Human interphase chromosomes: A review of available molecular cytogenetic technologies

Molecular Cytogenetics

Volumn 3, Issue 1, 2010, Pages

  Vorsanova, Svetlana G ^a,b   Yurov, Yuri B ^a,b   Iourov, Ivan Y ^a,b  

^a PIROGOV RUSSIAN NATIONAL RESEARCH MEDICAL UNIVERSITY   (Russian Federation)

^b MENTAL HEALTH RESEARCH CENTER   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

PEPTIDE NUCLEIC ACID;

ANEUPLOIDY; CENTROMERE; CHROMOSOME; CHROMOSOME DELETION; CHROMOSOME DUPLICATION; CHROMOSOME INVERSION; CHROMOSOME TRANSLOCATION; COMPARATIVE GENOMIC HYBRIDIZATION; CYTOGENETICS; FLUORESCENCE IN SITU HYBRIDIZATION; GENE PROBE; GENETIC VARIABILITY; HUMAN; INTERPHASE; POLYPLOIDY; PRIMED IN SITU LABELING; PRIORITY JOURNAL; REVIEW;

EUKARYOTA;

EID: 77649292704     PISSN: None     EISSN: 17558166     Source Type: Journal    
DOI: 10.1186/1755-8166-3-1     Document Type: Review

References (117)

1. SL Gersen MB Keagle, The principles of clinical cytogenetics Totowa, NJ: Humana Press 2 2005
2. Multicolor-FISH approaches for the characterization of human chromosomes in clinical genetics and tumor cytogenetics. T Liehr U Claussen, Curr Genomics 2002 3 231 235 10.2174/1389202023350525 (Pubitemid 34568184)
3. Recent patents on molecular cytogenetics. IY Iourov SG Vorsanova YB Yurov, Recent Pat DNA Gene Seq 2008 2 6 15 10.2174/187221508783406585 19075939
4. Clinical utility of contemporary molecular cytogenetics. BA Bejjani LG Shaffer, Annu Rev Genomics Hum Genet 2008 9 71 86 10.1146/annurev.genom.9. 081307.164207 18949852
5. Multicolor FISH probe sets and their applications. T Liehr H Starke A Weise H Lehrer U Claussen, Histol Histopathol 2004 19 229 237 14702191
6. The new cytogenetics: blurring the boundaries with molecular biology. MR Speicher NP Carter, Nat Rev Genet 2005 6 782 792 10.1038/nrg1692 16145555
7. Chromosomal variations in mammalian neuronal cells: known facts and attractive hypotheses. IY Iourov SG Vorsanova YB Yurov, Int Rev Cytol 2006 249 143 191 10.1016/S0074-7696(06)49003-3 16697283
8. Methods and strategies for analyzing copy number variation using DNA microarrays. NP Carter, Nat Genet 2007 39 16 S21 10.1038/ng2028 17597776
9. Gene expression and the myth of the average cell. JM Levsky RH Singer, Trends Cell Biol 2003 13 4 6 10.1016/S0962-8924(02)00002-8 12480334
10. Intercellular genomic (chromosomal) variations resulting in somatic mosaicism: mechanisms and consequences. IY Iourov SG Vorsanova YB Yurov, Curr Genomics 2006 7 435 446 10.2174/138920206779116756 (Pubitemid 44942065)
11. From microscopes to microarrays: dissecting recurrent chromosomal rearrangements. BS Emanuel SC Saitta, Nat Rev Genet 2007 8 869 883 10.1038/nrg2136 17943194
12. Chromosomal mosiacism goes global. IY Iourov SG Vorsanova YB Yurov, Mol Cytogenet 2008 1 26 10.1186/1755-8166-1-26 19032785
13. T Liehr, Fluorescence in situ hybridization (FISH) - Application guide Berlin, Heidelberg: Springer 2009
14. Chromosome instability is common in human cleavage-stage embryos. E Vanneste T Voet C Le Caignec M Ampe P Konigs C Mellote S Debrock M Amyere M Vikkula F Schuit JP Fryns G Verbeke T D'Hooghe Y Moreau JR Vermeesch, Nat Med 2009 15 577 583 10.1038/nm.1924 19396175
15. Chromosome territories - a functional nuclear landscape. T Cremer M Cremer S Dietzel S Muller I Solovei S Fakan, Curr Opin Cell Biol 2006 18 307 316 10.1016/j.ceb.2006.04.007 16687245
16. Three-dimensional genome organization in interphase and its relation to genome function. S Goetze J Mateos-Langerak R van Driel, Semin Cell Dev Biol 2007 18 707 714 10.1016/j.semcdb.2007.08.007 17905616
17. Dynamics and interplay of nuclear architecture, genome organization, and gene expression. R Schneider R Grosschedl, Genes Dev 2007 21 3027 3043 10.1101/gad.1604607 18056419
18. Chromosome crosstalk in three dimensions. A Gondor R Ohlsson, Nature 2009 461 212 217 10.1038/nature08453 19741702
19. Chromosome distribution in human sperm - a 3D multicolor banding-study. M Manvelyan F Hunstig S Bhatt K Mrasek F Pellestor A Weise I Simonian R Aroutiounian T Liehr, Mol Cytogenet 2008 1 25 10.1186/1755-8166-1-9 19014589
20. Multicolor fluorescent in situ hybridization on post mortem brain in schizophrenia as an approach for identification of low-level chromosomal aneuploidy in neuropsychiatric diseases. YB Yurov VM Vostrikov SG Vorsanova VV Monakhov IY Iourov, Brain Dev 2001 23 Suppl 1 186 190 10.1016/S0387-7604(01) 00363-1 (Pubitemid 33111053)
21. Evidence for high frequency of chromosomal mosaicism in spontaneous abortions revealed by interphase FISH analysis. SG Vorsanova AD Kolotii IY Iourov VV Monakhov EA Kirillova IV Soloviev YB Yurov, J Histochem Cytochem 2005 53 375 380 10.1369/jhc.4A6424.2005 15750024
22. The variation of aneuploidy frequency in the developing and adult human brain revealed by an interphase FISH study. YB Yurov IY Iourov VV Monakhov IV Soloviev VM Vostrikov SG Vorsanova, J Histochem Cytochem 2005 53 385 390 10.1369/jhc.4A6430.2005 15750026
23. Visualization of interphase chromosomes in postmitotic cells of the human brain by multicolour banding (MCB). IY Iourov T Liehr SG Vorsanova AD Kolotii YB Yurov, Chromosome Res 2006 14 223 229 10.1007/s10577-006-1037-6 16628493
24. Aneuploidy and confined chromosomal mosaicism in the developing human brain. YB Yurov IY Iourov SG Vorsanova T Liehr AD Kolotii SI Kutsev F Pellestor AK Beresheva IA Demidova VS Kravets VV Monakhov IV Soloviev, PLoS ONE 2007 2 558 10.1371/journal.pone.0000558 17593959
25. Unexplained autism is frequently associated with low-level mosaic aneuploidy. YB Yurov SG Vorsanova IY Iourov IA Demidova AK Beresheva VS Kravetz VV Monakhov AD Kolotii VY Voinova-Ulas NL Gorbachevskaya, J Med Genet 2007 44 521 535 10.1136/jmg.2007.049312 17483303
26. The schizophrenia brain exhibits low-level aneuploidy involving chromosome 1. YB Yurov IY Iourov SG Vorsanova IA Demidova VS Kravetz AK Beresheva AD Kolotii VV Monakchov NA Uranova VM Vostrikov IV Soloviev T Liehr, Schizophr Res 2008 98 137 147 10.1016/j.schres.2007.07.035 (Pubitemid 350245588)
27. Molecular cytogenetics and cytogenomics of brain diseases. IY Iourov SG Vorsanova YB Yurov, Curr Genomics 2008 9 452 465 10.2174/138920208786241216 19506734
28. Aneuploidy in the normal, Alzheimer's disease and ataxia-telangiectasia brain: differential expression and pathological meaning. IY Iourov SG Vorsanova T Liehr YB Yurov, Neurobiol Dis 2009 34 212 220 10.1016/j.nbd.2009.01.003 19344645
29. Increased chromosome instability dramatically disrupts neural genome integrity and mediates cerebellar degeneration in the ataxia-telangiectasia brain. IY Iourov SG Vorsanova T Liehr AD Kolotii YB Yurov, Hum Mol Genet 2009 18 2656 2669 10.1093/hmg/ddp207 19414482
30. High resolution fluorescence in situ hybridization using cyanine and fluorescin dyes: ultra-rapid chromosome detection by directly fluorescently labeled alphoid DNA probes. YB Yurov IV Soloviev SG Vorsanova B Marcais G Roizes R Lewis, Hum Genet 1996 97 390 398 10.1007/BF02185780 8786090
31. The DNA-based structure of human chromosome 5 in interphase. J Lemke J Claussen S Michel I Chudoba P Muhlig P Westermann K Sperling N Rubtsov UW Grummt P Ullmann K Kromeyer-Hauschild T Liehr U Claussen, Am J Hum Genet 2002 71 1051 1059 10.1086/344286 12370837
32. An approach for quantitative assessment of fluorescence in situ hybridization (FISH) signals for applied human molecular cytogenetics. IY Iourov IV Soloviev SG Vorsanova VV Monakhov YB Yurov, J Histochem Cytochem 2005 53 401 408 10.1369/jhc.4A6419.2005 15750029
33. Interphase chromosome-specific multicolor banding (ICS-MCB): a new tool for analysis of interphase chromosomes in their integrity. IY Iourov T Liehr SG Vorsanova YB Yurov, Biomol Eng 2007 24 415 417 10.1016/j.bioeng.2007.05.003 17627882
34. Position of chromosomes 18, 19, 21 and 22 in 3D-preserved interphase nuclei of human and gorilla and white hand gibbon. M Manvelyan F Hunstig K Mrasek S Bhatt F Pellestor A Weise T Liehr, Mol Cytogenet 2008 1 9 10.1186/1755-8166-1-9 18471270
35. Interphase FISH: detection of intercellular genomic variations and somatic chromosomal mosaicism. IY Iourov SG Vorsanova IV Soloviev YB Yurov, Fluorescence in situ hybridization (FISH) - Application guide Berlin, Heidelberg: Springer Verlag, Liehr T, 2009 301 311 full-text
36. Current developments in molecular cytogenetic techniques. T Liehr U Claussen, Curr Mol Med 2002 2 283 297 10.2174/1566524024605725 12041731
37. PRINS and In Situ PCR protocols. F Pellestor Ed, Methods Mol Biol 2 2006 334 1 243
38. Multicolor PRINS and multicolor PNA. F Pellestor P Paulasova B Andreo F Lefort S Hamamah, Cytogenet Genome Res 2006 114 263 269 10.1159/000094211 16954664
39. Multicolor spectral karyotyping of human chromosomes. E Schrock S du Manoir T Veldman B Schoell J Weinberg MA Ferguson-Smith Y Ning DH Ledbetter I Bar-Am D Soenksen Y Garini T Ried, Science 1996 273 494 497 10.1126/science.273. 5274.494 8662537
40. Karyotyping human chromosomes by combinatorial multi-fluor FISH. MR Speicher GS Ballard DC Ward, Nat Genet 1996 12 368 375 10.1038/ng0496-368 8630489
41. Double color in situ hybridization of alpha-satellite chromosome 13, 21 specific cosmid clones for a rapid screening of their specificity. IV Soloviev YB Yurov SG Vorsanova P Malet TE Zerova TI Buzhievskaya, Tsitol Genet 1998 32 60 64 9813889
42. Fluorescent in situ hybridization analysis of -satellite DNA in cosmid libraries specific for human chromosomes 13, 21 and 22. IV Soloviev YB Yurov SG Vorsanova B Marcais EI Rogaev BI Kapanadze VM Brodiansky NK Yankovsky G Roizes, Rus J Genet 1998 34 1247 1255 (Pubitemid 128502463)
43. Microdissection based high resolution multicolor banding for all 24 human chromosomes. T Liehr A Heller H Starke N Rubtsov V Trifonov K Mrasek A Weise A Kuechler U Claussen, Int J Mol Med 2002 9 335 339 11891523
44. A new multicolor-FISH approach for the characterization of marker chromosomes: centromer-specific multicolor-FISH (cenM-FISH). A Nietzel M Rocchi H Starke A Heller W Fiedler I Wlodarska IF Loncarevic V Beensen U Claussen T Liehr, Hum Genet 2001 108 199 204 10.1007/s004390100459 11354630
45. Multicolor chromosome banding (MCB) with YAC/BAC-based probes and region specific microdissection DNA libraries. T Liehr A Weise A Heller H Starke K Mrasek A Kuechler H-UG Weier U Claussen, Cytogenet Genome Res 2002 97 43 50 10.1159/000064043 12438737
46. Chromosome-specific DNA repeat probes. A Baumgartner JF Weier H-UG Weier, J Histochem Cytochem 2006 54 1363 1370 10.1369/jhc.6A6974.2006 16924124
47. Prenatal diagnosis of trisomy 21 using interphase fluorescence in situ hybridization of postreplicated cells with site-specific cosmid and cosmid contig probes. IV Soloviev YB Yurov SG Vorsanova F Fayet G Roizes P Malet, Prenat Diagn 1995 15 237 248 10.1002/pd.1970150307 7784382
48. Detection of structural and numerical chromosome abnormalities in interphase cells using spectral imaging. J Fung H-UG Weier RA Pedersen, J Histochem Cytochem 2001 49 797 798 11373329
49. Interphase M-FISH applications using commercial probes in prenatal and PGD diagnostics. M Stumm R-D Wegner M Bloechle H Eckel, Cytogenet Genome Res 2006 114 296 301 10.1159/000094217 16954670
50. DNA probe pooling for rapid delineation of chromosomal breakpoints. CM Lu J Kwan A Baumgartner JF Weier M Wang T Escudero S Munne HF Zitzelsberger H-UG Weier, J Histochem Cytochem 2009 57 587 597 10.1369/jhc.2009.953638 19223294
51. Quantitative DNA fiber mapping. H-UG Weier M Wang JC Mullikin Y Zhu JF Cheng KM Greulich A Bensimon JW Gray, Hum Mol Genet 1995 4 1903 1910 10.1093/hmg/4.10.1903 8595414
52. DNA fiber mapping techniques for the assembly of high-resolution physical maps. H-UG Weier, J Histochem Cytochem 2001 49 939 948 11457922
53. Comprehensive chromosomal analysis of human preimplantation embryos using whole genome amplification and single cell comparative genomic hybridization. D Wells JDA Delhanty, Mol Hum Reprod 2000 6 1055 1062 10.1093/molehr/6.11.1055 11044470
54. Single-cell chromosomal imbalances detection by array CGH. C Le Caignec C Spits K Sermon M De Rycke B Thienpont S Debrock C Staessen Y Moreau JP Fryns A Van Steirteghem I Liebaers JR Vermeesch, Nucleic Acids Res 2006 34 68 10.1093/nar/gkl336 16698960
55. Novel molecular cytogenetic techniques for identifying complex chromosomal rearrangements: technology and applications in molecular medicine. N McNeil T Ried, Expert Rev Mol Med 2000 2 1 14 10.1017/S1462399400001940
56. Telomeres and aging. G Aubert PM Lansdorp, Physiol Rev 2008 88 557 579 10.1152/physrev.00026.2007 18391173
57. Three-dimensional arrangements of centromeres and telomeres in nuclei of human and murine lymphocytes. C Weierich A Brero S Stein J von Hase C Cremer T Cremer I Solovei, Chromosome Res 2003 11 485 502 10.1023/A:1025016828544 12971724
58. Cytogenetic and molecular-cytogenetic studies of Rett syndrome (RTT): a retrospective analysis of a Russian cohort of RTT patients (the investigation of 57 girls and three boys). SG Vorsanova YB Yurov VY Ulas IA Demidova AD Kolotii NL Gorbatchevskaia AK Beresheva IV Soloviev, Brain Dev 2001 23 196 S201 10.1016/S0387-7604(01)00347-3 11738872
59. Non-disjunction of chromosome 21, alphoid DNA variation, and sociogenetic features of Down syndrome. SG Vorsanova IY Iourov AK Beresheva IA Demidova VV Monakhov VS Kravets OB Bartseva EA Goyko IV Soloviev YB Yurov, Tsitol Genet 2005 39 6 30 36 16396318
60. Chimerism and multiple numerical chromosome imbalances in a spontaneously aborted fetus. SG Vorsanova IY Iourov IA Demidova EA Kirillova IV Soloviev YB Yurov, Tsitol Genet 2006 40 5 28 30 17385415
61. Partial monosomy 7q34-qter and 21pter-q22.13 due to cryptic unbalanced translocation t(7;21) but not monosomy of the whole chromosome 21: a case report plus review of the literature. SG Vorsanova IY Iourov VY Voinova-Ulas A Weise VV Monakhov AD Kolotii IV Soloviev PV Novikov YB Yurov T Liehr, Mol Cytogenet 2008 1 13 10.1186/1755-8166-1-13 18564437
62. In situ hybridization of cloned repeating DNA sequences and differential staining of human chromosomes. YB Yurov, Bull Exp Biol Med 1984 97 643 647 10.1007/BF00808254
63. 18p- syndrome: an unusual case and diagnosis by in situ hybridization with chromosome 18-specific alphoid DNA sequence. SG Vorsanova YB Yurov IA Alexandrov IA Demidova SP Mitkevich AF Tirskaya, Hum Genet 1986 72 185 187 10.1007/BF00283945 3753696
64. Translocation t(1;17)(q12;q25) with a clinical picture like a proximal deletion of 1q: identification by in situ hybridization with chromosome 1-sepcific satellite DNA probe. SG Vorsanova YB Yurov MB Kurbatov LZ Kazantseva, Hum Genet 1990 86 173 174 10.1007/BF00197700 2265830
65. The structure and evolution of centromeric transition regions within the human genome. X She JE Horvath Z Jiang G Liu TS Furey R Christ T Graves CL Gulden C Alkan JA Bailey C Sahinalp M Rocchi D Haussler RK Wilson W Miller S Schwartz EE Eichler, Nature 2004 430 857 864 10.1038/nature02806 15318213
66. Differences in centromere positioning of cycling and postmitotic human cell types. I Solovei L Schermelleh k During A Engelhardt S Stein C Cremer T Cremer, Chromosoma 2004 112 410 423 10.1007/s00412-004-0287-3 15197559
67. Alphoid DNA from different chromosomes forms de novo minichromosomes with high efficiency. T Kaname A McGuigan A Georghiou Y Yurov K Osoegawa PJ De jong P Ioannou C Huxley, Chromosome 2005 13 411 422 10.1007/s10577-005-0979-4 (Pubitemid 40853835)
68. Pericentric inversion inv(7)(p11q21.1): report on two cases and genotype-phenotype correlations. SG Vorsanova IY Iourov IA Demidova AD Kolotii IV Soloviev YB Yurov, Tsitol Genet 2006 40 3 45 48 16933852
69. Folding and organization of a contiguous chromosome region according to the gene distribution pattern in primary genomic sequence. LS Shopland CR Lynch KA Peterson K Thornton N Keeper J van Hase S Stein S Vincent KR Molloy G Kreth C Cremer CJ Bult TP O'Brien, J Cell Biol 2006 174 27 38 10.1083/jcb.200603083 16818717
70. Three-dimensional maps of all chromosomes in human male fibroblast nuclei and prometaphase rosettes. A Bolzer G Kreth I Solovei D Koehler K Saracoglu C Fauth S Muller R Ellis C Cremer MR Speicher T Cremer, PLoS Biol 2005 3 157 10.1371/journal.pbio.0030157 15839726
71. Differences in the location and morphology of chromosomes in the human nucleus. JA Croft JM Bridger S Boyle P Perry P Teague WA Bickmore, J Cell Biol 1999 145 1119 1131 10.1083/jcb.145.6.1119 10366586
72. Rise, fall and resurrection of chromosome territories: a historical perspective. Part II. Fall and resurrection of chromosome territories during the 1950s to 1980s. Part III. Chromosome territories and the functional nuclear architecture: experiments and models from the 1990s to the present. T Cremer C Cremer, Eur J Histochem 2006 50 223 272 17213034
73. The hierarchically organized splitting of chromosomal bands for all human chromosomes. N Kosyakova A Weise K Mrasek U Claussen T Liehr H Nelle, Mol Cytogenet 2009 2 4 10.1186/1755-8166-2-4 19171032
74. Evidence for interphase DNA decondensation transverse to the chromosome axis: a multicolour banding analysis. A Weise H Starke A Heller U Claussen T Liehr, Int J Mol Med 2002 9 359 361 11891527
75. Preferred co-localization of chromosomes 8 and 21 in myeloid bone marrow cells detected by three dimensional molecular cytogenetics. M Manvelyan P Kempf A Weise K Mrasek A Heller A Liehr K Hoffken HJ Friecke HG Sayer T Liehr H Mkrtchan, Int J Mol Med 2009 24 335 341 19639225
76. Quantitative DNA fiber mapping. CM Lu M Wang K Greulich-Bode JF Weier HUG Weier, Fluorescence in situ hybridization (FISH) - Application guide Berlin, Heidelberg: Springer Verlag, Liehr T, 2009 269 291
77. Comparative genomic hybridization. D Pinkel DG Albertson, Annu Rev Genomics Hum Genet 2005 6 331 354 10.1146/annurev.genom.6.080604.162140 16124865
78. Brain tissue preparations for chromosomal PRINS labeling. IY Iourov SG Vorsanova F Pellestor YB Yurov, Methods Mol Biol 2006 334 123 132 16861758
79. Microscopy and imaging systems. IY Iourov, Fluorescence in situ hybridization (FISH) - Application guide Berlin, Heidelberg: Springer Verlag, Liehr T, 2009 75 84 full-text
80. Multicolor FISH in human cytogenetics. T Liehr, Cytogenet Genome Res 2006 114 183 389 10.1159/000095450
81. Detection of aneuploidy in neural stem cells of the developing and adult human brain. IY Iourov SG Vorsanova YB Yurov, Electron J Biol 2008 4 36 42
82. Diagnosis of aneuploidy by in situ hybridization: analysis of interphase nuclei. SG Vorsanova YB Yurov GV Deryagin IV Soloviev GA Bytenskaya, Bull Exp Biol Med 1991 112 413 415 10.1007/BF00841378
83. Human centromeric DNAs. C Lee R Wevrick RB Fisher MA Ferguson-Smith CC Lin, Hum Genet 1997 100 291 304 10.1007/s004390050508 9272147
84. Variation in alphoid DNA sequences escape detection of aneuploidy in interphase FISH technique. RS Verma S Luke, Genomics 1992 14 113 116 10.1016/S0888-7543(05)80291-5 1427817
85. Centromeric alphoid DNA heteromorphisms of chromosome 22 as revealed by FISH-technique. T Liehr RA Pfeiffer U Trautmann E Gebhart, Clin Genet 1998 53 231 232 9630084
86. Two new cases of the christchurch (Ch1) chromosome 21: evidence for clinical consequences of de novo deletion 21p-. SG Vorsanova YB Yurov D Brusquant E Carles G Roizes, Tsitol Genet 2002 36 1 46 49 12012596
87. Fluorescence in situ hybridization system improved sensitivity of BCR-ABL detection: a triple-probe three-color. PB Sinclair AR Green C Grace EP Nacheva, Blood 1997 90 1395 1402 9269756
88. The impact of translocations and gene fusions on cancer causation. F Mitelman B Johanson F Martens, Nat Rev Cencer 2007 7 233 245 10.1038/nrc2091 (Pubitemid 46480968)
89. FISH mapping of Philadelphia negative BCR/ABL1 positive CML. A Virgili D Brazma AG Reid J Howard-Reeves M Valgãán A Chanalaris VAS De Melo D Marin JF Apperley C Grace EP Nacheva, Mol Cytogenet 2008 1 14 10.1186/1755-8166-1-14 18638369
90. Human molecular cytogenetics: diagnosis, prognosis, and disease management. K Kucheria V Jobanputra R Talwar ME Ahmad R Dada TA Sivakumaran, Teratogenesis Carcinog Mutagen Suppl 1 225 233
91. Mosaic 22q11.2 microdeletion syndrome: diagnosis and clinical manifestations of two cases. A Halder M Jain M Kabra N Gupta, Mol Cytogenet 2008 1 18 10.1186/1755-8166-1-18 18691436
92. Microduplication 22q11.2: a new chromosomal syndrome. MF Portnoi, Eur J Med Genet 2009 52 88 93 10.1016/j.ejmg.2009.02.008 19254783
93. Towards many colors in FISH on 3D-preserved interphase nuclei. J Walter B Joffe A Bolzer H Albiez PA Benedetti S Muller MR Speicher T Cremer M Cremer I Solovei, Cytogenet Genome Res 2006 114 367 378 10.1159/000094227 16954680
94. Raising the curtains on interchromosomal interactions. C Krueger CS Osborne, Trends Genet 2006 22 637 639 10.1016/j.tig.2006.09.008 16997416
95. Fluorescence intensity profiles of in situ hybridization signals depict genome architecture within human interphase nuclei. IY Iourov SG Vorsanova YB Yurov, Tsitol Genet 2008 42 5 3 8 19140435
96. Combined immunocytochemistry and fluorescence in situ hybridization for simultaneous tricolor detection of cell cycle, genomic, and phenotypic parameters of tumor cells. EJM Speel J Herbergs FCS Ramaekers AHN Hopman, J Histochem Cytochem 1994 42 961 966 8014480
97. Analysis of alphoid DNA variation and kinetochore size in human chromosome 21: evidence against pathological significance of alphoid satellite DNA diminutions. B Marzais SG Vorsanova G Roizes YB Yurov, Tsitol Genet 1999 33 1 25 31 10330695
98. Dual Y-chromosome painting and immunofluorescence staining of archival human liver transplant biopsies. SR Dundas S Boyle CO Bellamy W Hawkins OJ Garden JA Ross W Bickmore, J Histochem Cytochem 2001 49 1321 1322 11561017
99. Cytogenetic and immuno-FISH analysis of the 4q subtelomeric region, which is associated with facioscapulohumeral muscular dystrophy. F Yang C Shao V Vedanarayanan M Ehrlich, Chromosoma 2004 112 350 359 10.1007/s00412-004-0280-x 15138770
100. Biochemistry meets nuclear architecture: multicolor immuno-FISH for co-localization analysis of chromosome segments and differentially expressed gene loci with various histone methylations. R Zinner K Teller R Versteeg T Cremer M Cremer, Adv Enzyme Regul 2007 47 223 241 10.1016/j.advenzreg.2007.01. 005 17442381
101. Disease-specific gene repositioning in breast cancer. KJ Meaburn PR Gudla S Khan SJ Lockett T Misteli, J Cell Biol 2009 187 801 812 10.1083/jcb.200909127 19995938
102. Suspension (S)-FISH, a new technique for interphase nuclei. U Steinhaeuser H Starke A Nietzel J Lindenau P Ullmann U Claussen T Liehr, J Histochem Cytochem 2002 50 1697 1698 12486094
103. Copy number variation in human health, disease, and evolution. F Zhang W Gu ME Hurles JR Lupski, Annu Rev Genomics Hum Genet 2009 10 451 81 10.1146/annurev.genom.9.081307.164217 19715442
104. Mosaic X chromosome aneuploidy can help to explain the male-to-female ratio in autism. IY Iourov YB Yurov SG Vorsanova, Med Hypotheses 2008 70 456 10.1016/j.mehy.2007.05.037 17651908
105. Maternal smoking as a cause of mosaic aneuploidy in spontaneous abortions. SG Vorsanova YB Yurov IY Iourov, Med Hypotheses 2008 71 607 10.1016/j.mehy.2008.05.027 18639386
106. Developmental chromosome instability as a possible cause of childhood brain cancers. IY Iourov SG Vorsanova YB Yurov, Med Hypotheses 2009 72 615 616 10.1016/j.mehy.2008.12.003 19136219
107. Neurodegeneration mediated by chromosome instability suggests changes in strategy for therapy development in ataxia-telangiectasia. YB Yurov IY Iourov SG Vorsanova, Med Hypotheses 2009 73 1075 1076 10.1016/j.mehy.2009.07.030 19666210
108. GIN'n'CIN hypothesis of brain aging: deciphering the role of somatic genetic instabilities and neural aneuploidy during ontogeny. YB Yurov SG Vorsanova IY Iourov, Mol Cytogenet 2009 2 23 10.1186/1755-8166-2-23 19939257
109. On the origin of trisomy 21 Down syndrome. MA Hulten SD Patel M Tankimanova M Westgren N Papadogiannakis AM Johnson E Iwarsson, Mol Cytogenet 2008 1 21 10.1186/1755-8166-1-21 18801168
110. Sex chromosomes loss and aging: in situ hybridization studies on human interphase nuclei. M Guttenbach B Koschorz U Bernthaler T Grimm M Schmid, Am J Hum Genet 1995 57 1143 1150 7485166
111. Analysis of gene expression patterns and chromosomal changes associated with aging. JB Geigl S Langer S Barwisch K Pfleghaar G Lederer MR Speicher, Cancer Res 2004 64 8850 8557 10.1158/0008-5472.CAN-04-2151 (Pubitemid 39552067)
112. Induction of aneuploidy by increasing chromosomal instability during dedifferentiation of hepatocellular carcinoma. L Wilkens P Flemming M Gebel J Bleck C Terkamp L Wingen H Kreipe B Schelgelberger, Proc Natl Acad Sci USA 2004 101 1309 1314 10.1073/pnas.0305817101 14745031
113. Parental-origin-determination fluorescence in situ hybridization distinguishes homologous human chromosomes on a single-cell level. A Weise M Gross K Mrasek H Mkrtchyan B Horsthemke C Jonsrud F Von Eggeling S Hinreiner V Witthuhn U Claussen T Liehr, Int J Mol Med 2008 21 189 200 18204785
114. Rapid prenatal diagnostics in the interphase nucleus: procedure and cut-off rates. T Liehr M Ziegler, J Histochem Cytochem 2005 53 289 291 10.1369/jhc.4B6394.2005 15750004
115. On the karyotypic origin and evolution of cancer cells. JM Nicholson P Duesberg, Cancer Genet Cytogenet 2009 194 96 110 10.1016/j.cancergencyto.2009. 06.008 19781442
116. Three unusual but cytogenetically similar cases with up to five different cell lines involving structural and numerical abnormalities of chromosome 18. IM Carreira A Mascarenhas E Matoso AB Couceiro L Ramos A Dufke M Mazauric R Stressig N Kosyakova JB Melo T Liehr, J Histochem Cytochem 2007 55 1123 1128 10.1369/jhc.7A7244.2007 17595336
117. Dynamic mosaicism manifesting as loss, gain and rearrangement of an isodicentric Y chromosome in a male child with growth retardation and abnormal external genitalia. IY Iourov SG Vorsanova T Liehr VV Monakhov IV Soloviev YB Yurov, Cytogenet Genome Res 2008 121 302 306 10.1159/000138903 18758177