β-arrestins - Scaffolds and signalling elements essential for WNT/Frizzled signalling pathways?

British Journal of Pharmacology

Volumn 159, Issue 5, 2010, Pages 1051-1058

  Schulte, Gunnar ^a   Schambony, Alexandra ^b   Bryja, Vítězslav ^c,d  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c MASARYK UNIVERSITY   (Czech Republic)

^d INSTITUTE OF BIOPHYSICS   (Czech Republic)

Author keywords

catenin; Canonical signalling; Casein kinase; Desensitization; Dishevelled; Endocytosis; Internalization; Non canonical signalling; ROR; RYK

Indexed keywords

BETA ARRESTIN; BETA CATENIN; FRIZZLED PROTEIN; PHOSPHOPROTEIN; WNT PROTEIN;

CELL COMMUNICATION; DESENSITIZATION; DROSOPHILA; IN VIVO STUDY; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN SECRETION; REVIEW;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ARRESTINS; CELL COMMUNICATION; FRIZZLED RECEPTORS; HUMANS; PHOSPHOPROTEINS; SIGNAL TRANSDUCTION; WNT PROTEINS;

EID: 77949411833     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00466.x     Document Type: Review

References (58)

1. Alexander SP, Mathie A, Peters JA (2008). Guide to receptors and channels (GRAC), 3rd edn. Br J Pharmacol 153 (Suppl. 2): S1-209.
2. van Amerongen R, Mikels A, Nusse R (2008). Alternative wnt signaling is initiated by distinct receptors. Sci Signal 1: re9.
3. Axelrod JD, Miller JR, Shulman JM, Moon RT, Perrimon N (1998). Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways. Genes Dev 12: 2610-2622.
4. Benovic JL, Kühn H, Weyand I, Codina J, Caron MG, Lefkowitz RJ (1987). Functional desensitization of the isolated beta-adrenergic receptor by the beta-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa protein). Proc Natl Acad Sci U S A 84: 8879-8882.
5. Blitzer JT, Nusse R (2006). A critical role for endocytosis in Wnt signaling. BMC Cell Biol 7: 28.
6. Bryja V, Cajánek L, Grahn A, Schulte G (2007a). Inhibition of endocytosis blocks Wnt signalling to beta-catenin by promoting dishevelled degradation. Acta Physiol (Oxf) 190: 55-61.
7. Bryja V, Gradl D, Schambony A, Arenas E, Schulte G (2007b). Beta-arrestin is a necessary component of Wnt/beta-catenin signaling in vitro and in vivo. Proc Natl Acad Sci U S A 104: 6690-6695.
8. Bryja V, Schulte G, Arenas E (2007c). Wnt-3a utilizes a novel low dose and rapid pathway that does not require casein kinase 1-mediated phosphorylation of Dvl to activate beta-catenin. Cell Signal 19: 610-616.
9. Bryja V, Schulte G, Rawal N, Grahn A, Arenas E (2007d). Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism. J Cell Sci 120: 586-595.
10. Bryja V, Schambony A, Cajánek L, Dominguez I, Arenas E, Schulte G (2008). Beta-arrestin and casein kinase 1/2 define distinct branches of non-canonical WNT signalling pathways. EMBO Rep 9: 1244-1250.
11. Chen W, Hu LA, Semenov MV, Yanagawa S, Kikuchi A, Lefkowitz RJ et al. (2001). beta-Arrestin1 modulates lymphoid enhancer factor transcriptional activity through interaction with phosphorylated dishevelled proteins. Proc Natl Acad Sci USA 98: 14889-14894.
12. Chen W, Kirkbride KC, How T, Nelson CD, Mo J, Frederick JP et al. (2003a). Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling. Science 301: 1394-1397.
13. Chen W, ten Berge D, Brown J, Ahn S, Hu LA, Miller WE et al. (2003b). Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4. Science 301: 1391-1394.
14. Chen W, Ren XR, Nelson CD, Barak LS, Chen JK, Beachy PA et al. (2004). Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2. Science 306: 2257-2260.
15. Cong F, Schweizer L, Varmus H (2004). Casein kinase Iepsilon modulates the signaling specificities of dishevelled. Mol Cell Biol 24: 2000-2011.
16. DasGupta R, Kaykas A, Moon RT, Perrimon N (2005). Functional genomic analysis of the Wnt-wingless signaling pathway. Science 308: 826-833.
17. Dewire SM, Ahn S, Lefkowitz RJ, Shenoy SK (2007). Beta-arrestins and cell signaling. Annu Rev Physiol 69: 483-510.
18. Foord SM, Bonner TI, Neubig RR, Rosser EM, Pin JP, Davenport AP et al. (2005). International Union of Pharmacology. XLVI. G protein-coupled receptor list. Pharmacol Rev 57: 279-288.
19. Girnita L, Shenoy SK, Sehat B, Vasilcanu R, Girnita A, Lefkowitz RJ et al. (2005). {beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase. J Biol Chem 280: 24412-24419.
20. Goodman OB, Krupnick JG, Santini F, Gurevich VV, Penn RB, Gagnon AW et al. (1996). Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor. Nature 383: 447-450.
21. Gordon MD, Nusse R (2006). Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors. J Biol Chem 281: 22429-22433.
22. Gurevich VV, Pals-Rylaarsdam R, Benovic JL, Hosey MM, Onorato JJ (1997). Agonist-receptor-arrestin, an alternative ternary complex with high agonist affinity. J Biol Chem 272: 28849-28852.
23. Habas R, Dawid IB, He X (2003). Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation. Genes Dev 17: 295-309.
24. Hendrickx M, Leyns L (2008). Non-conventional Frizzled ligands and Wnt receptors. Dev Growth Differ 50: 229-243.
25. Hupfeld CJ, Olefsky JM (2007). Regulation of receptor tyrosine kinase signaling by GRKs and beta-arrestins. Annu Rev Physiol 69: 561-577.
26. Kikuchi A, Yamamoto H (2007). Regulation of Wnt signaling by receptor-mediated endocytosis. J Biochem (Tokyo) 141: 443-451.
27. Kikuchi A, Yamamoto H, Sato A (2009). Selective activation mechanisms of Wnt signaling pathways. Trends Cell Biol 19: 119-129.
28. Kim GH, Han JK (2007). Essential role for beta-arrestin 2 in the regulation of Xenopus convergent extension movements. EMBO J 26: 2513-2526.
29. Kim GH, Her JH, Han JK (2008). Ryk cooperates with Frizzled 7 to promote Wnt11-mediated endocytosis and is essential for Xenopus laevis convergent extension movements. J Cell Biol 182: 1073-1082.
30. Klein TJ, Jenny A, Djiane A, Mlodzik M (2006). CKIepsilon/discs overgrown promotes both Wnt-Fz/beta-catenin and Fz/PCP signaling in Drosophila. Curr Biol 16: 1337-1343.
31. Kohn AD, Moon RT (2005). Wnt and calcium signaling: beta- cateninindependent pathways. Cell Calcium 38: 439-446.
32. Lefkowitz RJ (2007). Seven transmembrane receptors: something old, something new. Acta Physiol (Oxf) 190: 9-19.
33. Lefkowitz RJ, Shenoy SK (2005). Transduction of receptor signals by beta-arrestins. Science 308: 512-517.
34. Lohse MJ, Benovic JL, Codina J, Caron MG, Lefkowitz RJ (1990). beta-Arrestin: a protein that regulates beta-adrenergic receptor function. Science 248: 1547-1550.
35. Lu W, Yamamoto V, Ortega B, Baltimore D (2004). Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. Cell 119: 97-108.
36. Luttrell LM, Ferguson SS, Daaka Y, Miller WE, Maudsley S, Della Rocca GJ et al. (1999). Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Science 283: 655-661.
37. Macdonald BT, Semenov MV, He X (2007). SnapShot: Wnt/Betacatenin signaling. Cell 131: 1204.
38. Mukherjee A, Veraksa A, Bauer A, Rosse C, Camonis J, Artavanis-Tsakonas S (2005). Regulation of Notch signalling by non-visual beta-arrestin. Nat Cell Biol 7: 1191-1201.
39. Nusse R (2003). Wnts and Hedgehogs: lipid-modified proteins and similarities in signaling mechanisms at the cell surface. Development 130: 5297-5305.
40. Nusse R (2005). Wnt signaling in disease and in development. Cell Res 15: 28-32.
41. Ossipova O, Dhawan S, Sokol S, Green JB (2005). Distinct PAR-1 proteins function in different branches of Wnt signaling during vertebrate development. Dev Cell 8: 829-841.
42. Polakis P (2000). Wnt signaling and cancer. Genes Dev 14: 1837-1851.
43. Punchihewa C, Ferreira AM, Cassell R, Rodrigues P, Fujii N (2009). Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins. Protein Sci 18: 994-1002.
44. Rives AF, Rochlin KM, Wehrli M, Schwartz SL, DiNardo S (2006). Endocytic trafficking of Wingless and its receptors, Arrow and DFrizzled-2, in the Drosophila wing. Dev Biol 293: 268-283.
45. Roman G, He J, Davis RL (2000). Kurtz, a novel nonvisual arrestin, is an essential neural gene in Drosophila. Genetics 155: 1281-1295.
46. Rosanò L, Cianfrocca R, Masi S, Spinella F, Di Castro V, Biroccio A et al. (2009). Beta-arrestin links endothelin A receptor to beta-catenin signaling to induce ovarian cancer cell invasion and metastasis. Proc Natl Acad Sci U S A 106: 2806-2811.
47. Schambony A, Wedlich D (2007). Wnt-5A/Ror2 regulate expression of XPAPC through an alternative noncanonical signaling pathway. Dev Cell 12: 779-792.
48. Schulte G, Bryja V (2007). The Frizzled family of unconventional G-protein-coupled receptors. Trends Pharmacol Sci 28: 518-525.
49. Schwarz-Romond T, Merrifield C, Nichols BJ, Bienz M (2005). The Wnt signalling effector Dishevelled forms dynamic protein assemblies rather than stable associations with cytoplasmic vesicles. J Cell Sci 118: 5269-5277.
50. Semenov MV, Habas R, Macdonald BT, He X (2007). SnapShot: noncanonical wnt signaling pathways. Cell 131: 1378.
51. Seto ES, Bellen HJ (2006). Internalization is required for proper Wingless signaling in Drosophila melanogaster. J Cell Biol 173: 95-106.
52. Strutt H, Price MA, Strutt D (2006). Planar polarity is positively regulated by casein kinase Iepsilon in Drosophila. Curr Biol 16: 1329-1336.
53. Tsai IC, Amack JD, Gao ZH, Band V, Yost HJ, Virshup DM (2007). A Wnt-CKIvarepsilon-Rap1 pathway regulates gastrulation by modulating SIPA1L1, a Rap GTPase activating protein. Dev Cell 12: 335-347.
54. Wong HC, Bourdelas A, Krauss A, Lee HJ, Shao Y, Wu D et al. (2003). Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled. Mol Cell 12: 1251-1260.
55. Xiao K, McClatchy DB, Shukla AK, Zhao Y, Chen M, Shenoy SK et al. (2007). Functional specialization of beta-arrestin interactions revealed by proteomic analysis. Proc Natl Acad Sci U S A 104: 12011-12016.
56. Yamamoto H, Komekado H, Kikuchi A (2006). Caveolin is necessary for Wnt-3a-dependent internalization of LRP6 and accumulation of beta-catenin. Dev Cell 11: 213-223.
57. Yamamoto H, Sakane H, Yamamoto H, Michiue T, Kikuchi A (2008). Wnt3a and Dkk1 regulate distinct internalization pathways of LRP6 to tune the activation of beta-catenin signaling. Dev Cell 15: 37-48.
58. Yu A, Rual JF, Tamai K, Harada Y, Vidal M, He X et al. (2007). Association of Dishevelled with the clathrin AP-2 adaptor is required for Frizzled endocytosis and planar cell polarity signaling. Dev Cell 12: 129-141.