Amplification, up-regulation and over-expression of C3G (CRK SH3 domain-binding guanine nucleotide-releasing factor) in non-small cell lung cancers

Journal of Human Genetics

Volumn 49, Issue 6, 2004, Pages 290-295

  Hirata, Tomomi ^a   Nagai, Hisaki ^a   Koizumi, Kiyoshi ^a   Okino, Keiko ^a   Harada, Akima ^a   Onda, Masamitsu ^a   Nagahata, Takemitsu ^a   Mikami, Iwao ^a   Hirai, Kyoji ^a   Haraguchi, Syuji ^a   Jin, Enjing ^a   Kawanami, Oichi ^a   Shimizu, Kazuo ^a   Emi, Mitsuru ^a  

^a NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

Allelic imbalance; C3G, CRK SH3 domain binding guanine nucleotide releasing factor; Gene amplification; Immunohistochemistry; MRNA expression; NSCLC, non small cell lung cancer

Indexed keywords

ADAPTOR PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; MESSENGER RNA; MICROSATELLITE DNA; PROTEIN C3G; PROTEIN CRK; RAP PROTEIN; RAS PROTEIN; UNCLASSIFIED DRUG; CRK PROTEIN, HUMAN; DNA; ONCOPROTEIN; RAP1 PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; VESICULAR TRANSPORT ADAPTOR PROTEIN;

ADULT; AGED; ALLELE; ARTICLE; BRONCHIOLE; BRONCHUS MUCOSA; CHROMOSOME 9Q; CONTROLLED STUDY; CYTOPLASM; FEMALE; GENE AMPLIFICATION; GENE CONTROL; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LUNG ALVEOLUS CELL; LUNG CARCINOGENESIS; LUNG NON SMALL CELL CANCER; MALE; MULTIGENE FAMILY; NUCLEOLUS; NUCLEOTIDE SEQUENCE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAIN; BIOSYNTHESIS; CHEMISTRY; CHROMOSOME 9; GENE DOSAGE; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; LUNG TUMOR; METABOLISM; MIDDLE AGED; TUMOR CELL LINE; UPREGULATION;

BRONCHUS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADAPTOR PROTEINS, VESICULAR TRANSPORT; ADULT; AGED; AGED, 80 AND OVER; ALLELES; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL NUCLEOLUS; CHROMOSOMES, HUMAN, PAIR 9; CYTOPLASM; DNA; FEMALE; GENE DOSAGE; GENE EXPRESSION REGULATION, NEOPLASTIC; GUANINE NUCLEOTIDE-RELEASING FACTOR 2; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; PROTO-ONCOGENE PROTEINS C-CRK; RAP1 GTP-BINDING PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 3042721497     PISSN: 14345161     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10038-004-0148-1     Document Type: Article

References (24)

1. Alberg AJ, Samet JM (2003) Epidemiology of non-small cell lung cancer. Chest 123:21S-49S
2. Bourne HR (1990) The GTPase superfamily: a conserved switch for diverse cell functions. Nature 348:125-132
3. Campbell SL, Khosravi-Far R, Rossmann KL, Clark GJ, Der CJ (1998) Increasing complexity of Ras signaling, Oncogene 17:1395-1413
4. Chengbiao W, Chun-Fai L, William CM (2001) Nerve growth factor activates persistent Rap1 signaling in endosomes. J Neurosci 21(15):5406-5416
5. Downward J (1992) Regulation of p21ras by GTPase activating proteins and guanine nucleotide exchange proteins. Curr Opin Genet Dev 2(1):13-18 (review)
6. Fujiwara Y, Monden M, Mori T, Nakamura Y, Emi M (1993) Frequent multiplication of the long arm of chromosome 8 in hepatocellular carcinoma. Cancer Res 53:857-860
7. Kitayama H, Sugimoto Y, Matsuzaki T, Ikawa Y, Noda M (1989) A ras-related gene with transformation suppressor activity. Cell 56:77-84
8. Knudsen BS, Feller MS, Hanafusa H (1994) Four proline-rich sequences of the guanine-nucleotide exchange factor C3G bind with unique specificity to the first Src Homology 3 domain of Crk. J Biol Chem 269:32781-32787
9. Kumar R, Sukumar S, Barbacid M (1990) Activation of ras oncogenes preceding the onset of neoplasia. Science 248:1101-1104
10. Li Z-H, Zheng J, Weiss LM, Shibata D (1994) c-K-ras and p53 mutations occur very early in adenocarcinoma of the lung. Am J Pathol 144:3039
11. Mochizuki N, Ohba Y, Kobayashi S (1999) CRK activation of JNK via C3G and R-Ras. J Biol Chem 274(53):37525-37532
12. Nishihara H, Tanaka S, Tsuda M, Oikawa S, Maeda M, Shimizu M, Shinomiya H, Tanigami A, Sawa Hirofumi, Nagashima K (2002) Molecular and immunohistochemical analysis of signaling adaptor protein CRK in human cancers. Cancer Lett 180:55-61
13. Ohba Y, Mochizuki N, Matsuo K, Yamashita S, Nakaya N, Hashimoto Y, Hamaguchi M, Kurata T, Nagashima K, Matsuda M (2000) Rap2 as a slowly responding molecular switch in the Rap1 signaling cascade. Mol Cell Biol 20:6047-6083
14. Ohba Y, Ikuta K, Ogura A, Matsuda J, Mochizuki N, Nagashima K, Kurokawa K, Bruce JM, Maki K, Miyazaki J, Matsuda M (2001) Requiment for C3G-depemdent Rap1 activation to cell adhesion and embryogenesis. Eur Mol Biol Organ 20:3333-3341
15. Rodenhuis S, Slebos RJ (1992) Clinical significance of ras oncogene activation in human non-small cell lung cancer. Cancer Res 52:2665-2669
16. Sakoda T, Kaibuchi K, Kishi K, Kishida S, Doi K, Hoshino M, Hattori S, Takai Y (1992) smg/rap1/kreb-1 p21s inhibit the signal pathway to the c-fos promoter/enhancer from c-ki-ras p21 but not from c-faf-1 kinase in NIH3T3 cells. Oncogene 7:1705-1711
17. Sato T, Tanigami A, Yamakawa K, Akiyama F, Kasumi F, Sakamoto G, Nakamura Y (1990) Allelotype of breast cancer: cumulative allele losses promote tumor progression in primary breast cancer. Cancer Res 50:7184-7189
18. Tsukamoto K, Yoshimoto M, Kasumi F, Akiyama F, Sakamoto G, Nakamura Y, Emi M (1999) Frequent multiplication of chromosome 1q in non-invasive and papillotubular carcinoma of the breast. Cancer Lett 141:21-28
19. Tanaka S, Morishita T, Hashimoto Y, Hattori S, Nakamura S, Shibuya M, Matuoka K, Takenawa T, Kurata T, Nagashima K, Matsuda M (1994) C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and CRB2/ASH proteins. Proc Natl Acad Sci USA 91:3443-3447
20. Uemura N, Griffin TD (2000) The adaptor protein Crk1 links Cb1 to C3G after integrin ligation and enhances cell migration. J Biol Chem 275(17):12667-12671
21. Vossler MR (1997) cAMP activates MAP kinase and Elk-1 through a B-Raf and Rap1-dependent pathway Cell 89:73-82
22. William HW (2000) Early glandular neoplasia of the lung. Respir Res 97(1):13-21 (review)
23. Yokota T, Yoshimoto M, Akiyama F, Sakamoto G, Kasumi F, Nakamura Y, Emi M (1999) Frequent multiplication of chromosomal region 8q24.1 associated with aggressive histologic types of breast cancers. Cancer Lett 139:7-13
24. York RD, Hong Y, Tara D, Cindy LE, Stephany PE, Edwin WM, Pillip JS (1998) Rap1 mediates sustained MAP kinase activation induced by nerve growth factor. Nature 392:622-626