Evaluation of transcriptional activity of caspase-3 gene as a marker of acute neurotoxicity in rat cerebellar granular cells

Toxicology in Vitro

Volumn 24, Issue 2, 2010, Pages 465-471

  Folch, Jaume ^b   Alvira, Daniel ^a   López Querol, Marta ^b   Tajes, Marta ^a   Sureda, Francesc X ^b   Forsby, Anna ^c   Rimbau, Víctor ^a   Camins, Antoni ^a   Pallàs, Mercè ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b FACULTAT DE MEDICINA I CIÈNCIES DE LA SALUT   (Spain)

^c STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

Acute toxicity; Apoptosis; Caspase 3; Cell cycle; Cerebellar granule neurons; Oxidative stress

Indexed keywords

2 PROPANOL; 2,4 DICHLOROPHENOXYACETIC ACID; ACETONITRILE; ADRENALIN; AMIODARONE; AMITRIPTYLINE; ARSENIC TRIOXIDE; ATROPINE; BUTYL HYDROPEROXIDE; CADMIUM CHLORIDE; CAFFEINE; CARBAMAZEPINE; CASPASE 3; CHLORAL HYDRATE; CISPLATIN; COLCHICINE; CYCLOSPORIN A; DICHLORVOS; DIETHYLENE GLYCOL; DIGOXIN; ETHINYLESTRADIOL; FLUOROURACIL; LINDANE; N,N DIMETHYLFORMAMIDE; PHENOBARBITAL; REACTIVE OXYGEN METABOLITE; RIFAMPICIN; UNINDEXED DRUG; VERAPAMIL; XENOBIOTIC AGENT;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN CELL; CELL CYCLE; CELL CYCLE REGULATION; CELL TYPE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CULTURE MEDIUM; ENZYME ACTIVITY; ENZYME ASSAY; GENETIC TRANSCRIPTION; GRANULAR CELL; INCUBATION TIME; NERVE CELL CULTURE; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; POLYMERASE CHAIN REACTION; RAT; UPREGULATION;

ANIMALS; BIOLOGICAL MARKERS; CASPASE 3; CEREBELLUM; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION, ENZYMOLOGIC; NEURONS; NEUROTOXINS; RATS; RATS, SPRAGUE-DAWLEY; TRANSCRIPTION, GENETIC;

RATTUS;

EID: 76749124821     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2009.09.023     Document Type: Article

References (60)

1. Alvira D., Yeste-Velasco M., Folch J., Casadesús G., Smith M.A., Pallàs M., and Camins A. Neuroprotective effects of caffeine against complex I inhibition-induced apoptosis are mediated by inhibition of the Atm/p53/E2F-1 path in cerebellar granule neurons. Journal of Neuroscience Research 85 (2007) 3079-3088
2. Belmadani A., Steyn P.S., Tramu G., Betbedera A.M., Baudrimont I., and Creppy E.E. Selective toxicity of ochratoxin A in primary cultures from different brain regions. Archives of Toxicology 73 (1999) 108-114
3. Bittigau P., Sifringer M., and Ikonomidou C. Antiepileptic drugs and apoptosis in the developing brainvolume. Annals of New York Academy of Science 993 (2003) 103-114
4. Bonfoco E., Ceccatelli S., Manzo L., and Nicotera P. Colchicine induces apoptosis in cerebellar granule cells. Experimental Cell Research 218 (1995) 189-200
5. Bragadin M., Toninello A., Bindoli A., Rigobello M.P., and Canton M. Thallium induces apoptosis in Jurkat cells. Annals of New York Academy of Sciences 1010 (2003) 283-291
6. Davison K., Mann K.K., Waxman S., and Miller W.H. JNK activation is a mediator of arsenic trioxide-induced apoptosis in acute promyelocytic leukemia cells. Blood 103 (2004) 3496-3502
7. De Moliner K.L., Evangelista de Duffard A.M., Soto E., Duffard R., and Adamo A.M. Induction of apoptosis in cerebellar granule cells by 2,4-dichlorophenoxyacetic acid. Neurochemical Research 27 (2002) 1439-1446
8. 2+ involved mitochondrial pathway. Toxicological Science 91 (2006) 59-69
9. Ekwall B. Screening of toxic compounds in mammalian cell cultures. Annals of New York Academy of Sciences 407 (1983) 64-77
10. Ezendam J., Staedtler F., Pennings J., Vandebriel R.J., Pieters R., Harleman J.H., and Vos J.G. Toxicogenomics of subchronic hexachlorobenzene exposure in Brown Norway rats. Environmental Health Perspectives 112 (2004) 782-791
11. Forsby A., Bal-Price A.K., Camins A., Coecke S., Fabre N., Gustafsson H., Honegger P., Kinsner-Ovaskainen A., Pallas M., Rimbau V., Rodríguez-Farré E., Suñol C., Vericat J.A., and Zurich M.G. Neuronal in vitro models for the estimation of acute systemic toxicity. Toxicology In Vitro 23 (2009) 1564-1569
12. Fu Y., Sies H., and Lei X.G. Opposite roles of selenium-dependent glutathione peroxidase-1 in superoxide generator diquat- and peroxynitrite-induced apoptosis and signaling. Journal of Biological Chemistry 276 (2001) 43004-43009
13. Garrido R., Mattson M.P., Hennig B., and Toborek M. Nicotine protects against arachidonic-acid-induced caspase activation, cytochrome c release and apoptosis of cultured spinal cord neurons. Journal of Neurochemistry 76 (2001) 1395-1403
14. Gorman A.M., Bonfoco E., Zhivotovsky B., Orrenius S., and Ceccatelli S. Cytochrome c release and caspase-3 activation during colchicine-induced apoptosis of cerebellar granule cells. European Journal of Neuroscience 11 (1999) 1072-1099
15. Han J.Y., Joo Y., Kim Y.S., Lee Y.K., Kim H.J., Cho G.J., Choi W.S., and Kang S.S. Ethanol induces cell death by activating caspase-3 in the rat cerebral cortex. Molecular Cell 20 (2005) 189-195
16. Jiang Z., Hu J., Li X., Jiang Y., Zhou W., and Lu D. Expression analyses of 27 DNA repair genes in astrocytoma by TaqMan low-density array. Neuroscience Letters 409 (2006) 112-117
17. Jorda E.G., Verdaguer E., Canudas A.M., Jimenez A., Bruna A., Caelles C., Bravo R., Escubedo E., Pubill D., Camarasa J., Pallas M., and Camins A. Neuroprotective action of flavopiridol, a cyclin-dependent kinase inhibitor, in colchicine-induced apoptosis. Neuropharmacology 45 (2003) 672-683
18. Jordà E., Verdaguer E., Morano A., Jiménez A., Canudas A.M., Camins A., and Pallàs M. Lithium prevents colchicine-induced apoptosis in rat cerebellar granule neurons. Bipolar Disorders 6 (2004) 144-149
19. Julka D., Pal R., and Gill K.D. Neurotoxicity of dichlorvos: effect on antioxidant defense system in the rat central nervous system. Experimental and Molecular Pathology 56 (1992) 144-152
20. Kang S.H., Lee Y.A., Won S.J., Rhee K.H., and Gwag B.J. Caffeine-induced neuronal death in neonatal rat brain and cortical cell cultures. Neuroreport 28 (2002) 1945-1950
21. Kim S.D., Moon C.K., Eun S.Y., Ryu P.D., and Jo S.A. Identification of ASK1, MKK4, JNK, c-Jun, and caspase-3 as a signaling cascade involved in cadmium-induced neuronal cell apoptosis. Biochemical and Biophysical Research Communications 328 (2005) 326-334
22. Kim J., Kondratyev A., and Gale K. Antiepileptic drug-induced neuronal cell death in the immature brain: effects of carbamazepine, topiramate, and levetiracetam as monotherapy versus polytherapy. Journal of Pharmacology and Experimental Therapeutics 323 (2007) 165-173
23. Kruman I.I. Why do neurons enter the cell cycle?. Cell Cycle 3 (2004) 769-773
24. Kruman I.I., Wersto R.P., and Cardozo-Pelaez M. Cell cycle activation linked to neuronal cell death initiated by DNA damage. Neuron 41 (2004) 549-561
25. Li L., Shou Y., Borowitz J.L., and Isom G.E. Reactive oxygen species mediate pyridostigmine-induced neuronal apoptosis: involvement of muscarinic and NMDA receptors. Toxicology and Applied Pharmacology 15 (2001) 17-25
26. Lirk P., Haller I., Hausott B., Ingorokva S., Deibl M., Gerner P., and Klimaschewski L. The neurotoxic effects of amitriptyline are mediated by apoptosis and are effectively blocked by inhibition of caspase activity. Anaesthesia and Analgesia 102 (2006) 1728-1733
27. Livak K.J., and Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)). Methodology Methods 25 (2001) 402-408
28. López E., Figueroa S., Oset-Gasque M.J., and González M.P. Apoptosis and necrosis: two distinct events induced by cadmium in cortical neurons in culture. British Journal of Pharmacology 138 (2003) 901-911
29. Lovell M.A., Xie C., and Markesbery W.R. Acrolein, a product of lipid peroxidation, inhibits glucose and glutamate uptake in primary neuronal cultures. Free Radical Biology and Medicine 29 (2000) 714-720
30. Lovell M.A., Xie C., and Markesbery W.R. Acrolein is increased in Alzheimer's disease brain and is toxic to primary hippocampal cultures. Neurobiology of Aging 22 (2001) 87-94
31. Masoud L., Vijayasarathy C., Fernandez-Cabezudo M., Petroianu G., and Saleh A.M. Effect of malathion on apoptosis of murine L929 fibroblasts: a possible mechanism for toxicity in low dose exposure. Toxicology 185 (2003) 89-102
32. Matsui A., Matsuo H., Takanaga H., Sasaki S., Maeda M., and Sawada Y. Prediction of catalepsies induced by amiodarone, aprindine and procaine: similarity in conformation of diethylaminoethyl side chain1. Journal of Pharmacology and Experimental Therapeutics 287 (1998) 725-732
33. Mellerick D.M., and Liu H. Methanol exposure interferes with morphological cell movements in the Drosophila embryo and causes increased apoptosis in the CNS. Journal of Neurobiology 60 (2004) 308-318
34. Namgung U., and Xia Z. Arsenite-induced apoptosis in cortical neurons is mediated by c-Jun N-terminal protein kinase 3 and p38 mitogen-activated protein kinase. Journal of Neuroscience 20 (2000) 6442-6451
35. Okeda R., Shibutani M., Matsuo T., Kuroiwa T., Shimokawa R., and Tajima T. Experimental neurotoxicity of 5-fluorouracil and its derivatives is due to poisoning by the monofluorinated organic metabolites, monofluoroacetic acid and alpha-fluoro-beta-alanine. Acta Neuropathologyca 81 (1990) 66-73
36. Ozkisacik E.A., Discigil B., Boga M., Gurcun U., Badak M.I., Kurtoglu T., Yenisey C., and Dikicioglu E. Effects of cyclosporin A on neurological outcome and serum biomarkers in the same setting of spinal cord ischemia model. Annals of Vascular Surgery 20 (2006) 243-249
37. Parihar M.S., and Pandit M.K. Free radical induced increase in protein carbonyl is attenuated by low dose of adenosine in hippocampus and mid brain: implication in neurodegenerative disorders. General Physiology and Biophysics 22 (2003) 29-39
38. Piao F., Ma N., Hiraku Y., Murata M., Oikawa S., Cheng F., Zhong L., Yamauchi T., Kawanishi S., and Yokoyama K. Oxidative DNA damage in relation to neurotoxicity in the brain of mice exposed to arsenic at environmentally relevant levels. Journal of Occupational 47 (2005) 445-449
39. Pomés A., Frandsen A., Suñol C., Sanfeliu C., Rodríguez-Farré E., and Schousboe A. Lindane cytotoxicity in cultured neocortical neurons is ameliorated by GABA and flunitrazepam. Journal of Neuroscience Research 39 (1994) 663-668
40. Pretorius E., Bornman M.S., Marx J., Smit E., and van der Merwe C.F. Ultrastructural effects of low dosage endocrine disrupter chemicals on neural cells of the chicken embryo model. Hormone and Metabolism Research 38 (2006) 639-649
41. Raheja G., and Dip Gill K. Calcium homeostasis and dichlorvos induced neurotoxicity in rat brain. Molecular and Cellular Biochemistry 232 (2002) 13-18
42. Sadava D., and Winesburg J. Contaminants of PC-SPES are not responsible for cytotoxicity in human small-cell lung carcinoma cells. Cancer Letters 220 (2005) 171-175
43. Sakhi S., Bruce A., Sun N., Tocco G., Baudry M., and Schreiber S.S. p53 induction is associated with neuronal damage in the central nervous system. Proceedings of National Academy of Science USA 91 (1994) 7525-7529
44. Sakhi S., Sun N., Wing L.L., Mehta P., and Schreiber S.S. Nuclear accumulation of p53 protein following kainic acid-induced seizures. Neuroreport 7 (1996) 493-496
45. Salzman M. Methanol neurotoxicity. Clinical Toxicology 44 (2006) 89-90
46. Saunders C.R., Das S.K., Ramesh A., Shockley D.C., and Mukherjee S. Benzo(a)pyrene-induced acute neurotoxicity in the F-344 rat: role of oxidative stress. Journal Applied Toxicology 26 (2006) 427-438
47. Sava V., Reunova O., Velasquez A., Harbison R., and Sánchez-Ramos J. Acute neurotoxic effects of the fungal metabolite ochratoxin-A. Neurotoxicology 27 (2006) 82-92
48. Sava V., Reunova O., Velasquez A., and Sanchez-Ramos J. Can low level exposure to ochratoxin-A cause parkinsonism?. Journal Neurological Sciences 249 (2006) 68-75
49. Schwartz E.I., Smilenov L.B., Price M.A., Osredkar T., Baker R.A., Ghosh S., Shi F.D., Vollmer T.L., Lencinas A., Stearns D.M., Gorospe M., and Kruman I.I. Cell cycle activation in postmitotic neurons is essential for DNA repair. Cell Cycle 6 (2007) 318-329
50. Smith M.A. Oxidative stress and iron imbalance in Alzheimer disease: how rust became the fuss. Journal of Alzheimer Disease 9 (2006) 305-308
51. Smith W.W., Gorospe M., and Kusiak J.W. Signaling mechanisms underlying Abeta toxicity: potential therapeutic targets for Alzheimer's disease CNS. Neurological Disorders Drug Targets 5 (2006) 355-361
52. Sureda F.X., Gabriel C., Pallàs M., Adan J., Martínez J.M., Escubedo E., Camarasa J., and Camins A. In vitro and in vivo protective effect of orphenadrine on glutamate neurotoxicity. Neuropharmacology 38 (1999) 671-677
53. Ton C., Lin Y., and Willett C. Zebrafish as a model for developmental neurotoxicity testing. Birth Defects Research A Clinical and Molecular Teratology 76 (2006) 553-567
54. Uberti D., Belloni M., Grilli M., Spano P., and Memo M. Induction of tumour-suppressor phosphoprotein p53 in the apoptosis of cultured rat cerebellar neurones triggered by excitatory amino acids. European Journal of Neuroscience 10 (1998) 246-254
55. Verdaguer E., Jorda E.G., Canudas A.M., Jimenez A., Pubill D., Escubedo E., Camarasa J., Pallàs M., and Camins A. Antiapoptotic effects of roscovitine in cerebellar granule cells deprived of serum and potassium: a cell cycle-related mechanism. Neurochemistry International 44 (2004) 251-261
56. Xiang H., Hochman D.W., Saya H., Fujiwara T., Schwartzkroin P.A., and Morrison R.S. Evidence for p53-mediated modulation of neuronal viability. Journal of Neuroscience 16 (1996) 6753-6765
57. Xiao H., Rawal M., Hahm E.R., and Singh S.V. Benzo[a]pyrene-7, 8-diol-9, 10-epoxide causes caspase-mediated apoptosis in H460 human lung cancer cell line. Cell Cycle 6 (2007) 2826-2834
58. Yeste-Velasco M., Alvira D., Sureda F.X., Rimbau V., Forsby A., Pallàs M., Camins A., and Folch J. DNA low-density array analysis of colchicine neurotoxicity in rat cerebellar granular neurons. Neurotoxicology 29 (2008) 309-317
59. Yin W., Deng X.K., Yin F.Z., Zhang X.C., and Cai B.C. The cytotoxicity induced by brucine from the seed of Strychnos nux-vomica proceeds via apoptosis and is mediated by cyclooxygenase 2 and caspase 3 in SMMC 7221 cells. Food and Chemical Toxicology 9 (2007) 1700-1708
60. Zhu X., Perry G., Moreira P.I., Aliev G., Cash A.D., Hirai K., and Smith M.A. Mitochondrial abnormalities and oxidative imbalance in Alzheimer disease. Journal of Alzheimer Disease 9 (2006) 147-153