Determination of selectivity and efficacy of fatty acid synthesis inhibitors

Journal of Biological Chemistry

Volumn 280, Issue 2, 2005, Pages 1669-1677

  Kodali, Srinivas ^a   Galgoci, Andrew ^a   Young, Katherine ^a   Painter, Ronald ^a   Silver, Lynn L ^a,b   Herath, Kithsiri B ^a   Singh, Sheo B ^a   Cully, Doris ^a   Barrett, John F ^a   Schmatz, Dennis ^a   Wang, Jim ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b LL Silver Consulting LLC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; BACTERIA; DRUG DOSAGE; ENZYME INHIBITION; ESCHERICHIA COLI; PATHOLOGY; SYNTHESIS (CHEMICAL); THROUGHPUT;

DRUG DISCOVERY; TYPE II FATTY ACID SYNTHESIS (FASII);

FATTY ACIDS;

ACYL COENZYME A; BISCHLOROANTHRABENZOXOCINONE; CALCIUM ION; CERULENIN; DITHIOTHREITOL; MAGNESIUM ION; MANGANESE; MERCAPTOETHANOL; NATURAL PRODUCT; THIOLACTOMYCIN; TRICLOSAN; UNCLASSIFIED DRUG; ZINC ION;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; CONTROLLED STUDY; DRUG EFFICACY; DRUG SELECTIVITY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MECHANISM; ESCHERICHIA COLI; FATTY ACID SYNTHESIS; IC 50; NONHUMAN; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS;

ANTI-BACTERIAL AGENTS; BACTERIA; CATIONS, DIVALENT; DITHIOTHREITOL; DRUG EVALUATION, PRECLINICAL; FATTY ACIDS; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; INHIBITORY CONCENTRATION 50; KINETICS; MERCAPTOETHANOL; MICROBIAL SENSITIVITY TESTS; SENSITIVITY AND SPECIFICITY; SUBSTRATE SPECIFICITY;

BACILLUS SUBTILIS; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS;

EID: 19944430887     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M406848200     Document Type: Article

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