Attenuation of sugar cataract by ethyl pyruvate

Molecular and Cellular Biochemistry

Volumn 200, Issue 1-2, 1999, Pages 103-109

  Devamanoharan, P S ^a   Henein, M ^a   Ali, A H ^a   Varma, S D ^a  

^a UNIVERSITY OF MARYLAND   (United States)

Author keywords

Attenuation effects; Dulcitol; Ethyl pyruvate; Glycation; Oxidation; Pyruvate; Sugar cataract

Indexed keywords

ADENOSINE TRIPHOSPHATE; EYE DROPS; GALACTITOL; GALACTOSE; GLYCOSYLATED PROTEIN; PYRUVIC ACID DERIVATIVE; PYRUVIC ACID ETHYL ESTER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CATARACT; CONTROLLED STUDY; DRUG PENETRATION; INTRAOCULAR DRUG ADMINISTRATION; MALE; NONHUMAN; RAT;

ADENOSINE TRIPHOSPHATE; ANIMALS; AQUEOUS HUMOR; CATARACT; CRYSTALLINS; DIETARY SUCROSE; GALACTITOL; GALACTOSE; GALACTOSEMIAS; GLYCOSYLATION; MALE; OPHTHALMIC SOLUTIONS; PYRUVATES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0032884524     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1007055503748     Document Type: Article

References (35)

1. Townsend EH, Mason HH, Strong PS: Galactosemia and its relation with Laennec's cirrhosis. Review of literature and presentation of six additional cases. Pediatrics 7: 760, 1951
2. Klein R, Klein BE: Vision disorders in diabetes: In: M.J. Harris and R.F. Hammon (eds.). Diabetic data compiled 1984, U.S. Government Printing Service, Washington, D.C, pp. 1-36, 1985
3. Van Heyningen, R: Formation of polyols by lens of rat with sugar cataract. Nature 184: 194-196, 1959
4. Kinoshita JH: Mechanism initiating cataract formation. Invest Ophthalmol 13: 713-724, 1974
5. Chylack LT, Kinoshita JH: A biochemical evaluation of cataract induced by high glucose medium. Invest Ophthalmol 8: 401-412, 1969
6. Varma SD, Mizuno A, and Kinoshita JH: Diabetic cataracts and flavonoids. Science 195: 205-206, 1976
7. Taylor A, Jacques PF: Relationship between aging, antioxidant status and cataract. Am J Clin Nutr 62: 1439S-1447S, 1995
8. Zigler JS Jr, Goosey JD: Singlet oxygen as a possible factor in human senile nuclear cataract. Curr Eye Res 3: 39-45, 1984
9. Garner MH, Spector A: Sulphur oxidation in selected human cortical cataracts and nuclear cataracts. Exp Eye Res 31: 361-69, 1983
10. Vinson JA, Possanja CS, and Drake AV: The effect of ascorbic acid on galactose cataracts. Nutr Rep Int 33: 665-669, 1986
11. Srivastava SK, Ansari NH: Prevention of sugar-induced cataractogenesis in rats by BHT. Diabetes 11: 1505-1508, 1988
12. Creighton MO, Ross WM, Stewart-Dehann PJ, Sanwal M, Trevithick JR: Modeling cortical cataractogenesis III. Effects of vitamin E treatment on galactose induced cataracts. Exp Eye Res 40: 213-222, 1985
13. Ohta Y, Torii H, Yamasaki T, Niwa T, Majima Y, Ishiguro I: Preventive action of vitamin E containing liposomes on cataractogenesis in young adult rats fed a 25% galactose diet. J Ocular Pharmacol 13: 537-550, 1997
14. Jacques PF, Hartz SC, Chylack JT Jr., McGandy RB, Sadowski JA: Nutritional status in persons with and without senile cataract: blood vitamin and mineral levels. Am J Clin Nutr 48: 152-158, 1988
15. Mares-Perlman JA, Brady WE, Klien BEK, Klein R, Palta M, Bowen P, Stacewicz-SaPuntzakis M: Serum carotenoids and tocopherols and severity of nuclear and cortical opacities. Invest Ophthal Vis Sci 36: 276088, 1995
16. Yeh LA, Ashton MA: The increase in lipid peroxidation in diabetic rat lens can be reversed by oral sorbinil. Metabolism 39: 612-622, 1990
17. Hunt JV, Dean RT, Wolf SPC: Hydroxyl radical production and auto-oxidative glycosylation: Glucose auto-oxidation as the cause of protein damage in the experimental glycation model of diabetes mellitus and aging. Biochem J 256: 205-212, 1988
18. Wolf SP, Jiang ZY, Hunt JV: Protein glycation and oxidative stress in diabetes mellitus and aging. Free Rad Biol Med 10: 339-352, 1991
19. Crabbe MJC: Discussion on sugar cataracts: Ciba Foundation Symposium 106: 123-131, 1984
20. Stevens VJ, Rouzer CA, Monnier VM, Cerami A: Diabetic cataract formation. Potential role of glycosylation of lens crystallins. Proc Natl Acad Sci USA 75: 2918-2922, 1979
21. Perry RE, Swamy MS, Abraham EC: Progressive changes in lens crystallin glycation and high molecular weight aggregates formation leading to cataract development in streptozotocin diabetic rats. Exp Eye Res 44: 269-272, 1987
22. Monnier VM, Stevens VJ, Cerami A: Nonenzymatic glycosylation, sulphydryl oxidation and aggregation of lens proteins in experimental sugar cataracts. J Exp Med 150: 1098-1107, 1979
23. Kowluru RA, Kern TS, Engerman RL: Abnormalities of retinal metabolism in diabetes and experimental galactosemia IV Antioxidant defense system. Free Rad Biol Med 22: 587-592, 1997
24. Kador PF, Akagi Y, Teruhashi H, Wyman M, Kinoshita JH: Prevention of pericyte ghost formation in retinal capillaries of galactose fed dogs by aldose reductase inhibitors. Arch Ophthal 106: 1099-1102, 1988
25. Varma SD, Devamanoharan PS, Morris SM: Photoinduction of cataracts in lens in vitro. Prevention by pyruvate. Exp Eye Res 50: 805-812, 1990
26. Varma SD, Ramachandran S, Devamanoharan PS, Morris SM, Ali AH: Prevention of oxidative damage to rat lens in vitro by pyruvate: possible attenuation in vivo. Curr Eye Res 14: 643-649, 1995
27. Varma SD, Morris SM: Peroxide damage to eye lens in vitro. Prevention by pyruvate. Free Rad Res Comm 4: 283-290, 1988
28. Varma SD, Devamanoharan PS, Ali AH: Formation of advanced glycation end products in diabetes. Prevention by pyruvate and alpha ketoglutarate. Mol Cell Biochem 171: 23-28, 1997
29. Hockwin O, Dragomirescu V, Laser H et al.: Scheimpflug photography of anterior segment of the eye. Principle, instrumentation and application to clinical and experimental ophthalmology. J Ophthal Photogr 9: 104-111, 1986
30. Miwa I, Kanbara M, Wakazano H, Okuda J: Analysis of sorbitol, dulcitol and myoinositol in lens and nerve by HPLC. Annal Biochem 73: 39-44, 1986
31. Holleman MAF: Note on the action of oxygenated water on alpha-keto-acids and 1,2-diketones. Recl Trav Chi Pays-bas Belg 23: 169-172, 1904
32. Varma SD, Devamanoharan PS, Morris SM: Prevention of cataracts by nutritional and metabolic antioxidants. Crit Rev Food Sci Nutr 35: 111-129, 1995
33. Zhao W, Devamanoharan PS, Varma SD: Fructose induced deactivation of glucose-6-phosphate dehydrogenase and its prevention by pyruvate: Implications in cataract prevention. Free Rad Res (In press)
34. Henein M, Devamanoharan PS, Ramachandran S, Varma SD: Prevention of galactose cataract by pyruvate. Lens Eye Toxic Res 9: 25-36, 1992
35. Varma SD, Devamanoharan PS, and Ali AH: Prevention of intracellular oxidative stress to lens by pyruvate and its ester. Free Rad Res 28: 131-135, 1998