β-arrestin 2 mediates endocytosis of type III TGF-β receptor and down-regulation of its signaling

Science

Volumn 301, Issue 5638, 2003, Pages 1394-1397

  Chen, Wei ^a   Kirkbride, Kellye C ^a   How, Tam ^a   Nelson, Christopher D ^a   Mo, Jinyao ^a   Frederick, Joshua P ^a   Wang, Xiao Fan ^a   Lefkowitz, Robert J ^a   Blobe, Gerard C ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CELLS;

PHOSPHORYLATION;

ENZYMES;

BETA ARRESTIN; G PROTEIN COUPLED RECEPTOR; PROTEIN SERINE THREONINE KINASE; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

MICROBIOLOGY; PROTEIN;

ANIMAL CELL; ARTICLE; COMPLEX FORMATION; DRUG RECEPTOR BINDING; ENDOCYTOSIS; INTERNALIZATION; LIGAND BINDING; MEDIATOR RELEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN PHOSPHORYLATION; RECEPTOR AFFINITY; RECEPTOR DOWN REGULATION;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; ARRESTINS; CELL LINE; CELL MEMBRANE; CYTOPLASM; DOWN-REGULATION; ENDOCYTOSIS; HUMANS; KERATINOCYTES; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; MUTAGENESIS; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; PROTEOGLYCANS; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; RECOMBINANT FUSION PROTEINS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

ANIMALIA;

EID: 0042471943     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1083195     Document Type: Article

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26. We thank H. Kendall and C. Riebe for technical assistance, D. Addison and J. Turnbough for secretarial assistance, R. Wells for the TβRIIIΔgag construct, and R&D Systems for supply of TGF-β1. G.C.B. is supported by the NIH (grant CA 91816), R.J.L. is supported in part by the NIH (grant HL 16037) and is an Investigator of the Howard Hughes Medical Institute, and X.-F.W. is supported by the NIH (grant CA 75368).