Ethyl pyruvate protects against hypoxic-ischemic brain injury via anti-cell death and anti-inflammatory mechanisms

Neurobiology of Disease

Volumn 37, Issue 3, 2010, Pages 711-722

  Shen, Hongxia ^a   Hu, Xiaoming ^b,c   Liu, Can ^a   Wang, Suping ^b,c   Zhang, Wenting ^a   Gao, Hui ^a   Stetler, R Anne ^b,c   Gao, Yanqin ^a,b   Chen, Jun ^a,b,c  

^a FUDAN UNIVERSITY   (China)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Calcium; Calpain; Cell death; Inflammation; Microglia; Neonatal hypoxia ischemia; Neuroprotection; NF B

Indexed keywords

CALCIUM ION; CALPAIN; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; NERVE GROWTH FACTOR BETA SUBUNIT; PYRUVIC ACID DERIVATIVE; PYRUVIC ACID ETHYL ESTER; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRAIN ISCHEMIA; BRAIN PROTECTION; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CELL CULTURE; CELL DEATH; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVATION; MICROGLIA; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ANIMALS; ANIMALS, NEWBORN; ASPHYXIA NEONATORUM; BRAIN; CALCIUM SIGNALING; CALPAIN; CELL DEATH; CYTOPROTECTION; DISEASE MODELS, ANIMAL; ENCEPHALITIS; HUMANS; HYPOXIA-ISCHEMIA, BRAIN; INFANT, NEWBORN; INFLAMMATION MEDIATORS; MICROGLIA; NERVE DEGENERATION; NEURONS; NEUROPROTECTIVE AGENTS; NF-KAPPA B; PYRUVATES; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TREATMENT OUTCOME;

EID: 75949122041     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2009.12.010     Document Type: Article

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