Novel matrix metalloproteinase inhibitors derived from quinoxalinone scaffold (Part I)

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 4, 2010, Pages 1516-1525

  Li, Yonggang ^a   Zhang, Jian ^a   Xu, Wenfang ^a   Zhu, Huawei ^a   Li, Xun ^a  

^a SHANDONG UNIVERSITY   (China)

Author keywords

Anti tumor; MMP 2 inhibitors; Peptidomimetic; Quinoxalinone derivatives

Indexed keywords

2 [2 (3 METHYL 2 OXOQUINOXALIN 1(2H) YL)ACETAMIDO] 3 PHENYL N (PYRIDINE 3 YL)PROPANAMIDE; 2 [2 (3 METHYL 2 OXOQUINOXALIN 1(2H) YL)ACETAMIDO] 3 PHENYL N 4 TOLYLPROPANAMIDE; 2 [2 (3 METHYL 2 OXOQUINOXALIN 1(2H) YL)ACETAMIDO] 3 PHENYL N M TOLYLPROPANAMIDE; 2 [2 (3 METHYL 2 OXOQUINOXALIN 1(2H) YL)ACETAMIDO] 3 PHENYL N O TOLYLPROPANAMIDE; 2 [2 (3 METHYL 2 OXOQUINOXALIN 1(2H) YL)ACETAMIDO] 3 PHENYL N PROPYLPROPANAMIDE; 2 [2 (3 METHYL 2 OXOQUINOXALIN 1(2H) YL)ACETAMIDO] N,3 DIPHENYLPROPANAMIDE; GELATINASE A; LY 52; MATRIX METALLOPROTEINASE INHIBITOR; METHYL 4 [2 [2 (3 METHYL 2 OXOQUINOXALIN 1(2H) YL)ACETAMIDO] 3 PHENYLPROPANAMIDO] 4 (METHYLTHIO)BUTANOATE; METHYL 4 [2 [2 (3-METHYL 2 OXOQUINOXALIN 1(2H) YL)ACETAMIDO] 3 PHENYLPROPANAMIDO]BUTANOATE; METHYL 4 METHYL 2 [2 [2 (3 METHYL 2 OXOQUINOXALIN 1(2H) YL)ACETAMIDO]] 3 PHENYLPROPANAMIDE; METHYL 6 [2 [2 (3 METHYL 2 OXOQUINOXALIN 1(2H) YL)ACETAMIDO] 3 PHENYLPROPANAMIDO]HEXANOATE; MICROSOMAL AMINOPEPTIDASE; N [3 CHLORO 4 FLUOROPHENYL) 2 (3 METHYL 2 OXOQUINOXALIN 1(2H) YL)ACETAMIDO] 3 PHENYLPROPANAMIDE; N [3,4 DICHLOROPHENYL) 2 (3 METHYL 2 OXOQUINOXALIN 1(2H) YL]ACETAMIDO) 3 PHENYLPROPANAMIDE; N [3,4 DIFLUOROPHENYL) 2 (3 METHYL 2 OXOQUINOXALIN 1(2H) YL)ACETAMIDO] 3 PHENYLPROPANAMIDE; N [4 BROMOPHENYL) 2 (3 METHYL 2 OXOQUINOXALIN 1(2H) YL)ACETAMIDO] 3 PHENYLPROPANAMIDE; N [4 CHLOROPHENYL) 2 (3 METHYL 2 OXOQUINOXALIN 1(2H) YL)ACETAMIDO] 3 PHENYLPROPANAMIDE; N [4 FLUOROPHENYL) 2 (3 METHYL 2 OXOQUINOXALIN 1(2H) YL)ACETAMIDO] 3 PHENYLPROPANAMIDE; N BUTYL 2 [2 (3 METHYL 2 OXOQUINOXALIN 1(2H) YL)ACETAMIDO] 3 PHENYLPROPANAMIDE; N ISOPROPYL 2 [2 (3 METHYL 2 OXOQUINOXALIN 1(2H) YL)ACETAMIDO] 3 PHENYLPROPANAMIDE; N,N DIETHYL 2 [2 (3 METHYL 2 OXOQUINOXALIN 1(2H) YL)ACETAMIDO] 3 PHENYLPROPANAMIDE; PEPTIDOMIMETIC AGENT; PYRROLIDINE DERIVATIVE; SCAFFOLD PROTEIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG RESEARCH; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; STRUCTURE ACTIVITY RELATION;

MAGNETIC RESONANCE SPECTROSCOPY; MATRIX METALLOPROTEINASES; MODELS, MOLECULAR; PROTEASE INHIBITORS; QUINOXALINES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 75849116752     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.01.008     Document Type: Article

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