Quinazolin-2-ylamino-quinazolin-4-ols as novel non-nucleoside inhibitors of bacterial DNA polymerase III

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 3, 2009, Pages 800-802

  Guiles, Joseph ^a   Sun, Xicheng ^a   Critchley, Ian A ^a   Ochsner, Urs ^a   Tregay, Ming ^a   Stone, Kim ^a   Bertino, Jennifer ^a   Green, Louis ^a   Sabin, Rob ^a   Dean, Frank ^a   Garry Dallmann, H ^b   McHenry, Charles S ^b   Janjic, Nebojsa ^a  

^a Replidyne Inc   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Bacterial; DNA; Inhibitors; Non nucleoside; Polymerase

Indexed keywords

AMINE; DNA DIRECTED DNA POLYMERASE GAMMA; QUINAZOLIN 2 YLAMINOQUINAZOLIN 4 OL; QUINAZOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL CELL; BACTERIAL CHROMOSOME; BINDING AFFINITY; CELL DEATH; CONCENTRATION RESPONSE; DNA REPLICATION; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; SINGLE DRUG DOSE; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION; STREPTOCOCCUS PNEUMONIAE; STRUCTURE ACTIVITY RELATION;

CELL DEATH; CHEMISTRY, PHARMACEUTICAL; DNA; DNA POLYMERASE III; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HUMANS; MODELS, BIOLOGICAL; MODELS, CHEMICAL; MOLECULAR STRUCTURE; QUINAZOLINES; STREPTOCOCCUS PYOGENES; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS);

EID: 58549098026     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.12.038     Document Type: Article

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