Early activation of pulmonary nuclear factor κB and nuclear factor interleukin-6 in polymicrobial sepsis

Journal of Trauma - Injury, Infection and Critical Care

Volumn 46, Issue 4, 1999, Pages 590-596

  Browder, William ^a   Ha, Tuanzhu ^a   Li, Chuanfu ^a   Kalbfleisch, John H ^a   Ferguson, Donald A ^a   Williams, David L ^a  

^a East Tennessee State University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; MESSENGER RNA; NUCLEAR FACTOR; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ADULT RESPIRATORY DISTRESS SYNDROME; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CECUM; CONTROLLED STUDY; CYTOKINE PRODUCTION; ELECTROPHORETIC MOBILITY; LIGATION; LUNG INJURY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PUNCTURE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEPSIS;

EID: 0032917428     PISSN: 00225282     EISSN: 15298809     Source Type: Journal    
DOI: 10.1097/00005373-199904000-00006     Document Type: Article

References (21)

1. Baldwin AS Jr. The NF-κB, and I-κB proteins: new discoveries and insights. Annu Rev Immunol. 1996;14:649-683.
2. Wedel A, Ziegler-Heitbrock HW. The C/EBP family of transcription factors. Immunobiology. 1995;193:171-185.
3. Barnes PJ. Nuclear factor-κB. Int J Biochem Cell Biol. 1997;29:867-870.
4. Blackwell TS, Christman JW. The role of nuclear factor-κB in cytokine gene regulation. Am J Respir Cell Mol Biol. 1997;17:3-9.
5. Schwartz MD, Moore EE, Moore FA, et al. Nuclear factor-κB is activated in alveolar macrophages from patients with acute respiratory distress syndrome. Crit Care Med. 1996; 24:1285-1292.
6. Böhrer H, Qiu F, Zimmermann T, et al. Role of NFκB in the mortality of sepsis. J Clin Invest. 1997;100:972-985.
7. Baker CC, Chaudry IH, Gaines HO, Baue AE. Evaluation of factors affecting mortality rate after sepsis in a murine cecal ligation and puncture model. Surgery. 1983;94:331-335.
8. Ayala A, Urbanich MA, Herdon CD, Chaudry IH. Is sepsisinduced apoptosis associated with macrophage dysfunction? J Trauma. 1996;40:568-574.
9. Chang CK, Llanes S, Schumer W. Effect of dexamethasone on NF-κB activation, tumor necrosis factor formation, and glucose dyshomeostasis in septic rats. J Surg Res. 1997; 72:141-145.
10. Holdeman LV, Kelley RW, Moore WEC. Anaerobic gram-negative straight, curved, and helical rods. In: Krieg NR, Holt JG, eds. Manual of Systematic Bacteriology. Baltimore, Md: Williams & Wilkins; 1984;1:602-662.
11. Murray PR, Baron EJ, Pfaller MA, Tenover FC, Yolken RH, eds. Manual of Clinical Microbiology. Washington, DC: ASM Press; 1995.
12. Wilson CS, Seatter SC, Rodriguez JL, et al. In vivo endotoxin tolerance: impaired LPS-stimulated TNF release of monocytes from patients with sepsis, but not SIRS. J Surg Res. 1997;69:101-106.
13. Salkowski CA, Detore G, Franks A, Falk MC, Vogel SN. Pulmonary and hepatic gene expression following cecal ligation and puncture: monophosphoryl lipid A prophylaxis attenuates sepsis-induced cytokine and chemokine expression and neutrophil infiltration. Infect Immun. 1998;66:3569-3578.
14. Martin C, Boisson C, Haccoun M, Thomachot L, Mege JL. Patterns of cytokine evolution (tumor necrosis factor-alpha and interleukin-6) after septic shock, hemorrhagic shock, and severe trauma. Crit Care Med. 1997;25:1813-1819.
15. Akira S, Kishimoto T. NF-IL6 and NF-κB in cytokine gene regulation. Adv Imnumol. 1997;65:1-46.
16. Akira S, Kishimoto T. Role of interleukin-6 in macrophage function. Curr Opin Hematol. 1996;3:87-93.
17. Pope RM, Leutz A, Ness SA. C/EBPβ regulation of tumor necrosis factor α gene. J Clin Invest. 1994;94:1449-1455.
18. Velasco M, Diaz-Guerra MJ, Martin-Sanz P, Alvarez A, Bosca L. Rapid up-regulation of IκBβ and abrogation of NF-κB activity in peritoneal macrophages stimulated with lipopolysaccharide. J Biol Chem. 1997;272:23025-23030.
19. Blackwell TS, Blackwell TR, Christman JW. Impaired activation of nuclear factor-KB in endotoxin-tolerant rats is associated with down-regulation of chemokine gene expression and inhibition of neutrophilic lung inflammation. J Immimol. 1997;158:5934-5940.
20. Dellinger RP. Tumor necrosis factor in septic shock and multiple system trauma. Crit Care Med. 1997;25:1771-1773.
21. Grau GE Maennel DN. TNF inhibition and sepsis: sounding a cautionary note. Nature Med. 1997;3:1193-1195.