Parallel Multiplicative Target Screening against Divergent Bacterial Replicases: Identification of Specific Inhibitors with Broad Spectrum Potential

Biochemistry

Volumn 49, Issue 11, 2010, Pages 2551-2562

  Garry Dallmann, H ^a   Fackelmayer, Oliver J ^a   Tomer, Guy ^a   Chen, Joe ^a   Wiktor Becker, Anna ^a   Ferrara, Tracey ^a   Pope, Casey ^a   Oliveira, Marcos T ^c   Burgers, Peter M J ^b   Kaguni, Laurie S ^c   McHenry, Charles S ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Michigan State University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBACTERIAL INHIBITORS; BROAD SPECTRUM; COMPLEX REACTIONS; COMPLEX SYSTEMS; GRAM-POSITIVE BACTERIUM; LINEAR RANGE; PURIFIED PROTEIN; SPECIFIC INHIBITORS; TARGET SCREENING; WHOLE CELL;

ASSAYS; BACTERIA; BACTERIOLOGY; COMPLEXATION; PROTEINS; PURIFICATION;

TARGETS;

ANTIINFECTIVE AGENT; DNA POLYMERASE;

ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HIGH THROUGHPUT SCREENING; NONHUMAN; PRIORITY JOURNAL; PROTEIN PURIFICATION;

BACTERIA; DNA REPLICATION; DNA, BACTERIAL; DNA-DIRECTED DNA POLYMERASE; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; SMALL MOLECULE LIBRARIES; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS); NEGIBACTERIA; POSIBACTERIA;

EID: 77949513909     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi9020764     Document Type: Article

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