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47
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11844260267
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[9]), where the absolute configurations were wrongly assigned.
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[9]), where the absolute configurations were wrongly assigned.
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48
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Selected examples of process using a combination of biphosphine ligand and copper: a B. H. Lipshutz, H. Shimizu, Angew. Chem. 2004, 116, 2278;
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67
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77149170469
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The authors thank Prof. Dr. J. P. Genêt and Dr. V. Vidal-Ratovelomanana for a generous gift of ligands L12 and L13
-
The authors thank Prof. Dr. J. P. Genêt and Dr. V. Vidal-Ratovelomanana for a generous gift of ligands L12 and L13.
-
-
-
-
68
-
-
77149158236
-
-
Ligands L14 to L17 were generously donated by Solvias.
-
Ligands L14 to L17 were generously donated by Solvias.
-
-
-
-
69
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-
77149175759
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See Experimental Section
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See Experimental Section.
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70
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0035805286
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According to the work of Bäckvall, the reaction of allylmagnesium bromide led to poor conversion and low ee (60% after 18 h, 54% ee). A. S. E. Karlstrom, J. E. Bäckvall, Chem. Eur. J. 2001, 7, 1981.
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According to the work of Bäckvall, the reaction of allylmagnesium bromide led to poor conversion and low ee (60% after 18 h, 54% ee). A. S. E. Karlstrom, J. E. Bäckvall, Chem. Eur. J. 2001, 7, 1981.
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-
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71
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77149159854
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31P NMR, showed that the chiral ligand was damaged.
-
31P NMR, showed that the chiral ligand was damaged.
-
-
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72
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77149127498
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To determine the absolute configuration of the products stemming from the addition of secondary or tertiary alkyl-Grignard reagents to substrate 6, the following procedure was carried out. 3-(S)-Cyclohexyl-1,7- octadiene (78% ee) was prepared according to a reported procedure, K. Tissot-Croset, D. Polet, S. Gille, C. Hawner, A. Alexakis, Angew. Chem. 2004, 116, 2480-2482;
-
To determine the absolute configuration of the products stemming from the addition of secondary or tertiary alkyl-Grignard reagents to substrate 6, the following procedure was carried out. 3-(S)-Cyclohexyl-1,7- octadiene (78% ee) was prepared according to a reported procedure. (K. Tissot-Croset, D. Polet, S. Gille, C. Hawner, A. Alexakis, Angew. Chem. 2004, 116, 2480-2482;
-
-
-
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73
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3042695125
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[9]), where the absolute configurations were wrongly assigned.
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[9]), where the absolute configurations were wrongly assigned.
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-
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74
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0027240732
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[1b]
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[1b]
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75
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77149142358
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Selected examples of Cu-catalyzed asymmetric allylic methylation: a U. Piarulli, P. Daubos, C. Claverie, M. Roux, C. Gennari, Angew. Chem. 2003, 115, 244;
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Selected examples of Cu-catalyzed asymmetric allylic methylation: a) U. Piarulli, P. Daubos, C. Claverie, M. Roux, C. Gennari, Angew. Chem. 2003, 115, 244;
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For information about DKR and DYKAT see: a
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In particular cases the leaving group avoids the formation of a p-allyl, see ref.[2g
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