Crk and CrkL adaptor proteins: Networks for physiological and pathological signaling

Cell Communication and Signaling

Volumn 7, Issue , 2009, Pages

  Birge, Raymond B ^a   Kalodimos, Charalampos ^b   Inagaki, Fuyuhiko ^c   Tanaka, Shinya ^d  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c HOKKAIDO UNIVERSITY   (Japan)

^d HOKKAIDO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77949828806     PISSN: None     EISSN: 1478811X     Source Type: Journal    
DOI: 10.1186/1478-811X-7-13     Document Type: Review

References (206)

1. A novel viral oncogene with structural similarity to phospholipase C. BJ Mayer, M Hamaguchi, H Hanafusa, Nature 1988 332 272 275 2450282
2. Characterization of p47gag-crk, a novel oncogene product with sequence similarity to a putative modulatory domain of protein-tyrosine kinases and phospholipase C. BJ Mayer, M Hamaguchi, H Hanafusa, Cold Spring Harb Symp Quant Biol 1988 53 Pt 2 907 914 2855503
3. A newly isolated avian sarcoma virus, ASV-1, carries the crk oncogene. H Tsuchie, CH Chang, M Yoshida, PK Vogt, Oncogene 1989 4 1281 1284 2554234
4. Identification of domains of the v-crk oncogene product sufficient for association with phosphotyrosine-containing proteins. M Matsuda, BJ Mayer, H Hanafusa, Mol Cell Biol 1991 11 1607 1613 1705010
5. Binding of transforming protein, P47gag-crk, to a broad range of phosphotyrosine-containing proteins. M Matsuda, BJ Mayer, Y Fukui, H Hanafusa, Science 1990 248 1537 1539 1694307
6. The product of the cellular crk gene consists primarily of SH2 and SH3 regions. CT Reichman, BJ Mayer, S Keshav, H Hanafusa, Cell Growth Differ 1992 3 451 460 1329926
7. Two species of human CRK cDNA encode proteins with distinct biological activities. M Matsuda, S Tanaka, S Nagata, A Kojima, T Kurata, M Shibuya, Mol Cell Biol 1992 12 3482 3489 1630456
8. Cell transformation by the viral src oncogene. R Jove, H Hanafusa, Annu Rev Cell Biol 1987 3 31 56 2446642
9. Avian sarcoma viruses. LH Wang, H Hanafusa, Virus Res 1988 9 159 203 2833047
10. c-Abl kinase regulates the protein binding activity of c-Crk. SM Feller, B Knudsen, H Hanafusa, Embo J 1994 13 2341 2351 8194526
11. Constitutive activation of Src family kinases in mouse embryos that lack Csk. S Nada, T Yagi, H Takeda, T Tokunaga, H Nakagawa, Y Ikawa, M Okada, S Aizawa, Cell 1993 73 1125 1135 8513497
12. Csk inhibition of c-Src activity requires both the SH2 and SH3 domains of Src. G Superti-Furga, S Fumagalli, M Koegl, SA Courtneidge, G Draetta, Embo J 1993 12 2625 2634 7687537
13. Structures of Src-family tyrosine kinases. F Sicheri, J Kuriyan, Curr Opin Struct Biol 1997 7 777 785 9434895
14. Direct demonstration of an intramolecular SH2-phosphotyrosine interaction in the Crk protein. MK Rosen, T Yamazaki, GD Gish, CM Kay, T Pawson, LE Kay, Nature 1995 374 477 479 7700361
15. Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK. Y Kobashigawa, M Sakai, M Naito, M Yokochi, H Kumeta, Y Makino, K Ogura, S Tanaka, F Inagaki, Nat Struct Mol Biol 2007 14 503 510 17515907
16. Delay in serum stimulation of Erk activity caused by oncogenic transformation. H Greulich, C Reichman, H Hanafusa, Oncogene 1996 12 1689 1695 8622889
17. Crk family adaptors-signalling complex formation and biological roles. SM Feller, Oncogene 2001 20 6348 6371 11607838
18. Detection of SH3-binding proteins in total cell lysates with glutathione S-transferase-SH3 fusion proteins: SH3 blot assay. SM Feller, B Knudsen, TW Wong, H Hanafusa, Methods Enzymol 1995 255 369 378 8524122
19. A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner. R Sakai, A Iwamatsu, N Hirano, S Ogawa, T Tanaka, H Mano, Y Yazaki, H Hirai, Embo J 1994 13 3748 3756 8070403
20. The proto-oncogene product p120CBL and the adaptor proteins CRKL and c-CRK link c-ABL, p190BCR/ABL and p210BCR/ABL to the phosphatidylinositol-3' kinase pathway. M Sattler, R Salgia, K Okuda, N Uemura, MA Durstin, E Pisick, G Xu, JL Li, KV Prasad, JD Griffin, Oncogene 1996 12 839 846 8632906
21. Expression of the v-crk oncogene product in PC12 cells results in rapid differentiation by both nerve growth factor- and epidermal growth factor-dependent pathways. BL Hempstead, RB Birge, JE Fajardo, R Glassman, D Mahadeo, R Kraemer, H Hanafusa, Mol Cell Biol 1994 14 1964 1971 7509449
22. Nerve growth factor stimulates the tyrosine phosphorylation of endogenous Crk-II and augments its association with p130Cas in PC-12 cells. V Ribon, AR Saltiel, J Biol Chem 1996 271 7375 7380 8631760
23. Tyrosine phosphorylation of Cbl upon epidermal growth factor (EGF) stimulation and its association with EGF receptor and downstream signaling proteins. T Fukazawa, S Miyake, V Band, H Band, J Biol Chem 1996 271 14554 14559 8662998
24. Epidermal growth factor modulates tyrosine phosphorylation of p130Cas. Involvement of phosphatidylinositol 3'-kinase and actin cytoskeleton. M Ojaniemi, K Vuori, J Biol Chem 1997 272 25993 25998 9325334
25. The proto-oncogene product c-Crk associates with insulin receptor substrate-1 and 4PS. Modulation by insulin growth factor-I (IGF) and enhanced IGF-I signaling. D Beitner-Johnson, VA Blakesley, Z Shen-Orr, M Jimenez, B Stannard, LM Wang, J Pierce, D LeRoith, J Biol Chem 1996 271 9287 9290 8621590
26. c-Crk, a substrate of the insulin-like growth factor-1 receptor tyrosine kinase, functions as an early signal mediator in the adipocyte differentiation process. S Jin, B Zhai, Z Qiu, J Wu, MD Lane, K Liao, J Biol Chem 2000 275 34344 34352 10926934
27. Binding of SH2 domains of phospholipase C gamma 1, GAP, and Src to activated growth factor receptors. D Anderson, CA Koch, L Grey, C Ellis, MF Moran, T Pawson, Science 1990 250 979 982 2173144
28. Identification of Tyr-762 in the platelet-derived growth factor alpha-receptor as the binding site for Crk proteins. K Yokote, U Hellman, S Ekman, Y Saito, L Ronnstrand, CH Heldin, S Mori, Oncogene 1998 16 1229 1239 9546424
29. Direct recruitment of CRK and GRB2 to VEGFR-3 induces proliferation migration, and survival of endothelial cells through the activation of ERK AKT, and JNK pathways. A Salameh, F Galvagni, M Bardelli, F Bussolino, S Oliviero, Blood 2005 106 3423 3431 16076871
30. Met-induced JNK activation is mediated by the adapter protein Crk and correlates with the Gab1-Crk signaling complex formation. M Garcia-Guzman, F Dolfi, K Zeh, K Vuori, Oncogene 1999 18 7775 7786 10618718
31. The EphB4 receptor suppresses breast cancer cell tumorigenicity through an Abl-Crk pathway. NK Noren, G Foos, CA Hauser, EB Pasquale, Nat Cell Biol 2006 8 815 825 16862147
32. Melanoma growth stimulatory activity signaling through the class II interleukin-8 receptor enhances the tyrosine phosphorylation of Crk-associated substrate, p130, and a 70-kilodalton protein. W Schraw, A Richmond, Biochemistry 1995 34 13760 13767 7577968
33. Erythropoietin and interleukin-3 activate tyrosine phosphorylation of CBL and association with CRK adaptor proteins. DL Barber, JM Mason, T Fukazawa, KA Reedquist, BJ Druker, H Band, AD D'Andrea, Blood 1997 89 3166 3174 9129019
34. Tyrosine phosphorylation and association of p130Cas and c-Crk II by ANG II in vascular smooth muscle cells. T Takahashi, Y Kawahara, T Taniguchi, M Yokoyama, Am J Physiol 1998 274 1059 1065 9575907
35. Cytoskeleton-dependent tyrosine phosphorylation of the p130(Cas) family member HEF1 downstream of the G protein-coupled calcitonin receptor. Calcitonin induces the association of HEF1, paxillin, and focal adhesion kinase. Z Zhang, L Hernandez-Lagunas, WC Horne, R Baron, J Biol Chem 1999 274 25093 25098 10455189
36. Thrombopoietin and interleukin-2 induce association of CRK with STAT5. A Oda, H Wakao, M Fujihara, K Ozaki, N Komatsu, S Tanaka, H Ikeda, A Miyajima, K Ikebuchi, Biochem Biophys Res Commun 2000 278 299 305 11097834
37. Involvement of cell-cell interactions in the rapid stimulation of Cas tyrosine phosphorylation and Src kinase activity by transforming growth factor-beta 1. JT Kim, CK Joo, J Biol Chem 2002 277 31938 31948 12065577
38. Janus kinase 2 is involved in stromal cell-derived factor-1alpha-induced tyrosine phosphorylation of focal adhesion proteins and migration of hematopoietic progenitor cells. XF Zhang, JF Wang, E Matczak, JA Proper, JE Groopman, Blood 2001 97 3342 3348 11369622
39. Interaction between Dab1 and CrkII is promoted by Reelin signaling. K Chen, PG Ochalski, TS Tran, N Sahir, M Schubert, A Pramatarova, BW Howell, J Cell Sci 2004 117 4527 4536 15316068
40. Crk interacts with tyrosine-phosphorylated p116 upon T cell activation. S Sawasdikosol, KS Ravichandran, KK Lee, JH Chang, SJ Burakoff, J Biol Chem 1995 270 2893 2896 7531694
41. Interactions of Cbl with two adapter proteins, Grb2 and Crk, upon T cell activation. L Buday, A Khwaja, S Sipeki, A Farago, J Downward, J Biol Chem 1996 271 6159 6163 8626404
42. Adhesion through the interaction of lymphocyte function-associated antigen-1 with intracellular adhesion molecule-1 induces tyrosine phosphorylation of p130cas and its association with c-CrkII. L Petruzzelli, M Takami, R Herrera, J Biol Chem 1996 271 7796 7801 8631823
43. Rho stimulates tyrosine phosphorylation of focal adhesion kinase, p130 and paxillin. HM Flinn, AJ Ridley, J Cell Sci 1996 109 Pt 5 1133 1141 8743960
44. Activation of m3 muscarinic receptors induces rapid tyrosine phosphorylation of p125(FAK), p130(cas), and paxillin in rat pancreatic acini. JA Rosado, GM Salido, LJ Garcia, Arch Biochem Biophys 2000 377 85 94 10775445
45. Chemokine receptor CCR6 transduces signals that activate p130Cas and alter cAMP-stimulated ion transport in human intestinal epithelial cells. CC Yang, H Ogawa, MB Dwinell, DF McCole, L Eckmann, MF Kagnoff, Am J Physiol Cell Physiol 2005 288 321 328 15483227
46. Tyrosine phosphorylation of p130Cas in cell adhesion and transformation. Y Nojima, T Mimura, N Morino, K Hamasaki, H Furuya, R Sakai, T Nakamoto, Y Yazaki, H Hirai, Hum Cell 1996 9 169 174 9183645
47. The integrin beta1 subunit transmembrane domain regulates phosphatidylinositol 3-kinase-dependent tyrosine phosphorylation of Crk-associated substrate. A Armulik, T Velling, S Johansson, Mol Biol Cell 2004 15 2558 2567 15034138
48. uPAR promotes formation of the p130Cas-Crk complex to activate Rac through DOCK180. HW Smith, P Marra, CJ Marshall, J Cell Biol 2008 182 777 790 18725541
49. Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas. KM Eisenmann, JB McCarthy, MA Simpson, PJ Keely, JL Guan, K Tachibana, L Lim, E Manser, LT Furcht, J Iida, Nat Cell Biol 1999 1 507 513 10587647
50. Shear stress stimulation of p130(cas) tyrosine phosphorylation requires calcium-dependent c-Src activation. M Okuda, M Takahashi, J Suero, CE Murry, O Traub, H Kawakatsu, BC Berk, J Biol Chem 1999 274 26803 26809 10480886
51. Force sensing by mechanical extension of the Src family kinase substrate p130Cas. Y Sawada, M Tamada, BJ Dubin-Thaler, O Cherniavskaya, R Sakai, S Tanaka, MP Sheetz, Cell 2006 127 1015 1026 17129785
52. Phosphorylation of tyrosine residues 31 and 118 on paxillin regulates cell migration through an association with CRK in NBT-II cells. V Petit, B Boyer, D Lentz, CE Turner, JP Thiery, AM Valles, J Cell Biol 2000 148 957 970 10704446
53. A Crk-II/TC10 signaling pathway is required for osmotic shock-stimulated glucose transport. P Gual, S Shigematsu, M Kanzaki, T Gremeaux, T Gonzalez, JE Pessin, Y Le Marchand-Brustel, JF Tanti, J Biol Chem 2002 277 43980 43986 12215429
54. Extracellular-regulated kinase activation and CAS/Crk coupling regulate cell migration and suppress apoptosis during invasion of the extracellular matrix. SY Cho, RL Klemke, J Cell Biol 2000 149 223 236 10747099
55. Laminin-10/11 and fibronectin differentially regulate integrin-dependent Rho and Rac activation via p130(Cas)-CrkII-DOCK180 pathway. J Gu, Y Sumida, N Sanzen, K Sekiguchi, J Biol Chem 2001 276 27090 27097 11369773
56. TIMP-2 upregulates RECK expression via dephosphorylation of paxillin tyrosine residues 31 and 118. J Oh, T Diaz, B Wei, H Chang, M Noda, WG Stetler-Stevenson, Oncogene 2006 25 4230 4234 16491114
57. p130CAS is required for netrin signaling and commissural axon guidance. G Liu, W Li, X Gao, X Li, C Jurgensen, HT Park, NY Shin, J Yu, ML He, SK Hanks, JY Wu, KL Guan, Y Rao, J Neurosci 2007 27 957 968 17251438
58. Crk associates with ERM proteins and promotes cell motility toward hyaluronic acid. M Tsuda, Y Makino, T Iwahara, H Nishihara, H Sawa, K Nagashima, H Hanafusa, S Tanaka, J Biol Chem 2004 279 46843 46850 15326184
59. CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans. PW Reddien, HR Horvitz, Nat Cell Biol 2000 2 131 136 10707082
60. alphavbeta5 integrin recruits the CrkII-Dock180-rac1 complex for phagocytosis of apoptotic cells. ML Albert, JI Kim, RB Birge, Nat Cell Biol 2000 2 899 905 11146654
61. CD36 signals to the actin cytoskeleton and regulates microglial migration via a p130Cas complex. LM Stuart, SA Bell, CR Stewart, JM Silver, J Richard, JL Goss, AA Tseng, A Zhang, JB El Khoury, KJ Moore, J Biol Chem 2007 282 27392 27401 17623670
62. Association of p130CAS with phosphatidylinositol-3-OH kinase mediates adenovirus cell entry. E Li, DG Stupack, SL Brown, R Klemke, DD Schlaepfer, GR Nemerow, J Biol Chem 2000 275 14729 14735 10799562
63. CAS/Crk signalling mediates uptake of Yersinia into human epithelial cells. CL Weidow, DS Black, JB Bliska, AH Bouton, Cell Microbiol 2000 2 549 560 11207607
64. Abl tyrosine kinases are required for infection by Shigella flexneri. EA Burton, R Plattner, AM Pendergast, Embo J 2003 22 5471 5479 14532119
65. Host adaptor proteins Gab1 and CrkII promote InlB-dependent entry of Listeria monocytogenes. H Sun, Y Shen, H Dokainish, M Holgado-Madruga, A Wong, K Ireton, Cell Microbiol 2005 7 443 457 15679846
66. Interaction of CagA with Crk plays an important role in Helicobacter pylori-induced loss of gastric epithelial cell adhesion. M Suzuki, H Mimuro, T Suzuki, M Park, T Yamamoto, C Sasakawa, J Exp Med 2005 202 1235 1247 16275761
67. Fluoroaluminate stimulates phosphorylation of p130 Cas and Fak and increases attachment and spreading of preosteoblastic MC3T3-E1 cells. F Freitas, M Jeschke, I Majstorovic, DR Mueller, P Schindler, H Voshol, J Van Oostrum, M Susa, Bone 2002 30 99 108 11792571
68. G(i)-mediated Cas tyrosine phosphorylation in vascular endothelial cells stimulated with sphingosine 1-phosphate: possible involvement in cell motility enhancement in cooperation with Rho-mediated pathways. T Ohmori, Y Yatomi, H Okamoto, Y Miura, G Rile, K Satoh, Y Ozaki, J Biol Chem 2001 276 5274 5280 11056155
69. Sphingosine 1-phosphate induces membrane ruffling and increases motility of human umbilical vein endothelial cells via vascular endothelial growth factor receptor and CrkII. A Endo, K Nagashima, H Kurose, S Mochizuki, M Matsuda, N Mochizuki, J Biol Chem 2002 277 23747 23754 11956190
70. The opsonin MFG-E8 is a ligand for the alphavbeta5 integrin and triggers DOCK180-dependent Rac1 activation for the phagocytosis of apoptotic cells. S Akakura, S Singh, M Spataro, R Akakura, JI Kim, ML Albert, RB Birge, Exp Cell Res 2004 292 403 416 14697347
71. Identification of a factor that links apoptotic cells to phagocytes. R Hanayama, M Tanaka, K Miwa, A Shinohara, A Iwamatsu, S Nagata, Nature 2002 417 182 187 12000961
72. p130Cas interacts with estrogen receptor alpha and modulates non-genomic estrogen signaling in breast cancer cells. S Cabodi, L Moro, G Baj, M Smeriglio, P Di Stefano, S Gippone, N Surico, L Silengo, E Turco, G Tarone, P Defilippi, J Cell Sci 2004 117 1603 1611 15020686
73. Tamoxifen treatment promotes phosphorylation of the adhesion molecules, p130Cas/BCAR1, FAK and Src, via an adhesion-dependent pathway. LN Cowell, JD Graham, AH Bouton, CL Clarke, GM O'Neill, Oncogene 2006 25 7597 7607 16799644
74. The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interaction. KH Kirsch, MM Georgescu, T Shishido, WY Langdon, RB Birge, H Hanafusa, J Biol Chem 2001 276 4957 4963 11067845
75. A new twist to adaptor proteins contributes to regulation of lymphocyte cell signaling. N Isakov, Trends Immunol 2008 29 388 396 18599349
76. Mice lacking the homologue of the human 22q11.2 gene CRKL phenocopy neurocristopathies of DiGeorge syndrome. DL Guris, J Fantes, D Tara, BJ Druker, A Imamoto, Nat Genet 2001 27 293 298 11242111
77. Crkl deficiency disrupts Fgf8 signaling in a mouse model of 22q11 deletion syndromes. AM Moon, DL Guris, JH Seo, L Li, J Hammond, A Talbot, A Imamoto, Dev Cell 2006 10 71 80 16399079
78. Dose-dependent interaction of Tbx1 and Crkl and locally aberrant RA signaling in a model of del22q11 syndrome. DL Guris, G Duester, VE Papaioannou, A Imamoto, Dev Cell 2006 10 81 92 16399080
79. Cardiovascular and craniofacial defects in Crk-null mice. TJ Park, K Boyd, T Curran, Mol Cell Biol 2006 26 6272 6282 16880535
80. Mutant mice lacking Crk-II caused by the gene trap insertional mutagenesis: Crk-II is not essential for embryonic development. T Imaizumi, K Araki, K Miura, M Araki, M Suzuki, H Terasaki, K Yamamura, Biochem Biophys Res Commun 1999 266 569 574 10600543
81. Reelin is a ligand for lipoprotein receptors. G D'Arcangelo, R Homayouni, L Keshvara, DS Rice, M Sheldon, T Curran, Neuron 1999 24 471 479 10571240
82. Tyrosine phosphorylated Disabled 1 recruits Crk family adapter proteins. Y Huang, S Magdaleno, R Hopkins, C Slaughter, T Curran, L Keshvara, Biochem Biophys Res Commun 2004 318 204 212 15110774
83. Migration of sympathetic preganglionic neurons in the spinal cord is regulated by Reelin-dependent Dab1 tyrosine phosphorylation and CrkL. YP Yip, P Kronstadt-O'Brien, C Capriotti, JA Cooper, JW Yip, J Comp Neurol 2007 502 635 643 17394141
84. Dual Functions of Dab1 during Brain Development. L Feng, JA Cooper, Mol Cell Biol 2009 29 324 332 18981215
85. Reduction of Crk and CrkL expression blocks reelin-induced dendritogenesis. T Matsuki, A Pramatarova, BW Howell, J Cell Sci 2008 121 1869 1875 18477607
86. Crk and Crk-like play essential overlapping roles downstream of disabled-1 in the Reelin pathway. TJ Park, T Curran, J Neurosci 2008 28 13551 13562 19074029
87. Characterization of the kinase activity essential for tyrosine phosphorylation of p130Cas in fibroblasts. R Sakai, T Nakamoto, K Ozawa, S Aizawa, H Hirai, Oncogene 1997 14 1419 1426 9136985
88. v-Crk activates the phosphoinositide 3-kinase/AKT pathway in transformation. T Akagi, T Shishido, K Murata, H Hanafusa, Proc Natl Acad Sci USA 2000 97 7290 7295 10852971
89. CrkII regulates focal adhesion kinase activation by making a complex with Crk-associated substrate, p130Cas. T Iwahara, T Akagi, Y Fujitsuka, H Hanafusa, Proc Natl Acad Sci USA 2004 101 17693 17698 15598735
90. Focal adhesion targeting of v-Crk is essential for FAK phosphorylation and cell migration in mouse embryo fibroblasts deficient src family kinases or p130CAS. MG Yeo, BH Sung, HJ Oh, ZY Park, EE Marcantonio, WK Song, J Cell Physiol 2008 214 604 613 17786957
91. p130Cas: a versatile scaffold in signaling networks. P Defilippi, P Di Stefano, S Cabodi, Trends Cell Biol 2006 16 257 263 16581250
92. Tyrosine-phosphorylated epidermal growth factor receptor and cellular p130 provide high affinity binding substrates to analyze Crk-phosphotyrosine- dependent interactions in vitro. RB Birge, JE Fajardo, BJ Mayer, H Hanafusa, J Biol Chem 1992 267 10588 10595 1375224
93. Ornithine decarboxylase- and ras-induced cell transformations: reversal by protein tyrosine kinase inhibitors and role of pp130CAS. M Auvinen, A Paasinen-Sohns, H Hirai, LC Andersson, E Holtta, Mol Cell Biol 1995 15 6513 6525 8524216
94. Cardiovascular anomaly, impaired actin bundling and resistance to Src-induced transformation in mice lacking p130Cas. H Honda, H Oda, T Nakamoto, Z Honda, R Sakai, T Suzuki, T Saito, K Nakamura, K Nakao, T Ishikawa, M Katsuki, Y Yazaki, H Hirai, Nat Genet 1998 19 361 365 9697697
95. p130Cas as a new regulator of mammary epithelial cell proliferation survival, and HER2-neu oncogene-dependent breast tumorigenesis. S Cabodi, A Tinnirello, P Di Stefano, B Bisaro, E Ambrosino, I Castellano, A Sapino, R Arisio, F Cavallo, G Forni, M Glukhova, L Silengo, F Altruda, E Turco, G Tarone, P Defilippi, Cancer Res 2006 66 4672 4680 16651418
96. Breast cancer antiestrogen resistance-3 expression regulates breast cancer cell migration through promotion of p130Cas membrane localization and membrane ruffling. RS Schrecengost, RB Riggins, KS Thomas, MS Guerrero, AH Bouton, Cancer Res 2007 67 6174 6182 17616674
97. A novel association between p130Cas and resistance to the chemotherapeutic drug adriamycin in human breast cancer cells. HQ Ta, KS Thomas, RS Schrecengost, AH Bouton, Cancer Res 2008 68 8796 8804 18974122
98. Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeleton. D Barkan, H Kleinman, JL Simmons, H Asmussen, AK Kamaraju, MJ Hoenorhoff, ZY Liu, SV Costes, EH Cho, S Lockett, C Khanna, AF Chambers, JE Green, Cancer Res 2008 68 6241 6250 18676848
99. A p130Cas tyrosine phosphorylated substrate domain decoy disrupts v-crk signaling. K Kirsch, M Kensinger, H Hanafusa, A August, BMC Cell Biol 2002 3 18 12119061
100. Crk-associated substrate (Cas) signaling protein functions with integrins to specify axon guidance during development. Z Huang, U Yazdani, KL Thompson-Peer, AL Kolodkin, JR Terman, Development 2007 134 2337 2347 17537798
101. v-Crk-induced cell transformation: changes in focal adhesion composition and signaling. MG Nievers, RB Birge, H Greulich, AJ Verkleij, H Hanafusa, PM van Bergen en Henegouwen, J Cell Sci 1997 110 Pt 3 389 399 9057091
102. Focal adhesion targeting of v-Crk is essential for FAK phosphorylation and cell migration in mouse embryo fibroblasts deficient src family kinases or p130CAS. MG Yeo, BH Sung, HJ Oh, ZY Park, EE Marcantonio, WK Song, J Cell Physiol 2008 214 3 604 13 17786957
103. Processive phosphorylation of p130Cas by Src depends on SH3-polyproline interactions. P Pellicena, WT Miller, J Biol Chem 2001 276 28190 28196 11389136
104. Individual Cas phosphorylation sites are dispensable for processive phosphorylation by Src and anchorage-independent cell growth. P Patwardhan, Y Shen, GS Goldberg, WT Miller, J Biol Chem 2006 281 20689 20697 16707485
105. Identification of p130Cas as a mediator of focal adhesion kinase-promoted cell migration. LA Cary, DC Han, TR Polte, SK Hanks, JL Guan, J Cell Biol 1998 140 211 221 9425168
106. Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130Cas. TR Polte, SK Hanks, Proc Natl Acad Sci USA 1995 92 10678 10682 7479864
107. The related adhesion focal tyrosine kinase is tyrosine-phosphorylated after beta1-integrin stimulation in B cells and binds to p130cas. A Astier, H Avraham, SN Manie, J Groopman, T Canty, S Avraham, AS Freedman, J Biol Chem 1997 272 228 232 8995252
108. Regulation of integrin-mediated cellular responses through assembly of a CAS/Crk scaffold. D Chodniewicz, RL Klemke, Biochim Biophys Acta 2004 1692 63 76 15246680
109. Phosphorylation of p130Cas initiates Rac activation and membrane ruffling. A Sharma, BJ Mayer, BMC Cell Biol 2008 9 50 18793427
110. Functional analysis of Src homology 3-encoding exon (exon 2) of p130Cas in primary fibroblasts derived from exon 2-specific knockout mice. T Tazaki, K Miyazaki, E Hiyama, T Nakamoto, R Sakai, N Yamasaki, Z Honda, M Noda, N Miyasaka, T Sueda, H Honda, Genes Cells 2008 13 145 157 18233957
111. Identification and characterization of a high-affinity interaction between v-Crk and tyrosine-phosphorylated paxillin in CT10-transformed fibroblasts. RB Birge, JE Fajardo, C Reichman, SE Shoelson, Z Songyang, LC Cantley, H Hanafusa, Mol Cell Biol 1993 13 4648 4656 7687742
112. Adaptor molecule Crk is required for sustained phosphorylation of Grb2-associated binder 1 and hepatocyte growth factor-induced cell motility of human synovial sarcoma cell lines. T Watanabe, M Tsuda, Y Makino, S Ichihara, H Sawa, A Minami, N Mochizuki, K Nagashima, S Tanaka, Mol Cancer Res 2006 4 499 510 16849525
113. A switch from p130Cas/Crk to Gab1/Crk signaling correlates with anchorage independent growth and JNK activation in cells transformed by the Met receptor oncoprotein. L Lamorte, DM Kamikura, M Park, Oncogene 2000 19 5973 5981 11146548
114. C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins. S Tanaka, T Morishita, Y Hashimoto, S Hattori, S Nakamura, M Shibuya, K Matuoka, T Takenawa, T Kurata, K Nagashima, et al. Proc Natl Acad Sci USA 1994 91 3443 3447 7512734
115. Four proline-rich sequences of the guanine-nucleotide exchange factor C3G bind with unique specificity to the first Src homology 3 domain of Crk. BS Knudsen, SM Feller, H Hanafusa, J Biol Chem 1994 269 32781 32787 7806500
116. Identification of Rap1 as a target for the Crk SH3 domain-binding guanine nucleotide-releasing factor C3G. T Gotoh, S Hattori, S Nakamura, H Kitayama, M Noda, Y Takai, K Kaibuchi, H Matsui, O Hatase, H Takahashi, et al. Mol Cell Biol 1995 15 6746 6753 8524240
117. Mitogenic and oncogenic properties of the small G protein Rap1b. DL Altschuler, F Ribeiro-Neto, Proc Natl Acad Sci USA 1998 95 7475 7479 9636174
118. Microinjection of smg/rap1/Krev-1 p21 into Swiss 3T3 cells induces DNA synthesis and morphological changes. Y Yoshida, M Kawata, Y Miura, T Musha, T Sasaki, A Kikuchi, Y Takai, Mol Cell Biol 1992 12 3407 3414 1321333
119. Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice. D Ishida, K Kometani, H Yang, K Kakugawa, K Masuda, K Iwai, M Suzuki, S Itohara, T Nakahata, H Hiai, H Kawamoto, M Hattori, N Minato, Cancer Cell 2003 4 55 65 12892713
120. Spa-1 (Sipa1) and Rap signaling in leukemia and cancer metastasis. N Minato, M Hattori, Cancer Sci 2009 100 1 17 23 Epub 2008 Nov 24 19037996
121. Development of Notch-dependent T-cell leukemia by deregulated Rap1 signaling. SF Wang, M Aoki, Y Nakashima, Y Shinozuka, H Tanaka, M Taniwaki, M Hattori, N Minato, Blood 2008 111 2878 2886 18180377
122. Downstream of Crk adaptor signaling pathway: activation of Jun kinase by v-Crk through the guanine nucleotide exchange protein C3G. S Tanaka, T Ouchi, H Hanafusa, Proc Natl Acad Sci USA 1997 94 2356 2361 9122199
123. Guanine-nucleotide exchange protein C3G activates JNK1 by a ras-independent mechanism. JNK1 activation inhibited by kinase negative forms of MLK3 and DLK mixed lineage kinases. S Tanaka, H Hanafusa, J Biol Chem 1998 273 1281 1284 9430657
124. RET/papillary thyroid carcinoma oncogenic signaling through the Rap1 small GTPase. V De Falco, MD Castellone, G De Vita, AM Cirafici, JM Hershman, C Guerrero, A Fusco, RM Melillo, M Santoro, Cancer Res 2007 67 381 390 17210721
125. C3G mediated suppression of malignant transformation involves activation of PP2A phosphatases at the subcortical actin cytoskeleton. S Martin-Encabo, E Santos, C Guerrero, Exp Cell Res 2007 313 3881 3891 17825818
126. Characterization of p87C3G, a novel, truncated C3G isoform that is overexpressed in chronic myeloid leukemia and interacts with Bcr-Abl. J Gutierrez-Berzal, E Castellano, S Martin-Encabo, N Gutierrez-Cianca, JM Hernandez, E Santos, C Guerrero, Exp Cell Res 2006 312 938 948 16443220
127. Linking Rap to cell adhesion. JL Bos, Curr Opin Cell Biol 2005 17 123 128 15780587
128. Rap1 is a potent activation signal for leukocyte function-associated antigen 1 distinct from protein kinase C and phosphatidylinositol-3-OH kinase. K Katagiri, M Hattori, N Minato, S Irie, K Takatsu, T Kinashi, Mol Cell Biol 2000 20 1956 1969 10688643
129. RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion. EM Lafuente, AA van Puijenbroek, M Krause, CV Carman, GJ Freeman, A Berezovskaya, E Constantine, TA Springer, FB Gertler, VA Boussiotis, Dev Cell 2004 7 585 595 15469846
130. Rap1 regulates the formation of E-cadherin-based cell-cell contacts. C Hogan, N Serpente, P Cogram, CR Hosking, CU Bialucha, SM Feller, VM Braga, W Birchmeier, Y Fujita, Mol Cell Biol 2004 24 6690 6700 15254236
131. Activation of C3G guanine nucleotide exchange factor for Rap1 by phosphorylation of tyrosine 504. T Ichiba, Y Hashimoto, M Nakaya, Y Kuraishi, S Tanaka, T Kurata, N Mochizuki, M Matsuda, J Biol Chem 1999 274 14376 14381 10318861
132. Phosphorylated guanine nucleotide exchange factor C3G, induced by pervanadate and Src family kinases localizes to the Golgi and subcortical actin cytoskeleton. V Radha, A Rajanna, G Swarup, BMC Cell Biol 2004 5 31 15320955
133. Rap1 mediates sustained MAP kinase activation induced by nerve growth factor. RD York, H Yao, T Dillon, CL Ellig, SP Eckert, EW McCleskey, PJ Stork, Nature 1998 392 622 626 9560161
134. An SH3-SH2-SH3 protein is required for p21Ras1 activation and binds to sevenless and Sos proteins in vitro. MA Simon, GS Dodson, GM Rubin, Cell 1993 73 169 177 8462097
135. Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. P Chardin, JH Camonis, NW Gale, L van Aelst, J Schlessinger, MH Wigler, D Bar-Sagi, Science 1993 260 1338 1343 8493579
136. Mechanisms through which Sos-1 coordinates the activation of Ras and Rac. M Innocenti, P Tenca, E Frittoli, M Faretta, A Tocchetti, PP Di Fiore, G Scita, J Cell Biol 2002 156 125 136 11777939
137. Genotype differences in cognitive functioning in Noonan syndrome. EI Pierpont, ME Pierpont, NJ Mendelsohn, AE Roberts, E Tworog-Dube, MS Seidenberg, Genes Brain Behav 2009 8 3 275 82 Epub 2008 Dec 11 19077116
138. Germline gain-of-function mutations in SOS1 cause Noonan syndrome. AE Roberts, T Araki, KD Swanson, KT Montgomery, TA Schiripo, VA Joshi, L Li, Y Yassin, AM Tamburino, BG Neel, RS Kucherlapati, Nat Genet 2007 39 70 74 17143285
139. DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane. H Hasegawa, E Kiyokawa, S Tanaka, K Nagashima, N Gotoh, M Shibuya, T Kurata, M Matsuda, Mol Cell Biol 1996 16 1770 1776 8657152
140. Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins. M Matsuda, S Ota, R Tanimura, H Nakamura, K Matuoka, T Takenawa, K Nagashima, T Kurata, J Biol Chem 1996 271 14468 14472 8662907
141. Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex. E Brugnera, L Haney, C Grimsley, M Lu, SF Walk, AC Tosello-Trampont, IG Macara, H Madhani, GR Fink, KS Ravichandran, Nat Cell Biol 2002 4 574 582 12134158
142. PH domain of ELMO functions in trans to regulate Rac activation via Dock180. M Lu, JM Kinchen, KL Rossman, C Grimsley, C deBakker, E Brugnera, AC Tosello-Trampont, LB Haney, D Klingele, J Sondek, MO Hengartner, KS Ravichandran, Nat Struct Mol Biol 2004 11 756 762 15247908
143. BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module. D Park, AC Tosello-Trampont, MR Elliott, M Lu, LB Haney, Z Ma, AL Klibanov, JW Mandell, KS Ravichandran, Nature 2007 450 430 434 17960134
144. Phagocytosis of apoptotic cells is regulated by a UNC-73/TRIO-MIG-2/RhoG signaling module and armadillo repeats of CED-12/ELMO. CD deBakker, LB Haney, JM Kinchen, C Grimsley, M Lu, D Klingele, PK Hsu, BK Chou, LC Cheng, A Blangy, J Sondek, MO Hengartner, YC Wu, KS Ravichandran, Curr Biol 2004 14 2208 2216 15620647
145. Elmo1 inhibits ubiquitylation of Dock180. Y Makino, M Tsuda, S Ichihara, T Watanabe, M Sakai, H Sawa, K Nagashima, S Hatakeyama, S Tanaka, J Cell Sci 2006 119 923 932 16495483
146. Evidence that DOCK180 up-regulates signals from the CrkII-p130(Cas) complex. E Kiyokawa, Y Hashimoto, T Kurata, H Sugimura, M Matsuda, J Biol Chem 1998 273 24479 24484 9733740
147. Identification of two signaling submodules within the CrkII/ELMO/Dock180 pathway regulating engulfment of apoptotic cells. AC Tosello-Trampont, JM Kinchen, E Brugnera, LB Haney, MO Hengartner, KS Ravichandran, Cell Death Differ 2007 14 963 972 17304244
148. C-terminal SH3 domain of CrkII regulates the assembly and function of the DOCK180/ELMO Rac-GEF. S Akakura, B Kar, S Singh, L Cho, N Tibrewal, R Sanokawa-Akakura, C Reichman, KS Ravichandran, RB Birge, J Cell Physiol 2005 204 344 351 15700267
149. Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity. JF Cote, K Vuori, J Cell Sci 2002 115 4901 4913 12432077
150. GEF what? Dock180 and related proteins help Rac to polarize cells in new ways. JF Cote, K Vuori, Trends Cell Biol 2007 17 383 393 17765544
151. CZH proteins: a new family of Rho-GEFs. N Meller, S Merlot, C Guda, J Cell Sci 2005 118 4937 4946 16254241
152. DOCK5 and DOCK1 Regulate Caco-2 Intestinal Epithelial Cell Spreading and Migration on Collagen IV. MA Sanders, D Ampasala, MD Basson, J Biol Chem 2009 284 27 35 19004829
153. DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines. H Nishihara, M Maeda, A Oda, M Tsuda, H Sawa, K Nagashima, S Tanaka, Blood 2002 100 3968 3974 12393632
154. The atypical Rac activator Dock180 (Dock1) regulates myoblast fusion in vivo. M Laurin, N Fradet, A Blangy, A Hall, K Vuori, JF Cote, Proc Natl Acad Sci USA 2008 105 15446 15451 18820033
155. A direct interaction between JNK1 and CrkII is critical for Rac1-induced JNK activation. SE Girardin, M Yaniv, Embo J 2001 20 3437 3446 11432831
156. Integrin-mediated activation of focal adhesion kinase is required for signaling to Jun NH2-terminal kinase and progression through the G1 phase of the cell cycle. M Oktay, KK Wary, M Dans, RB Birge, FG Giancotti, J Cell Biol 1999 145 1461 1469 10385525
157. PVR plays a critical role via JNK activation in thorax closure during Drosophila metamorphosis. S Ishimaru, R Ueda, Y Hinohara, M Ohtani, H Hanafusa, Embo J 2004 23 3984 3994 15457211
158. Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding sites. R Ren, ZS Ye, D Baltimore, Genes Dev 1994 8 783 795 7926767
159. A crucial role in cell spreading for the interaction of Abl PxxP motifs with Crk and Nck adaptors. S Antoku, K Saksela, GM Rivera, BJ Mayer, J Cell Sci 2008 121 3071 3082 18768933
160. Integrins regulate the association and phosphorylation of paxillin by c-Abl. JM Lewis, MA Schwartz, J Biol Chem 1998 273 14225 14230 9603926
161. Nuclear-cytoplasmic shuttling of C-ABL tyrosine kinase. S Taagepera, D McDonald, JE Loeb, LL Whitaker, AK McElroy, JY Wang, TJ Hope, Proc Natl Acad Sci USA 1998 95 7457 7462 9636171
162. Abl tyrosine kinases regulate cell-cell adhesion through Rho GTPases. NL Zandy, M Playford, AM Pendergast, Proc Natl Acad Sci USA 2007 104 17686 17691 17965237
163. Abl-dependent tyrosine phosphorylation of Sos-1 mediates growth-factor-induced Rac activation. P Sini, A Cannas, AJ Koleske, PP Di Fiore, G Scita, Nat Cell Biol 2004 6 268 274 15039778
164. Crk family adaptor proteins trans-activate c-Abl kinase. T Shishido, T Akagi, A Chalmers, M Maeda, T Terada, MM Georgescu, H Hanafusa, Genes Cells 2001 6 431 440 11380621
165. Transactivation of Abl by the Crk II adapter protein requires a PNAY sequence in the Crk C-terminal SH3 domain. C Reichman, K Singh, Y Liu, S Singh, H Li, JE Fajardo, A Fiser, RB Birge, Oncogene 2005 24 8187 8199 16158059
166. Mitotic phosphorylation rescues Abl from F-actin-mediated inhibition. PJ Woodring, T Hunter, JY Wang, J Biol Chem 2005 280 10318 10325 15632178
167. A potential SH3 domain-binding site in the Crk SH2 domain. M Anafi, MK Rosen, GD Gish, LE Kay, T Pawson, J Biol Chem 1996 271 21365 21374 8702917
168. Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide. LW Donaldson, G Gish, T Pawson, LE Kay, JD Forman-Kay, Proc Natl Acad Sci USA 2002 99 14053 14058 12384576
169. Induction of cell retraction by the combined actions of Abl-CrkII and Rho-ROCK1 signaling. X Huang, D Wu, H Jin, D Stupack, JY Wang, J Cell Biol 2008 183 711 723 19001122
170. Abl functions as a negative regulator of Met-induced cell motility via phosphorylation of the adapter protein CrkII. A Cipres, YA Abassi, K Vuori, Cell Signal 2007 19 1662 1670 17399949
171. Inhibitory receptor signaling via tyrosine phosphorylation of the adaptor Crk. ME Peterson, EO Long, Immunity 2008 29 578 588 18835194
172. Tyrosine 221 in Crk regulates adhesion-dependent membrane localization of Crk and Rac and activation of Rac signaling. YA Abassi, K Vuori, Embo J 2002 21 4571 4582 12198159
173. Phosphorylation of c-Crk II on the negative regulatory Tyr222 mediates nerve growth factor-induced cell spreading and morphogenesis. M Escalante, J Courtney, WG Chin, KK Teng, JI Kim, JE Fajardo, BJ Mayer, BL Hempstead, RB Birge, J Biol Chem 2000 275 24787 24797 10825157
174. Structural basis for the specific interaction of lysine-containing proline-rich peptides with the N-terminal SH3 domain of c-Crk. X Wu, B Knudsen, SM Feller, J Zheng, A Sali, D Cowburn, H Hanafusa, J Kuriyan, Structure 1995 3 215 226 7735837
175. The C-terminal SH3 domain of CRKL as a dynamic dimerization module transiently exposing a nuclear export signal. M Harkiolaki, RJ Gilbert, EY Jones, SM Feller, Structure 2006 14 1741 1753 17161365
176. Solution structure and folding characteristics of the C-terminal SH3 domain of c-Crk-II. V Muralidharan, K Dutta, J Cho, M Vila-Perello, DP Raleigh, D Cowburn, TW Muir, Biochemistry 2006 45 8874 8884 16846230
177. Moving parts: how the adaptor protein CRK is regulated, and regulates. D Cowburn, Nat Struct Mol Biol 2007 14 465 466 17549081
178. Proline cis-trans isomerization controls autoinhibition of a signaling protein. P Sarkar, C Reichman, T Saleh, RB Birge, CG Kalodimos, Mol Cell 2007 25 413 426 17289588
179. Constitutive association of EGF receptor with the CrkII-23 mutant that inhibits transformation of NRK cells by EGF and TGF-beta. S Ota, S Kizaka-Kondoh, Y Hashimoto, H Nishihara, K Nagashima, T Kurata, H Okayama, M Matsuda, Cell Signal 1998 10 283 290 9617486
180. Activation of the focal adhesion kinase signaling pathway by structural alterations in the carboxyl-terminal region of c-Crk II. A Zvara, JE Fajardo, M Escalante, G Cotton, T Muir, KH Kirsch, RB Birge, Oncogene 2001 20 951 961 11314030
181. Apoptotic regulation by the Crk adapter protein mediated by interactions with Wee1 and Crm1/exportin. JJ Smith, DA Richardson, J Kopf, M Yoshida, RE Hollingsworth, S Kornbluth, Mol Cell Biol 2002 22 1412 1423 11839808
182. Proapoptotic function of the nuclear Crk II adaptor protein. B Kar, CT Reichman, S Singh, JP O'Connor, RB Birge, Biochemistry 2007 46 10828 10840 17764157
183. The ins and outs of programmed cell death during C. elegans development. MO Hengartner, HR Horvitz, Philos Trans R Soc Lond B Biol Sci 1994 345 243 246 7846120
184. Genetics of programmed cell death in C. elegans: past, present and future. MM Metzstein, GM Stanfield, HR Horvitz, Trends Genet 1998 14 410 416 9820030
185. Apoptosis: corralling the corpses. MO Hengartner, Cell 2001 104 325 328 11239389
186. Cas, Fak and Pyk2 function in diverse signaling cascades to promote Yersinia uptake. PJ Bruce-Staskal, CL Weidow, JJ Gibson, AH Bouton, J Cell Sci 2002 115 2689 2700 12077360
187. Uncoupling Crk signal transduction by Pseudomonas exoenzyme T. Q Deng, J Sun, JT Barbieri, J Biol Chem 2005 280 35953 35960 16123042
188. RNAi screen reveals an Abl kinase-dependent host cell pathway involved in Pseudomonas aeruginosa internalization. JF Pielage, KR Powell, D Kalman, JN Engel, PLoS Pathog 2008 4 1000031 18369477
189. Avian and 1918 Spanish influenza a virus NS1 proteins bind to Crk/CrkL Src homology 3 domains to activate host cell signaling. LS Heikkinen, A Kazlauskas, K Melen, R Wagner, T Ziegler, I Julkunen, K Saksela, J Biol Chem 2008 283 5719 5727 18165234
190. Increased C-CRK proto-oncogene expression is associated with an aggressive phenotype in lung adenocarcinomas. CT Miller, G Chen, TG Gharib, H Wang, DG Thomas, DE Misek, TJ Giordano, J Yee, MB Orringer, SM Hanash, DG Beer, Oncogene 2003 22 7950 7957 12970743
191. CrkI adapter protein modulates cell migration and invasion in glioblastoma. T Takino, M Nakada, H Miyamori, J Yamashita, KM Yamada, H Sato, Cancer Res 2003 63 2335 2337 12727859
192. Involvement of adaptor protein Crk in malignant feature of human ovarian cancer cell line MCAS. H Linghu, M Tsuda, Y Makino, M Sakai, T Watanabe, S Ichihara, H Sawa, K Nagashima, N Mochizuki, S Tanaka, Oncogene 2006 25 3547 3556 16491127
193. Signaling adaptor protein Crk is indispensable for malignant feature of glioblastoma cell line KMG4. L Wang, K Tabu, T Kimura, M Tsuda, H Linghu, M Tanino, S Kaneko, H Nishihara, S Tanaka, Biochem Biophys Res Commun 2007 362 976 981 17825249
194. Molecular and immunohistochemical analysis of signaling adaptor protein Crk in human cancers. H Nishihara, S Tanaka, M Tsuda, S Oikawa, M Maeda, M Shimizu, H Shinomiya, A Tanigami, H Sawa, K Nagashima, Cancer Lett 2002 180 55 61 11911970
195. MicroRNA-126 inhibits invasion in non-small cell lung carcinoma cell lines. M Crawford, E Brawner, K Batte, L Yu, MG Hunter, GA Otterson, G Nuovo, CB Marsh, SP Nana-Sinkam, Biochem Biophys Res Commun 2008 373 607 612 18602365
196. ELMO1 and Dock180, a bipartite Rac1 guanine nucleotide exchange factor, promote human glioma cell invasion. MJ Jarzynka, B Hu, KM Hui, I Bar-Joseph, W Gu, T Hirose, LB Haney, KS Ravichandran, R Nishikawa, SY Cheng, Cancer Res 2007 67 7203 7211 17671188
197. Amplification, up-regulation and over-expression of C3G (CRK SH3 domain-binding guanine nucleotide-releasing factor) in non-small cell lung cancers. T Hirata, H Nagai, K Koizumi, K Okino, A Harada, M Onda, T Nagahata, I Mikami, K Hirai, S Haraguchi, E Jin, O Kawanami, K Shimizu, M Emi, J Hum Genet 2004 49 290 295 15138850
198. Involvement of the c-Src-Crk-C3G-Rap1 signaling in the nectin-induced activation of Cdc42 and formation of adherens junctions. T Fukuyama, H Ogita, T Kawakatsu, T Fukuhara, T Yamada, T Sato, K Shimizu, T Nakamura, M Matsuda, Y Takai, J Biol Chem 2005 280 815 825 15504743
199. Physiological signals and oncogenesis mediated through Crk family adapter proteins. SM Feller, G Posern, J Voss, C Kardinal, D Sakkab, J Zheng, BS Knudsen, J Cell Physiol 1998 177 535 552 10092207
200. Crkl is the major tyrosine-phosphorylated protein in neutrophils from patients with chronic myelogenous leukemia. T Oda, C Heaney, JR Hagopian, K Okuda, JD Griffin, BJ Druker, J Biol Chem 1994 269 22925 22928 8083188
201. CRKL links p210BCR/ABL with paxillin in chronic myelogenous leukemia cells. R Salgia, N Uemura, K Okuda, JL Li, E Pisick, M Sattler, R de Jong, B Druker, N Heisterkamp, LB Chen, et al. J Biol Chem 1995 270 29145 29150 7493940
202. Thrombopoietin induces association of Crkl with STAT5 but not STAT3 in human platelets. K Ozaki, A Oda, H Wakao, J Rhodes, BJ Druker, A Ishida, M Wakui, S Okamoto, K Morita, M Handa, et al. Blood 1998 92 4652 4662 9845531
203. CrkL functions as a nuclear adaptor and transcriptional activator in Bcr-Abl-expressing cells. J Rhodes, RD York, D Tara, K Tajinda, BJ Druker, Exp Hematol 2000 28 305 310 10720695
204. The CrkL adapter protein is required for type I interferon-dependent gene transcription and activation of the small G-protein Rap1. F Lekmine, A Sassano, S Uddin, B Majchrzak, O Miura, BJ Druker, EN Fish, A Imamoto, LC Platanias, Biochem Biophys Res Commun 2002 291 744 750 11866427
205. Role of Stat5 in type I interferon-signaling and transcriptional regulation. S Uddin, F Lekmine, A Sassano, H Rui, EN Fish, LC Platanias, Biochem Biophys Res Commun 2003 308 325 330 12901872
206. Wee1-regulated apoptosis mediated by the crk adaptor protein in Xenopus egg extracts. JJ Smith, EK Evans, M Murakami, MB Moyer, MA Moseley, GV Woude, S Kornbluth, J Cell Biol 2000 151 1391 1400 11134069