메뉴 건너뛰기




Volumn 18, Issue 5, 2007, Pages 707-714

Three-dimensional genome organization in interphase and its relation to genome function

Author keywords

Chromatin folding; Genome function; Human transcriptome map; Nuclear organization

Indexed keywords

CHROMATIN STRUCTURE; DNA SYNTHESIS; DNA TRANSCRIPTION; FLUORESCENCE IN SITU HYBRIDIZATION; GENE CONTROL; GENE EXPRESSION; GENE FUNCTION; GENE STRUCTURE; GENOME ANALYSIS; INTERPHASE; REVIEW; THREE DIMENSIONAL IMAGING;

EID: 35648945777     PISSN: 10849521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.semcdb.2007.08.007     Document Type: Review
Times cited : (28)

References (69)
  • 1
    • 25844496592 scopus 로고    scopus 로고
    • The role of chromatin structure in regulating the expression of clustered genes
    • Sproul D., Gilbert N., and Bickmore W.A. The role of chromatin structure in regulating the expression of clustered genes. Nat Rev Genet 6 (2005) 775-781
    • (2005) Nat Rev Genet , vol.6 , pp. 775-781
    • Sproul, D.1    Gilbert, N.2    Bickmore, W.A.3
  • 2
    • 20844440723 scopus 로고    scopus 로고
    • Identification of coexpressed gene clusters in a comparative analysis of transcriptome and proteome in mouse tissues
    • Mijalski T., Harder A., Halder T., Kersten M., Horsch M., Strom T.M., et al. Identification of coexpressed gene clusters in a comparative analysis of transcriptome and proteome in mouse tissues. Proc Natl Acad Sci USA 102 (2005) 8621-8626
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 8621-8626
    • Mijalski, T.1    Harder, A.2    Halder, T.3    Kersten, M.4    Horsch, M.5    Strom, T.M.6
  • 3
    • 0003328368 scopus 로고    scopus 로고
    • Evidence for large domains of similarly expressed genes in the Drosophila genome
    • Spellman P.T., and Rubin G.M. Evidence for large domains of similarly expressed genes in the Drosophila genome. J Biol 1 (2002) 5
    • (2002) J Biol , vol.1 , pp. 5
    • Spellman, P.T.1    Rubin, G.M.2
  • 4
    • 0035895502 scopus 로고    scopus 로고
    • The human transcriptome map: clustering of highly expressed genes in chromosomal domains
    • Caron H., van Schaik B., van der Mee M., Baas F., Riggins G., van Sluis P., et al. The human transcriptome map: clustering of highly expressed genes in chromosomal domains. Science 291 (2001) 1289-1292
    • (2001) Science , vol.291 , pp. 1289-1292
    • Caron, H.1    van Schaik, B.2    van der Mee, M.3    Baas, F.4    Riggins, G.5    van Sluis, P.6
  • 5
    • 0141854009 scopus 로고    scopus 로고
    • The human transcriptome map reveals extremes in gene density, intron length, GC content, and repeat pattern for domains of highly and weakly expressed genes
    • Versteeg R., van Schaik B.D., van Batenburg M.F., Roos M., Monajemi R., Caron H., et al. The human transcriptome map reveals extremes in gene density, intron length, GC content, and repeat pattern for domains of highly and weakly expressed genes. Genome Res 13 (2003) 1998-2004
    • (2003) Genome Res , vol.13 , pp. 1998-2004
    • Versteeg, R.1    van Schaik, B.D.2    van Batenburg, M.F.3    Roos, M.4    Monajemi, R.5    Caron, H.6
  • 6
    • 0036613754 scopus 로고    scopus 로고
    • Clustering of housekeeping genes provides a unified model of gene order in the human genome
    • Lercher M.J., Urrutia A.O., and Hurst L.D. Clustering of housekeeping genes provides a unified model of gene order in the human genome. Nat Genet 31 (2002) 180-183
    • (2002) Nat Genet , vol.31 , pp. 180-183
    • Lercher, M.J.1    Urrutia, A.O.2    Hurst, L.D.3
  • 7
    • 33644853802 scopus 로고    scopus 로고
    • Histone modifications: signalling receptors and potential elements of a heritable epigenetic code
    • Nightingale K.P., ONeill L.P., and Turner B.M. Histone modifications: signalling receptors and potential elements of a heritable epigenetic code. Curr Opin Genet Dev 16 (2006) 125-136
    • (2006) Curr Opin Genet Dev , vol.16 , pp. 125-136
    • Nightingale, K.P.1    ONeill, L.P.2    Turner, B.M.3
  • 8
    • 0034750744 scopus 로고    scopus 로고
    • Non-random radial higher-order chromatin arrangements in nuclei of diploid human cells
    • Cremer M., vonHase J., Volm T., Brero A., Kreth G., Walter J., et al. Non-random radial higher-order chromatin arrangements in nuclei of diploid human cells. Chromosome Res 9 (2001) 541-567
    • (2001) Chromosome Res , vol.9 , pp. 541-567
    • Cremer, M.1    vonHase, J.2    Volm, T.3    Brero, A.4    Kreth, G.5    Walter, J.6
  • 9
    • 0037459063 scopus 로고    scopus 로고
    • Considering nuclear compartmentalization in the light of nuclear dynamics
    • Chubb J.R., and Bickmore W.A. Considering nuclear compartmentalization in the light of nuclear dynamics. Cell 112 (2003) 403-406
    • (2003) Cell , vol.112 , pp. 403-406
    • Chubb, J.R.1    Bickmore, W.A.2
  • 10
  • 11
    • 33846283384 scopus 로고    scopus 로고
    • Dynamic genome architecture in the nuclear space: regulation of gene expression in three dimensions
    • Lanctot C., Cheutin T., Cremer M., Cavalli G., and Cremer T. Dynamic genome architecture in the nuclear space: regulation of gene expression in three dimensions. Nat Rev Genet 8 (2007) 104-115
    • (2007) Nat Rev Genet , vol.8 , pp. 104-115
    • Lanctot, C.1    Cheutin, T.2    Cremer, M.3    Cavalli, G.4    Cremer, T.5
  • 12
    • 0028019457 scopus 로고
    • Visualization of G1 chromosomes: a folded, twisted, supercoiled chromonema model of interphase chromatid structure
    • Belmont A.S., and Bruce K. Visualization of G1 chromosomes: a folded, twisted, supercoiled chromonema model of interphase chromatid structure. J Cell Biol 127 (1994) 287-302
    • (1994) J Cell Biol , vol.127 , pp. 287-302
    • Belmont, A.S.1    Bruce, K.2
  • 13
    • 0041878327 scopus 로고    scopus 로고
    • From DNA structure to gene expression: mediators of nuclear compartmentalization and dynamics
    • Bode J., Goetze S., Heng H., Krawetz S.A., and Benham C. From DNA structure to gene expression: mediators of nuclear compartmentalization and dynamics. Chromosome Res 11 (2003) 435-445
    • (2003) Chromosome Res , vol.11 , pp. 435-445
    • Bode, J.1    Goetze, S.2    Heng, H.3    Krawetz, S.A.4    Benham, C.5
  • 14
    • 1842584772 scopus 로고    scopus 로고
    • Chromatin loops are selectively anchored using scaffold/matrix-attachment regions
    • Heng H.H., Goetze S., Ye C.J., Liu G., Stevens J.B., Bremer S.W., et al. Chromatin loops are selectively anchored using scaffold/matrix-attachment regions. J Cell Sci 117 (2004) 999-1008
    • (2004) J Cell Sci , vol.117 , pp. 999-1008
    • Heng, H.H.1    Goetze, S.2    Ye, C.J.3    Liu, G.4    Stevens, J.B.5    Bremer, S.W.6
  • 15
  • 16
    • 0042880630 scopus 로고    scopus 로고
    • Spatial organization of gene expression: the active chromatin hub
    • deLaat W., and Grosveld F. Spatial organization of gene expression: the active chromatin hub. Chromosome Res 11 (2003) 447-459
    • (2003) Chromosome Res , vol.11 , pp. 447-459
    • deLaat, W.1    Grosveld, F.2
  • 17
    • 33750465872 scopus 로고    scopus 로고
    • SATB1 packages densely looped, transcriptionally active chromatin for coordinated expression of cytokine genes
    • Cai S.T., Lee C.C., and Kohwi-Shigematsu T. SATB1 packages densely looped, transcriptionally active chromatin for coordinated expression of cytokine genes. Nat Genet 38 (2006) 1278-1288
    • (2006) Nat Genet , vol.38 , pp. 1278-1288
    • Cai, S.T.1    Lee, C.C.2    Kohwi-Shigematsu, T.3
  • 18
    • 33750212321 scopus 로고    scopus 로고
    • Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture-on-chip (4C)
    • Simonis M., Klous P., Splinter E., Moshkin Y., Willemsen R., de Wit E., et al. Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture-on-chip (4C). Nat Genet 38 (2006) 1348-1354
    • (2006) Nat Genet , vol.38 , pp. 1348-1354
    • Simonis, M.1    Klous, P.2    Splinter, E.3    Moshkin, Y.4    Willemsen, R.5    de Wit, E.6
  • 19
    • 33749400168 scopus 로고    scopus 로고
    • Chromosome conformation capture carbon copy (5C): a massively parallel solution for mapping interactions between genomic elements
    • Dostie J., Richmond T.A., Arnaout R.A., Selzer R.R., Lee W.L., Honan T.A., et al. Chromosome conformation capture carbon copy (5C): a massively parallel solution for mapping interactions between genomic elements. Genome Res 16 (2006) 1299-1309
    • (2006) Genome Res , vol.16 , pp. 1299-1309
    • Dostie, J.1    Richmond, T.A.2    Arnaout, R.A.3    Selzer, R.R.4    Lee, W.L.5    Honan, T.A.6
  • 21
    • 0029129565 scopus 로고
    • Evidence for the organization of chromatin in megabase pair-sized loops arranged along a random walk path in the human G0/G1 interphase nucleus
    • Yokota H., van den Engh G., Hearst J.E., Sachs R.K., and Trask B.J. Evidence for the organization of chromatin in megabase pair-sized loops arranged along a random walk path in the human G0/G1 interphase nucleus. J Cell Biol 130 (1995) 1239-1249
    • (1995) J Cell Biol , vol.130 , pp. 1239-1249
    • Yokota, H.1    van den Engh, G.2    Hearst, J.E.3    Sachs, R.K.4    Trask, B.J.5
  • 22
    • 33745593972 scopus 로고    scopus 로고
    • Folding and organization of a contiguous chromosome region according to the gene distribution pattern in primary genomic sequence
    • Shopland L.S., Lynch C.R., Peterson K.A., Thornton K., Kepper N., Hase J., et al. Folding and organization of a contiguous chromosome region according to the gene distribution pattern in primary genomic sequence. J Cell Biol 174 (2006) 27-38
    • (2006) J Cell Biol , vol.174 , pp. 27-38
    • Shopland, L.S.1    Lynch, C.R.2    Peterson, K.A.3    Thornton, K.4    Kepper, N.5    Hase, J.6
  • 23
    • 0033593366 scopus 로고    scopus 로고
    • Compartmentalization of interphase chromosomes observed in simulation and experiment
    • Munkel C., Eils R., Dietzel S., Zink D., Mehring C., Wedemann G., et al. Compartmentalization of interphase chromosomes observed in simulation and experiment. J Mol Biol 285 (1999) 1053-1065
    • (1999) J Mol Biol , vol.285 , pp. 1053-1065
    • Munkel, C.1    Eils, R.2    Dietzel, S.3    Zink, D.4    Mehring, C.5    Wedemann, G.6
  • 24
    • 9344239339 scopus 로고    scopus 로고
    • Long-range compaction and flexibility of interphase chromatin in budding yeast analyzed by high-resolution imaging techniques
    • Bystricky K., Heun P., Gehlen L., Langowski J., and Gasser S.M. Long-range compaction and flexibility of interphase chromatin in budding yeast analyzed by high-resolution imaging techniques. Proc Natl Acad Sci USA 101 (2004) 16495-16500
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 16495-16500
    • Bystricky, K.1    Heun, P.2    Gehlen, L.3    Langowski, J.4    Gasser, S.M.5
  • 27
    • 0028139575 scopus 로고
    • The 30 nm chromatin fiber as a flexible polymer
    • Ostashevsky J.Y., and Lange C.S. The 30 nm chromatin fiber as a flexible polymer. J Biomol Struct Dynam 11 (1994) 813-820
    • (1994) J Biomol Struct Dynam , vol.11 , pp. 813-820
    • Ostashevsky, J.Y.1    Lange, C.S.2
  • 28
    • 0026737923 scopus 로고
    • Estimating genomic distance from DNA sequence location in cell nuclei by a random walk model
    • Vandenengh G., Sachs R., and Trask B.J. Estimating genomic distance from DNA sequence location in cell nuclei by a random walk model. Science 257 (1992) 1410-1412
    • (1992) Science , vol.257 , pp. 1410-1412
    • Vandenengh, G.1    Sachs, R.2    Trask, B.J.3
  • 31
    • 5444268559 scopus 로고    scopus 로고
    • Differential large-scale chromatin compaction and intranuclear positioning of transcribed versus non-transcribed transgene arrays containing beta-globin regulatory sequences
    • Dietzel S., Zolghadr K., Hepperger C., and Belmont A.S. Differential large-scale chromatin compaction and intranuclear positioning of transcribed versus non-transcribed transgene arrays containing beta-globin regulatory sequences. J Cell Sci 117 (2004) 4603-4614
    • (2004) J Cell Sci , vol.117 , pp. 4603-4614
    • Dietzel, S.1    Zolghadr, K.2    Hepperger, C.3    Belmont, A.S.4
  • 32
    • 19744379789 scopus 로고    scopus 로고
    • Nuclear re-organisation of the Hoxb complex during mouse embryonic development
    • Chambeyron S., Da Silva N.R., Lawson K.A., and Bickmore W.A. Nuclear re-organisation of the Hoxb complex during mouse embryonic development. Development 132 (2005) 2215-2223
    • (2005) Development , vol.132 , pp. 2215-2223
    • Chambeyron, S.1    Da Silva, N.R.2    Lawson, K.A.3    Bickmore, W.A.4
  • 33
    • 0034065032 scopus 로고    scopus 로고
    • Large-scale chromatin organization of the major histocompatibility complex and other regions of human chromosome 6 and its response to interferon in interphase nuclei
    • Volpi E.V., Chevret E., Jones T., Vatcheva R., Williamson J., Beck S., et al. Large-scale chromatin organization of the major histocompatibility complex and other regions of human chromosome 6 and its response to interferon in interphase nuclei. J Cell Sci 113 (2000) 1565-1576
    • (2000) J Cell Sci , vol.113 , pp. 1565-1576
    • Volpi, E.V.1    Chevret, E.2    Jones, T.3    Vatcheva, R.4    Williamson, J.5    Beck, S.6
  • 34
    • 0036061468 scopus 로고    scopus 로고
    • Subchromosomal positioning of the epidermal differentiation complex (EDC) in keratinocyte and lymphoblast interphase nuclei
    • Williams R.R., Broad S., Sheer D., and Ragoussis J. Subchromosomal positioning of the epidermal differentiation complex (EDC) in keratinocyte and lymphoblast interphase nuclei. Exp Cell Res 272 (2002) 163-175
    • (2002) Exp Cell Res , vol.272 , pp. 163-175
    • Williams, R.R.1    Broad, S.2    Sheer, D.3    Ragoussis, J.4
  • 35
    • 0037049548 scopus 로고    scopus 로고
    • Gene density and transcription influence the localization of chromatin outside of chromosome territories detectable by FISH
    • Mahy N.L., Perry P.E., and Bickmore W.A. Gene density and transcription influence the localization of chromatin outside of chromosome territories detectable by FISH. J Cell Biol 159 (2002) 753-763
    • (2002) J Cell Biol , vol.159 , pp. 753-763
    • Mahy, N.L.1    Perry, P.E.2    Bickmore, W.A.3
  • 36
    • 0033612538 scopus 로고    scopus 로고
    • Large-scale chromatin unfolding and remodeling induced by VP16 acidic activation domain
    • Tumbar T., Sudlow G., and Belmont A.S. Large-scale chromatin unfolding and remodeling induced by VP16 acidic activation domain. J Cell Biol 145 (1999) 1341-1354
    • (1999) J Cell Biol , vol.145 , pp. 1341-1354
    • Tumbar, T.1    Sudlow, G.2    Belmont, A.S.3
  • 39
  • 40
    • 4444258534 scopus 로고    scopus 로고
    • Chromatin architecture of the human genome: gene-rich domains are enriched in open chromatin fibers
    • Gilbert N., Boyle S., Fiegler H., Woodfine K., Carter N.P., and Bickmore W.A. Chromatin architecture of the human genome: gene-rich domains are enriched in open chromatin fibers. Cell 118 (2004) 555-566
    • (2004) Cell , vol.118 , pp. 555-566
    • Gilbert, N.1    Boyle, S.2    Fiegler, H.3    Woodfine, K.4    Carter, N.P.5    Bickmore, W.A.6
  • 41
    • 4544255977 scopus 로고    scopus 로고
    • Transcription-dependent spatial arrangements of CFTR and adjacent genes in human cell nuclei
    • Zink D., Amaral M.D., Englmann A., Lang S., Clarke L.A., Rudolph C., et al. Transcription-dependent spatial arrangements of CFTR and adjacent genes in human cell nuclei. J Cell Biol 166 (2004) 815-825
    • (2004) J Cell Biol , vol.166 , pp. 815-825
    • Zink, D.1    Amaral, M.D.2    Englmann, A.3    Lang, S.4    Clarke, L.A.5    Rudolph, C.6
  • 42
    • 1842855742 scopus 로고    scopus 로고
    • Nuclear organization in differentiating oligodendrocytes
    • Nielsen J.A., Hudson L.D., and Armstrong R.C. Nuclear organization in differentiating oligodendrocytes. J Cell Sci 115 (2002) 4071-4079
    • (2002) J Cell Sci , vol.115 , pp. 4071-4079
    • Nielsen, J.A.1    Hudson, L.D.2    Armstrong, R.C.3
  • 43
    • 11144296359 scopus 로고    scopus 로고
    • Sir-mediated repression can occur independently of chromosomal and subnuclear contexts
    • Gartenberg M.R., Neumann F.R., Laroche T., Blaszczyk M., and Gasser S.M. Sir-mediated repression can occur independently of chromosomal and subnuclear contexts. Cell 119 (2004) 955-967
    • (2004) Cell , vol.119 , pp. 955-967
    • Gartenberg, M.R.1    Neumann, F.R.2    Laroche, T.3    Blaszczyk, M.4    Gasser, S.M.5
  • 44
    • 2342501365 scopus 로고    scopus 로고
    • Genome-wide localization of the nuclear transport machinery couples transcriptional status and nuclear organization
    • Casolari J.M., Brown C.R., Komili S., West J., Hieronymus H., and Silver P.A. Genome-wide localization of the nuclear transport machinery couples transcriptional status and nuclear organization. Cell 117 (2004) 427-439
    • (2004) Cell , vol.117 , pp. 427-439
    • Casolari, J.M.1    Brown, C.R.2    Komili, S.3    West, J.4    Hieronymus, H.5    Silver, P.A.6
  • 45
    • 0032490917 scopus 로고    scopus 로고
    • Perinuclear localization of chromatin facilitates transcriptional silencing
    • Andrulis E.D., Neiman A.M., Zappulla D.C., and Sternglanz R. Perinuclear localization of chromatin facilitates transcriptional silencing. Nature 394 (1998) 592-595
    • (1998) Nature , vol.394 , pp. 592-595
    • Andrulis, E.D.1    Neiman, A.M.2    Zappulla, D.C.3    Sternglanz, R.4
  • 46
    • 1942503933 scopus 로고    scopus 로고
    • Separation of silencing from perinuclear anchoring functions in yeast Ku80, Sir4 and Esc1 proteins
    • Taddei A., Hediger F., Neumann F.R., Bauer C., and Gasser S.M. Separation of silencing from perinuclear anchoring functions in yeast Ku80, Sir4 and Esc1 proteins. EMBO J 23 (2004) 1301-1312
    • (2004) EMBO J , vol.23 , pp. 1301-1312
    • Taddei, A.1    Hediger, F.2    Neumann, F.R.3    Bauer, C.4    Gasser, S.M.5
  • 47
    • 33744977019 scopus 로고    scopus 로고
    • Nuclear pore association confers optimal expression levels for an inducible yeast gene
    • Taddei A., Van Houwe G., Hediger F., Kalck V., Cubizolles F., Schober H., et al. Nuclear pore association confers optimal expression levels for an inducible yeast gene. Nature 441 (2006) 774-778
    • (2006) Nature , vol.441 , pp. 774-778
    • Taddei, A.1    Van Houwe, G.2    Hediger, F.3    Kalck, V.4    Cubizolles, F.5    Schober, H.6
  • 48
    • 0034628607 scopus 로고    scopus 로고
    • Re-modelling of nuclear architecture in quiescent and senescent human fibroblasts
    • Bridger J.M., Boyle S., Kill I.R., and Bickmore W.A. Re-modelling of nuclear architecture in quiescent and senescent human fibroblasts. Curr Biol 10 (2000) 149-152
    • (2000) Curr Biol , vol.10 , pp. 149-152
    • Bridger, J.M.1    Boyle, S.2    Kill, I.R.3    Bickmore, W.A.4
  • 49
    • 21844444077 scopus 로고    scopus 로고
    • Three-dimensional maps of all chromosomes in human male fibroblast nuclei and prometaphase rosettes
    • Bolzer A., Kreth G., Solovei I., Koehler D., Saracoglu K., Fauth C., et al. Three-dimensional maps of all chromosomes in human male fibroblast nuclei and prometaphase rosettes. PLoS Biol 3 (2005) e157
    • (2005) PLoS Biol , vol.3
    • Bolzer, A.1    Kreth, G.2    Solovei, I.3    Koehler, D.4    Saracoglu, K.5    Fauth, C.6
  • 50
    • 0035316574 scopus 로고    scopus 로고
    • Chromosome territories, nuclear architecture and gene regulation in mammalian cells
    • Cremer T., and Cremer C. Chromosome territories, nuclear architecture and gene regulation in mammalian cells. Nat Rev Genet 2 (2001) 292-301
    • (2001) Nat Rev Genet , vol.2 , pp. 292-301
    • Cremer, T.1    Cremer, C.2
  • 51
    • 33646729244 scopus 로고    scopus 로고
    • Intermingling of chromosome territories in interphase suggests role in translocations and transcription-dependent associations
    • Branco M.R., and Pombo A. Intermingling of chromosome territories in interphase suggests role in translocations and transcription-dependent associations. PLoS Biol 4 (2006) e138
    • (2006) PLoS Biol , vol.4
    • Branco, M.R.1    Pombo, A.2
  • 52
    • 15644364244 scopus 로고    scopus 로고
    • Separate and variably shaped chromosome arm domains are disclosed by chromosome arm painting in human cell nuclei
    • Dietzel S., Jauch A., Kienle D., Qu G., Holtgreve-Grez H., Eils R., et al. Separate and variably shaped chromosome arm domains are disclosed by chromosome arm painting in human cell nuclei. Chromosome Res 6 (1998) 25-33
    • (1998) Chromosome Res , vol.6 , pp. 25-33
    • Dietzel, S.1    Jauch, A.2    Kienle, D.3    Qu, G.4    Holtgreve-Grez, H.5    Eils, R.6
  • 53
    • 0032752799 scopus 로고    scopus 로고
    • Chromosomes as well as chromosomal subdomains constitute distinct units in interphase nuclei
    • Visser A.E., and Aten J.A. Chromosomes as well as chromosomal subdomains constitute distinct units in interphase nuclei. J Cell Sci 112 (1999) 3353-3360
    • (1999) J Cell Sci , vol.112 , pp. 3353-3360
    • Visser, A.E.1    Aten, J.A.2
  • 54
    • 0028090269 scopus 로고
    • Replicon clusters may form structurally stable complexes of chromatin and chromosomes
    • Sparvoli E., Levi M., and Rossi E. Replicon clusters may form structurally stable complexes of chromatin and chromosomes. J Cell Sci 107 (1994) 3097-3103
    • (1994) J Cell Sci , vol.107 , pp. 3097-3103
    • Sparvoli, E.1    Levi, M.2    Rossi, E.3
  • 56
    • 0035253606 scopus 로고    scopus 로고
    • The spatial organization of human chromosomes within the nuclei of normal and emerin-mutant cells
    • Boyle S., Gilchrist S., Bridger J.M., Mahy N.L., Ellis J.A., and Bickmore W.A. The spatial organization of human chromosomes within the nuclei of normal and emerin-mutant cells. Hum Mol Genet 10 (2001) 211-219
    • (2001) Hum Mol Genet , vol.10 , pp. 211-219
    • Boyle, S.1    Gilchrist, S.2    Bridger, J.M.3    Mahy, N.L.4    Ellis, J.A.5    Bickmore, W.A.6
  • 57
    • 25144450143 scopus 로고    scopus 로고
    • Contributions of low molecule number and chromosomal positioning to stochastic gene expression
    • Becskei A., Kaufmann B.B., and van Oudenaarden A. Contributions of low molecule number and chromosomal positioning to stochastic gene expression. Nat Genet 37 (2005) 937-944
    • (2005) Nat Genet , vol.37 , pp. 937-944
    • Becskei, A.1    Kaufmann, B.B.2    van Oudenaarden, A.3
  • 58
    • 0242416539 scopus 로고    scopus 로고
    • Blake WJ, KAErn M, Cantor CR, Collins JJ. Noise in eukaryotic gene expression. Nature 2003;422:633-7.
  • 61
    • 0037165965 scopus 로고    scopus 로고
    • Visualizing chromatin dynamics in interphase nuclei
    • Gasser S.M. Visualizing chromatin dynamics in interphase nuclei. Science 296 (2002) 1412-1416
    • (2002) Science , vol.296 , pp. 1412-1416
    • Gasser, S.M.1
  • 62
    • 0141994824 scopus 로고    scopus 로고
    • Perturbations of chromatin structure in human genetic disease: recent advances
    • Bickmore W.A., and van der Maarel S.M. Perturbations of chromatin structure in human genetic disease: recent advances. Hum Mol Genet 12 (2003) R207-R213
    • (2003) Hum Mol Genet , vol.12
    • Bickmore, W.A.1    van der Maarel, S.M.2
  • 63
    • 0042357071 scopus 로고    scopus 로고
    • Chromatin compaction by human MeCP2-assembly of novel secondary chromatin structures in the absence of DNA methylation
    • Georgel P.T., HorowitzScherer R.A., Adkins N., Woodcock C.L., Wade P.A., and Hansen J.C. Chromatin compaction by human MeCP2-assembly of novel secondary chromatin structures in the absence of DNA methylation. J Biol Chem 278 (2003) 32181-32188
    • (2003) J Biol Chem , vol.278 , pp. 32181-32188
    • Georgel, P.T.1    HorowitzScherer, R.A.2    Adkins, N.3    Woodcock, C.L.4    Wade, P.A.5    Hansen, J.C.6
  • 65
    • 0035475924 scopus 로고    scopus 로고
    • Human diseases with underlying defects in chromatin structure and modification
    • Hendrich B., and Bickmore W. Human diseases with underlying defects in chromatin structure and modification. Hum Mol Genet 10 (2001) 2233-2242
    • (2001) Hum Mol Genet , vol.10 , pp. 2233-2242
    • Hendrich, B.1    Bickmore, W.2
  • 66
    • 2942643923 scopus 로고    scopus 로고
    • Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome
    • Goldman R.D., Shumaker D.K., Erdos M.R., Eriksson M., Goldman A.E., Gordon L.B., et al. Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome. Proc Natl Acad Sci USA 101 (2004) 8963-8968
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 8963-8968
    • Goldman, R.D.1    Shumaker, D.K.2    Erdos, M.R.3    Eriksson, M.4    Goldman, A.E.5    Gordon, L.B.6
  • 67
    • 8344274464 scopus 로고    scopus 로고
    • Genome-scale expression profiling of Hutchinson-Gilford progeria syndrome reveals widespread transcriptional misregulation leading to mesodermal/mesenchymal defects and accelerated atherosclerosis
    • Csoka A.B., English S.B., Simkevich C.P., Ginzinger D.G., Butte A.J., Schatten G.P., et al. Genome-scale expression profiling of Hutchinson-Gilford progeria syndrome reveals widespread transcriptional misregulation leading to mesodermal/mesenchymal defects and accelerated atherosclerosis. Aging Cell 3 (2004) 235-243
    • (2004) Aging Cell , vol.3 , pp. 235-243
    • Csoka, A.B.1    English, S.B.2    Simkevich, C.P.3    Ginzinger, D.G.4    Butte, A.J.5    Schatten, G.P.6
  • 68
    • 2542491127 scopus 로고    scopus 로고
    • Employment opportunities for non-coding RNAs
    • Morey C., and Avner P. Employment opportunities for non-coding RNAs. FEBS Lett 567 (2004) 27-34
    • (2004) FEBS Lett , vol.567 , pp. 27-34
    • Morey, C.1    Avner, P.2
  • 69
    • 1942425450 scopus 로고    scopus 로고
    • A role for macromolecular crowding effects in the assembly and function of compartments in the nucleus
    • Hancock R. A role for macromolecular crowding effects in the assembly and function of compartments in the nucleus. J Struct Biol 146 (2004) 281-290
    • (2004) J Struct Biol , vol.146 , pp. 281-290
    • Hancock, R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.