Role of Stat5 in Type I interferon-signaling and transcriptional regulation

Biochemical and Biophysical Research Communications

Volumn 308, Issue 2, 2003, Pages 325-330

  Uddin, Shahab ^a   Lekmine, Fatima ^b   Sassano, Antonella ^b   Rui, Halgeir ^c   Fish, Eleanor N ^d,e   Platanias, Leonidas C ^b  

^a UNIVERSITY OF CHICAGO   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c GEORGETOWN UNIVERSITY   (United States)

^d UNIVERSITY HEALTH NETWORK   (Canada)

^e UNIVERSITY OF TORONTO   (Canada)

Author keywords

Interferon; Kinase; Phosphorylation; Serine; Signaling; Stat5; Transcription

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; ALPHA INTERFERON; BETA INTERFERON; INTERFERON; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN; PROTEIN SERINE KINASE; PROTEIN TYROSINE KINASE; SB 202580; SERINE; STAT5 PROTEIN; STAT5A PROTEIN; STAT5B PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG TARGETING; EMBRYO; ENZYME ACTIVITY; FIBROBLAST; GENE; GENETIC TRANSCRIPTION; HUMAN; HUMAN TISSUE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STAT5A GENE; STAT5B GENE; TRANSCRIPTION REGULATION;

EID: 0043095397     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(03)01382-2     Document Type: Article

References (34)

1. Pestka S., Langer J.A., Zoon K.C., Samuel C.E. Interferons and their actions. Annu. Rev. Biochem. 56:1987;727-777.
2. Darnell J.E., Kerr I.M., Stark G.R. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science. 264:1994;1415-1419.
3. Stark G.R., Kerr I.M., Williams B.R.G., Silverman R.H., Schreiber R.D. How cells respond to interferons. Annu. Rev. Biochem. 67:1998;227-232.
4. Platanias L.C., Fish E.N. Signaling pathways activated by interferons. Exp. Hematol. 27:1999;1583-1590.
5. Verma A., Kambhampati S., Parmar S., Platanias L.C. Jak family of kinases in cancer. Cancer Metastasis Rev. 22:2003;423-434.
6. Platanias L.C. The p38 mitogen-activated protein kinase pathway and its role in interferon signaling. Pharmacol. Ther. 98:2003;129-142.
7. Verma A., Platanias L.C. Signaling via the interferon-alpha receptor in chronic myelogenous leukemia cells. Leuk. Lymphoma. 43:2002;703-709.
8. ′ -kinase J. Biol. Chem. 270:1995;15938-15941.
9. Platanias L.C., Uddin S., Yetter A., Sun X., White M.F. The type I interferon receptor mediates tyrosine phosphorylation of insulin receptor substrate 2. J. Biol. Chem. 271:1996;278-282.
10. Uddin S., Fish E.N., Sher D., Gardziola C., White M.F., Platanias L.C. Activation of the phosphatidylinositol 3-kinase serine kinase by IFN-alpha. J. Immunol. 158:1997;2390-2397.
11. Uddin S., Fish E.N., Sher D., Gardziola C., Colamonici O.R., Kellum M., Pitha P.M., White M.F., Platanias L.C. The IRS-pathway operates distinctively from the Stat-pathway in hematopoietic cells and transduces common and distinct signals during engagement of the insulin or interferon-alpha receptors. Blood. 90:1997;2574-2582.
12. Uddin S., Majchrzak B., Woodson J., Arunkumar P., Alsayed Y., Pine R., Young P.R., Fish E.N., Platanias L.C. Activation of the p38 mitogen-activated protein kinase by type I interferons. J. Biol. Chem. 274:1999;30127-30131.
13. Uddin S., Lekmine F., Sharma N., Majchrzak B., Mayer I., Young P.R., Bokoch G.M., Fish E.N., Platanias L.C. The Rac1/p38 mitogen-activated protein kinase pathway is required for interferon alpha-dependent transcriptional activation but not serine phosphorylation of Stat proteins. J. Biol. Chem. 275:2000;27634-27640.
14. Verma A., Deb D.K., Sassano A., Uddin S., Varga J., Wickrema A., Platanias L.C. Activation of the p38 mitogen-activated protein kinase signaling pathway mediates cytokine-induced hemopoietic suppression in aplastic anemia. J. Biol. Chem. 277:2002;7726-7735.
15. Mayer I.A., Verma A., Grumbach I.M., Uddin S., Lekmine F., Ravandi F., Majchrzak B., Fujita S., Fish E.N., Platanias L.C. The p38 MAPK pathway mediates the growth inhibitory effects of interferon-alpha in BCR-ABL-expressing cells. J. Biol. Chem. 276:2001;28570-28577.
16. Platanias L.C. Map kinase signaling pathways and hematologic malignancies. Blood. 101:2003;4667-4679.
17. Ahmad S., Alsayed Y., Druker B.J., Platanias L.C. The type I interferon receptor mediates tyrosine phosphorylation of the CrkL adaptor protein. J. Biol. Chem. 272:1997;29991-29996.
18. Fish E.N., Uddin S., Korkmaz M., Majchrzak B., Druker B.J., Platanias L.C. Activation of a CrkL-stat5 signaling complex by type I interferons. J. Biol. Chem. 274:1999;571-573.
19. Alsayed Y., Uddin S., Majchrzak B., Druker B.J., Fish E.N., Platanias L.C. IFN-gamma activates the C3G/Rap1 signaling pathway. J. Immunol. 164:2000;1800-1806.
20. Lekmine F., Sassano A., Uddin S., Majchrzak B., Miura O., Druker B.J., Fish E.N., Imamoto A., Platanias L.C. The CrkL adapter protein is required for type I interferon-dependent gene transcription and activation of the small G-protein Rap1. Biochem. Biophys. Res. Commun. 291:2002;744-750.
21. Meinke A., Barahmand-Pour F., Wohrl S., Stoiber D., Decker T. Activation of different Stat5 isoforms contributes to cell-type-restricted signaling in response to interferons. Mol. Cell. Biol. 16:1996;6937-6944.
22. Uddin S., Sassano A., Deb D.K., Verma A., Majchrzak B., Rahman A., Malik A.B., Fish E.N., Platanias L.C. Protein kinase C-delta (PKC-delta ) is activated by type I interferons and mediates phosphorylation of Stat1 on serine 727. J. Biol. Chem. 277:2002;14408-14416.
23. Yamashita H., Xu J., Erwin R.A., Farrar W.L., Kirken R.A., Rui H. Differential control of the phosphorylation state of proline-juxtaposed serine residues Ser725 of Stat5a and Ser730 of Stat5b in prolactin-sensitive cells. J. Biol. Chem. 273:1998;30218-30224.
24. David M., Petricoin E., Benjamin C., Pine R., Weber M.J., Larner A.C. Requirement for MAP kinase (ERK2) activity in interferon alpha- and interferon beta-stimulated gene expression through STAT proteins. Science. 269:1995;1721-1723.
25. Teglund S., McKay C., Schuetz E., van Deursen J.M., Stravopodis D., Wang D., Brown M., Bodner S., Grosveld G., Ihle J.N. Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. Cell. 93:1998;841-850.
26. Oda A., Wakao H., Fujihara M., Ozaki K., Komatsu N., Tanaka S., Ikeda H., Miyajima A., Ikebuchi K. Thrombopoietin and interleukin-2 induce association of CRK with STAT5. Biochem. Biophys. Res. Commun. 278:2000;299-305.
27. Schulze H., Ballmaier M., Welte K., Germeshausen M. Thrombopoietin induces the generation of distinct Stat1, Stat3, Stat5a and Stat5b homo- and heterodimeric complexes with different kinetics in human platelets. Exp. Hematol. 28:2000;294-304.
28. Oda A., Sawada K., Druker B.J., Ozaki K., Takano H., Koizumi K., Fukada Y., Handa M., Koike T., Ikeda Y. Erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B in primary cultured human erythroid precursors. Blood. 92:1998;443-451.
29. Rhodes J., York R.D., Tara D., Tajinda K., Druker B.J. CrkL functions as a nuclear adaptor and transcriptional activator in BCR-ABL-expressing cells. Exp. Hematol. 28:2000;305-310.
30. Stadler M., Chelbi-Alix M.K., Koken M.H.M., Venturini L., Lee C., Saib A., Quignon F., Pelicano L., Guillemin M.-C., Schindler C., de Thé H. Transcriptional induction of the PML growth suppressor gene by interferons is mediated through an ISRE and a GAS element. Oncogene. 11:1995;2565-2573.
31. Grumbach I.M., Mayer I.A., Uddin S., Lekmine F., Majchrzak B., Yamauchi H., Fujita S., Druker B.J., Fish E.N., Platanias L.C. Engagement of the CrkL adaptor in interferon alpha signalling in BCR-ABL-expressing cells. Br. J. Haematol. 112:2001;327-336.
32. Kirken R.A., Malabarba M.G., Xu J., Liu X., Farrar W.L., Hennighausen L., Larner A.C., Grimley P.M., Rui H. Prolactin stimulates serine/tyrosine phosphorylation and formation of heterocomplexes of multiple Stat5 isoforms in Nb2 lymphocytes. J. Biol. Chem. 272:1997;14098-14103.
33. Kirken R.A., Malabarba M.G., Xu J., DaSilva L., Erwin R.A., Liu X., Hennighausen L., Rui H., Farrar W.L. Two discrete regions of interleukin-2 (IL2) receptor beta independently mediate IL2 activation of a PD98059/rapamycin/wortmannin-insensitive Stat5a/b serine kinase. J. Biol. Chem. 272:1997;15459-15465.
34. Park S.H., Yamashita H., Rui H., Waxman D.J. Serine phosphorylation of GH-activated signal transducer and activator of transcription 5a (STAT5a) and STAT5b: impact on STAT5 transcriptional activity. Mol. Endocrinol. 15:2001;2157-2171.