Structure of a small-molecule inhibitor of a DNA polymerase sliding clamp

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 32, 2008, Pages 11116-11121

  Georgescu, Roxana E ^a,b   Yurieva, Olga ^a,b   Kim, Seung Sup ^e   Kuriyan, John ^c,d   Kong, Xiang Peng ^e   O'Donnell, Mike ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d LAWRENCE LIVERMORE NATIONAL LABORATORY   (United States)

^e NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antibiotic target; Crystallography; Fluorescence anisotropy; Rational drug design

Indexed keywords

DNA DIRECTED DNA POLYMERASE ALPHA; DNA DIRECTED DNA POLYMERASE GAMMA; DNA POLYMERASE; ESCHERICHIA COLI PROTEIN; PROTEIN BETA CLAMP;

ARTICLE; DNA BINDING; DNA REPLICATION; ENZYME ACTIVITY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DNA POLYMERASE III; ENZYME INHIBITORS; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HETEROCYCLIC COMPOUNDS, 2-RING; PROTEIN STRUCTURE, TERTIARY;

ESCHERICHIA COLI;

EID: 49649087259     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0804754105     Document Type: Article

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