Diazoxide prevents mitochondrial swelling and Ca2+ accumulation in CA1 pyramidal cells after cerebral ischemia in newborn pigs

Brain Research

Volumn 1019, Issue 1-2, 2004, Pages 97-104

  Domoki, Ferenc ^a   Bari, Ferenc ^a   Nagy, Krisztina ^a   Busija, David W ^b   Siklós, László ^c  

^a UNIVERSITY OF SZEGED   (Hungary)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

^c INSTITUTE OF BIOCHEMISTRY   (Hungary)

Author keywords

Disorders of the nervous system; Hippocampus; Ischemia; Mitochondrial ATP sensitive potassium channels; Neuroprotection; Oxalate pyroantimonate electron cytochemistry; Potassium channel opener

Indexed keywords

5 HYDROXYDECANOIC ACID; ADENOSINE TRIPHOSPHATE; ANTIMONY DERIVATIVE; CALCIUM ION; DIAZOXIDE; OXALIC ACID; PYROANTIMONIC ACID; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANESTHESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CALCIUM CELL LEVEL; CONTROLLED STUDY; CYTOCHEMISTRY; DRUG EFFECT; DRUG SCREENING; ELECTRON; FEMALE; INTRACRANIAL PRESSURE; MALE; MITOCHONDRION SWELLING; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; REPERFUSION INJURY; STRUCTURE ANALYSIS; SWINE; TIME;

ANIMALS; ANIMALS, NEWBORN; BRAIN ISCHEMIA; CALCIUM; DIAZOXIDE; FEMALE; MALE; MITOCHONDRIAL SWELLING; PYRAMIDAL CELLS; SWINE;

EID: 4043092661     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2004.05.088     Document Type: Article

References (43)

1. Bajgar R., Seetharaman S., Kowaltowski A.J., Garlid K.D., Paucek P. Identification and properties of a novel intracellular (mitochondrial) ATP-sensitive potassium channel in brain. J. Biol. Chem. 276:2001;33369-33374
2. Bari F., Errico R.A., Louis T.M., Busija D.W. Differential effects of short-term hypoxia and hypercapnia on N-methyl-D-aspartate-induced cerebral vasodilatation in piglets. Stroke. 27:1996;1634-1639. (discussion 1639-1640)
3. Beasley T.C., Bari F., Thore C., Thrikawala N., Louis T., Busija D. Cerebral ischemia/reperfusion increases endothelial nitric oxide synthase levels by an indomethacin-sensitive mechanism. J. Cereb. Blood Flow Metab. 18:1998;88-96
4. Berger R., Garnier Y. Pathophysiology of perinatal brain damage. Brain Res., Brain Res. Rev. 30:1999;107-134
5. Borgers M., De Brabander M., Van Reempts J., Awouters F., Jacob W.A. Intranuclear microtubules in lung mast cells of guinea pigs in anaphylactic shock. Lab. Invest. 37:1977;1-8
6. Borgers M., Thone F., van Nueten J.M. The subcellular distribution of calcium and the effects of calcium-antagonists as evaluated with a combined oxalate-pyroantimonate technique. Acta Histochem., Suppl. 24:1981;327-332
7. Brustovetsky N., Jemmerson R., Dubinsky J.M. Calcium-induced Cytochrome c release from rat brain mitochondria is altered by digitonin. Neurosci. Lett. 332:2002;91-94
8. Busija D.W., Meng W., Bari F., McGough P.S., Errico R.A., Tobin J.R., Louis T.M. Effects of ischemia on cerebrovascular responses to N-methyl-D-aspartate in piglets. Am. J. Physiol. 270:1996;H1225-H1230
9. Choi D.W. Calcium: still center-stage in hypoxic-ischemic neuronal death. Trends Neurosci. 18:1995;58-60
10. Degi R., Thore C., Bari F., Thrikawala N., Nogradi A., Robins G., Domoki F., Beasley T.C., Busija D.W. Ischemia increases prostaglandin H synthase-2 levels in retina and visual cortex in piglets. Graefe Arch. Clin. Exp. Ophthalmol. 239:2001;59-65
11. Delesse M. Procédé mécanique pour determiner la composition des roches. C. R. Acad. Sci. Paris. 25:1847;544-545
12. Domoki F., Perciaccante J.V., Veltkamp R., Bari F., Busija D.W. Mitochondrial potassium channel opener diazoxide preserves neuronal-vascular function after cerebral ischemia in newborn pigs. Stroke. 30:1999;2713-2718. (discussion 2718-2719)
13. Dux E., Kloiber O., Hossmann K.A., Siklos L. Calcium in hippocampus following lidocaine induced seizures: an electron cytochemical study. Acta Biol. Hung. 38:1987;213-224
14. Dux E., Mies G., Hossmann K.A., Siklos L. Calcium in the mitochondria following brief ischemia of gerbil brain. Neurosci. Lett. 78:1987;295-300
15. Dykens J.A. Isolated cerebral and cerebellar mitochondria produce free radicals when exposed to elevated CA2+ and Na+: implications for neurodegeneration. J. Neurochem. 63:1994;584-591
16. Engelhardt J.I., Siklos L., Komuves L., Smith R.G., Appel S.H. Antibodies to calcium channels from ALS patients passively transferred to mice selectively increase intracellular calcium and induce ultrastructural changes in motoneurons. Synapse. 20:1995;185-199
17. Fiskum G. Mitochondrial participation in ischemic and traumatic neural cell death. J. Neurotrauma. 17:2000;843-855
18. Friberg H., Wieloch T. Mitochondrial permeability transition in acute neurodegeneration. Biochimie. 84:2002;241-250
19. Garcia de Arriba S., Franke H., Pissarek M., Nieber K., Illes P. Neuroprotection by ATP-dependent potassium channels in rat neocortical brain slices during hypoxia. Neurosci. Lett. 273:1999;13-16
20. Gunter T.E., Pfeiffer D.R. Mechanisms by which mitochondria transport calcium. Am. J. Physiol. 258:1990;C755-C786
21. Halestrap A.P. The mitochondrial permeability transition: its molecular mechanism and role in reperfusion injury. Biochem. Soc. Symp. 66:1999;181-203
22. Hanley P.J., Mickel M., Loffler M., Brandt U., Daut J. K(ATP) channel-independent targets of diazoxide and 5-hydroxydecanoate in the heart. J. Physiol. 542:2002;735-741
23. Hu H., Sato T., Seharaseyon J., Liu Y., Johns D.C., O'Rourke B., Marban E. Pharmacological and histochemical distinctions between molecularly defined sarcolemmal KATP channels and native cardiac mitochondrial KATP channels. Mol. Pharmacol. 55:1999;1000-1005
24. Inoue I., Nagase H., Kishi K., Higuti T. ATP-sensitive K+ channel in the mitochondrial inner membrane. Nature. 352:1991;244-247
25. Leffler C.W., Busija D.W., Mirro R., Armstead W.M., Beasley D.G. Effects of ischemia on brain blood flow and oxygen consumption of newborn pigs. Am. J. Physiol. 257:1989;H1917-H1926
26. Liu D., Lu C., Wan R., Auyeung W.W., Mattson M.P. Activation of mitochondrial ATP-dependent potassium channels protects neurons against ischemia-induced death by a mechanism involving suppression of Bax translocation and cytochrome c release. J. Cereb. Blood Flow Metab. 22:2002;431-443
27. Maciel E.N., Vercesi A.E., Castilho R.F. Oxidative stress in Ca(2+)-induced membrane permeability transition in brain mitochondria. J. Neurochem. 79:2001;1237-1245
28. Mayhew T.M. A review of recent advances in stereology for quantifying neural structure. J. Neurocytol. 21:1992;313-328
29. Nakagawa I., Nakase H., Aketa S., Kamada Y., Yamashita M., Sakaki T. ATP-dependent potassium channel mediates neuroprotection by chemical preconditioning with 3-nitropropionic acid in gerbil hippocampus. Neurosci. Lett. 320:2002;33-36
30. Newman G.C., Hospod F.E., Patlak C.S., Trowbridge S.D., Wilke R.J., Fuhrmann M., Jones K.W. Calcium compartments in brain. J. Cereb. Blood Flow Metab. 22:2002;479-489
31. Ozcan C., Bienengraeber M., Dzeja P.P., Terzic A. Potassium channel openers protect cardiac mitochondria by attenuating oxidant stress at reoxygenation. Am. J. Physiol., Heart Circ. Physiol. 282:2002;H531-H539
32. Puka-Sundvall M., Gajkowska B., Cholewinski M., Blomgren K., Lazarewicz J.W., Hagberg H. Subcellular distribution of calcium and ultrastructural changes after cerebral hypoxia-ischemia in immature rats. Brain Res., Dev. Brain Res. 125:2000;31-41
33. Rajapakse N., Shimizu K., Kis B., Snipes J., Lacza Z., Busija D. Activation of mitochondrial ATP-sensitive potassium channels prevents neuronal cell death after ischemia in neonatal rats. Neurosci. Lett. 327:2002;208-212
34. Shake J.G., Peck E.A., Marban E., Gott V.L., Johnston M.V., Troncoso J.C., Redmond J.M., Baumgartner W.A. Pharmacologically induced preconditioning with diazoxide: a novel approach to brain protection. Ann. Thorac. Surg. 72:2001;1849-1854
35. Shimizu K., Lacza Z., Rajapakse N., Horiguchi T., Snipes J., Busija D.W. MitoK(ATP) opener, diazoxide, reduces neuronal damage after middle cerebral artery occlusion in the rat. Am. J. Physiol., Heart Circ. Physiol. 283:2002;H1005-H1011
36. Siklos L., Kuhnt U., Parducz A., Szerdahelyi P. Intracellular calcium redistribution accompanies changes in total tissue Na+, K+ and water during the first two hours of in vitro incubation of hippocampal slices. Neuroscience. 79:1997;1013-1022
37. Siklos L., Engelhardt J.I., Alexianu M.E., Gurney M.E., Siddique T., Appel S.H. Intracellular calcium parallels motoneuron degeneration in SOD-1 mutant mice. J. Neuropathol. Exp. Neurol. 57:1998;571-587
38. Silver I.A., Erecinska M. Ion homeostasis in rat brain in vivo: intra- and extracellular [Ca2+] and [H+] in the hippocampus during recovery from short-term, transient ischemia. J. Cereb. Blood Flow Metab. 12:1992;759-772
39. Thomson E. Quantitative microscopic analysis. J. Geol. 38:1930;193
40. Veltkamp R., Domoki F., Bari F., Busija D.W. Potassium channel activators protect the N-methyl-D-aspartate-induced cerebral vascular dilation after combined hypoxia and ischemia in piglets. Stroke. 29:1998;837-842. (discussion 842-833)
41. Werth J.L., Thayer S.A. Mitochondria buffer physiological calcium loads in cultured rat dorsal root ganglion neurons. J. Neurosci. 14:1994;348-356
42. Yu S.W., Wang H., Poitras M.F., Coombs C., Bowers W.J., Federoff H.J., Poirier G.G., Dawson T.M., Dawson V.L. Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor. Science. 297:2002;259-263
43. Zaidan E., Sims N.R. The calcium content of mitochondria from brain subregions following short-term forebrain ischemia and recirculation in the rat. J. Neurochem. 63:1994;1812-1819