The neurotoxic effects of amitriptyline are mediated by apoptosis and are effectively blocked by inhibition of caspase activity

Anesthesia and Analgesia

Volumn 102, Issue 6, 2006, Pages 1728-1733

  Lirk, Philipp ^a   Haller, Ingrid ^a   Hausott, Barbara ^b   Ingorokva, Shota ^b   Deibl, Martina ^d   Gerner, Peter ^c   Klimaschewski, Lars ^b  

^a UNIVERSITY HOSPITAL INNSBRUCK   (Austria)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMITRIPTYLINE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE; CASPASE 3; CYTOCHROME C; LOCAL ANESTHETIC AGENT; N PHENYLETHYLAMITRYPTYLINE; N PROPYLAMITRYPTYLINE; TRICYCLIC ANTIDEPRESSANT AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME RELEASE; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; SPINAL GANGLION;

EID: 33744456738     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/01.ane.0000216018.62549.bb     Document Type: Article

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