    • Singh, L.P.1    Crook, E.D.2
  • 31
    • 0035099711 scopus 로고    scopus 로고
    • Glucose-induced insulin resistance of phosphatidylinositol 3′OH kinase and AKT/PKB is mediated by the hexosamine biosynthetic pathway
    • Singh LP, Gennerette D, Simmons S, Crook ED. Glucose-induced insulin resistance of phosphatidylinositol 3′OH kinase and AKT/PKB is mediated by the hexosamine biosynthetic pathway. J Diab Compl 2001; 15: 88-96.
    • (2001) J Diab Compl , vol.15 , pp. 88-96
    • Singh, L.P.1    Gennerette, D.2    Simmons, S.3    Crook, E.D.4
  • 32
    • 0942279632 scopus 로고    scopus 로고
    • Hexosamines and TGF-betal use similar signaling pathways to mediate matrix protein synthesis in mesangial cells
    • Singh LP, Green K, Alexander M, Bassly S, Crook ED. Hexosamines and TGF-betal use similar signaling pathways to mediate matrix protein synthesis in mesangial cells. Am J Physiol Renal Physiol 2004; 286: F409-F416.
    • (2004) Am J Physiol Renal Physiol , vol.286
    • Singh, L.P.1    Green, K.2    Alexander, M.3    Bassly, S.4    Crook, E.D.5
  • 33
    • 26444490645 scopus 로고    scopus 로고
    • Transforming growth factor-betal regulation of laminin gammal and fibronectin expression and survival of mouse mesangial cells
    • Jiang Y, Cheng DW, Crook ED, Singh LP. Transforming growth factor-betal regulation of laminin gammal and fibronectin expression and survival of mouse mesangial cells. Mol Cell Biochem 2005; 278: 165-175.
    • (2005) Mol Cell Biochem , vol.278 , pp. 165-175
    • Jiang, Y.1    Cheng, D.W.2    Crook, E.D.3    Singh, L.P.4
  • 34
    • 6944233576 scopus 로고    scopus 로고
    • Role of interleukin-1β in the development of retinopathy in rats: Effect of antioxidants
    • Kowluru A, Odenbach D. Role of interleukin-1β in the development of retinopathy in rats: effect of antioxidants. Invest Ophthalmol Vis Sci 2004; 45: 4161-4166.
    • (2004) Invest Ophthalmol Vis Sci , vol.45 , pp. 4161-4166
    • Kowluru, A.1    Odenbach, D.2
  • 35
    • 0034048176 scopus 로고    scopus 로고
    • Transcriptional regulation of TGF-β1 by glucose: Investigation into the role of the hexosamine biosynthesis pathway
    • Daniels MC, McClain DA, Crook ED. Transcriptional regulation of TGF-β1 by glucose: investigation into the role of the hexosamine biosynthesis pathway. Am J Med Sci 2000; 319: 138-142.
    • (2000) Am J Med Sci , vol.319 , pp. 138-142
    • Daniels, M.C.1    McClain, D.A.2    Crook, E.D.3
  • 36
    • 0034083716 scopus 로고    scopus 로고
    • Glucosamine activates the plasminogen activator inhibitor 1 gene promoter through Sp1 DNA binding sites in glomerular mesangial cells
    • Goldberg HJ, Scholey J, Fantus IG. Glucosamine activates the plasminogen activator inhibitor 1 gene promoter through Sp1 DNA binding sites in glomerular mesangial cells. Diabetes 2000; 49: 863-871.
    • (2000) Diabetes , vol.49 , pp. 863-871
    • Goldberg, H.J.1    Scholey, J.2    Fantus, I.G.3
  • 37
    • 0142249401 scopus 로고    scopus 로고
    • Vitamin D3 up-regulated protein-1 regulates collagen expression in mesangial cells
    • Kobayashi T, Uehara S, Ikeda T, Itadani H, Kotani H. Vitamin D3 up-regulated protein-1 regulates collagen expression in mesangial cells. Kidney Int 2003; 64: 1632-1642.
    • (2003) Kidney Int , vol.64 , pp. 1632-1642
    • Kobayashi, T.1    Uehara, S.2    Ikeda, T.3    Itadani, H.4    Kotani, H.5
  • 38
    • 3142751251 scopus 로고    scopus 로고
    • Hyperglycemia promotes oxidative stress through inhibition of thioredoxin function by thioredoxin-interacting protein
    • Schulze PC, Yoshioka J, Takahashi T, He Z, King GL, Lee RT. Hyperglycemia promotes oxidative stress through inhibition of thioredoxin function by thioredoxin-interacting protein. J Biol Chem 2004; 279: 30369-30374.
    • (2004) J Biol Chem , vol.279 , pp. 30369-30374
    • Schulze, P.C.1    Yoshioka, J.2    Takahashi, T.3    He, Z.4    King, G.L.5    Lee, R.T.6
  • 39
    • 17744377972 scopus 로고    scopus 로고
    • Reactive oxygen species mediate high glucose-induced plasminogen activator inhibitor-1 up-regulation in mesangial cells and in diabetic kidney
    • Lee EA, Seo JY, Jiang Z, et al. Reactive oxygen species mediate high glucose-induced plasminogen activator inhibitor-1 up-regulation in mesangial cells and in diabetic kidney. Kidney Int 2005; 67: 1762-1771.
    • (2005) Kidney Int , vol.67 , pp. 1762-1771
    • Lee, E.A.1    Seo, J.Y.2    Jiang, Z.3
  • 40
    • 0034851575 scopus 로고    scopus 로고
    • Therapeutic potential of antioxidants and diabetic retinopathy
    • Kowluru RA, Kennedy A. Therapeutic potential of antioxidants and diabetic retinopathy. Expert Opin Investig Drugs 2001; 10: 1665-1676.
    • (2001) Expert Opin Investig Drugs , vol.10 , pp. 1665-1676
    • Kowluru, R.A.1    Kennedy, A.2
  • 41
    • 8144228247 scopus 로고    scopus 로고
    • The preventive anti-oxidant action of thiazolidinediones: A new therapeutic prospect in diabetes and insulin resistance
    • Da Ros R, Assaloni R, Ceriello A. The preventive anti-oxidant action of thiazolidinediones: a new therapeutic prospect in diabetes and insulin resistance. Diabet Med 2004; 21: 1249-1252.
    • (2004) Diabet Med , vol.21 , pp. 1249-1252
    • Da Ros, R.1    Assaloni, R.2    Ceriello, A.3
  • 42
    • 0028234516 scopus 로고
    • Vitamin E prevents glucose-induced lipid peroxidation and increased collagen production in cultured rat mesangial cells
    • Trachman H. Vitamin E prevents glucose-induced lipid peroxidation and increased collagen production in cultured rat mesangial cells. Microvas Res 1994; 47: 232-239.
    • (1994) Microvas Res , vol.47 , pp. 232-239
    • Trachman, H.1
  • 43
    • 1542378856 scopus 로고    scopus 로고
    • Exogenous attenuation of p21Waf1/Cip1 decreases mesangial cell hypertrophy as a result of hyperglycemia and IGF1
    • Fan YP, Weiss RH. Exogenous attenuation of p21Waf1/Cip1 decreases mesangial cell hypertrophy as a result of hyperglycemia and IGF1. J Am Soc Nephml 2004; 15: 575-584.
    • (2004) J Am Soc Nephml , vol.15 , pp. 575-584
    • Fan, Y.P.1    Weiss, R.H.2
  • 44
    • 20544441287 scopus 로고    scopus 로고
    • Glucosamine induces cell-cycle arrest and hypertrophy of mesangial cells: Implications of gangliosides
    • Masson E, Wiernsperger N, Lagarde M, El Bawab S. Glucosamine induces cell-cycle arrest and hypertrophy of mesangial cells: implications of gangliosides. Biochem J 2005; 388: 537-544.
    • (2005) Biochem J , vol.388 , pp. 537-544
    • Masson, E.1    Wiernsperger, N.2    Lagarde, M.3    El Bawab, S.4
  • 45
    • 0032704528 scopus 로고    scopus 로고
    • The cyclin kinase inhibitor p21WAF1/CIP1 is required for glomerular hypertrophy in experimental diabetic nephropathy
    • Al-Douahji M, Brugarolas J, Brown PA, Stehman-Breen CO, Alpers CE, Shankland SJ. The cyclin kinase inhibitor p21WAF1/CIP1 is required for glomerular hypertrophy in experimental diabetic nephropathy. Kidney Int 1999; 56: 1691-1699.
    • (1999) Kidney Int , vol.56 , pp. 1691-1699
    • Al-Douahji, M.1    Brugarolas, J.2    Brown, P.A.3    Stehman-Breen, C.O.4    Alpers, C.E.5    Shankland, S.J.6
  • 46
    • 0642347909 scopus 로고    scopus 로고
    • Cell cycle control in glomerular disease
    • Wolf G, Shankland SJ. Cell cycle control in glomerular disease. Prog Cell Cycle Res 2003; 5: 71-79.
    • (2003) Prog Cell Cycle Res , vol.5 , pp. 71-79
    • Wolf, G.1    Shankland, S.J.2
  • 47
    • 0036237648 scopus 로고    scopus 로고
    • The hypertrophic effect of transforming growth factor-beta is reduced in the absence of cyclin-dependent kinase-inhibitors p21 and p27
    • Monkawa T, Hiromura K, Wolf G, Shankland SJ. The hypertrophic effect of transforming growth factor-beta is reduced in the absence of cyclin-dependent kinase-inhibitors p21 and p27. J Am Soc Nephrol 2002; 13: 1172-8117.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 1172-8117
    • Monkawa, T.1    Hiromura, K.2    Wolf, G.3    Shankland, S.J.4
  • 48
    • 0037342855 scopus 로고    scopus 로고
    • Effect of reinstitution of good glycemic control on retinal oxidative stress and nitrative stress in diabetic rats
    • Kowluru A. Effect of reinstitution of good glycemic control on retinal oxidative stress and nitrative stress in diabetic rats. Diabetes 2003; 52: 818-823.
    • (2003) Diabetes , vol.52 , pp. 818-823
    • Kowluru, A.1


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