Intestinal absorption and biodistribution of cosalane and its amino acid conjugates: Novel anti-HIV agents

International Journal of Pharmaceutics

Volumn 231, Issue 2, 2002, Pages 197-211

  Kuchimanchi, K R ^a   Gandhi, M D ^b   Sheta, R R ^b   Johnston, T P ^b   Santhosh, K C ^c   Cushman, M ^c   Mitra, A K ^b  

^a IQVIA   (United States)

^b UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

^c PURDUE UNIVERSITY   (United States)

Author keywords

Absorption enhancement; Amino acid conjugates; Biodistribution; Closed loop method; Cosalane; Intestinal transport

Indexed keywords

AMINO ACID DERIVATIVE; ANTIVIRUS AGENT; ASPARTIC ACID DERIVATIVE; COSALANE; GLYCINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL MEMBRANE PERMEABILITY; CONCENTRATION RESPONSE; CONJUGATE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DISPOSITION; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG PENETRATION; DRUG UPTAKE; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INTESTINE ABSORPTION; INTESTINE CELL; INTESTINE MUCOSA PERMEABILITY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RETICULOENDOTHELIAL SYSTEM;

ANIMALS; ANTI-HIV AGENTS; AURINTRICARBOXYLIC ACID; INTESTINAL ABSORPTION; MALE; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION;

EID: 0037074101     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(01)00884-5     Document Type: Article

References (40)

1. Bile acid active and passive ileal transport in the rabbit: Effect of luminal stirring
2. Novel formulation strategies for improving oral bioavailability of drugs with poor membrane permeation or presystemic metabolism
3. Influence of leucine on intestinal baclofen absorption as a model compound of neutral alpha-aminoacids
4. Physiochemical and physiological mechanisms for the effects of food on drug adsorption: The role of lipids and pH
5. A model of human small intestinal absorptive cells. 1. Transport barrier
6. Design, synthesis and biological evaluation of cosalane a novel anti-HIV agent which inhibits multiple features of virus replication
7. Effect of sodium taurodeoxycholate on biological membranes: Release of phosphorus, phospholipid, and protein from everted rat small intestine
8. Utilizing bile acid carrier mechanisms to enhance liver and small intestine absorption
9. Effect of bile salts on the gastrointestinal absorption of drugs. II. Mechanism of the enhancement of the intestinal absorption of sulfaguanidine by bile salts
10. Pharmacokinetics, biliary excretion, and tissue distribution of novel anti-HIV agents, cosalane and dihydrocosalane, in Sprague-Dawley rats
11. Intestinal bile salt transport: Structure-activity relationships and other properties
12. The relationship between rat intestinal permeability and hydrophilic probe size
13. Relationship between drug absorption enhancing activity and membrane perturbing effects of acylcarnitines
14. Selection of development candidates based on in vitro permeability measurements
15. Reperfusion injury after liver preservation for transplantation
16. Jejunal permeability and hepatic extraction of fluvastatin in humans
17. Comparison of the function of the tight junctions of endothelial cells and epithelial cells in regulating the movement of electrolytes and macromolecules across the cell monolayer
18. Effect of the interaction of drug-beta-cyclodextrin complex with bile salts on the drug absorption from rat small intestinal lumen
19. Mucosal in vitro permeability in the intestinal tract of the pig, the rat, and man: Species- and region-related differences
20. Endotoxin, reticuloendothelial function, and liver injury
21. Transport of cosalane - A highly lipophilic novel anti-HIV agent - Across caco-2 cell monolayers
22. Intestinal absorption of drugs. III. The influence of taurocholate on the disappearance kinetics of hydrophilic and lipophilic drugs from the small intestine of the rat
23. Intestinal absorption of drugs. I: The influence of taurocholate on the absorption of dantrolene in the small intestine of the rat
24. Effects of absorption enhancers on the transport of model compounds in Caco-2 cell monolayers: Assessment by confocal laser scanning microscopy
25. Correlation of anti-HIV activity with anion spacing in a series of cosalane analogs with extended polycarboxylate pharmacophores
26. Anti-HIV activity of a series of cosalane amino acid conjugates
27. Intravenous glycine improves survival in rat liver transplantation
28. Characterization of the kinetics of the passive and active transport mechanisms for bile acid absorption in the small intestine and colon of the rat
29. The physical chemistry of cholanic acids
30. A saturable transport mechanism in the intestinal absorption of gabapentin is the underlying cause of the lack of proportionality between increasing dose and drug levels in plasma
31. Enhanced transepithelial transport of peptides by conjunction to cholic acid
32. +-coupled amino acid transporter
33. Disposition of cosalane, a novel anti-HIV agent, in isolated perfused rat livers
34. Effects of permeation enhancers on the transport of a peptidomimetic thrombin inhibitor (CRC 220) in a human intestinal cell line (Caco-2)
35. High lipophilicity decreases drug transport across intestinal epithelial cells
36. Effect of adjuvants on charge-selective permeability and electrical resistance of rat jejunal membrane
37. Intestinal peptide transport systems and oral drug availability
38. Evaluation of drug absorption and presystemic metabolism using an in situ intestinal preparation
39. Permeability and absorption of leuprolide from various intestinal regions in rabbits and rats