Binding of β-carbolines at imidazoline I2 receptors: A structure-affinity investigation

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 4, 2004, Pages 999-1002

  Glennon, Richard A ^a   Grella, Brian ^a   Tyacke, Robin J ^b   Lau, Alice ^b   Westaway, Julie ^b   Hudson, Alan L ^b  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 DIHYDRO BETA CARBOLINE; ALPHA 2 ADRENERGIC RECEPTOR; BETA CARBOLINE DERIVATIVE; IMIDAZOLINE; IMIDAZOLINE I2 RECEPTOR; TRYPTOLINE; UNCLASSIFIED DRUG;

ADRENERGIC SYSTEM; ARTICLE; BINDING AFFINITY; BINDING SITE; DRUG BINDING; DRUG STRUCTURE; PROTEIN ANALYSIS; REDUCTION; RING OPENING;

EID: 0842302969     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2003.11.078     Document Type: Article

References (13)

1. Parini A., Moudanos C.G., Pizzinat N., Lanier S.M. Trends Pharmacol. Sci. 17:1996;13.
2. Eglen R.M., Hudson A.L., Kendall D.A., Nutt D.J., Morgan N.G., Wilson V.G., Dillon M.P. Trends Pharmacol. Sci. 19:1998;381.
3. Hudson A.L., Nutt D.J., Husbands S.M. Pharmaceut. News. 8:2001;18.
4. Hudson A.L., Price R., Tyacke R.J., Lalies M.D., Parker C.A., Nutt D.J. Br. J. Pharmacol. 126:1999;2. P.
5. Husbands S.M., Glennon R.A., Gorgerat S., Gough R., Tyacke R., Crosby J., Nutt D.J., Lewis J.W., Hudson A.L. Drug Alcohol Depend. 64:2001;203.
6. 12.
7. Synthesis of the β-carbolines shown in Table 1 has been described: Grella, B.; Teitler, M.; Smith, C.; Herrick-Davis, K.; Glennon, R. A. Bioorg. Med. Chem. Lett., in press.
8. Compound 13 HCl salt from MeOH, mp 254-257°C, analyzed within 0.4% of theory for C, H, and N.
9. Compound 14 HCl was prepared as described by Ismaiel A.M., Titeler M., Glennon R.A. Mansoura J. Pharm. (Egypt). 6:1989;1.
10. Compound 15 HCl (i.e., U-22,394A) was obtained as a gift from the Upjon Company, Kalamazoo, MI.
11. 3, and analyzed within 0.4% of theory for C, H, and N.
12. Cheng Y.C., Prusoff W.H. Biochem. Pharmacol. 22:1973;3099.
13. Narayanan K., Schindler L., Cook J.M. J. Org. Chem. 56:1991;359.