Evidence That Glutathione Depletion Is a Mechanism Responsible for the Anti-Inflammatory Effects of Ethyl Pyruvate in Cultured Lipopolysaccharide-Stimulated RAW 264.7 Cells

Journal of Pharmacology and Experimental Therapeutics

Volumn 308, Issue 1, 2004, Pages 307-316

  Song, Mingchen ^a   Kellum, John A ^a   Kaldas, Hoda ^a   Fink, Mitchell P ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b 616A Scaife Hall ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; GLUTATHIONE; GLUTATHIONE ETHYL ESTER; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITE; PYRUVIC ACID DERIVATIVE; PYRUVIC ACID ETHYL ESTER; REACTIVE OXYGEN METABOLITE; SCAVENGER; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG POTENCY; ENZYME RELEASE; LIPID PEROXIDATION; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN DNA BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELLS, CULTURED; DNA; GLUTATHIONE; INFLAMMATION; INTERLEUKIN-10; INTERLEUKIN-6; LIPID PEROXIDATION; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PYRUVATES; RNA, MESSENGER;

EID: 0347758406     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.056622     Document Type: Article

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