Early activation of hepatic NFκB and NF-IL6 in polymicrobial sepsis correlates with bacteremia, cytokine expression, and mortality

Annals of Surgery

Volumn 230, Issue 1, 1999, Pages 95-104

  Williams, David L ^a   Ha, Tuanzhu ^a   Li, Chuanfu ^a   Kalbfleisch, John H ^a   Ferguson Jr , Donald A ^a  

^a East Tennessee State University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; MESSENGER RNA; NUCLEAR FACTOR; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTEREMIA; BACTEROIDES; CECUM; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENSITOMETRY; ELECTROPHORETIC MOBILITY; ENTEROCOCCUS; GRAM NEGATIVE BACTERIUM; LIGATION; MALE; MORTALITY; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PUNCTURE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEPSIS;

ANIMALS; BACTEREMIA; CCAAT-ENHANCER-BINDING PROTEINS; CYTOKINES; DNA-BINDING PROTEINS; INTERLEUKIN-6; LIVER; MALE; MICE; MICE, INBRED ICR; NF-KAPPA B; NUCLEAR PROTEINS; SEPSIS; TIME FACTORS; TRANSCRIPTION FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0033504127     PISSN: 00034932     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000658-199907000-00014     Document Type: Article

References (58)

1. Marshall J. Both the disposition and means of cure: "Severe SIRS," "sterile shock" and the ongoing challenge of description. Crit Care Med 1997; 25:1765-1766.
2. Muckart DJJ, Bhagwanjee S. American College of Chest Physicians Society of Critical Care Medicine Consensus Conference: Definitions of the systemic inflammatory response syndrome and allied disorders in relation to critically injured patients. Crit Care Med 1997; 25:1789-1795.
3. Quartin AA, Schein RMH, Kett DH, Peduzzi PN. Magnitude and duration of the effect of sepsis on survival. JAMA 1997; 277:1058-1063.
4. Bone RC. Important new findings in sepsis. JAMA 1997; 278:249-249.
5. Bone RC. Sir Isaac Newton, sepsis, SIRS, and CARS. Crit Care Med 1996; 24:1125-1128.
6. Dellinger RP, Bone RC. To SIRS with love. Crit Care Med 1998; 26:178-179.
7. Bone RC, Grodzin CJ, Balk RA. Sepsis: a new hypothesis for pathogenesis of the disease process. Chest 1997; 112:235-243.
8. Martin C, Boisson C, Haccoun M, Thomachot L, Mege JL. Patterns of cytokine evolution (tumor necrosis factor-alpha and interleukin-6) after septic shock, hemorrhagic shock, and severe trauma. Crit Care Med 1997; 25:1813-1819.
9. Remick D, Manohar P, Bolgos G, Rodriguez J, Moldawer L, Wollenburg G. Blockade of tumor necrosis factor reduces lipopolysaccharide lethality, but not the lethality of cecal ligation and puncture. Shock 1995; 4:89-95.
10. Salkowski CA, Detore G, Franks A, Falk MC, Vogel SN. Pulmonary and hepatic gene expression following cecal ligation and puncture: monophosphoryl lipid A prophylaxis attenuates sepsis-induced cytokine and chemokine expression and neutrophil infiltration. Infect Immun 1998; 66:3569-3578.
11. Dellinger RP. Tumor necrosis factor in septic shock and multiple system trauma. Crit Care Med 1997; 25:1771-1773.
12. Grau GE, Maennel DN. TNF inhibition and sepsis - sounding a cautionary note. Nature Med 1997; 3:1193-1195.
13. Zeni F, Freeman B, Natanson C. Anti-inflammatory therapies to treat sepsis and septic shock: a reassessment. Crit Care Med 1997; 25:1095-1100.
14. Vincent JL. Search for effective immunomodulating strategies against sepsis. Lancet 1998; 351:922-923.
15. Baldwin AS, Jr. The NF-kappa B and I-kappa B proteins: new discoveries and insights. Ann Rev Immunol 1996; 14:649-683.
16. Barnes PJ. Nuclear factor-kappa B. Int J Biochem Cell Biol 1997; 29:867-870.
17. Wedel A, Ziegler-Heitbrock HW. The C/EBP family of transcription factors. Immunobiology 1995; 193:171-185.
18. Xia C, Cheshire JK, Patel H, Woo P. Cross-talk between transcription factors NF-kappa B and C/EBP in the transcriptional regulation of genes. Int J Biochem Cell Biol 1997; 29:1525-1539.
19. Ruttinger D, Vollmar B, Kempter B, Messmer K. Failure of Kupffer cell blockade to prevent disseminated intravascular coagulation in endotoxemic rats despite improved survival. Arch Surg 1998; 383:75-80.
20. Zagariya A, Mungre S, Lovis R, et al. Tumor necrosis factor alpha gene regulation: enhancement of C/EBPβ-induced activation by c-Jun. Mol Cell Biol 1998; 18:2815-2824.
21. Schwartz MD, Moore EE, Moore FA, et al. Nuclear factor-kappa B is activated in alveolar macrophages from patients with acute respiratory distress syndrome. Crit Care Med 1996; 24:1285-1292.
22. Böhrer H, Qiu F, Zimmermann T, et al. Role of NFκB in the mortality of sepsis. J Clin Invest 1997; 100:972-985.
23. Chang CK, Llanes S, Schumer W. Effect of dexamethasone on NFκB activation, tumor necrosis factor formation, and glucose dyshomeostasis in septic rats. J Surg Res 1997; 72:141-145.
24. Chapin RB, Roy S, Charboneau R, et al. Regulation of the transcription factor C/EBPα following peritoneal sepsis. J Surg Res 1995; 59:460-467.
25. Baker CC, Chaudry IH, Gaines HO, Baue AE. Evaluation of factors affecting mortality rate after sepsis in a murine cecal ligation and puncture model. Surgery 1983; 94:331-335.
26. Ayala A, Karr SM, Evans TA, Chaudry IH. Factors responsible for peritoneal granulocyte apoptosis during sepsis. J Surg Res 1997; 69:67-75.
27. Holdeman LV, Kelley RW, Moore WEC. Anaerobic gram-negative straight, curved and helical rods. In Krieg NR, Holt JG (eds). Manual of systematic bacteriology, vol 1. Baltimore: Williams & Wilkins; 1984:602-662.
28. Murray RR, Baron EJ, Pfaller MA, Tenover FC, Volkers RH. Manual of clinical microbiology. Washington, DC: ASM Press; 1995.
29. Blackwell TS, Christman JW. The role of nuclear factor-kappa B in cytokine gene regulation. Am J Respir Cell Mol Biol 1997; 17:3-9.
30. Xia C, Cheshire JK, Patel H, Woo P. Cross-talk between transcription factors NF-kappa B and C/EBP in the transcriptional regulation of genes. Int J Biochem Cell Biol 1997; 29:1529-1539.
31. Barnes PJ, Karin M. Nuclear factor-κB - a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 1997; 336:1066-1071.
32. Diaz-Guerra MJM, Velasco M, Martin-Sanz P, Bosca L. Nuclear factor kappa-B is required for the transcriptional control of type II NO synthase in regenerating liver. Biochem J 1997; 326:791-797.
33. Inoue H, Tanabe T. Transcriptional role of the nuclear factor kappa-B site in the induction by lipopolysaccharide and suppression by dexamethasone of cyclooxygenase-2 in U937 cells. Biochem Biophys Res Commun 1998; 244:143-148.
34. Blackwell TS, Blackwell TR, Holden EP, Christman BW, Christman JW. In vivo antioxidant treatment suppresses nuclear factor B activation and neutrophilic lung inflammation. J Immunol 1996; 157:1630-1637.
35. Blackwell TS, Blackwell TR, Christman JW. Induction of endotoxin tolerance depletes nuclear factor κB and suppresses its activation in rat alveolar macrophages. J Leuko Biol 1997; 62:885-891.
36. Breton JJ, Chabot-Fletcher MC. The natural product hymenialdisine inhibits interleukin-8 production in U937 cells by inhibition of nuclear factor kappa B. J Pharmacol Exp Ther 1997; 282:459-466.
37. Molnar RG, Wang P, Ayala A, Ganey PE, Roth RA, Chaudry IH. The role of neutrophils in producing hepatocellular dysfunction during the hyperdynamic stage of sepsis in rats. J Surg Res 1997; 73:117-122.
38. Trauner M, Arrese M, Lee H, Boyer JL, Karpen SJ. Endotoxin down-regulates rat hepatic ntcp gene expression via decreased activity of critical transcription factors. J Clin Invest 1998; 101:2092-2100.
39. Wang P, Ba ZF, Cioffi WG, Bland KI, Chaudry IH. Is gut the "motor" for producing hepatocellular dysfunction after trauma and hemorrhagic shock? J Surg Res 1998; 74:141-148.
40. Deutschman CS, Andrejko KM, Haber BA, et al. Sepsis-induced depression of rat glucose-6-phosphatase gene expression and activity. Am J Physiol 1997; 273:R1709-R1718.
41. Meduri GU, Kanangat S. Glucocorticoid treatment of sepsis and acute respiratory distress syndrome: time for a critical reappraisal. Crit Care Med 1998; 26:630-633.
42. Matot I, Sprung CL. Corticosteroids in septic shock: resurrection of the last rites? Crit Care Med 1998; 26:627-630.
43. Bolleart P-E, Charpentier B, Levy B, Debouverie M, Audibert G, Larcan A. Reversal of late septic shock with physiologic doses of hydrocortisone. Crit Care Med 1998; 26:645-650.
44. Scheinman RI, Cogswell PC, Lofquist AK, Baldwin AS. Role of transcriptional activation of IκBα in mediation of immunosuppression by glucocorticoids. Science 1995; 270:283-286.
45. Wissink S, van Heerde EC, vand der Burg B, van der Saag PT. A dual mechanism mediates repression of NF-kappaB activity by glucocorticoids. Mol Endocrinol 1998; 12:355-363.
46. Heck S, Bender K, Kulimann M, Gottlicher M, Herrlich P, Cato AC. I kappaB alpha-independent downregulation of NF-kappaB activity by glucocorticoid receptor. EMBO J 1997; 16:4698-4707.
47. De Bosscher K, Schmitz ML, Vanden Berghe W, Plaisance S, Fiers W, Haegeman G. Glucocorticoid-mediated repression of nuclear factor-kappaB-dependent transcription involves direct interference with transactivation. PNAS 1997; 94:13504-13509.
48. Ayala A, O'Neill PJ, Uebele SA, Herdon CD, Chaudry IH. Mechanism of splenic immunosuppression during sepsis: key role of Kupffer cell mediators. J Trauma 1997; 42:882-888.
49. Ayala A, Xu YX, Ayala CA, et al. Increased mucosal B-lymphocyte apoptosis during polymicrobial sepsis is a Fas ligand but not an endotoxin-mediated process. Blood 1998; 91:1362-1372.
50. Ayala A, Herdon CD, Lehman DL, Ayala CA, Chaudry IH. Differential induction of apoptosis in lymphoid tissues during sepsis: variation in onset, frequency, and the nature of the mediators. Blood 1996; 87:4261-4275.
51. Ayala A. Lymphoid apoptosis during sepsis: now that we've found it, what do we do with it? Crit Care Med 1997; 25:1261-1262.
52. Iimuro Y, Nishiura T, Hellerbrand C, et al. NFkappaB prevents apoptosis and liver dysfunction during liver regeneration. J Clin Invest 1998; 101:802-811.
53. Wang C-Y, Mayo MW, Baldwin AS. TNF-and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappa B. Science 1996; 274:784-787.
54. Ruckdeschel K, Harb S, Roggenkamp A, et al. Yersinia enterocolitica impairs activation of transcription factor NF-kappaB: involvement in the induction of programmed cell death and in the suppression of the macrophage tumor necrosis factor alpha production. J Exp Med 1998; 187:1069-1079.
55. Takasuka N, Matsuura K, Yamamoto S, Akagawa K. Suppression of TNF-alpha mRNA expression in LPS-primed macrophages occurs at the level of nuclear factor-κB activation, but not at the level of protein kinase C or CD14 expression. J Immunol 1995; 154:4803-4812.
56. Ayala A, Perrin MM, Kidala JM, Ertel W, Chaudry IH. Polymicrobial sepsis selectively activates peritoneal but not alveolar macrophages to release inflammatory mediators (interleukin-1 and -6 and tumor necrosis factor). Circ Shock 1992; 36:191-199.
57. Duncan MR, Hasan A, Berman B. Pentoxifylline, pentifylline, and interferons decrease type I and III procollagen mRNA levels in dermal fibroblasts: evidence for mediation by nuclear factor 1 down-regulation. J Invest Dermatol 1995; 104:282-286.
58. Brigelius-Flohe R, Friedrichs B, Maurer S, Schultz M, Streicher R. Interleukin-1-induced nuclear factor kappaB activation is inhibited by overexpression of phospholipid hydroperoxide glutathione peroxidase in a human endothelial cell line. Biochem J 1997; 328:199-203.