Tyrosine 221 in Crk regulates adhesion-dependent membrane localization of Crk and Rac and activation of Rac signaling

EMBO Journal

Volumn 21, Issue 17, 2002, Pages 4571-4582

  Abassi, Yama A ^a   Vuori, Kristiina ^a  

^a BURNHAM INSTITUTE   (United States)

Author keywords

Adhesion; Crk; Integrin; Rac; Rho family GTPase

Indexed keywords

ADAPTOR PROTEIN; PAXILLIN; PROTEIN CRK; RAC PROTEIN; RHO FACTOR; STRESS ACTIVATED PROTEIN KINASE; TYROSINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ADHESION; CELL MEMBRANE TRANSPORT; CELL MIGRATION; CELL MOTILITY; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; GENE ACTIVATION; GENE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

AMINO ACID MOTIFS; ANIMALS; CELL ADHESION; CELL MEMBRANE; CELL MOVEMENT; CELL SURFACE EXTENSIONS; CERCOPITHECUS AETHIOPS; COS CELLS; CYTOSKELETAL PROTEINS; FIBRONECTINS; GUANINE NUCLEOTIDE-RELEASING FACTOR 2; GUANOSINE TRIPHOSPHATE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE SIGNALING SYSTEM; MEMBRANE PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASES; PAXILLIN; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TRANSPORT; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-CRK; RAC GTP-BINDING PROTEINS; RATS; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; STRUCTURE-ACTIVITY RELATIONSHIP; TYROSINE;

ANIMALIA;

EID: 0037009371     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdf446     Document Type: Article

References (41)

1. Vav2 is an activator of Cdc42, Rac1 and RhoA
2. A potential SH3 domain-binding site in the Crk SH2 domain
3. Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation
4. Insulin-like growth factor-I stimulates tyrosine phosphorylation of endogenous c-Crk
5. Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases
6. Sphingosine 1-phosphate stimulates tyrosine phosphorylation of Crk
7. Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway
8. The association of CRKII with C3G can be regulated by integrins and defines a novel means to regulate the mitogen-activated protein kinases
9. FAK accompanies cell adhesion to extracellular matrix: A role in cytoskeletal assembly
10. Regulation of cell contraction and membrane ruffling by distinct signals in migratory cells
11. Rho GTPases control migration and polarization of adhesion molecules and cytoskeletal ERM components in T lymphocytes
12. Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK
13. The adaptor protein Crk connects0 multiple cellular stimuli to the JNK signaling pathway
14. Phosphorylation of c-Crk II on the negative regulatory Tyr222 mediates nerve growth factor-induced cell spreading and morphogenesis
15. Crk family adaptors-signalling complex formation and biological roles
16. c-Abl kinase regulates the protein binding activity of c-Crk
17. Met-induced JNK activation is mediated by the adapter protein Crk and correlates with the Gab1-Crk signaling complex formation
18. A direct interaction between JNK1 and CrkII is critical for Racl-induced JNK activation
19. CED-12/ELMO, a novel member of the CrkII/Dock18O/Rac pathway, is required for phagocytosis and cell migration
20. Rho GTPases and the actin cytoskeleton
21. Cas, a substrate associated with v-Src and v-Crk, localizes to focal adhesions and binds to focal adhesion kinase
22. Phosphorylation of CrkII adaptor protein at tyrosine 221 by epidermal growth factor receptor
23. Inhibition of cell migration by Ab1 family tyrosine kinases through uncoupling of Crk-CAS complexes
24. cas with Crk and Grb2 adaptor proteins
25. Activation of Rac1 by a Crk SH3-binding protein, DOCK180
26. CAS/Crk coupling serves as a 'molecular switch' for induction of cell migration
27. Three C. elegans Rac proteins and several alternative Rac regulators control axon guidance, cell migration and apoptotic cell phagocytosis
28. Emerging components of the Crk oncogene product: The first identified adaptor protein
29. Cas, a Src homology 3-containing molecule having multiple Src homology 2-binding motifs
30. Insulin regulates the dynamic balance between Ras and Rap1 signaling by coordinating the assembly states of the Grb2-SOS and CrkII-C3G complexes
31. Adhesion-induced tyrosine phosphorylation of the p130 src substrate
32. CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegans
33. Phagocytosis promotes programmed cell death in C. elegans
34. Cas in PC-12 cells
35. Direct demonstration of an intramolecular SH2-phosphotyrosine interaction in the Crk protein
36. Fibronectin: Purification, immunochemical properties and biological activities
37. Multiple stimuli induce tyrosine phosphorylation of the Crk-binding sites of paxillin
38. Evidence for a conserved role for CRKII and Rac in engulfment of apoptotic cells
39. Cas and cortactin accompanies integrin-mediated cell adhesion to extracellular matrix
40. Membrane compartmentation is required for efficient T cell activation
41. Activation of the focal adhesion kinase signaling pathway by structural alterations in the carboxyl-terminal region of c-Crk II