The variation of aneuploidy frequency in the developing and adult human brain revealed by an interphase FISH study

Journal of Histochemistry and Cytochemistry

Volumn 53, Issue 3, 2005, Pages 385-390

  Yurov, Yuri B ^a   Iourov, Ivan Y ^a   Monakhov, Viktor V ^a   Soloviev, Ilia V ^a   Vostrikov, Viktor M ^a   Versanova, Svetlana G ^b  

^a INSTITUTE OF BIOMEDICAL CHEMISTRY   (Russian Federation)

^b N N BLOKHIN NATIONAL MEDICAL RESEARCH CENTER OF ONCOLOGY   (Russian Federation)

Author keywords

Aneuploidy; Developing and adult human brain; DNA probes; FISH

Indexed keywords

ADULT; ANEUPLOIDY; BRAIN DEVELOPMENT; BRAIN NERVE CELL; CADAVER; CHROMOSOMAL INSTABILITY; CHROMOSOME 1; CHROMOSOME 13; CHROMOSOME 18; CHROMOSOME 21; CHROMOSOME MOSAICISM; CHROMOSOME MUTATION; CONFERENCE PAPER; CYTOGENETICS; DNA PROBE; EMBRYO; FEMALE; FETUS; FLUORESCENCE IN SITU HYBRIDIZATION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; HUMAN TISSUE; INTERPHASE; MALE; MEDULLA OBLONGATA; NERVE CELL CULTURE; NERVE CELL DIFFERENTIATION; PRIORITY JOURNAL; X CHROMOSOME; Y CHROMOSOME;

ANEUPLOIDY; BRAIN; FEMALE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; INTERPHASE; MALE;

EID: 14844328676     PISSN: 00221554     EISSN: None     Source Type: Journal    
DOI: 10.1369/jhc.4A6430.2005     Document Type: Conference Paper

References (16)

1. Alexandrov IA, Mitkevich SP, Yurov YB (1988) The phylogeny of human chromosome specific alpha satellites. Chromosoma 96: 443-453
2. Lodish H, Berk A, Ziputsky L, Matsudaria P, Baltimore D, Darnell J (2000) Molecular Cell Biology, 4th ed. New York, W.H. Freeman Publishers
3. Osada T, Kusakabe H, Akutsu H, Yagi T, Yamagimachi R (2002) Adult murine neurons: their chromatin and chromosome changes and failure to support embryonic development as revealed by nuclear transfer. Cytogenet Genome Res 97:7-12
4. Rehen SK, McConnell MJ, Kaushal D, Kingsbury MA, Yang AH, Chun J (2001) Chromosomal variation in neurons of the developing and adult mammalian nervous system. Proc Natl Acad Sci U S A 98:13361-13366
5. Soloviev IV, Yurov YB, Vorsanova SG, Fayet F, Roizes G, Malet P (1995) Prenatal diagnosis of trisomy 21 using interphase fluorescence in situ hybridization of post-replicated cells with site-specific cosmid and cosmid contig probes. Prenat Diagn 15:237-248
6. Soloviev IV, Yurov YB, Vorsanova SG, Malet P (1994) Microwave activation of fluorescence in situ hybridization: a novel method for rapid chromosome detection and analysis. Focus 16:115-116
7. Soloviev IV, Yurov YB, Vorsanova SG, Marcais B, Rogaev EI, Kapanadze BI, Brodiansky VM, et al. (1998) Fluorescent in situ hybridization analysis of α-satellite DNA in cosmid libraries specific for human chromosomes 13, 21 and 22. Rus J Genet 34: 1247-1255
8. Victorov IV, Lyjin AA, Aleksandrove OP (2001) A modified roller method for organotypic brain cultures: free-floating slices of postnatal rat hippocampus. Brain Res Protocols 7:30-37
9. Vorsanova SG, Yurov YB, Alexandrov IA, Demidova IA, Mitkevich SP, Tirskaya AF (1986) 18p-Syndrome: an unusual case and diagnosis by in situ hybridization with chromosome 18-specific alphoid DNA sequence. Hum Genet 72:185-187
10. Vorsanova SG, Yurov YB, Soloviev IV, Demidova IA, Malet P (1994) Rapid identification of marker chromosomes by in situ hybridization under different stringency conditions. Anal Cell Pathol 7:251-259
11. Yang Y, Geldmacher DS, Herrup K (2001) DNA replication precedes neuronal cell death in Alzheimer's disease. J Neurosci 21: 2661-2668
12. Yurov YB, Saias MJ, Vorsanova SG, Erny R, Soloviev IV, Sharonin VO, Guichaoua MR, et al. (1996a) Rapid chromosomal analysis of germ-line cells by FISH: an investigation of an infertile male with large-headed spermatozoa. Mol Hum Reprod 9:665-668
13. Yurov YB, Soloviev IV, Vorsanova SG, Marcais B, Roizes G, Lewis R (1996b) High resolution fluorescence in situ hybridization using cyanine and fluorescein dyes: ultra-rapid chromosome detection by directly fluorescently labeled alphoid DNA probes. Hum Genet 97:390-398
14. Yurov YB, Vorsanova SG, Soloviev FV, Demidova IA, Alexandrov IA, Sharonin VO, Beresheva AK (2002) Original collection of DNA probes for preimplantational, fetal prenatal and postnatal diagnosis of chromosomal analysis by FISH. In Macek M Sr, Bianchi D, Cuckle H, eds. Early Prenatal Diagnosis, Fetal Cells and DNA in Mother. Present State and Perspectives. Prague, The Karolinum Press, 275-283
15. Yurov YB, Vostrikov VM, Monakhov VV, Iourov IY, Vorsanova SG (2003) Evidence for large scale chromosomal variations in neuronal cells of the fetal human brain. Balkan J Med Genet 6(suppl 3-4):95-99
16. Yurov YB, Vostrikov VM, Vorsanova SG, Monakhov VV, Iourov IY (2001) Multicolor fluorescent in situ hybridization on post mortem brain in schizophrenia as an approach for identification of low-level chromosomal aneuploidy in neuropsychiatric diseases. Brain Dev 23(suppl 1):186-190