Neuroprotective effects of ethyl pyruvate on brain energy metabolism after ischemia-reperfusion injury: A 31P-nuclear magnetic resonance study

Neurochemical Research

Volumn 34, Issue 4, 2009, Pages 775-785

  Tokumaru, Osamu ^a   Kuroki, Chihiro ^a   Yoshimura, Noriko ^a   Sakamoto, Tetsuro ^a   Takei, Hidehiro ^b   Ogata, Kazue ^a   Kitano, Takaaki ^a   Nisimaru, Naoko ^a   Yokoi, Isao ^a  

^a OITA UNIVERSITY   (Japan)

^b HOUSTON METHODIST HOSPITAL   (United States)

Author keywords

31P NMR; ATP; Brain energy metabolism; Ethyl pyruvate; Ischemia reperfusion injury; Phosphocreatine

Indexed keywords

CREATINE PHOSPHATE; ETHYLPYRUVATE; FLUOROCITRIC ACID; LACTIC ACID; PYRUVIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; BRAIN METABOLISM; CELL PH; CEREBROSPINAL FLUID; CONTROLLED STUDY; DRUG MECHANISM; ENERGY METABOLISM; MALE; NEUROPROTECTION; NONHUMAN; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; SCAVENGING SYSTEM;

ADENOSINE TRIPHOSPHATE; ANIMALS; BRAIN; BRAIN ISCHEMIA; ELECTRON SPIN RESONANCE SPECTROSCOPY; ENERGY METABOLISM; HYDROGEN-ION CONCENTRATION; INTRACELLULAR FLUID; MAGNETIC RESONANCE SPECTROSCOPY; MALE; NEUROPROTECTIVE AGENTS; PHOSPHOCREATINE; PYRUVATES; RATS; REPERFUSION INJURY;

RATTUS;

EID: 62349126169     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11064-008-9871-x     Document Type: Article

References (48)

1. MP Fink 2003 Ethyl pyruvate: a novel anti-inflammatory agent Crit Care Med 31 (Suppl) S51 S56 10.1097/00003246-200301001-00008
2. A González-Falcón E Candelario-Jalil M García- Cabrera OS León 2003 Effects of pyruvate administration on infarct volume and neurological deficits following permanent focal cerebral ischemia in rats Brain Res 990 1 7 10.1016/S0006-8993(03)03378-X
3. SD Varma KR Hegde 2007 Lens thiol depletion by peroxynitrite. Protective effect of pyruvate Mol Cell Biochem 298 199 204 10.1007/s11010-006-9352-y
4. L Cicalese K Lee W Schraut 1996 Pyruvate prevents ischemia-reperfusion mucosal injury of rat small intestine Am J Surg 171 97 101 10.1016/S0002- 9610(99)80081-6
5. PD Mongan J Capacchione JL Fontana 2001 Pyruvate improves cerebral metabolism during hemorrhagic shock Am J Physiol Heart Circ Physiol 281 H854 H864
6. JY Lee YH Kim JY Koh 2001 Protection by pyruvate against transient forebrain ischemia in rats J Neurosci 21 RC171
7. J Zeng GY Yang W Ying 2007 Pyruvate improves recovery after PARP-1-associated energy failure induced by oxidative stress in neonatal rat cerebrocortical slices J Cereb Blood Flow Metab 27 304 315 10.1038/sj.jcbfm. 9600335
8. CA Bunton 1949 Oxidation of α-diketones and α-keto-acids by hydrogen peroxide Nature 163 444 10.1038/163444a0
9. J O'Donnell-Tormey CF Nathan K Lanks 1987 Secretion of pyruvate an antioxidant defense of mammalian cells J Exp Med 165 500 514 10.1084/jem.165.2.500
10. KA Brand U Hermfisse 1997 Aerobic glycolysis by proliferating cells: a protective strategy against reactive oxygen species FASEB J 11 388 395
11. CM Montgomery JL Webb 1956 Metabolic studies on heart mitochondria. II. The inhibitory action of parapyruvate on the tricarboxylic acid cycle J Biol Chem 221 359 368
12. CA Sims S Wattanasirichaigoon MJ Menconi 2001 Ringer's ethyl pyruvate solution ameliorates ischemia/reperfusion induced intestinal mucosal injury in rats Crit Care Med 29 1513 1518 10.1097/00003246-200108000-00003
13. MP Fink 2007 Ethyl pyruvate: a novel anti-inflammatory agent J Intern Med 261 349 362 10.1111/j.1365-2796.2007.01789.x
14. JB Kim YM Yu SW Kim 2005 Anti-inflammatory mechanism is involved in ethyl pyruvate-mediated efficacious neuroprotection in the postischemic brain Brain Res 1060 188 192 10.1016/j.brainres.2005.08.029
15. RY Lin JC Vera RSK Chaganti 1998 Human monocarboxylate transporter 2 (MCT2) is a high affinity pyruvate transporter J Biol Chem 44 28959 28965 10.1074/jbc.273.44.28959
16. J Zeng J Liu GY Yang 2007 Exogenous ethyl pyruvate versus pyruvate during metabolic recovery after oxidative stress in neonatal rat cerebrocortical slices Anesthesiology 107 630 640
17. YJ Woo MD Taylor JE Cohen 2004 Ethyl pyruvate preserves cardiac function and attenuates oxidative injury after prolonged myocardial ischemia J Thorac Cardiovasc Surg 127 1262 1269 10.1016/j.jtcvs.2003.11.032
18. L Ulloa M Ochani H Yang 2002 Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation Proc Natl Acad Sci USA 99 12351 12356 10.1073/pnas.192222999
19. R Yang DJ Gallo JJ Baust 2002 Ethyl pyruvate modulates inflammatory gene expression in mice subject to hemorrhagic shock Am J Physiol Gastrointest Liver Physiol 283 G212 G221
20. PL Sappington ME Fink R Yang 2003 Ethyl pyruvate provides durable protection against inflammation-induced intestinal epithelial barrier dysfunction Shock 20 521 528 10.1097/01.shk.0000092697.10326.8b
21. Y Han JA Englert R Yang 2005 Ethyl pyruvate inhibits nuclear factor-κB-dependent signaling by directly targeting p65 J Pharmacol Exp Ther 312 1097 1105 10.1124/jpet.104.079707
22. M Takei Y Kawano K Yamada 1992 Phosphorus nuclear magnetic resonance studies on the calcium-dependent energy metabolism of rat cerebrum under conditions of potassium in vitro Neurosci Res 12 596 605 10.1016/0168-0102(92) 90066-L
23. 31P-NMR study Neurosci Res 36 215 226 10.1016/S0168-0102(99)00124-8
24. T Kitano N Nisimaru E Shibata 2002 Lactate utilization as an energy substrate in ischemic preconditioned rat brain slices Life Sci 72 557 564 10.1016/S0024-3205(02)02251-8
25. 31P NMR study Mol Cell Biochem 244 77 81 10.1023/A:1022461118479
26. 31P nuclear magnetic resonance spectroscopy study J Neurosurg 105 Suppl 202 207 10.3171/sup.2006.105.7.202
27. 31P nuclear magnetic resonance spectroscopy Neurology 35 781 788
28. DD Clarke WJ Nicklas S Berl 1970 Tricarboxylic acid-cycle metabolism in brain. Effect of fluoroacetate and fluorocitrate on the labelling of glutamate, aspartate, glutamine and γ-aminobutyrate Biochem J 120 345 351
29. RE Paulsen A Contestabile L Villani 1987 An in vivo model for studying function of brain tissue temporarily devoid of glial cell metabolism: the use of fluorocitrate J Neurochem 48 1377 1385 10.1111/j.1471-4159.1987.tb05674.x
30. I Yokoi J Toma J Liu 1995 Adenosines scavenged hydroxyl radicals and prevented posttraumatic epilepsy Free Radic Biol Med 19 473 479 10.1016/0891-5849(95)00050-8
31. R Development Core Team (2008) R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. ISBN 3-900051-07-0, URL http://www.R-project.org
32. ES Flamm HB Demopoulos ML Seligman 1978 Free radicals in cerebral ischemia Stroke 9 445 447
33. O Peters T Back U Lindauer 1998 Increased formation of reactive oxygen species after permanent and reversible middle cerebral artery occlusion in the rat J Cereb Blood Flow Metab 18 196 205 10.1097/00004647-199802000-00011
34. YM Yu JB Kim KW Lee 2005 Inhibition of the cerebral ischemic injury by ethyl pyruvate with a wide therapeutic window Stroke 36 2238 2243 10.1161/01.STR.0000181779.83472.35
35. PJ Magistretti L Pellerin DL Rothman 1999 Energy on demand Science 283 496 497 10.1126/science.283.5401.496
36. F Hyder AB Patel A Gjedde 2006 Neuronal-glial glucose oxidation and glutamatergic-GABAergic function J Cereb Blood Flow Metab 26 865 877 10.1038/sj.jcbfm.9600263
37. A Schurr RS Payne JJ Miller 1997 Glia are the main source of lactate utilized by neurons for recovery of function posthypoxia Brain Res 774 221 224 10.1016/S0006-8993(97)81708-8
38. A Schurr 2006 Lactate: the ultimate cerebral oxidative energy substrate? J Cereb Blood Flow Metab 26 142 152 10.1038/sj.jcbfm.9600174
39. L Pellerin PJ Magistretti 1994 Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization Proc Natl Acad Sci USA 91 10625 10629 10.1073/pnas.91.22.10625
40. S Desagher J Glowinski J Premont 1996 Astrocytes protect neurons from hydrogen peroxide toxicity J Neurosci 16 2553 2562
41. G Zhao MP Flavin 2000 Differential sensitivity of rat hippocampal and cortical astrocytes to oxygen-glucose deprivation injury Neurosci Lett 285 177 180 10.1016/S0304-3940(00)01056-9
42. D Liu CL Smith FC Barone 1999 Astrocytic demise precedes delayed neuronal death in focal ischemic rat brain Brain Res Mol Brain Res 68 29 41 10.1016/S0169-328X(99)00063-7
43. AM Hamby SW Suh TM Kauppinen 2007 Use of a poly(ADPRibose) polymerase inhibitor to suppress inflammation and neuronal death after cerebral ischemia-reperfusion Stroke 38 632 636 10.1161/01.STR.0000250742.61241.79
44. K Lohmann 1934 Über die enzymatische Aufspaltung der Kreatinphosphorsäure; zugleich ein Beitrag zum Chemismus der Muskelkontraktion Biochem Z 271 264 277
45. JY Yager J Asselin 1996 Effect of mild hypothermia on cerebral energy metabolism during the evolution of hypoxic-ischemic brain damage in the immature rat Stroke 27 919 926
46. L Litt K Hirai VJ Basus 2003 Temperature control of respiring rat brain slices during high field NMR spectroscopy Brain Res Protoc 10 191 198 10.1016/S1385-299X(02)00218-0
47. 31P-MRS-based determination of brain intracellular and interstitial pH: its application to in vivo H+ compartmentation and cellular regulation during hypoxic/ischemic conditions Neurochem Res 25 1385 1396 10.1023/A:1007664700661
48. FQ Zhou 2005 Pyruvate in the correction of intracellular acidosis: a metabolic basis as a novel superior buffer Am J Nephrol 25 55 63 10.1159/000084141