The cytotoxicity induced by brucine from the seed of Strychnos nux-vomica proceeds via apoptosis and is mediated by cyclooxygenase 2 and caspase 3 in SMMC 7221 cells

Food and Chemical Toxicology

Volumn 45, Issue 9, 2007, Pages 1700-1708

  Yin, Wu ^a   Deng, Xu Kun ^b   Yin, Fang Zhou ^b   Zhang, Xiao Chun ^b   Cai, Bao Chang ^b  

^a NANJING UNIVERSITY   (China)

^b NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Apoptosis; Brucine; Caspase 3; Cyclooxygenase 2; SMMC 7721 cells; Strychnos nux vomica

Indexed keywords

BRUCINE; BRUCINE N OXIDE; CASPASE 3; CYCLOOXYGENASE 2; HERBACEOUS AGENT; ISOSTRYCHNINE; PLANT EXTRACT; STRYCHNINE; STRYCHNOS NUX VOMICA EXTRACT; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; DRUG MECHANISM; DRUG STRUCTURE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; STRYCHNOS NUX VOMICA;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CASPASE 3; CELL LINE, TUMOR; CELL PROLIFERATION; CYCLIC N-OXIDES; CYCLOOXYGENASE 2; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMANS; LIVER NEOPLASMS; SEEDS; STRYCHNINE; STRYCHNOS NUX-VOMICA;

STRYCHNOS NUX-VOMICA; STRYCHNOS TOXIFERA;

EID: 34547128611     PISSN: 02786915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fct.2007.03.004     Document Type: Article

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